{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:21:47Z","timestamp":1768735307713,"version":"3.49.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.juro.2011.10.022","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T13:39:27Z","timestamp":1323956367000},"page":"438-445","source":"Crossref","is-referenced-by-count":31,"title":["Anti-Angiogenic Effects of the Superantigen Staphylococcal Enterotoxin B and Bacillus Calmette-Gu\u00e9rin Immunotherapy for Nonmuscle Invasive Bladder Cancer"],"prefix":"10.1097","volume":"187","author":[{"given":"Leonardo O.","family":"Reis","sequence":"first","affiliation":[{"name":"Department of Urology, School of Medicine, University of Campinas, Campinas, S\u00e3o Paolo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubirajara","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, University of Campinas, Campinas, S\u00e3o Paolo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanase","family":"Billis","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Campinas, Campinas, S\u00e3o Paolo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria H.A.","family":"Cagnon","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Biology, University of Campinas, Campinas, S\u00e3o Paolo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wagner J.","family":"F\u00e1varo","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Biology, University of Campinas, Campinas, S\u00e3o Paolo, Brazil"},{"name":"Department of Anatomy, Institute of Biosciences, University Estadual Paulista, Botucatu, S\u00e3o Paolo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2011.10.022_bib1","author":"Altekruse"},{"key":"10.1016\/j.juro.2011.10.022_bib2","article-title":"Changing patterns of bladder cancer in the USA: evidence of heterogeneous disease","author":"Zhang","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2011.10.022_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/106689690501300203","article-title":"The 2004 WHO classification of bladder tumors: a summary and commentary","volume":"13","author":"Montironi","year":"2005","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.juro.2011.10.022_bib4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1464-410x.2001.02306.x","article-title":"A systematic review of intravesical bacillus Calmette-Guerin plus transurethral resection versus transurethral resection alone in Ta and T1 bladder cancer","volume":"88","author":"Shelley","year":"2001","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2011.10.022_bib5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/1097-0215(20000915)87:6<844::AID-IJC14>3.0.CO;2-5","article-title":"What are the immunologically active components of bacille Calmette-Gu\u00e9rin in therapy of superficial bladder cancer?","volume":"87","author":"Zlotta","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.juro.2011.10.022_bib6","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1158\/0008-5472.CAN-04-0374","article-title":"Tumor necrosis factor-related apoptosis-inducing ligand: a novel mechanism for Bacillus Calmette-Guerin-induced antitumor activity","volume":"64","author":"Ludwig","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.juro.2011.10.022_bib7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.urolonc.2007.11.031","article-title":"Role of neutrophils in BCG immunotherapy for bladder cancer","volume":"26","author":"Simons","year":"2008","journal-title":"Urol Oncol"},{"key":"10.1016\/j.juro.2011.10.022_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.0300-9475.2004.01404.x","article-title":"Interplay between superantigens and immunoreceptors","volume":"59","author":"Petersson","year":"2004","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.juro.2011.10.022_bib9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ijc.20941","article-title":"Preclinical evaluation of superantigen (Staphylococcal enterotoxin B) in the intravesical immunotherapy of superficial bladder cancer","volume":"115","author":"Perabo","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.juro.2011.10.022_bib10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00345-010-0545-3","article-title":"Evolution on experimental animal model for upper urothelium carcinogenesis","volume":"28","author":"Reis","year":"2010","journal-title":"World J Urol"},{"key":"10.1016\/j.juro.2011.10.022_bib11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/pros.20109","article-title":"The potential value of (Myo)fibroblastic stromal reaction in the diagnosis of prostatic adenocarcinoma","volume":"61","author":"Tomas","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.juro.2011.10.022_bib12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.eururo.2009.04.038","article-title":"An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Gu\u00e9rin for non-muscle-invasive bladder cancer","volume":"56","author":"Malmstr\u00f6m","year":"2009","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2011.10.022_bib13","first-page":"3565","article-title":"Superantigen-activated mononuclear cells induce apoptosis in transitional cell carcinoma","volume":"25","author":"Perabo","year":"2005","journal-title":"Anticancer Res"},{"key":"10.1016\/j.juro.2011.10.022_bib14","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.eururo.2007.04.062","volume":"52","author":"Ojea","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2011.10.022_bib15","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1128\/IAI.66.12.5743-5750.1998","article-title":"Mycobacterial dose defines the Th1\/Th2 nature of the immune response independently of whether immunization is administered by the intravenous, subcutaneous, or intradermal route","volume":"66","author":"Power","year":"1998","journal-title":"Infect Immunol"},{"key":"10.1016\/j.juro.2011.10.022_bib16","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.juro.2007.08.063","article-title":"Bacillus Calmette-Guerin mechanism of action: the role of immunity, apoptosis, necrosis and autophagy","volume":"178","author":"DiPaola","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.10.022_bib17","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/S0022-5347(05)67620-3","article-title":"BCG-induced urinary cytokines inhibit microvascular endothelial cell proliferation","volume":"163","author":"Pavlovich","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.10.022_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0090-4295(98)00188-5","article-title":"Intravesical bacille Calmette-Gu\u00e9rin induces the antiangiogenic chemokine interferon-inducible protein 10","volume":"52","author":"Poppas","year":"1998","journal-title":"Urology"},{"key":"10.1016\/j.juro.2011.10.022_bib19","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0022-5347(05)65752-7","article-title":"Serum levels of vascular endothelial growth factor as a prognostic factor in bladder cancer","volume":"166","author":"Bernardini","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.10.022_bib20","first-page":"1863","article-title":"The prognostic value of angiogenesis and metastasis related genes for progression of transitional cell carcinoma of renal pelvis and ureter","volume":"8","author":"Inoue","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.juro.2011.10.022_bib21","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0090-4295(02)02429-9","article-title":"Serum levels of endostatin and matrix metalloproteinase-9 associated with high stage and grade primary transitional cell carcinoma of the bladder","volume":"61","author":"Guan","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.juro.2011.10.022_bib22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/35036374","article-title":"Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis","volume":"2","author":"Bergers","year":"2000","journal-title":"Nature Cell Biol"},{"key":"10.1016\/j.juro.2011.10.022_bib23","doi-asserted-by":"crossref","first-page":"36288","DOI":"10.1074\/jbc.M201674200","article-title":"Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165","volume":"277","author":"Hashimoto","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.juro.2011.10.022_bib24","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1749-6632.1999.tb07765.x","article-title":"MMPs are IGFBP-degrading proteinases: implications for cell proliferation and tissue growth","volume":"878","author":"Fowlkes","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.juro.2011.10.022_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00295188","article-title":"Characterization of insulin-like growth factor I binding sites in human bladder cancer cell lines","volume":"21","author":"Iwamura","year":"1993","journal-title":"Urol Res"},{"key":"10.1016\/j.juro.2011.10.022_bib26","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.2353\/ajpath.2010.090904","article-title":"The insulin-like growth factor receptor 1 promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin","volume":"176","author":"Metalli","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.juro.2011.10.022_bib27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0022-5347(01)64485-9","article-title":"Prognostic value of Ki-67 for recurrence and progression of superficial bladder cancer","volume":"158","author":"Asakura","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.10.022_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1078-1439(03)00015-2","article-title":"The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression","volume":"22","author":"Yang","year":"2004","journal-title":"Urol Oncol"},{"key":"10.1016\/j.juro.2011.10.022_bib29","first-page":"5281","article-title":"Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer","volume":"57","author":"Crew","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.juro.2011.10.022_bib30","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1111\/j.1464-410X.2007.06931.x","article-title":"The type 1 insulin like growth factor receptor is over-expressed in bladder cancer","volume":"100","author":"Rochester","year":"2007","journal-title":"BJU Int"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711052669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711052669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2011.10.022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T02:22:20Z","timestamp":1651198940000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2011.10.022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1016\/j.juro.2011.10.022"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2011.10.022","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}