{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:46:28Z","timestamp":1793321188548,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.juro.2011.11.116","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T22:17:13Z","timestamp":1329430633000},"page":"1473-1482","source":"Crossref","is-referenced-by-count":79,"title":["Role of Mast Cells in Male Chronic Pelvic Pain"],"prefix":"10.1097","volume":"187","author":[{"given":"Joseph D.","family":"Done","sequence":"first","affiliation":[{"name":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Rudick","sequence":"additional","affiliation":[{"name":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha L.","family":"Quick","sequence":"additional","affiliation":[{"name":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Thumbikat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2011.11.116_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1001\/jama.2010.1913","article-title":"Management of chronic prostatitis\/chronic pelvic pain syndrome: a systematic review and network meta-analysis","volume":"305","author":"Anothaisintawee","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.juro.2011.11.116_bib2","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.4049\/jimmunol.160.9.4561","article-title":"Regulation of human mast cell beta-tryptase: conversion of inactive monomer to active tetramer at acid pH","volume":"160","author":"Ren","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.juro.2011.11.116_bib3","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.176.3.781","article-title":"Macrophage inflammatory protein-1 alpha activates basophils and mast cells","volume":"176","author":"Alam","year":"1992","journal-title":"J Exp Med"},{"key":"10.1016\/j.juro.2011.11.116_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2500\/108854101778148737","article-title":"MCP-1 and RANTES are mediators of acute and chronic inflammation","volume":"22","author":"Conti","year":"2001","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.juro.2011.11.116_bib5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/clin.1997.4427","article-title":"Inflammatory cells and MHC class II antigens expression in prostate during time-course experimental autoimmune prostatitis development","volume":"85","author":"Donadio","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.juro.2011.11.116_bib6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-5347(05)66153-8","article-title":"Cell relationship in a Wistar rat model of spontaneous prostatitis","volume":"166","author":"Keith","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.11.116_bib7","doi-asserted-by":"crossref","first-page":"14881","DOI":"10.1016\/S0021-9258(18)82415-2","article-title":"Mediator release from mast cells by nerve growth factor","volume":"268","author":"Horigome","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.juro.2011.11.116_bib8","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0090-4295(01)01597-7","article-title":"Nerve growth factor and chronic prostatitis\/chronic pelvic pain syndrome","volume":"59","author":"Miller","year":"2002","journal-title":"Urology"},{"key":"10.1016\/j.juro.2011.11.116_bib9","doi-asserted-by":"crossref","first-page":"R1268","DOI":"10.1152\/ajpregu.00836.2007","article-title":"Experimental autoimmune prostatitis induces chronic pelvic pain","volume":"294","author":"Rudick","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.juro.2011.11.116_bib10","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.juro.2008.01.028","article-title":"Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndrome","volume":"179","author":"Desireddi","year":"2008","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.11.116_bib11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1046\/j.1464-410x.2001.02193.x","article-title":"Consensus development of a histopathological classification system for chronic prostatic inflammation","volume":"87","author":"Nickel","year":"2001","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2011.11.116_bib12","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.neuro.29.051605.112929","article-title":"Neurotrophins: mediators and modulators of pain","volume":"29","author":"Pezet","year":"2006","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.juro.2011.11.116_bib13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/01.ju.0000136002.76898.04","article-title":"Mechanisms in prostatitis\/chronic pelvic pain syndrome","volume":"172","author":"Pontari","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.11.116_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0090-4295(99)80329-X","article-title":"Interstitial cystitis: a critique of current concepts with a new proposal for pathologic diagnosis and pathogenesis","volume":"49","author":"Elbadawi","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.juro.2011.11.116_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.urology.2006.08.1109","article-title":"The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis","volume":"69","author":"Sant","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.juro.2011.11.116_bib16","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0022-5347(05)00171-0","article-title":"Tumor necrosis factor promotes differential trafficking of bladder mast cells in neurogenic cystitis","volume":"175","author":"Chen","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.11.116_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000235190","article-title":"Mast cell activation in sterile bladder and prostate inflammation","volume":"92","author":"Theoharides","year":"1990","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.juro.2011.11.116_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000234197","article-title":"The role of mast cells in inflammatory processes: evidence for nerve\/mast cell interactions","volume":"82","author":"Bienenstock","year":"1987","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.juro.2011.11.116_bib19","first-page":"507","article-title":"Mast cell profile in prostatic lesions","volume":"52","author":"Amir","year":"1998","journal-title":"Indian J Med Sci"},{"key":"10.1016\/j.juro.2011.11.116_bib20","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1073\/pnas.91.9.3739","article-title":"Mast cells synthesize, store, and release nerve growth factor","volume":"91","author":"Leon","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.juro.2011.11.116_bib21","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0022-5347(01)61915-3","article-title":"Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients","volume":"161","author":"Okragly","year":"1999","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.11.116_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1464-410X.1995.tb07840.x","article-title":"Elevated mast cell tryptase in the urine of patients with interstitial cystitis","volume":"76","author":"Boucher","year":"1995","journal-title":"Br J Urol"},{"key":"10.1016\/j.juro.2011.11.116_bib23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1464-410X.2010.09716.x","article-title":"Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis\/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment","volume":"108","author":"Watanabe","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2011.11.116_bib24","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/clin.1995.1035","article-title":"Mast cells in accessory glands of experimentally induced prostatitis in male Wistar rats","volume":"74","author":"Rivero","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.juro.2011.11.116_bib25","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/S0022-5347(01)65548-4","article-title":"17 beta-estradiol induced prostatitis in the rat is an autoimmune disease","volume":"156","author":"Seethalakshmi","year":"1996","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.11.116_bib26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2005.12.001","article-title":"Novel class of pain drugs based on antagonism of NGF","volume":"27","author":"Hefti","year":"2006","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.juro.2011.11.116_bib27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/bja\/83.3.442","article-title":"Inflammation of the rat urinary bladder is associated with a referred thermal hyperalgesia which is nerve growth factor dependent","volume":"83","author":"Jaggar","year":"1999","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.juro.2011.11.116_bib28","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.juro.2010.12.088","article-title":"Proof of concept trial of tanezumab for the treatment of symptoms associated with interstitial cystitis","volume":"185","author":"Evans","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2011.11.116_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2490-9-16","article-title":"Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis","volume":"9","author":"Rudick","year":"2009","journal-title":"BMC Urol"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711057946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534711057946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2011.11.116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T15:42:43Z","timestamp":1686757363000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2011.11.116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1016\/j.juro.2011.11.116"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2011.11.116","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}