{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:14:43Z","timestamp":1791234883867,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.juro.2012.08.198","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T09:45:46Z","timestamp":1349689546000},"page":"762-768","source":"Crossref","is-referenced-by-count":40,"title":["Molecular Analysis of Erection Regulatory Factors in Sickle Cell Disease Associated Priapism in the Human Penis"],"prefix":"10.1097","volume":"189","author":[{"given":"Gwen","family":"Lagoda","sequence":"first","affiliation":[{"name":"Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena F.","family":"Sezen","sequence":"additional","affiliation":[{"name":"Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo R.","family":"Cabrini","sequence":"additional","affiliation":[{"name":"Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Musicki","sequence":"additional","affiliation":[{"name":"Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur L.","family":"Burnett","sequence":"additional","affiliation":[{"name":"Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2012.08.198_bib1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/jcp.22195","article-title":"Sickle cell anemia and vascular dysfunction: the nitric oxide connection","volume":"224","author":"Akinsheye","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.juro.2012.08.198_bib2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/ajh.21475","article-title":"Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions","volume":"84","author":"Kato","year":"2009","journal-title":"Am J Hematol"},{"key":"10.1016\/j.juro.2012.08.198_bib3","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1440-1681.2007.04639.x","article-title":"Sickle cell disease: role of reactive oxygen and nitrogen metabolites","volume":"34","author":"Wood","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.juro.2012.08.198_bib4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1743-6109.2009.01625.x","article-title":"Priapism: pathogenesis, epidemiology, and management","volume":"7","author":"Broderick","year":"2010","journal-title":"J Sex Med"},{"key":"10.1016\/j.juro.2012.08.198_bib5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0090-4295(99)80059-4","article-title":"Evaluation of erectile function in men with sickle cell disease","volume":"45","author":"Burnett","year":"1995","journal-title":"Urology"},{"key":"10.1016\/j.juro.2012.08.198_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1743-6109.2011.02411.x","article-title":"Sexual health outcomes improvement in sickle cell disease: a matter of health policy?","volume":"9","author":"Burnett","year":"2012","journal-title":"J Sex Med"},{"key":"10.1016\/j.juro.2012.08.198_bib7","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1046\/j.1464-410X.2002.03022.x","article-title":"Priapism in sickle-cell disease; incidence, risk factors and complications\u2014an international multicentre study","volume":"90","author":"Adeyoju","year":"2002","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2012.08.198_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/01.ju.0000046303.22757.f2","article-title":"Pathophysiology of priapism: dysregulatory erection physiology thesis","volume":"170","author":"Burnett","year":"2003","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2012.08.198_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1743-6109.2011.02288.x","article-title":"New insights into the pathophysiology of sickle cell disease-associated priapism","volume":"9","author":"Bivalacqua","year":"2012","journal-title":"J Sex Med"},{"key":"10.1016\/j.juro.2012.08.198_bib10","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1111\/j.1743-6109.2009.01359.x","article-title":"Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism","volume":"6","author":"Bivalacqua","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.juro.2012.08.198_bib11","doi-asserted-by":"crossref","first-page":"510.e7","DOI":"10.1016\/j.urology.2010.02.050","article-title":"Attenuated RhoA\/Rho-kinase signaling in penis of transgenic sickle cell mice","volume":"76","author":"Bivalacqua","year":"2010","journal-title":"Urology"},{"key":"10.1016\/j.juro.2012.08.198_bib12","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1073\/pnas.0407183102","article-title":"Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism","volume":"102","author":"Champion","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.juro.2012.08.198_bib13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ijir.2010.27","article-title":"Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue","volume":"22","author":"Kanika","year":"2010","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.juro.2012.08.198_bib14","doi-asserted-by":"crossref","first-page":"C916","DOI":"10.1152\/ajpcell.00656.2008","article-title":"The mechanism of opiorphin-induced experimental priapism in rats involves activation of the polyamine synthetic pathway","volume":"297","author":"Kanika","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"suppl.","key":"10.1016\/j.juro.2012.08.198_bib15","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1743-6109.2008.01187.x","article-title":"Adenosine signaling, priapism and novel therapies","volume":"6","author":"Dai","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.juro.2012.08.198_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/j.1743-6109.2012.02798.x","article-title":"Targeting NADPH oxidase decreases oxidative stress in the transgenic sickle cell mouse penis","author":"Musicki","year":"2012","journal-title":"J Sex Med"},{"key":"10.1016\/j.juro.2012.08.198_bib17","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S0022-5347(05)67329-6","article-title":"Cholinergic nerves in human corpus cavernosum and spongiosum contain nitric oxide synthase and heme oxygenase","volume":"164","author":"Hedlund","year":"2000","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2012.08.198_bib18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1124\/mol.104.010678","article-title":"Erection capability is potentiated by long-term sildenafil treatment: role of blood flow-induced endothelial nitric-oxide synthase phosphorylation","volume":"68","author":"Musicki","year":"2005","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.juro.2012.08.198_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1295\/polymj.PJ2008335","article-title":"Preparation and properties of polyamines: part II-controlled and sustained release of nitric oxide (NO) from nitrosated polymers","volume":"41","author":"Wang","year":"2009","journal-title":"Polymer J"},{"key":"10.1016\/j.juro.2012.08.198_bib20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1743-6109.2010.02123.x","article-title":"Post-translational inactivation of endothelial nitric oxide synthase in the transgenic sickle cell mouse penis","volume":"8","author":"Musicki","year":"2011","journal-title":"J Sex Med"},{"key":"10.1016\/j.juro.2012.08.198_bib21","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/j.1939-4640.2002.tb02601.x","article-title":"Noncholinergic penile erection in mice lacking the gene for endothelial nitric oxide synthase","volume":"23","author":"Burnett","year":"2002","journal-title":"J Androl"},{"key":"10.1016\/j.juro.2012.08.198_bib22","doi-asserted-by":"crossref","first-page":"15215","DOI":"10.1073\/pnas.221292098","article-title":"Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease","volume":"98","author":"Aslan","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.juro.2012.08.198_bib23","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.freeradbiomed.2008.01.008","article-title":"Sickle cell disease vasculopathy: a state of nitric oxide resistance","volume":"44","author":"Wood","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.juro.2012.08.198_bib24","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/j.1365-2141.1995.tb05397.x","article-title":"The metabolites of nitric oxide in sickle-cell disease","volume":"91","author":"Rees","year":"1995","journal-title":"Br J Haematol"},{"key":"10.1016\/j.juro.2012.08.198_bib25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/83258","article-title":"Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway","volume":"7","author":"Chitaley","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.juro.2012.08.198_bib26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2164\/jandrol.108.006999","article-title":"Posttranslational modification of constitutive nitric oxide synthase in the penis","volume":"30","author":"Musicki","year":"2009","journal-title":"J Androl"},{"key":"10.1016\/j.juro.2012.08.198_bib27","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.eururo.2006.10.061","article-title":"Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis","volume":"51","author":"Bivalacqua","year":"2007","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2012.08.198_bib28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0014-5793(96)00811-3","article-title":"ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine\/threonine kinase in mice","volume":"392","author":"Nakagawa","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.juro.2012.08.198_bib29","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1096\/fj.04-3218fje","article-title":"Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice","volume":"19","author":"Wood","year":"2005","journal-title":"FASEB J"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712048811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712048811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2012.08.198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:02:08Z","timestamp":1651201328000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2012.08.198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1016\/j.juro.2012.08.198"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2012.08.198","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}