{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:01:56Z","timestamp":1790240516903,"version":"4.1.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.juro.2012.11.165","type":"journal-article","created":{"date-parts":[[2012,12,8]],"date-time":"2012-12-08T05:08:23Z","timestamp":1354943303000},"page":"2364-2370","source":"Crossref","is-referenced-by-count":22,"title":["Spinal Cord FAAH in Normal Micturition Control and Bladder Overactivity in Awake Rats"],"prefix":"10.1097","volume":"189","author":[{"given":"Claudius","family":"F\u00fcllhase","sequence":"first","affiliation":[{"name":"Department of Urology, Ludwig-Maximilians-Universitat, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Russo","sequence":"additional","affiliation":[{"name":"Urological Research Institute, San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Castiglione","sequence":"additional","affiliation":[{"name":"Urological Research Institute, San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Benigni","sequence":"additional","affiliation":[{"name":"Urological Research Institute, San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lysanne","family":"Campeau","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montorsi","sequence":"additional","affiliation":[{"name":"Urological Research Institute, San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gratzke","sequence":"additional","affiliation":[{"name":"Department of Urology, Ludwig-Maximilians-Universitat, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Bettiga","sequence":"additional","affiliation":[{"name":"Urological Research Institute, San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stief","sequence":"additional","affiliation":[{"name":"Department of Urology, Ludwig-Maximilians-Universitat, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Erik","family":"Andersson","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petter","family":"Hedlund","sequence":"additional","affiliation":[{"name":"Urological Research Institute, San Raffaele University, Milan, Italy"},{"name":"Departments of Clinical and Experimental Pharmacology, Lund University, Lund and Clinical Pharmacology, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2012.11.165_bib1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/3-540-26573-2_2","article-title":"Cannabinoid receptor signaling","volume":"168","author":"Howlett","year":"2005","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.juro.2012.11.165_bib2","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1111\/j.1476-5381.1996.tb15643.x","article-title":"Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder","volume":"118","author":"Pertwee","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.juro.2012.11.165_bib3","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.urology.2008.03.044","article-title":"Functional and immunohistochemical characterization of CB1 and CB2 receptors in rat bladder","volume":"72","author":"Hayn","year":"2008","journal-title":"Urology"},{"key":"10.1016\/j.juro.2012.11.165_bib4","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.juro.2008.11.078","article-title":"Differential expression of functional cannabinoid receptors in human bladder detrusor and urothelium","volume":"181","author":"Tyagi","year":"2009","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2012.11.165_bib5","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.juro.2008.11.079","article-title":"Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder","volume":"181","author":"Gratzke","year":"2009","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2012.11.165_bib6","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1177\/1352458510378020","article-title":"Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis","volume":"16","author":"Kavia","year":"2010","journal-title":"Mult Scler"},{"key":"10.1016\/j.juro.2012.11.165_bib7","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1007\/s00192-006-0086-x","article-title":"The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS)","volume":"17","author":"Freeman","year":"2006","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"10.1016\/j.juro.2012.11.165_bib8","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.1523\/JNEUROSCI.22-16-07147.2002","article-title":"Contrasting effects of WIN 55212\u20132 on motility of the rat bladder and uterus","volume":"22","author":"Dmitrieva","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.juro.2012.11.165_bib9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.urology.2007.02.069","article-title":"Effects of IP-751, ajulemic acid, on bladder overactivity induced by bladder irritation in rats","volume":"70","author":"Hiragata","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.juro.2012.11.165_bib10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.juro.2010.09.080","article-title":"Cannabinor, a selective cannabinoid-2 receptor agonist, improves bladder emptying in rats with partial urethral obstruction","volume":"185","author":"Gratzke","year":"2011","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2012.11.165_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.eururo.2011.09.025","article-title":"Taming the cannabinoids: new potential in the pharmacologic control of lower urinary tract dysfunction","volume":"61","author":"Apostolidis","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2012.11.165_bib12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nrd3673","article-title":"Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain","volume":"11","author":"Roques","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.juro.2012.11.165_bib13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.biochem.74.082803.133450","article-title":"Structure and function of fatty acid amide hydrolase","volume":"74","author":"McKinney","year":"2005","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.juro.2012.11.165_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.eururo.2011.09.002","article-title":"Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats","volume":"61","author":"Strittmatter","year":"2012","journal-title":"Eur Urol"},{"issue":"suppl.","key":"10.1016\/j.juro.2012.11.165_bib15","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1016\/j.juro.2012.02.068","article-title":"The fatty acid amide hydrolase inhibitor oleoyl ethyl amide increases bladder storage capacity and reduces detrusor overactivity in rats","volume":"187","author":"Gandaglia","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2012.11.165_bib16","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1523\/JNEUROSCI.4071-08.2009","article-title":"Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury","volume":"29","author":"Lever","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.juro.2012.11.165_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0169-328X(02)00167-5","article-title":"Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study","volume":"100","author":"Romero","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1016\/j.juro.2012.11.165_bib18","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1111\/j.1464-410X.2010.09583.x","article-title":"Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation","volume":"108","author":"Merriam","year":"2011","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2012.11.165_bib19","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.urology.2005.06.070","article-title":"Evaluation of two techniques of partial urethral obstruction in the male rat model of bladder outlet obstruction","volume":"66","author":"Melman","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.juro.2012.11.165_bib20","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0022-5347(17)44485-5","article-title":"Cystometrical evaluation of bladder instability in rats with infravesical outflow obstruction","volume":"137","author":"Malmgren","year":"1987","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2012.11.165_bib21","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0031-9384(76)90029-9","article-title":"Chronic catheterization of the spinal subarachnoid space","volume":"17","author":"Yaksh","year":"1976","journal-title":"Physiol Behav"},{"issue":"suppl.","key":"10.1016\/j.juro.2012.11.165_bib22","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1038\/sj.bjp.0706604","article-title":"Integrative control of the lower urinary tract: preclinical perspective","volume":"147","author":"de Groat","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.juro.2012.11.165_bib23","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/nau.21108","article-title":"Rodent models for urodynamic investigation","volume":"30","author":"Andersson","year":"2011","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.juro.2012.11.165_bib24","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1476-5381.2008.00029.x","article-title":"The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1","volume":"156","author":"Fowler","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.juro.2012.11.165_bib25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1464-410X.2009.09008.x","article-title":"Urodynamic evaluation of fesoterodine metabolite, doxazosin and their combination in a rat model of partial urethral obstruction","volume":"106","author":"F\u00fcllhase","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2012.11.165_bib26","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.juro.2006.11.070","article-title":"Urodynamic effects of a novel EP(1) receptor antagonist in normal rats and rats with bladder outlet obstruction","volume":"177","author":"Lee","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2012.11.165_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0304-3940(98)00621-1","article-title":"The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder","volume":"253","author":"Jaggar","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.juro.2012.11.165_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1744-8069-7-31","article-title":"Local activation of cannabinoid CB receptors in the urinary bladder reduces the inflammation-induced sensitization of bladder afferents","volume":"7","author":"Walczak","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.juro.2012.11.165_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0304-3959(03)00242-2","article-title":"Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats","volume":"105","author":"Lim","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.juro.2012.11.165_bib30","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1476-5381.2010.01046.x","article-title":"Central and peripheral sites of action for CB(2) receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats","volume":"162","author":"Hsieh","year":"2011","journal-title":"Br J Pharmacol"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712057977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534712057977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2012.11.165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T02:50:00Z","timestamp":1651200600000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2012.11.165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1016\/j.juro.2012.11.165"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2012.11.165","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}