{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:33:02Z","timestamp":1793572382497,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.juro.2013.09.058","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T17:31:10Z","timestamp":1380648670000},"page":"783-789","source":"Crossref","is-referenced-by-count":123,"title":["Population Based Nationwide Study of Hypospadias in Sweden, 1973 to 2009: Incidence and Risk Factors"],"prefix":"10.1097","volume":"191","author":[{"given":"Anna Skarin","family":"Nordenvall","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health, Pediatric Surgery Unit and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Fris\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nordenstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"Pediatric Endocrinology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agneta","family":"Nordenskj\u00f6ld","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Pediatric Surgery Unit and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"Pediatric Surgery, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2013.09.058_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jpedsurg.2005.11.059","article-title":"Hypospadias: anatomy, etiology, and technique","volume":"41","author":"Baskin","year":"2006","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.juro.2013.09.058_bib2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1542\/peds.100.5.831","article-title":"Hypospadias trends in two US surveillance systems","volume":"100","author":"Paulozzi","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.juro.2013.09.058_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1289\/ehp.99107297","article-title":"International trends in rates of hypospadias and cryptorchidism","volume":"107","author":"Paulozzi","year":"1999","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.juro.2013.09.058_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/bdra.23021","article-title":"Environmental and genetic contributors to hypospadias: a review of the epidemiologic evidence","volume":"94","author":"Carmichael","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.juro.2013.09.058_bib5","doi-asserted-by":"crossref","unstructured":"Loane M, Dolk H, Kelly A et\u00a0al: Paper 4: EUROCAT\u00a0statistical monitoring: identification and investigation of ten year trends of congenital anomalies in Europe. Birth Defects Res A Clin Mol Teratol, suppl., 2011; 91: S31.","DOI":"10.1002\/bdra.20778"},{"key":"10.1016\/j.juro.2013.09.058_bib6","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0022-5347(05)65334-7","article-title":"Heredity of hypospadias and the significance of low birth weight","volume":"167","author":"Fredell","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2013.09.058_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1399-0004.1976.tb01576.x","article-title":"Hypospadias in successive generations\u2014possible dominant gene inheritance","volume":"9","author":"Lowry","year":"1976","journal-title":"Clin Genet"},{"key":"10.1016\/j.juro.2013.09.058_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ajmg.1320210108","article-title":"Uncomplicated familial hypospadias: evidence for autosomal recessive inheritance","volume":"21","author":"Frydman","year":"1985","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.juro.2013.09.058_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0303-7207(01)00466-X","article-title":"Molecular basis of androgen insensitivity","volume":"179","author":"Brinkmann","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.juro.2013.09.058_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ucl.2010.03.010","article-title":"Hypospadias: etiology and current research","volume":"37","author":"Kalfa","year":"2010","journal-title":"Urol Clin North Am"},{"key":"10.1016\/j.juro.2013.09.058_bib11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/jmg.27.9.559","article-title":"Genetic and environmental factors in hypospadias","volume":"27","author":"Stoll","year":"1990","journal-title":"J Med Genet"},{"key":"10.1016\/j.juro.2013.09.058_bib12","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0022-5347(01)62294-8","article-title":"Hypospadias is related to birth weight in discordant monozygotic twins","volume":"160","author":"Fredell","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2013.09.058_bib13","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1289\/ehp.7243","article-title":"Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborn boys","volume":"112","author":"Pierik","year":"2004","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.juro.2013.09.058_bib14","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1289\/ehp.10791","article-title":"Maternal and gestational risk factors for hypospadias","volume":"116","author":"Akre","year":"2008","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.juro.2013.09.058_bib15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/bdra.20620","article-title":"Maternal obesity and morbid obesity: the risk for birth defects in the offspring","volume":"88","author":"Blomberg","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.juro.2013.09.058_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/bdra.20645","article-title":"Congenital malformations in infants born after in\u00a0vitro fertilization in Sweden","volume":"88","author":"Kallen","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.juro.2013.09.058_bib17","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/humupd\/dms002","article-title":"Aetiology of hypospadias: a systematic review of genes and environment","volume":"18","author":"van der Zanden","year":"2012","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.juro.2013.09.058_bib18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/1471-2458-11-450","article-title":"External review and validation of the Swedish National Inpatient Register","volume":"11","author":"Ludvigsson","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.juro.2013.09.058_bib19","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0022-5347(05)66578-0","article-title":"Maternal age as a risk factor for hypospadias","volume":"165","author":"Fisch","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2013.09.058_bib20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/archpedi.161.8.745","article-title":"Prepregnancy obesity as a risk factor for structural birth defects","volume":"161","author":"Waller","year":"2007","journal-title":"Arch Pediatr Adolesc Med"},{"key":"10.1016\/j.juro.2013.09.058_bib21","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/00001648-199907000-00005","article-title":"Risk\u00a0factor patterns for cryptorchidism and hypospadias","volume":"10","author":"Akre","year":"1999","journal-title":"Epidemiology"},{"key":"10.1016\/j.juro.2013.09.058_bib22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-3016.2007.00809.x","article-title":"Maternal reproductive and demographic characteristics as risk factors for hypospadias","volume":"21","author":"Carmichael","year":"2007","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.juro.2013.09.058_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/humrep\/deh592","article-title":"A\u00a0multi-centre cohort study of the physical health of 5-year-old children conceived after\u00a0intracytoplasmic sperm injection, in\u00a0vitro fertilization and natural conception","volume":"20","author":"Bonduelle","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.juro.2013.09.058_bib24","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.earlhumdev.2010.06.015","article-title":"Male reproductive tract abnormalities: more common after assisted reproduction?","volume":"86","author":"Funke","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.juro.2013.09.058_bib25","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1093\/clinchem\/41.12.1896","article-title":"Do environmental estrogens contribute to the decline in male reproductive health?","volume":"41","author":"Jensen","year":"1995","journal-title":"Clin Chem"},{"key":"10.1016\/j.juro.2013.09.058_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/EDE.0b013e3181c15a50","article-title":"Familial\u00a0coaggregation of cryptorchidism and hypospadias","volume":"21","author":"Schnack","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.juro.2013.09.058_bib27","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/toxsci\/58.2.350","article-title":"Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat","volume":"58","author":"Gray","year":"2000","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.juro.2013.09.058_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1365-2605.2005.00563.x","article-title":"Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters","volume":"29","author":"Foster","year":"2006","journal-title":"Int J Androl"},{"key":"10.1016\/j.juro.2013.09.058_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2605.2009.01019.x","article-title":"Prenatal phthalate exposure and reduced masculine play in boys","volume":"33","author":"Swan","year":"2010","journal-title":"Int J Androl"},{"key":"10.1016\/j.juro.2013.09.058_bib30","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.juro.2012.08.007","article-title":"Epidemiological assessment of hypospadias by degree of severity","volume":"188","author":"Canon","year":"2012","journal-title":"J Urol"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534713055572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534713055572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2013.09.058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T10:06:59Z","timestamp":1716026819000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2013.09.058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1016\/j.juro.2013.09.058"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2013.09.058","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}