{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:00:00Z","timestamp":1784030400876,"version":"3.55.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.juro.2014.03.092","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T17:50:18Z","timestamp":1395769818000},"page":"600-606","source":"Crossref","is-referenced-by-count":11,"title":["Immunomodulatory Intervention with Interferon-\u03b3 in Escherichia coli Pyelonephritis"],"prefix":"10.1097","volume":"192","author":[{"given":"Matthew P.","family":"Katsaris","sequence":"first","affiliation":[{"name":"2nd Department of Urology, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Adamis","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Pistiki","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionyssia-Pinelopi","family":"Carrer","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Galani","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Labros","family":"Sabracos","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionyssia-Irini","family":"Droggiti","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Georgitsi","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Damoraki","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos J.","family":"Giamarellos-Bourboulis","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chrisofos","sequence":"additional","affiliation":[{"name":"2nd Department of Urology, University of Athens Medical School, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2014.03.092_bib1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1517\/14728214.2012.697151","article-title":"Emerging drugs for the treatment of sepsis","volume":"17","author":"Kotsaki","year":"2012","journal-title":"Expert Opin Emerg Drugs"},{"key":"10.1016\/j.juro.2014.03.092_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nri2402","article-title":"Harmful\u00a0molecular mechanisms in sepsis","volume":"8","author":"Rittirsch","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.juro.2014.03.092_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-\u03b3: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.juro.2014.03.092_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mpat.1993.1062","article-title":"pap, papG and prsG DNA sequences in Escherichia coli from the fecal flora and the urinary tract","volume":"15","author":"Johanson","year":"1993","journal-title":"Microb Pathog"},{"key":"10.1016\/j.juro.2014.03.092_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1086\/513824","article-title":"papG alleles of Escherichia coli strains causing first episode or recurrent acute cystitis in adult women","volume":"177","author":"Johnson","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.juro.2014.03.092_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/00365540510026832","article-title":"Clarithromycin: immunomodulatory therapy of experimental sepsis and acute pyelonephritis by Escherichia coli","volume":"37","author":"Giamarellos-Bourboulis","year":"2005","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.juro.2014.03.092_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijantimicag.2004.08.018","article-title":"Clarithromycin co-administered with amikacin attenuates systemic inflammation in experimental sepsis with Escherichia coli","volume":"25","author":"Giamarellos-Bourboulis","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.juro.2014.03.092_bib8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/jac\/dkl084","article-title":"Clarithromycin is an effective immunomodulator in experimental pyelonephritis caused by pan-resistant Klebsiella pneumoniae","volume":"57","author":"Giamarellos-Bourboulis","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.juro.2014.03.092_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1128\/AAC.48.1.93-99.2004","article-title":"Immunomodulatory clarithromycin treatment of experimental sepsis and acute pyelonephritis caused by multidrug-resistant Pseudomonas aeruginosa","volume":"48","author":"Giamarellos-Bourboulis","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.juro.2014.03.092_bib10","doi-asserted-by":"crossref","first-page":"e36446","DOI":"10.1371\/journal.pone.0036446","article-title":"Quantitative RT-PCR profiling of the rabbit immune response: assessment of acute Shigella flexneri infection","volume":"7","author":"Schnupf","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.juro.2014.03.092_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1570-0232(02)00273-8","article-title":"Rapid fluorometric-liquid chromatographic determination of malondialdehyde in biological samples","volume":"775","author":"Agarwal","year":"2002","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.juro.2014.03.092_bib12","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/SHK.0b013e31824b1793","article-title":"Time profile of oxidative stress and neutrophil activation in ovine acute lung injury and sepsis","volume":"37","author":"Lange","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.juro.2014.03.092_bib13","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/j.1538-7836.2010.03931.x","article-title":"Characterization of canine coagulation factor VII\u00a0and its complex formation with tissue factor:\u00a0canine-human cross-species compatibility","volume":"8","author":"Knudsen","year":"2010","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.juro.2014.03.092_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/jir.1989.9.275","article-title":"Significant differences in therapeutic responses to a\u00a0human interferon-alpha B\/D hybrid in Rauscher or Friend murine leukemia virus infections","volume":"9","author":"Gangemi","year":"1989","journal-title":"J\u00a0Interferon Res"},{"key":"10.1016\/j.juro.2014.03.092_bib15","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1128\/AAC.05798-11","article-title":"Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study","volume":"56","author":"Spyridaki","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.juro.2014.03.092_bib16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1001\/archinte.1997.00440250031004","article-title":"Interferon gamma-1b in the treatment of compensatory anti-inflammatory response syndrome","volume":"157","author":"Kox","year":"1997","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.juro.2014.03.092_bib17","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1164\/rccm.201204-0645OC","article-title":"Reversal of\u00a0immunoparalysis in humans in\u00a0vivo: a double-blind, placebo-controlled, randomized pilot study","volume":"186","author":"Leentjens","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.juro.2014.03.092_bib18","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/cc10513","article-title":"mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance","volume":"15","author":"Turrel-Davin","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.juro.2014.03.092_bib19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/01.shk.0000226343.70904.4f","article-title":"Bacterial clearance and mortality are not improved by a combination of IL-10 neutralization and IFN-gamma administration in a murine model of post-CLP immunosuppression","volume":"26","author":"Murphey","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.juro.2014.03.092_bib20","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.1128\/IAI.72.12.6892-6901.2004","article-title":"Gamma interferon does not enhance clearance of Pseudomonas aeruginosa but does amplify a proinflammatory response in a murine model of postseptic immunosuppression","volume":"72","author":"Murphey","year":"2004","journal-title":"Infect Immun"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534714030432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534714030432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2014.03.092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:28:09Z","timestamp":1651202889000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2014.03.092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1016\/j.juro.2014.03.092"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2014.03.092","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}