{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:18:06Z","timestamp":1767835086186,"version":"3.49.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.juro.2015.03.076","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T16:42:09Z","timestamp":1427301729000},"page":"1155-1161","source":"Crossref","is-referenced-by-count":7,"title":["Anatomical Targeting Improves Delivery of Unconjugated Nanoparticles to the Testicle"],"prefix":"10.1097","volume":"194","author":[{"given":"Devon C.","family":"Snow-Lisy","sequence":"first","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio"},{"name":"Department of Biomedical Engineering, Lerner Research Institute (VL), Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund S.","family":"Sabanegh","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio"},{"name":"Department of Biomedical Engineering, Lerner Research Institute (VL), Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary K.","family":"Samplaski","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio"},{"name":"Department of Biomedical Engineering, Lerner Research Institute (VL), Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Labhasetwar","sequence":"additional","affiliation":[{"name":"Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio"},{"name":"Department of Biomedical Engineering, Lerner Research Institute (VL), Cleveland Clinic, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2015.03.076_bib1","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1096\/fj.08-116947","article-title":"Nanoparticle-mediated delivery of superoxide dismutase to\u00a0the brain: an effective strategy to reduce ischemia-reperfusion injury","volume":"23","author":"Reddy","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.juro.2015.03.076_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s13346-011-0039-x","article-title":"Drug delivery to the testis: current status and potential pathways for the development of novel therapeutics","volume":"1","author":"Snow-Lisy","year":"2011","journal-title":"Drug Del Transl Res"},{"key":"10.1016\/j.juro.2015.03.076_bib3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.fertnstert.2012.05.034","article-title":"A\u00a0comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury","volume":"98","author":"Turkmen","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.juro.2015.03.076_bib4","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1095\/biolreprod59.5.1037","article-title":"Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa","volume":"59","author":"Aitken","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1016\/j.juro.2015.03.076_bib5","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.fertnstert.2009.12.030","article-title":"Semen characteristics and sperm DNA fragmentation in infertile men with low and high levels of seminal reactive oxygen species","volume":"94","author":"Mahfouz","year":"2010","journal-title":"Fertil Steril"},{"key":"10.1016\/j.juro.2015.03.076_bib6","doi-asserted-by":"crossref","first-page":"466 e9","DOI":"10.1016\/j.urology.2012.09.021","article-title":"Involvement of reactive oxygen species and TATA box-binding protein-related factor 2 in testicular torsion\/detorsion-induced injury","volume":"81","author":"Wei","year":"2013","journal-title":"Urology"},{"key":"10.1016\/j.juro.2015.03.076_bib7","doi-asserted-by":"crossref","first-page":"e93334","DOI":"10.1371\/journal.pone.0093334","article-title":"Neuroprotective effect of TAT-14-3-3epsilon fusion protein against cerebral ischemia\/reperfusion injury in rats","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.juro.2015.03.076_bib8","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/dvdy.22261","article-title":"Differential time course of FSH\/FSH receptor complex endocytosis within Sertoli and germ cells during rat testis development","volume":"239","author":"Segretain","year":"2010","journal-title":"Dev Dyn"},{"key":"10.1016\/j.juro.2015.03.076_bib9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.fertnstert.2013.10.034","article-title":"Superoxide dismutase-loaded biodegradable nanoparticles targeted with a follicle-stimulating hormone peptide protect Sertoli cells from oxidative stress","volume":"101","author":"Snow-Lisy","year":"2014","journal-title":"Fertil Steril"},{"key":"10.1016\/j.juro.2015.03.076_bib10","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/aid.2010.0295","article-title":"Efficacy of Tat-conjugated ritonavir-loaded nanoparticles in reducing HIV-1 replication in monocyte-derived macrophages and cytocompatibility with macrophages and human neurons","volume":"27","author":"Borgmann","year":"2011","journal-title":"AIDS Res Hum Retroviruses"},{"key":"10.1016\/j.juro.2015.03.076_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0378-5173(01)00923-1","article-title":"Characterization of nanoparticle uptake by endothelial cells","volume":"233","author":"Davda","year":"2002","journal-title":"Int J Pharm"},{"key":"10.1016\/j.juro.2015.03.076_bib12","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/S0142-9612(00)00115-0","article-title":"The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices","volume":"21","author":"Jain","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.juro.2015.03.076_bib13","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.juro.2012.02.017","article-title":"Comparative analysis of detorsion alone versus detorsion and tunica albuginea decompression (fasciotomy) with tunica vaginalis flap coverage in the surgical management of prolonged testicular ischemia","volume":"188","author":"Figueroa","year":"2012","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2015.03.076_bib14","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.addr.2004.02.014","article-title":"Nanoparticle and targeted systems for cancer therapy","volume":"56","author":"Brannon-Peppas","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.juro.2015.03.076_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biolcel.2003.11.008","article-title":"Receptor-mediated transcytosis of follicle-stimulating hormone through the rat testicular microvasculature","volume":"96","author":"Vu Hai","year":"2004","journal-title":"Biol Cell"},{"key":"10.1016\/j.juro.2015.03.076_bib16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nature03206","article-title":"Structure of human follicle-stimulating hormone in complex with its receptor","volume":"433","author":"Fan","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.juro.2015.03.076_bib17","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1095\/biolreprod58.3.821","article-title":"In\u00a0vivo effects of human follicle-stimulating hormone-related synthetic peptide hFSH-beta-(81-95) and its subdomain hFSH-beta-(90-95) on\u00a0the mouse estrous cycle","volume":"58","author":"Grasso","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1016\/j.juro.2015.03.076_bib18","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1016\/j.biomaterials.2010.01.065","article-title":"Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles","volume":"31","author":"He","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.juro.2015.03.076_bib19","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1021\/js980021f","article-title":"Arterial uptake of biodegradable nanoparticles: effect of surface modifications","volume":"87","author":"Labhasetwar","year":"1998","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.juro.2015.03.076_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/path.1711600111","article-title":"The blood-testis barrier in experimental unilateral cryptorchidism","volume":"160","author":"Stewart","year":"1990","journal-title":"J Pathol"},{"key":"10.1016\/j.juro.2015.03.076_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/01913129609016317","article-title":"The\u00a0human blood-testis barrier in impaired spermatogenesis","volume":"20","author":"Cavicchia","year":"1996","journal-title":"Ultrastruct Pathol"},{"key":"10.1016\/j.juro.2015.03.076_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s004410050678","article-title":"Capillaries in the lamina propria of human seminiferous tubules are partly fenestrated","volume":"286","author":"Ergun","year":"1996","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.juro.2015.03.076_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF00305816","article-title":"Dye permeability and alkaline phosphatase activity of testicular capillaries in the postnatal rat","volume":"9","author":"Kormano","year":"1967","journal-title":"Histochemie"},{"key":"10.1016\/j.juro.2015.03.076_bib24","doi-asserted-by":"crossref","first-page":"C1708","DOI":"10.1152\/ajpcell.1998.274.6.C1708","article-title":"Occludin is concentrated at tight junctions of mouse\/rat but not human\/guinea pig Sertoli cells in testes","volume":"274","author":"Moroi","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.juro.2015.03.076_bib25","series-title":"Molecular Mechanisms in Spermatogenesis","first-page":"212","article-title":"Blood-testis barrier, junctional and transport proteins and spermatogenesis","author":"Setchell","year":"2008"},{"key":"10.1016\/j.juro.2015.03.076_bib26","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.fertnstert.2007.03.057","article-title":"Semen quality and oxidative stress scores in fertile and infertile patients with varicocele","volume":"89","author":"Pasqualotto","year":"2008","journal-title":"Fertil Steril"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002253471503373X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002253471503373X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2015.03.076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:57:00Z","timestamp":1651204620000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2015.03.076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1016\/j.juro.2015.03.076"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2015.03.076","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}