{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:40:23Z","timestamp":1761597623563},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.juro.2015.07.088","type":"journal-article","created":{"date-parts":[[2015,7,26]],"date-time":"2015-07-26T14:38:49Z","timestamp":1437921529000},"page":"1777-1786","source":"Crossref","is-referenced-by-count":18,"title":["Target Inhibition of IL-1 Receptor Prevents Ifosfamide Induced Hemorrhagic Cystitis in Mice"],"prefix":"10.1097","volume":"194","author":[{"given":"Caio A.V.G.","family":"Leite","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"},{"name":"Department of Clinical Oncology, Haroldo Jua\u00e7aba Hospital, Cancer Institute of Cear\u00e1, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane T.L.","family":"Alencar","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davi L.R.","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.S.C.","family":"Mota","sequence":"additional","affiliation":[{"name":"Department of Clinics, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo H.","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia T.C.","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deysi V.T.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro J.C.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arm\u00eanio A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerly A.C.","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Morphology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto C.P.","family":"Lima-J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Q.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronaldo A.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Cear\u00e1, S\u00e3o Paulo, Brazil"},{"name":"Department of Clinical Oncology, Haroldo Jua\u00e7aba Hospital, Cancer Institute of Cear\u00e1, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2015.07.088_bib1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1200\/JCO.1987.5.5.799","article-title":"The efficacy of mesna (2-mercaptoethane sodium sulfonate) as an uroprotectant in patients with hemorrhagic cystitis receiving further oxazaphosphorine chemotherapy","volume":"5","author":"Andriole","year":"1987","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.juro.2015.07.088_bib2","unstructured":"Moy B: Cystitis in patients with cancer. UpToDate\u00ae, Version 23.1. Available at http:\/\/www.uptodate.com\/contents\/cystitis-in-patients-with-cancer. Accessed February 9, 2015."},{"key":"10.1016\/j.juro.2015.07.088_bib3","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1200\/JCO.1991.9.11.2016","article-title":"Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation","volume":"9","author":"Shepherd","year":"1991","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.juro.2015.07.088_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.urolonc.2006.12.015","article-title":"Continuous bladder irrigation prevents hemorrhagic cystitis after allogeneic hematopoietic cell transplantation","volume":"26","author":"Hadjibabaie","year":"2008","journal-title":"Urol Oncol"},{"key":"10.1016\/j.juro.2015.07.088_bib5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00280-006-0307-5","article-title":"Histological changes in bladders of patients submitted to ifosfamide chemotherapy even with mesna prophylaxis","volume":"59","author":"Lima","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.juro.2015.07.088_bib6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/pbc.21826","article-title":"Late effects on the urinary bladder in patients treated for cancer in childhood: a report from the Children's Oncology Group","volume":"52","author":"Ritchey","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.juro.2015.07.088_bib7","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/0006-2952(79)90222-3","article-title":"Cyclophosphamide cystitis-identification of acrolein as the causative agent","volume":"28","author":"Cox","year":"1979","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.juro.2015.07.088_bib8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10565-006-0078-0","article-title":"Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation","volume":"23","author":"Korkmaz","year":"2007","journal-title":"Cell Biol Toxicol"},{"key":"10.1016\/j.juro.2015.07.088_bib9","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/S0022-5347(05)65134-8","article-title":"Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice","volume":"167","author":"Ribeiro","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2015.07.088_bib10","first-page":"247","article-title":"Involvement of nitric oxide in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis","volume":"150","author":"Souza-Fiho","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.juro.2015.07.088_bib11","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00280-010-1392-z","article-title":"Cyclooxygenase-2 contributes to functional changes seen on experimental hemorrhagic cystitis induced by ifosfamide in rat urinary bladder","volume":"67","author":"Macedo","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.juro.2015.07.088_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5455\/jeim.080312.ir.010","article-title":"Chemotherapy-induced hemorrhagic cystitis: pathogenesis, pharmacological approaches and new insights","volume":"2","author":"Ribeiro","year":"2012","journal-title":"J Exp Integr Med"},{"key":"10.1016\/j.juro.2015.07.088_bib13","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1056\/NEJM200408263510922","article-title":"New drugs for rheumatoid arthritis","volume":"351","author":"Messori","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.juro.2015.07.088_bib14","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cgh.2008.03.014","article-title":"Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: meta-analysis of placebo-controlled trials","volume":"6","author":"Peyrin-Biroulet","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.juro.2015.07.088_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0022-5347(17)44929-9","article-title":"Evaluation of misoprostol cytoprotection of the bladder with cyclophosphamide (cytoxan) therapy","volume":"136","author":"Gray","year":"1986","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2015.07.088_bib16","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1182\/blood.V60.3.618.618","article-title":"Cellular and extracellular myeloperoxidase in pyogenic inflammation","volume":"60","author":"Bradley","year":"1982","journal-title":"Blood"},{"key":"10.1016\/j.juro.2015.07.088_bib17","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0304-3959(01)00275-5","article-title":"A new model of visceral pain and referred hyperalgesia in the mouse","volume":"92","author":"Laird","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.juro.2015.07.088_bib18","doi-asserted-by":"crossref","first-page":"F1248","DOI":"10.1152\/ajprenal.90259.2008","article-title":"Differential effects of urethane and isoflurane on external urethral sphincter electromyography and cystometry in rats","volume":"295","author":"Chang","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.juro.2015.07.088_bib19","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00280-007-0534-4","article-title":"Role of cytokines (TNF-alpha, IL-1beta and KC) in the pathogenesis of CPT-11-induced intestinal mucositis in mice: effect of pentoxifylline and thalidomide","volume":"61","author":"Melo","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.juro.2015.07.088_bib20","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1128\/IAI.56.9.2255-2263.1988","article-title":"Provocation of pulmonary vascular endothelial injury in rabbits by human recombinant interleukin-1 beta","volume":"56","author":"Goldblum","year":"1988","journal-title":"Infect Immun"},{"key":"10.1016\/j.juro.2015.07.088_bib21","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/sj.bjp.0703434","article-title":"Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist","volume":"130","author":"Cunha","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.juro.2015.07.088_bib22","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.juro.2012.09.054","article-title":"Improvement by phytotherapeutic agent of detrusor overactivity, down-regulation of pharmacological receptors and urinary cytokines in rats with cyclophosphamide induced cystitis","volume":"189","author":"Nasrin","year":"2013","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2015.07.088_bib23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-2999(03)02178-2","article-title":"Nerve-mediated bladder contraction is impaired by cytokines: involvement of inducible nitric oxide synthase","volume":"476","author":"Johansson","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.juro.2015.07.088_bib24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.neuroscience.2003.10.048","article-title":"Role of spinal nitric oxide synthase-dependent processes in the initiation of the micturition hyperreflexia associated with cyclophosphamide-induced cystitis","volume":"125","author":"Lagos","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.juro.2015.07.088_bib25","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.4049\/jimmunol.1102048","article-title":"IL-1\u03b1 and IL-1\u03b2 recruit different myeloid cells and promote different stages of sterile inflammation","volume":"187","author":"Rider","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.juro.2015.07.088_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejphar.2011.01.060","article-title":"Tumor necrosis factor-\u03b1 induces increased lung vascular permeability: a role for GSK3\u03b1\/\u03b2","volume":"657","author":"Barton-Pai","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.juro.2015.07.088_bib27","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/j.1742-4658.2011.08017.x","article-title":"Tumor necrosis factor receptor cross-talk","volume":"278","author":"Naud\u00e9","year":"2011","journal-title":"FEBS J"},{"key":"10.1016\/j.juro.2015.07.088_bib28","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/sj.bjp.0704549","article-title":"TNF ligands and receptors\u2013a matter of life and death","volume":"135","author":"MacEwan","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.juro.2015.07.088_bib29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.clim.2009.01.002","article-title":"Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor","volume":"131","author":"Kaymakcalan","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1016\/j.juro.2015.07.088_bib30","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1053\/j.gastro.2004.11.060","article-title":"Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha","volume":"128","author":"Mitoma","year":"2005","journal-title":"Gastroenterology"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534715044900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534715044900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2015.07.088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T04:02:23Z","timestamp":1651204943000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2015.07.088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1016\/j.juro.2015.07.088"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2015.07.088","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]}}}