{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:52:52Z","timestamp":1772121172354,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jurology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.juro.2015.12.081","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T12:32:02Z","timestamp":1451565122000},"page":"270-278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fetal Rat Gubernaculum Mesenchymal Cells Adopt Myogenic and Myofibroblast-Like Phenotypes"],"prefix":"10.1097","volume":"196","author":[{"given":"Alan K.","family":"Robbins","sequence":"first","affiliation":[{"name":"Pediatric Urology Research Laboratory, Nemours Biomedical Research\/Alfred I. duPont Hospital for Children, Wilmington, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail B.","family":"Mateson","sequence":"additional","affiliation":[{"name":"Pediatric Urology Research Laboratory, Nemours Biomedical Research\/Alfred I. duPont Hospital for Children, Wilmington, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh","family":"Khandha","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Delaware, Newark, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan E.","family":"Pugarelli","sequence":"additional","affiliation":[{"name":"Pediatric Urology Research Laboratory, Nemours Biomedical Research\/Alfred I. duPont Hospital for Children, Wilmington, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Delaware, Newark, Delaware"},{"name":"Department of Biomedical Engineering, University of Delaware, Newark, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Akins","sequence":"additional","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Research Laboratory, Nemours Biomedical Research\/Alfred I. duPont Hospital for Children, Wilmington, Delaware"},{"name":"Department of Biomedical Engineering, University of Delaware, Newark, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Spencer","family":"Barthold","sequence":"additional","affiliation":[{"name":"Pediatric Urology Research Laboratory, Nemours Biomedical Research\/Alfred I. duPont Hospital for Children, Wilmington, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2015.12.081_bib1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1530\/REP-06-0272","article-title":"Cryptorchidism in common eutherian mammals","volume":"133","author":"Amann","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.juro.2015.12.081_bib2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00383-011-2983-4","article-title":"The role of cremaster muscle in testicular descent in humans and\u00a0animal models","volume":"27","author":"Lie","year":"2011","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.juro.2015.12.081_bib3","first-page":"240","article-title":"Cryptorchidism: a clinical perspective","volume":"11","author":"Kollin","year":"2014","journal-title":"Pediatr Endocrinol Rev"},{"key":"10.1016\/j.juro.2015.12.081_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-58353-7_1","article-title":"The testicular descent in human. Origin, development and fate of the gubernaculum Hunteri, processus vaginalis peritonei, and gonadal ligaments","volume":"156","author":"Barteczko","year":"2000","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.1016\/j.juro.2015.12.081_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1095\/biolreprod.113.112953","article-title":"Transcriptome analysis of the dihydrotestosterone-exposed fetal rat gubernaculum identifies common androgen and insulin-like 3 targets","volume":"89","author":"Barthold","year":"2013","journal-title":"Biol Reprod"},{"key":"10.1016\/j.juro.2015.12.081_bib6","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1210\/me.2010-0330","article-title":"Suppression of insulin-like3 receptor reveals the role of beta-catenin and Notch signaling in gubernaculum development","volume":"25","author":"Kaftanovskaya","year":"2011","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.juro.2015.12.081_bib7","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1210\/me.2011-1283","article-title":"Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis","volume":"26","author":"Kaftanovskaya","year":"2012","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.juro.2015.12.081_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1196\/annals.1282.003","article-title":"Characterization of the rat INSL3 receptor","volume":"1041","author":"Scott","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.juro.2015.12.081_bib9","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1210\/en.2005-0676","article-title":"Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate","volume":"146","author":"McKinnell","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.juro.2015.12.081_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/path.4161","article-title":"Left-sided cryptorchidism in mice with Wilms' tumour 1 gene deletion in gubernaculum testis","volume":"230","author":"Kaftanovskaya","year":"2013","journal-title":"J Pathol"},{"key":"10.1016\/j.juro.2015.12.081_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2164\/jandrol.107.003970","article-title":"Altered expression of muscle- and cytoskeleton-related genes in a rat strain with inherited cryptorchidism","volume":"29","author":"Barthold","year":"2008","journal-title":"J Androl"},{"key":"10.1016\/j.juro.2015.12.081_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1095\/biolreprod.114.119560","article-title":"Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling","volume":"91","author":"Barthold","year":"2014","journal-title":"Biol Reprod"},{"key":"10.1016\/j.juro.2015.12.081_bib13","first-page":"365","article-title":"Observations on the gubernaculum during descent of the testis","volume":"16","author":"Radhakrishnan","year":"1979","journal-title":"Invest Urol"},{"key":"10.1016\/j.juro.2015.12.081_bib14","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/mend.13.5.0272","article-title":"Targeted disruption of the Insl3 gene causes bilateral cryptorchidism","volume":"13","author":"Zimmermann","year":"1999","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.juro.2015.12.081_bib15","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1172\/JCI42297","article-title":"Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor","volume":"120","author":"Chapman","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.juro.2015.12.081_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF00193944","article-title":"Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity","volume":"425","author":"Schmitt-Graff","year":"1994","journal-title":"Virchows Arch"},{"key":"10.1016\/j.juro.2015.12.081_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1247\/csf.22.103","article-title":"Desmin in muscle formation and maintenance: knockouts and consequences","volume":"22","author":"Capetanaki","year":"1997","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.juro.2015.12.081_bib18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1432-0436.1990.tb00546.x","article-title":"Coexpression of \u03b1-sarcomeric actin, \u03b1-smooth muscle actin and desmin during myogenesis in rat and mouse embryos I. Skeletal muscle","volume":"44","author":"Babai","year":"1990","journal-title":"Differentiation"},{"key":"10.1016\/j.juro.2015.12.081_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0070-2153(01)51003-0","article-title":"Myofibroblasts: molecular crossdressers","volume":"51","author":"Walker","year":"2001","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.juro.2015.12.081_bib20","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1101\/gad.345505","article-title":"Pax3\/Pax7 mark a novel population of primitive myogenic cells during development","volume":"19","author":"Kassar-Duchossoy","year":"2005","journal-title":"Genes Dev"},{"key":"10.1016\/j.juro.2015.12.081_bib21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ydbio.2007.01.016","article-title":"Intrinsic phenotypic diversity of embryonic and fetal myoblasts is revealed by genome-wide gene expression analysis on purified cells","volume":"304","author":"Biressi","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.juro.2015.12.081_bib22","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/ar.21393","article-title":"Development of the gubernaculum during testicular descent in the rat","volume":"294","author":"Nation","year":"2011","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.juro.2015.12.081_bib23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/molehr\/gav060","article-title":"Polygenic inheritance of cryptorchidism susceptibility in the LE\/orl rat","volume":"22","author":"Barthold","year":"2016","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.juro.2015.12.081_bib24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ydbio.2014.05.015","article-title":"Specific pattern of cell cycle during limb fetal myogenesis","volume":"392","author":"Esteves de Lima","year":"2014","journal-title":"Dev Biol"},{"key":"10.1016\/j.juro.2015.12.081_bib25","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.jpedsurg.2011.02.053","article-title":"Gubernacular development in the mouse is similar to the rat and suggests that the processus vaginalis is derived from the urogenital ridge and is different from the parietal peritoneum","volume":"46","author":"Buraundi","year":"2011","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.juro.2015.12.081_bib26","doi-asserted-by":"crossref","first-page":"16626","DOI":"10.1073\/pnas.0808649105","article-title":"Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development","volume":"105","author":"Que","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.juro.2015.12.081_bib27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fphys.2014.00284","article-title":"The pleural mesothelium in development and disease","volume":"5","author":"Batra","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.juro.2015.12.081_bib28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCRESAHA.113.300203","article-title":"Pericytes in development and pathology of skeletal muscle","volume":"113","author":"Cappellari","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.juro.2015.12.081_bib29","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/ncb2610","article-title":"Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature","volume":"14","author":"Rinkevich","year":"2012","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.juro.2015.12.081_bib30","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/pros.2990190203","article-title":"Morphological and functional similarities between cultured prostatic stromal cells and testicular peritubular myoid cells","volume":"19","author":"Swinnen","year":"1991","journal-title":"Prostate"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534715055378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534715055378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2015.12.081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T23:54:19Z","timestamp":1651190059000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2015.12.081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1016\/j.juro.2015.12.081"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2015.12.081","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726064867.793513755","asserted-by":"object"}]},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fetal Rat Gubernaculum Mesenchymal Cells Adopt Myogenic and Myofibroblast-Like Phenotypes","name":"articletitle","label":"Article Title"},{"value":"The Journal of Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.juro.2015.12.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.","name":"copyright","label":"Copyright"}]}}