{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:08:24Z","timestamp":1781730504692,"version":"3.54.5"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jurology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.juro.2016.05.029","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:47:04Z","timestamp":1462927624000},"page":"1778-1787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy"],"prefix":"10.1097","volume":"196","author":[{"given":"Shouzhe","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada"},{"name":"Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazil","family":"Visram","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada"},{"name":"Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Haig","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Mok","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dameng","family":"Lian","sequence":"additional","affiliation":[{"name":"Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Wood","sequence":"additional","affiliation":[{"name":"School of Biosciences, University of Exeter, Exeter, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Torregrossa","sequence":"additional","affiliation":[{"name":"Medical School, University of Exeter, Exeter, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Whiteman","sequence":"additional","affiliation":[{"name":"Medical School, University of Exeter, Exeter, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Lobb","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada"},{"name":"Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada"},{"name":"Department of Surgery, University of Western Ontario, London, Ontario, Canada"},{"name":"Multi-Organ Transplant Program, London Health Sciences Center, London, Ontario, Canada"},{"name":"Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2016.05.029_bib1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.eururo.2012.03.052","article-title":"Prevalence of kidney stones in the United States","volume":"62","author":"Scales","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2016.05.029_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s11255-013-0520-1","article-title":"Unilateral ureteral obstruction: beyond obstruction","volume":"46","author":"Ucero","year":"2014","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.juro.2016.05.029_bib3","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1542\/peds.107.5.1004","article-title":"Obstructive nephropathy in children: long-term progression after relief of posterior urethral valve","volume":"107","author":"Roth","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.juro.2016.05.029_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.ki.5000054","article-title":"Renal fibrosis: new insights into the pathogenesis and therapeutics","volume":"69","author":"Liu","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.juro.2016.05.029_bib5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.juro.2016.05.029_bib6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/01.mnh.0000447017.28852.52","article-title":"Acute and chronic kidney injury in nephrolithiasis","volume":"23","author":"Tang","year":"2014","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.juro.2016.05.029_bib7","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1096\/fj.02-0211hyp","article-title":"Two\u2019s company, three's a crowd: can H2S be the third endogenous gaseous transmitter?","volume":"16","author":"Wang","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.juro.2016.05.029_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.niox.2014.10.004","article-title":"Hydrogen sulphide and the kidney: important roles in renal physiology and pathogenesis and treatment of kidney injury and disease","volume":"46","author":"Lobb","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.juro.2016.05.029_bib9","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/ki.2013.449","article-title":"Hydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy","volume":"85","author":"Song","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.juro.2016.05.029_bib10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/nau.22450","article-title":"Exogenous hydrogen sulfide prevents kidney damage following unilateral ureteral obstruction","volume":"33","author":"Jiang","year":"2014","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.juro.2016.05.029_bib11","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/CIRCULATIONAHA.107.753467","article-title":"Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide","volume":"117","author":"Li","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.juro.2016.05.029_bib12","doi-asserted-by":"crossref","first-page":"E1187","DOI":"10.1111\/j.1464-410X.2012.11526.x","article-title":"Supplemental hydrogen sulphide protects transplant kidney function and prolongs recipient survival after prolonged cold ischaemia-reperfusion injury by mitigating renal graft apoptosis and inflammation","volume":"110","author":"Lobb","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.juro.2016.05.029_bib13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.5489\/cuaj.1694","article-title":"Hydrogen sulfide treatment ameliorates long-term renal dysfunction resulting from prolonged warm renal ischemia-reperfusion injury","volume":"8","author":"Lobb","year":"2014","journal-title":"Can Urol Assoc J"},{"key":"10.1016\/j.juro.2016.05.029_bib14","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.juro.2015.07.096","article-title":"Hydrogen sulfide treatment mitigates renal allograft ischemia reperfusion injury during cold storage and improves early transplant kidney function and survival following allogeneic renal transplantation","volume":"194","author":"Lobb","year":"2015","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2016.05.029_bib15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/jcmm.12016","article-title":"The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells","volume":"17","author":"Li","year":"2013","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.juro.2016.05.029_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In\u00a0vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in\u00a0vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.juro.2016.05.029_bib17","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1124\/jpet.108.149963","article-title":"Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys","volume":"329","author":"Xia","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.juro.2016.05.029_bib18","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/cphy.c100043","article-title":"Neural control of renal function","volume":"1","author":"Johns","year":"2011","journal-title":"Compr Physiol"},{"key":"10.1016\/j.juro.2016.05.029_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrneph.2012.19","article-title":"Glomerular hyperfiltration: definitions, mechanisms and clinical implications","volume":"8","author":"Helal","year":"2012","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.juro.2016.05.029_bib20","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szab\u00f3","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.juro.2016.05.029_bib21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.niox.2015.01.005","article-title":"Hydrogen sulfide in renal physiology, disease and transplantation\u2014the smell of renal protection","volume":"46","author":"Koning","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.juro.2016.05.029_bib22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/ki.1996.303","article-title":"Cell apoptosis and proliferation in experimental chronic obstructive uropathy","volume":"50","author":"Truong","year":"1996","journal-title":"Kidney Int"},{"key":"10.1016\/j.juro.2016.05.029_bib23","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/S0022-3468(03)00578-5","article-title":"Ureteropelvic junction obstruction causes histologic alterations in contralateral kidney","volume":"38","author":"Ekinci","year":"2003","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.juro.2016.05.029_bib24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00383-013-3456-8","article-title":"Effect of stem cells on renal recovery in rat model of partial unilateral upper ureteric obstruction","volume":"30","author":"Sugandhi","year":"2014","journal-title":"Pediatr Surg Int"},{"issue":"suppl.","key":"10.1016\/j.juro.2016.05.029_bib25","first-page":"ix26","article-title":"How does early chronic kidney disease progress? A background paper prepared for the UK Consensus Conference on early chronic kidney disease","volume":"22","author":"Metcalfe","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.juro.2016.05.029_bib26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00441-011-1181-y","article-title":"TGF-\u03b21 \u2192 SMAD\/p53\/USF2 \u2192 PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis","volume":"347","author":"Samarakoon","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.juro.2016.05.029_bib27","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1440-1797.2010.01439.x","article-title":"Alteration in the phenotype of macrophages in the repair of renal interstitial fibrosis in mice","volume":"16","author":"Kushiyama","year":"2011","journal-title":"Nephrology"},{"key":"10.1016\/j.juro.2016.05.029_bib28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12931-014-0146-6","article-title":"Vitamin D regulating TGF-\u00df induced epithelial-mesenchymal transition","volume":"15","author":"Fischer","year":"2014","journal-title":"Respir Res"},{"key":"10.1016\/j.juro.2016.05.029_bib29","doi-asserted-by":"crossref","first-page":"C107","DOI":"10.1152\/ajpcell.00021.2015","article-title":"Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: role of BK channels and cholinergic neurotransmission","volume":"309","author":"Fernandes","year":"2015","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716303858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534716303858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2016.05.029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T05:01:10Z","timestamp":1655787670000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2016.05.029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1016\/j.juro.2016.05.029"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2016.05.029","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.juro.2016.05.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.","name":"copyright","label":"Copyright"}]}}