{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:58:21Z","timestamp":1790006301040,"version":"4.0.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jurology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.juro.2018.01.079","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T17:25:54Z","timestamp":1517505954000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["<sup>68<\/sup>\n            Ga-PSMA Positron Emission Tomography\/Computerized Tomography for Primary Diagnosis of Prostate Cancer in Men with Contraindications to or Negative Multiparametric Magnetic Resonance Imaging: A Prospective Observational Study"],"prefix":"10.1097","volume":"200","author":[{"given":"Egesta","family":"Lopci","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Saita","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Lughezzani","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piergiuseppe","family":"Colombo","sequence":"additional","affiliation":[{"name":"Pathology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2 Maria","family":"Buffi","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Hurle","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Marzo","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Peschechera","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Benetti","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Zandegiacomo","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Pasini","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Lista","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Cardone","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Castello","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Maffei","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Balzarini","sequence":"additional","affiliation":[{"name":"Radiology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Chiti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Humanitas Clinical and Research Hospital, Milan, Italy"},{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"},{"name":"Pathology Department, Humanitas Clinical and Research Hospital, Milan, Italy"},{"name":"Radiology Department, Humanitas Clinical and Research Hospital, Milan, Italy"},{"name":"Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Guazzoni","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"},{"name":"Pathology Department, Humanitas Clinical and Research Hospital, Milan, Italy"},{"name":"Radiology Department, Humanitas Clinical and Research Hospital, Milan, Italy"},{"name":"Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Casale","sequence":"additional","affiliation":[{"name":"Urology Department, Humanitas Clinical and Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1016\/j.juro.2018.01.079_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.juro.2018.01.079_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(14)61947-4","article-title":"Prostate cancer","volume":"387","author":"Attard","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.juro.2018.01.079_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.eururo.2014.11.037","article-title":"Magnetic resonance imaging-targeted biopsy may enhance the diagnostic accuracy of significant prostate cancer detection compared to standard transrectal ultrasound-guided biopsy","volume":"68","author":"Schoots","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2018.01.079_bib4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.eururo.2014.08.079","article-title":"Multifocality and prostate cancer detection by multiparametric magnetic resonance imaging: correlation with whole-mount histopathology","volume":"67","author":"Le","year":"2015","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2018.01.079_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00259-006-0190-7","article-title":"Value of 11C-choline PET and PET\/CT in patients with suspected prostate cancer","volume":"34","author":"Scher","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.juro.2018.01.079_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cpet.2016.08.004","article-title":"Molecular imaging and precision medicine in prostate cancer","volume":"12","author":"Ceci","year":"2017","journal-title":"PET Clin"},{"key":"10.1016\/j.juro.2018.01.079_bib7","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1016\/j.eururo.2016.03.025","article-title":"Re: Laura Evangelista, Alberto Briganti, Stefano Fanti, et\u00a0al. New Clinical Indications for 18F\/11C-choline, New Tracers for Positron Emission Tomography and a Promising Hybrid Device for Prostate Cancer Staging: A Systematic Review of the Literature","volume":"70","author":"Lopci","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2018.01.079_bib8","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.juro.2016.02.3000","article-title":"Prostate specific membrane antigen positron emission tomography may improve the diagnostic accuracy of multiparametric magnetic resonance imaging in localized prostate cancer","volume":"196","author":"Rhee","year":"2016","journal-title":"J Urol"},{"key":"10.1016\/j.juro.2018.01.079_bib9","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3390\/ph7070779","article-title":"Novel preclinical and radiopharmaceutical aspects of [68Ga]Ga-PSMA-HBED-CC: a new PET tracer for imaging of prostate cancer","volume":"7","author":"Eder","year":"2014","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.juro.2018.01.079_bib10","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1007\/s00259-015-3078-6","article-title":"(68)Ga-PSMA PET\/CT for restaging recurrent prostate cancer: which factors are associated with PET\/CT detection rate?","volume":"42","author":"Ceci","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.juro.2018.01.079_bib11","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/bc300103t","article-title":"Simplified NaCl based (68)Ga concentration and labeling procedure for rapid synthesis of (68)Ga radiopharmaceuticals in high radiochemical purity","volume":"23","author":"Mueller","year":"2012","journal-title":"Bioconjug Chem"},{"issue":"suppl.","key":"10.1016\/j.juro.2018.01.079_bib12","doi-asserted-by":"crossref","first-page":"e505","DOI":"10.1016\/S1569-9056(16)60507-9","article-title":"Targeted PET\/TRUS software fusion-guided biopsy in men with persistently elevated PSA and negative mpMRI after previous negative biopsy: a feasibility study and preliminary results","volume":"15","author":"Lopci","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2018.01.079_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s41824-017-0011-1","article-title":"Targeted 11C-choline PET-CT\/TRUS software fusion guided prostate biopsy in men with persistently elevated PSA and negative mpMRI or MRI contraindications after previous negative biopsy","volume":"1","author":"Lazzeri","year":"2017","journal-title":"Eur J Hybrid Imaging"},{"key":"10.1016\/j.juro.2018.01.079_bib14","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s11548-015-1233-y","article-title":"Multimodal image-guided prostate fusion biopsy based on automatic deformable registration","volume":"10","author":"Zettinig","year":"2015","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"10.1016\/j.juro.2018.01.079_bib15","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.eururo.2016.08.003","article-title":"EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: screening, diagnosis, and local treatment with curative intent","volume":"71","author":"Mottet","year":"2017","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2018.01.079_bib16","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/cncr.29874","article-title":"Prostate cancer detection with magnetic resonance-ultrasound fusion biopsy: the role of systematic and targeted biopsies","volume":"122","author":"Filson","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.juro.2018.01.079_bib17","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.eururo.2016.06.021","article-title":"Sensitivity, specificity, and predictors of positive 68Ga-prostate-specific membrane antigen positron emission tomography in advanced prostate cancer: a systematic review and meta-analysis","volume":"70","author":"Perera","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2018.01.079_bib18","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2256::AID-CNCR22>3.0.CO;2-S","article-title":"Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 184 cases","volume":"82","author":"Bostwick","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.juro.2018.01.079_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.euf.2016.11.002","article-title":"68Ga-labeled prostate-specific membrane antigen ligand positron emission tomography\/computed tomography for prostate cancer: a systematic review and meta-analysis","author":"von Eyben","year":"2016","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.juro.2018.01.079_bib20","article-title":"Immunohistochemical validation of PSMA-expression measured by 68Ga-PSMA PET\/CT in primary prostate cancer","author":"Woythal","year":"2017","journal-title":"J Nucl Med"},{"key":"10.1016\/j.juro.2018.01.079_bib21","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.2967\/jnumed.117.190314","article-title":"68Ga-PSMA-11 PET\/CT in newly diagnosed carcinoma of the prostate: correlation of intraprostatic PSMA uptake with several clinical parameters","volume":"58","author":"Koerber","year":"2017","journal-title":"J Nucl Med"},{"key":"10.1016\/j.juro.2018.01.079_bib22","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.2967\/jnumed.116.189233","article-title":"Intra-individual comparison of 18F-PSMA-1007-PET\/CT, multi-parametric MRI and radical prostatectomy specimen in patients with primary prostate cancer\u2014a retrospective, proof of concept study","volume":"58","author":"Kesch","year":"2017","journal-title":"J Nucl Med"},{"key":"10.1016\/j.juro.2018.01.079_bib23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2967\/jnumed.115.169243","article-title":"Correlation of intraprostatic tumor extent with 68Ga-PSMA distribution in patients with prostate cancer","volume":"57","author":"Rahbar","year":"2016","journal-title":"J Nucl Med"},{"key":"10.1016\/j.juro.2018.01.079_bib24","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.2967\/jnumed.116.172627","article-title":"68Ga-PSMA-HBED-CC PET\/CT detects location and extent of primary prostate cancer","volume":"57","author":"Fendler","year":"2016","journal-title":"J Nucl Med"},{"key":"10.1016\/j.juro.2018.01.079_bib25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.eururo.2015.12.053","article-title":"Simultaneous 68Ga-PSMA HBED-CC PET\/MRI improves the localization of primary prostate cancer","volume":"70","author":"Eiber","year":"2016","journal-title":"Eur Urol"},{"key":"10.1016\/j.juro.2018.01.079_bib26","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s11307-015-0850-8","article-title":"Initial evaluation of [(18)F]DCFPyL for prostate-specific membrane antigen (PSMA)-targeted PET imaging of prostate cancer","volume":"17","author":"Szabo","year":"2015","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.juro.2018.01.079_bib27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11307-015-0866-0","article-title":"Comparison of [(18)F]DCFPyL and [(68)Ga]Ga-PSMA-HBED-CC for PSMA-PET imaging in patients with relapsed prostate cancer","volume":"17","author":"Dietlein","year":"2015","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.juro.2018.01.079_bib28","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s00259-016-3573-4","article-title":"F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients","volume":"44","author":"Giesel","year":"2017","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.juro.2018.01.079_bib29","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s00259-016-3346-0","article-title":"Intra-individual comparison of 68Ga-PSMA-11-PET\/CT and multi-parametric MR for imaging of primary prostate cancer","volume":"43","author":"Giesel","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.juro.2018.01.079_bib30","doi-asserted-by":"crossref","first-page":"228","DOI":"10.7150\/thno.16638","article-title":"Comparison of 68Ga-HBED-CC PSMAPET\/CT and multiparametric MRI for gross tumour volume detection in patients with primary prostate cancer based on slice by slice comparison with histopathology","volume":"7","author":"Zamboglou","year":"2017","journal-title":"Theranostics"}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718301721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022534718301721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1016\/j.juro.2018.01.079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:06:16Z","timestamp":1651208776000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1016\/j.juro.2018.01.079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1016\/j.juro.2018.01.079"],"URL":"https:\/\/doi.org\/10.1016\/j.juro.2018.01.079","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"68Ga-PSMA Positron Emission Tomography\/Computerized Tomography for Primary Diagnosis of Prostate Cancer in Men with Contraindications to or Negative Multiparametric Magnetic Resonance Imaging: A Prospective Observational Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.juro.2018.01.079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.","name":"copyright","label":"Copyright"}]}}