{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:06:00Z","timestamp":1781305560214,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":478,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Value in Health"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.jval.2012.01.004","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T12:06:20Z","timestamp":1333022780000},"page":"420-428","source":"Crossref","is-referenced-by-count":16,"title":["Cost-Effectiveness of Aldosterone Antagonists for the Treatment of Post\u2013Myocardial Infarction Heart Failure"],"prefix":"10.1016","volume":"15","author":[{"given":"Claire","family":"McKenna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Lorgelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Fenwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Burch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Suekarran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameet","family":"Bakhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Harden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kath","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerys","family":"Woolacott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jval.2012.01.004_bib1","first-page":"205","article-title":"Heart failure after myocardial infarction: a neglected problem?","volume":"12","author":"Cowie","year":"2005","journal-title":"Br J Cardiol"},{"key":"10.1016\/j.jval.2012.01.004_bib2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.cardfail.2006.07.004","article-title":"Death or heart failure post acute myocardial infarction?","volume":"12","author":"Jessani","year":"2006","journal-title":"J Card Fail"},{"key":"10.1016\/j.jval.2012.01.004_bib3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejheart.2004.10.020","article-title":"Economic burden of post-acute myocardial infarction in the United Kingdom","volume":"7","author":"Lacey","year":"2005","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jval.2012.01.004_bib4","series-title":"Chronic Heart Failure","year":"2003"},{"key":"10.1016\/j.jval.2012.01.004_bib5","series-title":"Management of Chronic Heart Failure: A National Clinical Guideline","year":"2007"},{"key":"10.1016\/j.jval.2012.01.004_bib6","series-title":"Clinical Guidelines and Evidence Review for Post Myocardial Infarction: Secondary Prevention in Primary and Secondary Care for Patients Following a Myocardial Infarction","author":"Cooper","year":"2007"},{"key":"10.1016\/j.jval.2012.01.004_bib7","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2165\/00019053-200523100-00008","article-title":"Eplerenone: a pharmacoeconomic review of its use in post-myocardial infarction heart failure","volume":"23","author":"Croom","year":"2005","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.jval.2012.01.004_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2165\/00019053-200826090-00006","article-title":"Use of indirect and mixed treatment comparisons for technology assessment","volume":"26","author":"Sutton","year":"2008","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.jval.2012.01.004_bib9","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.2165\/00019053-200624110-00003","article-title":"Using value of information analysis to prioritise health research: some lessons from recent UK experience","volume":"24","author":"Claxton","year":"2006","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.jval.2012.01.004_bib10","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jval.2012.01.004_bib11","series-title":"Guide to the Methods of Technology Appraisal","year":"2008"},{"key":"10.1016\/j.jval.2012.01.004_bib12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/eurheartj\/ehn543","article-title":"Aldosterone blockade and left ventricular dysfunction: a systematic review of randomized clinical trials","volume":"30","author":"Ezekowitz","year":"2009","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jval.2012.01.004_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta14240","article-title":"A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness of aldosterone antagonists for postmyocardial infarction heart failure","volume":"14","author":"McKenna","year":"2010","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.jval.2012.01.004_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/eurheartj\/ehi023","article-title":"Spironolactone improves lung diffusion in chronic heart failure","volume":"26","author":"Agostoni","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jval.2012.01.004_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1536\/jhj.44.681","article-title":"Effects of spironolactone and metoprolol on QT dispersion in heart failure","volume":"44","author":"Akbulut","year":"2003","journal-title":"Jpn Heart J"},{"key":"10.1016\/j.jval.2012.01.004_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ejheart.2006.10.005","article-title":"Effects of aldosterone receptor blockade in patients with mild-moderate heart failure taking a beta-blocker","volume":"9","author":"Berry","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jval.2012.01.004_bib17","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jacc.2007.03.062","article-title":"Aldosterone receptor antagonism induces reverse remodeling when added to angiotensin receptor blockade in chronic heart failure","volume":"50","author":"Chan","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jval.2012.01.004_bib18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0735-1097(02)01965-4","article-title":"Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure","volume":"40","author":"Cicoira","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jval.2012.01.004_bib19","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cardfail.2006.11.015","article-title":"Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure","volume":"13","author":"Gao","year":"2007","journal-title":"J Card Fail"},{"key":"10.1016\/j.jval.2012.01.004_bib20","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0002-9149(96)00465-1","article-title":"Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (the Randomized Aldactone Evaluation Study [RALES])","volume":"78","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jval.2012.01.004_bib21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jval.2012.01.004_bib22","first-page":"643","article-title":"[Effects of ramipril and spironolactone on ventricular remodeling after acute myocardial infarction: randomized and double-blind study]","volume":"125","author":"Rodriguez","year":"1997","journal-title":"Rev Med Chil"},{"key":"10.1016\/j.jval.2012.01.004_bib23","first-page":"1249","article-title":"Effect of spironolactone on mortality in patients with severe left ventricular dysfunction after acute myocardial infarction","volume":"63","author":"Ruta","year":"2006","journal-title":"Przegl Lek"},{"key":"10.1016\/j.jval.2012.01.004_bib24","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/S0735-1097(01)01116-0","article-title":"Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure","volume":"37","author":"Tsutamoto","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jval.2012.01.004_bib25","first-page":"908","article-title":"The efficacy and safety of spironolactone in the treatment of chronic heart failure after acute myocardial infarction","volume":"9","author":"Tu","year":"2003","journal-title":"Hebei Med"},{"key":"10.1016\/j.jval.2012.01.004_bib26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2459\/JCM.0b013e3281053a9a","article-title":"Baseline characteristics of patients recruited in the AREA IN-CHF (Antiremodelling Effect of Aldosterone Receptors Blockade with Canrenone in Mild Chronic Heart Failure) study","volume":"8","author":"Boccanelli","year":"2007","journal-title":"J Cardiovasc Med"},{"key":"10.1016\/j.jval.2012.01.004_bib27","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.ahj.2005.03.032","article-title":"Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic function in patients with acute anterior myocardial infarction","volume":"150","author":"Di Pasquale","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.jval.2012.01.004_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1067\/mhj.2001.111258","article-title":"Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction","volume":"141","author":"Modena","year":"2001","journal-title":"Am Heart J"},{"key":"10.1016\/j.jval.2012.01.004_bib29","first-page":"72","article-title":"The Scottish Record Linkage System","volume":"51","author":"Kendrick","year":"1993","journal-title":"Health Bull (Edinb)"},{"key":"10.1016\/j.jval.2012.01.004_bib30","series-title":"National Schedule of Reference Costs 2007\u201308","year":"2009"},{"key":"10.1016\/j.jval.2012.01.004_bib31","series-title":"British National Formulary (BNF)","year":"2009"},{"issue":"1","key":"10.1016\/j.jval.2012.01.004_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1524-4733.2008.00425.x","article-title":"Utility estimates for decision-analytic modeling in chronic heart failure-health states based on New York Heart Association classes and number of rehospitalizations","volume":"12","author":"G\u00f6hler","year":"2009","journal-title":"Value Health"},{"key":"10.1016\/j.jval.2012.01.004_bib33","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/01.CIR.102.10.1126","article-title":"Evidence of improving prognosis in heart failure: trends in case fatality in 66547 patients hospitalized between 1986 and 1995","volume":"102","author":"MacIntyre","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jval.2012.01.004_bib34","series-title":"Life Tables","year":"2007"},{"key":"10.1016\/j.jval.2012.01.004_bib35","series-title":"Deaths Registered in 2007","year":"2007"},{"key":"10.1016\/j.jval.2012.01.004_bib36","series-title":"British Heart Foundation Statistics Website: Total Cost of Heart Failure to the NHS","year":"2009"},{"key":"10.1016\/j.jval.2012.01.004_bib37","series-title":"UK Population Norms for EQ-5D","author":"Kind","year":"1999"},{"key":"10.1016\/j.jval.2012.01.004_bib38","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0167-6296(93)90005-Y","article-title":"On the decision rules of cost-effectiveness analysis","volume":"12","author":"Johannesson","year":"1993","journal-title":"J Health Econ"},{"key":"10.1016\/j.jval.2012.01.004_bib39","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/hec.635","article-title":"Representing uncertainty: the role of cost-effectiveness acceptability curves","volume":"10","author":"Fenwick","year":"2001","journal-title":"Health Econ"},{"key":"10.1016\/j.jval.2012.01.004_bib40","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0167-6296(98)00039-3","article-title":"The irrelevance of inference: a decision-making approach to the stochastic evaluation of health care technologies","volume":"18","author":"Claxton","year":"1999","journal-title":"J Health Econ"},{"key":"10.1016\/j.jval.2012.01.004_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta8310","article-title":"A pilot study on the use of decision theory and value of information analysis as part of the NHS Health Technology Assessment programme","volume":"8","author":"Claxton","year":"2004","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.jval.2012.01.004_bib42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.hrtlng.2007.12.002","article-title":"Diastolic heart failure","volume":"37","author":"Gary","year":"2008","journal-title":"Heart Lung"}],"container-title":["Value in Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098301512000174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1098301512000174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T20:20:07Z","timestamp":1543090807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1098301512000174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S1098301512000174"],"URL":"https:\/\/doi.org\/10.1016\/j.jval.2012.01.004","relation":{},"ISSN":["1098-3015"],"issn-type":[{"value":"1098-3015","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}