{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:03:35Z","timestamp":1779915815910,"version":"3.53.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Veterinary Cardiology"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.jvc.2012.02.003","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T02:39:30Z","timestamp":1330137570000},"page":"3-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mitral valve degeneration: Still more questions than answers"],"prefix":"10.1016","volume":"14","author":[{"given":"E. Christopher","family":"Orton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvc.2012.02.003_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jvc.2012.01.011","article-title":"Historical review, epidemiology and natural history of degenerative mitral valve disease","volume":"14","author":"Borgarelli","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199907013410101","article-title":"Prevalence and clinical outcome of mitral-valve prolapse","volume":"341","author":"Freed","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvc.2012.02.003_bib3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jvc.2012.02.003_bib4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrcardio.2010.202","article-title":"Epidemiology of valvular heart disease in the adult","volume":"8","author":"Iung","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib5","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: the euro heart survey on valvular heart disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvc.2012.02.003_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jvc.2012.02.002","article-title":"Pharmacologic management of myxomatous mitral valve disease in dogs","volume":"14","author":"Atkins","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jvc.2012.01.012","article-title":"Left ventricular remodeling in preclinical experimental mitral regurgitation of dogs","volume":"14","author":"Dillon","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jvc.2012.01.004","article-title":"Mitral valve repair in dogs","volume":"14","author":"Uechi","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/cvr\/4.1.61","article-title":"Heart valve changes common to man and dog: a comparative study","volume":"4","author":"Pomerance","year":"1970","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jvc.2012.02.003_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jvc.2012.02.001","article-title":"Pathology of myxomatous mitral valve disease in the dog","volume":"14","author":"Fox","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib11","doi-asserted-by":"crossref","first-page":"H5","DOI":"10.1152\/ajpheart.00824.2009","article-title":"Mechanisms of aortic valve calcification: the LDL-density-radius theory: a translation from cell signaling to physiology","volume":"298","author":"Rajamannan","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jvc.2011.11.003","article-title":"Differentiating the aging of the mitral valve from human and canine myxomatous degeneration","volume":"14","author":"Connell","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jvc.2012.01.006","article-title":"Mitral valve disease in dogs: does size matter?","volume":"14","author":"Parker","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1586\/14779072.1.4.523","article-title":"Etiology of valvular heart disease","volume":"1","author":"Boudoulas","year":"2003","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.jvc.2012.02.003_bib15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jvc.2012.01.002","article-title":"The mechanbiology of mitral valve function, degeneration, and repair","volume":"14","author":"Richards","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jvc.2011.12.002","article-title":"Static and cyclic strain induce myxomatous effector proteins and serotonin in canine mitral valves","volume":"14","author":"Lacerda","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2012.02.003_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jvc.2011.12.001","article-title":"Signaling pathways in mitral valve degeneration","volume":"14","author":"Orton","year":"2012","journal-title":"J Vet Cardiol"}],"container-title":["Journal of Veterinary Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273412000252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273412000252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:40:47Z","timestamp":1761705647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1760273412000252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S1760273412000252"],"URL":"https:\/\/doi.org\/10.1016\/j.jvc.2012.02.003","relation":{},"ISSN":["1760-2734"],"issn-type":[{"value":"1760-2734","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitral valve degeneration: Still more questions than answers","name":"articletitle","label":"Article Title"},{"value":"Journal of Veterinary Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvc.2012.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}