{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:59:07Z","timestamp":1792803547538,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Veterinary Cardiology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jvc.2017.07.001","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T02:15:45Z","timestamp":1506651345000},"page":"433-440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anatomic regurgitant orifice area obtained using 3D-echocardiography as an indicator of severity of mitral regurgitation in dogs with myxomatous mitral valve disease"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1409-2650","authenticated-orcid":false,"given":"S.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-062X","authenticated-orcid":false,"given":"G.","family":"Menciotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Borgarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvc.2017.07.001_bib1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1749-6632.1965.tb49421.x","article-title":"The prevalence and types of cardiovascular disease in dogs","volume":"127","author":"Detweiler","year":"1965","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jvc.2017.07.001_bib2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/vr.120.15.365","article-title":"Valvular incompetence in Cavalier King Charles Spaniels","volume":"120","author":"Darke","year":"1987","journal-title":"Vet Rec"},{"key":"10.1016\/j.jvc.2017.07.001_bib3","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/j.1939-1676.2009.0392.x","article-title":"Guidelines for the diagnosis and treatment of canine chronic valvular heart disease","volume":"23","author":"Atkins","year":"2009","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0167-5273(02)00196-1","article-title":"Quantification of mitral regurgitation orifice area by 3-dimensional echocardiography: comparison with effective regurgitant orifice area by PISA method and proximal regurgitant jet diameter","volume":"86","author":"Lange","year":"2002","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib5","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1161\/01.CIR.103.13.1759","article-title":"Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment","volume":"103","author":"Grigioni","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jvc.2017.07.001_bib6","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jcmg.2012.07.013","article-title":"Quantitative assessment of mitral regurgitation: how best to do it","volume":"5","author":"Thavendiranathan","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jvc.2017.07.001_bib7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa041451","article-title":"Quantitative determinants of the outcome of asymptomatic mitral regurgitation","volume":"352","author":"Enriquez-Sarano","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jvc.2015.01.003","article-title":"Echocardiographic anatomy of the mitral valve in healthy dogs and dogs with myxomatous mitral valve disease","volume":"17","author":"Wesselowski","year":"2015","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvc.2014.11.001","article-title":"Echocardiographic predictors of survival in dogs with myxomatous mitral valve disease","volume":"17","author":"Sargent","year":"2015","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib10","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1939-1676.2011.0774.x","article-title":"Assessment of global and regional left ventricular volume and shape by real-time 3-dimensional echocardiography in dogs with myxomatous mitral valve disease","volume":"25","author":"Ljungvall","year":"2011","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib11","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/jvim.12380","article-title":"Assessment of mitral regurgitation severity by Doppler color flow mapping of the vena contracta in dogs","volume":"28","author":"Di Marcello","year":"2014","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib12","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.amjcard.2012.05.037","article-title":"Comparison of accuracy of mitral valve regurgitation volume determined by three-dimensional transesophageal echocardiography versus cardiac magnetic resonance imaging","volume":"110","author":"Hamada","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0894-7317(03)00335-3","article-title":"Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography","volume":"16","author":"Zoghbi","year":"2003","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jvc.2017.07.001_bib14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.amjcard.2010.09.043","article-title":"Comparison of direct planimetry of mitral valve regurgitation orifice area by three-dimensional transesophageal echocardiography to effective regurgitant orifice area obtained by proximal flow convergence method and vena contracta area determined by color","volume":"107","author":"Altiok","year":"2011","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib15","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1111\/jvim.12410","article-title":"Discrepancies in identification of left atrial enlargement using left atrial volume versus left atrial-to-aortic root ratio in dogs","volume":"28","author":"Wesselowski","year":"2014","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","article-title":"Recommendations for Standards in transthoracic two-dimensional echocardiography in the dog and cat","volume":"7","author":"Thomas","year":"1993","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib17","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","article-title":"Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiograph","volume":"18","author":"Lang","year":"2005","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.jvc.2017.07.001_bib18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1939-1676.2004.tb02551.x","article-title":"Allometric scaling of M-mode Cardiac measurements in normal adult dogs","volume":"18","author":"Cornell","year":"2004","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1760-2734(06)70050-9","article-title":"Regurgitant jet area by Doppler color flow mapping: quantitative assessment of mitral regurgitation severity in dogs","volume":"5","author":"Muzzi","year":"2003","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/jvim.12466","article-title":"Usefulness of conventional and tissue Doppler echocardiography to predict Congestive heart failure in dogs with myxomatous mitral valve disease","volume":"29","author":"Kim","year":"2015","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0022-2828(03)00013-0","article-title":"Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog","volume":"35","author":"Stewart","year":"2003","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1740-8261.2009.01559.x","article-title":"Echocardiographic assessment of 537 dogs with mitral valve prolapse and leaflet involvement","volume":"50","author":"Terzo","year":"2009","journal-title":"Vet Radiol Ultrasound"},{"key":"10.1016\/j.jvc.2017.07.001_bib23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0735-1097(98)00239-3","article-title":"Three-dimensional echocardiographic planimetry of maximal regurgitant orifice area in myxomatous mitral regurgitation: intraoperative comparison with proximal flow convergence","volume":"32","author":"Breburda","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib24","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jacc.2008.05.028","article-title":"Effect of dynamic flow rate and orifice area on mitral regurgitant stroke volume quantification using the proximal isovelocity surface area method","volume":"52","author":"Buck","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jvc.2011.08.003","article-title":"Proximal isovelocity surface area variability during systole in dogs with mitral valve prolapse","volume":"13","author":"Paiva","year":"2011","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1939-1676.2007.0008.x","article-title":"Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease","volume":"22","author":"Borgarelli","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib27","doi-asserted-by":"crossref","first-page":"H1015","DOI":"10.1152\/ajpheart.00275.2011","article-title":"A three-dimensional insight into the complexity of flow convergence in mitral regurgitation: adjunctive benefit of anatomic regurgitant orifice area","volume":"301","author":"Chandra","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1760-2734(06)70029-7","article-title":"Heart rate variability in young, clinically healthy Dachshunds: influence of sex, mitral valve prolapse status, sampling period and time of day","volume":"1","author":"Olsen","year":"1999","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2017.07.001_bib29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2460\/javma.231.3.399","article-title":"Quantification of mitral valve regurgitation in dogs with degenerative mitral valve disease by use of the proximal isovelocity surface area method","volume":"231","author":"Gouni","year":"2007","journal-title":"J Am Vet Med Assoc"},{"key":"10.1016\/j.jvc.2017.07.001_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1939-1676.2011.00860.x","article-title":"Survival characteristics and prognostic variables of dogs with preclinical chronic degenerative mitral valve disease attributable to myxomatous degeneration","volume":"26","author":"Borgarelli","year":"2012","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib31","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1939-1676.2008.0150.x","article-title":"Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study","volume":"22","author":"H\u00e4ggstr\u00f6m","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2017.07.001_bib32","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/jvim.14642","article-title":"Real-time 3-dimensional echocardiographic assessment of effective regurgitant orifice area in dogs with myxomatous mitral valve disease","volume":"31","author":"Tidholm","year":"2017","journal-title":"J Vet Intern Med"}],"container-title":["Journal of Veterinary Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273416301333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273416301333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T02:54:11Z","timestamp":1535338451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1760273416301333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1760273416301333"],"URL":"https:\/\/doi.org\/10.1016\/j.jvc.2017.07.001","relation":{},"ISSN":["1760-2734"],"issn-type":[{"value":"1760-2734","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anatomic regurgitant orifice area obtained using 3D-echocardiography as an indicator of severity of mitral regurgitation in dogs with myxomatous mitral valve disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Veterinary Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvc.2017.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}