{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:01:49Z","timestamp":1780441309305,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["FP7-LUPA"],"award-info":[{"award-number":["FP7-LUPA"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"crossref","award":["GA-201370"],"award-info":[{"award-number":["GA-201370"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agria Research Foundation"},{"name":"Swedish Kennel Club Research Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Veterinary Cardiology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jvc.2018.05.002","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T01:18:05Z","timestamp":1529371085000},"page":"244-253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in healthy dogs"],"prefix":"10.1016","volume":"20","author":[{"given":"K.","family":"H\u00f6glund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-023X","authenticated-orcid":false,"given":"J.","family":"H\u00e4ggstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Han\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.-C.","family":"Merveille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Gouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wiberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lundgren Willesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.Mc","family":"Entee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mejer S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tiret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.H.","family":"Sepp\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Chetboul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fredholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.-S.","family":"Lequarr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ljungvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvc.2018.05.002_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archpsyc.55.1.33","article-title":"Association between the tryptophan hydroxylase gene and manic-depressive illness","volume":"55","author":"Bellivier","year":"1998","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jvc.2018.05.002_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/jcp.21533","article-title":"What do we know about serotonin?","volume":"217","author":"Jonnakuty","year":"2008","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jvc.2018.05.002_bib3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.tips.2008.06.009","article-title":"5-hydroxytryptamine and cardiovascular regulation","volume":"29","author":"Ramage","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jvc.2018.05.002_bib4","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.14348\/molcells.2015.0258","article-title":"Peripheral serotonin: a new player in systemic energy homeostasis","volume":"38","author":"Namkung","year":"2015","journal-title":"Mol Cells"},{"key":"10.1016\/j.jvc.2018.05.002_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1053\/smrv.2001.0174","article-title":"Serotonin and sleep","volume":"6","author":"Ursin","year":"2002","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.jvc.2018.05.002_bib6","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1096\/fj.07-100743","article-title":"Maternal serotonin influences cardiac function in adult offspring","volume":"22","author":"Fligny","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.jvc.2018.05.002_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/7fdd5c53-e8ab-40b5-b297-e82c06a06e70","article-title":"Serotonin potentiates transforming growth factor-beta3 induced biomechanical remodeling in avian embryonic atrioventricular valves","volume":"7","author":"Buskohl","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jvc.2018.05.002_bib8","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s12013-013-9606-8","article-title":"Distinct signaling pathways activated by \"extracellular\" and \"intracellular\" serotonin in heart valve development and disease","volume":"67","author":"Pavone","year":"2013","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.jvc.2018.05.002_bib9","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.2233056100","article-title":"Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function","volume":"100","author":"Cote","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jvc.2018.05.002_bib10","first-page":"44","article-title":"Autocrine serotonin and transforming growth factor beta 1 signaling mediates spontaneous myxomatous mitral valve disease","volume":"18","author":"Disatian","year":"2009","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.jvc.2018.05.002_bib11","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.2460\/ajvr.67.8.1307","article-title":"Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease","volume":"67","author":"Oyama","year":"2006","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jvc.2018.05.002_bib12","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1939-1676.2009.0378.x","article-title":"Serum serotonin concentrations in dogs with degenerative mitral valve disease","volume":"23","author":"Arndt","year":"2009","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib13","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1111\/jvim.12420","article-title":"Serotonin concentrations in platelets, plasma, mitral valve leaflet, and left ventricular myocardial tissue in dogs with myxomatous mitral valve disease","volume":"28","author":"Cremer","year":"2014","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jvc.2011.12.002","article-title":"Static and cyclic tensile strain induce myxomatous effector proteins and serotonin in canine mitral valves","volume":"14","author":"Lacerda","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2018.05.002_bib15","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/jvim.12137","article-title":"Serum serotonin concentration is associated with severity of myxomatous mitral valve disease in dogs","volume":"27","author":"Ljungvall","year":"2013","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib16","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2460\/ajvr.76.6.520","article-title":"Plasma and serum serotonin concentrations and surface-bound platelet serotonin expression in Cavalier King Charles Spaniels with myxomatous mitral valve disease","volume":"76","author":"Cremer","year":"2015","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jvc.2018.05.002_bib17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jvc.2014.05.003","article-title":"Plasma and platelet serotonin concentrations in healthy dogs and dogs with myxomatous mitral valve disease","volume":"16","author":"Mangklabruks","year":"2014","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2018.05.002_bib18","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/0024-3205(87)90696-5","article-title":"Steady-state model for plasma free and platelet serotonin in man","volume":"41","author":"Anderson","year":"1987","journal-title":"Life Sci"},{"key":"10.1016\/j.jvc.2018.05.002_bib19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM199708283370901","article-title":"Valvular heart disease associated with fenfluramine-phentermine","volume":"337","author":"Connolly","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib20","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.4065\/77.12.1280","article-title":"Valvular heart disease in patients taking pergolide","volume":"77","author":"Pritchett","year":"2002","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jvc.2018.05.002_bib21","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1161\/01.CIR.0000159356.42064.48","article-title":"Long-term serotonin administration induces heart valve disease in rats","volume":"111","author":"Gustafsson","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jvc.2018.05.002_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.etp.2008.03.005","article-title":"5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats","volume":"60","author":"Elangbam","year":"2008","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.jvc.2018.05.002_bib23","first-page":"549","article-title":"Chronic valvular disease in the cavalier King Charles spaniel in Sweden","volume":"131","author":"H\u00e4ggstr\u00f6m","year":"1992","journal-title":"Vet Rec"},{"key":"10.1016\/j.jvc.2018.05.002_bib24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.rvsc.2015.05.020","article-title":"Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with variable predisposition for canine idiopathic pulmonary fibrosis","volume":"101","author":"Roels","year":"2015","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.jvc.2018.05.002_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tvjl.2011.06.013","article-title":"LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs","volume":"189","author":"Lequarre","year":"2011","journal-title":"Vet J"},{"key":"10.1016\/j.jvc.2018.05.002_bib26","first-page":"10","article-title":"Development and validation of a body condition score system for dogs: a clinical tool","volume":"22","author":"Laflamme","year":"1997","journal-title":"Canine Pract"},{"key":"10.1016\/j.jvc.2018.05.002_bib27","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1939-1676.2007.tb03005.x","article-title":"Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats","volume":"21","author":"Brown","year":"2007","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","article-title":"Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Echocardiography Committee of the Specialty of Cardiology, American College of Veterinary Internal Medicine","volume":"7","author":"Thomas","year":"1993","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123173","article-title":"The shepherds' tale: a genome-wide study across 9 dog breeds Implicates two loci in the regulation of fructosamine serum concentration in belgian shepherds","volume":"10","author":"Forsberg","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jvc.2018.05.002_bib30","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/jvim.13829","article-title":"Effect of breed on plasma Endothelin-1 concentration, plasma renin activity, and serum cortisol concentration in healthy dogs","volume":"30","author":"H\u00f6glund","year":"2016","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib31","series-title":"An introduction to medical statistics","first-page":"322","article-title":"Multifactorial methods","author":"Bland","year":"1995"},{"key":"10.1016\/j.jvc.2018.05.002_bib32","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1748-5827.1985.tb02199.x","article-title":"Observations on breed and sex in relation to canine heart-valve incompetence","volume":"26","author":"Thrusfield","year":"1985","journal-title":"J Small Anim Pract"},{"key":"10.1016\/j.jvc.2018.05.002_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0010058","article-title":"Canine genomics and genetics: running with the pack","volume":"1","author":"Parker","year":"2005","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jvc.2018.05.002_bib34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/jvim.12310","article-title":"Breed differences in natriuretic peptides in healthy dogs","volume":"28","author":"Sj\u00f6strand","year":"2014","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib35","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/j.1939-1676.2012.00999.x","article-title":"Blood pressure, heart rate, and urinary catecholamines in healthy dogs subjected to different clinical settings","volume":"26","author":"H\u00f6glund","year":"2012","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.rvsc.2016.03.016","article-title":"The prevalence of ABCB1:c.227_230delATAG mutation in affected dog breeds from European countries","volume":"106","author":"Firdova","year":"2016","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.jvc.2018.05.002_bib37","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/clinchem\/37.7.1178","article-title":"Rapid and specific enzyme immunoassay of serotonin","volume":"37","author":"Chauveau","year":"1991","journal-title":"Clin Chem"},{"key":"10.1016\/j.jvc.2018.05.002_bib38","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1093\/clinchem\/38.10.2087","article-title":"Serotonin concentrations in plasma and variations during the menstrual cycle","volume":"38","author":"Hindberg","year":"1992","journal-title":"Clin Chem"},{"issue":"Suppl 1","key":"10.1016\/j.jvc.2018.05.002_bib39","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1093\/jhered\/esr041","article-title":"Identification of 2 loci associated with development of myxomatous mitral valve disease in Cavalier King Charles Spaniels","volume":"102","author":"Madsen","year":"2011","journal-title":"J Hered"},{"key":"10.1016\/j.jvc.2018.05.002_bib40","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1939-1676.1999.tb01462.x","article-title":"Epidemiology and inheritance of mitral valve prolapse in Dachshunds","volume":"13","author":"Olsen","year":"1999","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib41","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.neubiorev.2016.03.008","article-title":"Temperament and arousal systems: a new synthesis of differential psychology and functional neurochemistry","volume":"64","author":"Trofimova","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jvc.2018.05.002_bib42","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1440-1681.2006.04410.x","article-title":"5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT)","volume":"33","author":"Ni","year":"2006","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.jvc.2018.05.002_bib43","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0278-5846(02)00259-2","article-title":"The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression","volume":"26","author":"Muck-Seler","year":"2002","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.jvc.2018.05.002_bib44","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jveb.2012.01.005","article-title":"Assessment of serotonin in serum, plasma, and platelets of aggressive dogs","volume":"7","author":"Le\u00f3n","year":"2012","journal-title":"J Vet Behav"},{"key":"10.1016\/j.jvc.2018.05.002_bib45","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.yjmcc.2008.12.019","article-title":"Platelet derived serotonin drives the activation of rat cardiac fibroblasts by 5-HT2A receptors","volume":"46","author":"Yabanoglu","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jvc.2018.05.002_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1939-1676.2009.0411.x","article-title":"Insights into serotonin signaling mechanisms associated with canine degenerative mitral valve disease","volume":"24","author":"Oyama","year":"2010","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib47","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.2460\/ajvr.2000.61.1248","article-title":"Platelet aggregation in dogs with mitral valve regurgitation","volume":"61","author":"Tanaka","year":"2000","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.jvc.2018.05.002_bib48","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1939-1676.2001.tb02313.x","article-title":"Increased platelet aggregation response in cavalier king charles spaniels with mitral valve prolapse","volume":"15","author":"Olsen","year":"2001","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib49","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.bbrc.2005.01.018","article-title":"5-hydroxytryptamine synthesis in HL-1 cells and neonatal rat cardiocytes","volume":"328","author":"Ikeda","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jvc.2018.05.002_bib50","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.molmed.2004.03.007","article-title":"Recent advances in understanding serotonin regulation of cardiovascular function","volume":"10","author":"Cote","year":"2004","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jvc.2018.05.002_bib51","first-page":"71","article-title":"Tryptophan hydroxylase 1 expression is increased in phenotype-altered canine and human degenerative myxomatous mitral valves","volume":"19","author":"Disatian","year":"2010","journal-title":"J Heart Valve Dis"}],"container-title":["Journal of Veterinary Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273417301972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273417301972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T22:19:15Z","timestamp":1604441955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1760273417301972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1760273417301972"],"URL":"https:\/\/doi.org\/10.1016\/j.jvc.2018.05.002","relation":{},"ISSN":["1760-2734"],"issn-type":[{"value":"1760-2734","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in healthy dogs","name":"articletitle","label":"Article Title"},{"value":"Journal of Veterinary Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvc.2018.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}