{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:32:30Z","timestamp":1789086750000,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Javna Agencija za Raziskovalno Dejavnost RS","doi-asserted-by":"publisher","award":["P4-0053"],"award-info":[{"award-number":["P4-0053"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Veterinary Cardiology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jvc.2023.03.001","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T16:33:14Z","timestamp":1678120394000},"page":"18-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Selected hematological, biochemical, and echocardiographic variables as predictors of survival in canine patients with myxomatous mitral valve disease and congestive heart failure"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-7904","authenticated-orcid":false,"given":"M.","family":"Brlo\u017enik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pe\u010djak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nemec Svete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5636-9163","authenticated-orcid":false,"given":"A.","family":"Domanjko Petri\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvc.2023.03.001_bib1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1939-1676.2007.0008.x","article-title":"Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease","volume":"22","author":"Borgarelli","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1939-1676.2011.00860.x","article-title":"Survival characteristics and prognostic variables of dogs with preclinical chronic degenerative mitral valve disease attributable to myxomatous degeneration","volume":"26","author":"Borgarelli","year":"2012","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/jvim.12564","article-title":"Prevalence and prognostic importance of pulmonary hypertension in dogs with myxomatous mitral valve disease","volume":"29","author":"Borgarelli","year":"2015","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jvc.2009.07.001","article-title":"Plasma N-terminal pro-B-type natriuretic peptide concentration helps to predict survival in dogs with symptomatic degenerative mitral valve disease regardless of and in combination with the initial clinical status at admission","volume":"11","author":"Serres","year":"2009","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2023.03.001_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1748-5827.2009.00889.x","article-title":"N-terminal pro B-type natriuretic peptide and left ventricular diameter independently predict mortality in dogs with mitral valve disease","volume":"51","author":"Moonarmart","year":"2010","journal-title":"J Small Anim Pract"},{"key":"10.1016\/j.jvc.2023.03.001_bib6","first-page":"1219","article-title":"Survival and echocardiographic data in dogs with congestive heart failure caused by mitral valve disease and treated by multiple drugs: a retrospective study of 21 cases","volume":"52","author":"Madron","year":"2011","journal-title":"Can Vet J"},{"key":"10.1016\/j.jvc.2023.03.001_bib7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1939-1676.2008.0071.x","article-title":"Association of body weight and body condition with survival in dogs with heart failure","volume":"22","author":"Slupe","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1939-1676.2012.00894.x","article-title":"The combined prognostic potential of serum high-sensitivity cardiac troponin I and N-terminal pro-B-type natriuretic peptide concentrations in dogs with degenerative mitral valve disease","volume":"26","author":"Hezell","year":"2012","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jvc.2012.01.009","article-title":"Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease","volume":"14","author":"Hezzell","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2023.03.001_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jvc.2012.05.005","article-title":"Lowered N-terminal pro-B-type natriuretic peptide levels in response to treatment predict survival in dogs with symptomatic mitral valve disease","volume":"14","author":"Wolf","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2023.03.001_bib11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/jvim.12039","article-title":"Risk factors for coughing in dogs with naturally acquired myxomatous mitral valve disease","volume":"27","author":"Ferasin","year":"2013","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib12","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/jvim.12544","article-title":"Clinical severity score system in dogs with degenerative mitral valve disease","volume":"29","author":"Lopez Alvarez","year":"2015","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib13","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/jvim.15126","article-title":"Clinical findings and survival time in dogs with advanced heart failure","volume":"32","author":"Beaumier","year":"2018","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvc.2014.11.001","article-title":"Echocardiographic predictors of survival in dogs with myxomatous mitral valve disease","volume":"17","author":"Sargent","year":"2015","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2023.03.001_bib15","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/jvim.15093","article-title":"Prognostic value of echocardiographic indices of left atrial morphology and function in dogs with myxomatous mitral valve disease","volume":"32","author":"Toaldo","year":"2018","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib16","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/jvim.14524","article-title":"Preliminary investigation of cardiovascular\u2013renal disorders in dogs with chronic mitral valve disease","volume":"30","author":"Martinelli","year":"2016","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.15547\/bjvm.2019-0003","article-title":"Blood variables associated with survival in canine congestive heart failure patients","volume":"23","author":"Nemec Svete","year":"2020","journal-title":"Bulg J Vet Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib18","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1111\/jvim.15566","article-title":"Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure","volume":"33","author":"Ineson","year":"2019","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib19","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1292\/jvms.71.925","article-title":"Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency","volume":"71","author":"Takemura","year":"2009","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.jvc.2023.03.001_bib20","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1939-1676.2009.0347.x","article-title":"Association of plasma N-terminal pro-B-type natriuretic peptide concentration with mitral regurgitation severity and outcome in dogs with asymptomatic degenerative mitral valve disease","volume":"23","author":"Chetboul","year":"2009","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib21","first-page":"347","article-title":"Quality of life score as a predictor of death in dogs with degenerative mitral valve disease","volume":"108","author":"Strunz","year":"2017","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.jvc.2023.03.001_bib22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.4142\/jvs.2017.18.3.369","article-title":"Retrospective study of degenerative mitral valve disease in small-breed dogs: survival and prognostic variables","volume":"18","author":"Kim","year":"2017","journal-title":"J Vet Sci"},{"key":"10.1016\/j.jvc.2023.03.001_bib23","first-page":"836","article-title":"Hematological and biochemical variables in congestive heart failure in dogs","volume":"4","author":"Deepti","year":"2015","journal-title":"Int J Sci Environ Technol"},{"key":"10.1016\/j.jvc.2023.03.001_bib24","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.4102\/jsava.v85i1.1101","article-title":"Advances in the understanding of the pathogenesis, progression and diagnosis of myxomatous mitral valve disease in dogs","volume":"85","author":"Burchell","year":"2014","journal-title":"J S Afr Vet Assoc"},{"key":"10.1016\/j.jvc.2023.03.001_bib25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0167-5273(96)02740-4","article-title":"Non-invasive prognostic factors in chronic heart failure. One year survival of 300 patients with a diagnosis of chronic heart failure due to ischemic heart disease or dilated cardiomyopathy","volume":"56","author":"Spinar","year":"1996","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jvc.2023.03.001_bib26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.cardfail.2007.04.008","article-title":"Worsening renal function and prognosis in heart failure: systematic review and meta-analysis","volume":"13","author":"Damman","year":"2007","journal-title":"J Card Fail"},{"key":"10.1016\/j.jvc.2023.03.001_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5603\/KP.a2016.0147","article-title":"Basic laboratory parameters as predictors of in-hospital death in patients with acute decompensated heart failure: data from a large single-centre cohort","volume":"75","author":"Ostrowska","year":"2017","journal-title":"Kardiol Pol"},{"key":"10.1016\/j.jvc.2023.03.001_bib28","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/jvim.15488","article-title":"ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs","volume":"33","author":"Keene","year":"2019","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1939-1676.1993.tb01015.x","article-title":"Recommendations for standards in transthoracic two-dimensional echocardiography in the dog and cat. Echocardiography Committee of the Specialty of Cardiology, American College of Veterinary Internal Medicine","volume":"7","author":"Thomas","year":"1993","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jvc.2012.01.001","article-title":"Pulmonary hypertension in canine degenerative mitral valve disease","volume":"14","author":"Kellihan","year":"2012","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2023.03.001_bib31","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1939-1676.2011.0707.x","article-title":"Holter monitoring in clinically healthy Cavalier King Charles Spaniels, Wire-haired Dachshunds, 607 and Cairn Terriers","volume":"25","author":"Rasmussen","year":"2011","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib32","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.rvsc.2011.12.014","article-title":"Sleeping respiratory rates in apparently healthy adult dogs","volume":"93","author":"Rishniw","year":"2012","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.jvc.2023.03.001_bib33","first-page":"311","article-title":"Allometric scaling of M-mode cardiac measurements in normal adult dogs","volume":"18","author":"Cornell","year":"2004","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib34","series-title":"R: a language and environment for statistical computing","year":"2020"},{"key":"10.1016\/j.jvc.2023.03.001_bib35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1292\/jvms.16-0069","article-title":"Efficacy of pimobendan on survival and reoccurrence of pulmonary edema in canine congestive heart failure","volume":"79","author":"Mizuno","year":"2017","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.jvc.2023.03.001_bib36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13028-018-0372-x","article-title":"Systemic inflammation in dogs with advanced-stage heart failure","volume":"60","author":"Domanjko Petri\u010d","year":"2018","journal-title":"Acta Vet Scand"},{"key":"10.1016\/j.jvc.2023.03.001_bib37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12917-021-02878-x","article-title":"Inflammation and its association with oxidative stress in dogs with heart failure","volume":"17","author":"Nemec Svete","year":"2021","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.jvc.2023.03.001_bib38","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1939-1676.2004.tb02575.x","article-title":"Lymphocyte subpopulations and hematologic variables in dogs with congestive heart failure","volume":"18","author":"Farabaugh","year":"2004","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib39","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/jsap.12809","article-title":"White blood cell differentials in dogs with congestive heart failure (CHF) in comparison to those in dogs without cardiac disease","volume":"59","author":"Hamilton-Elliott","year":"2018","journal-title":"J Small Anim Pract"},{"key":"10.1016\/j.jvc.2023.03.001_bib40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1042\/CS20050317","article-title":"Increased systemic inflammation and oxidative stress in patients with worsening congestive heart failure: improvement after short-term inotropic support","volume":"110","author":"White","year":"2006","journal-title":"Clin Sci"},{"key":"10.1016\/j.jvc.2023.03.001_bib41","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11897-017-0337-9","article-title":"Inflammation - cause or consequence of heart failure or both?","volume":"14","author":"Van Linthout","year":"2017","journal-title":"Curr Heart Fail Rep"},{"key":"10.1016\/j.jvc.2023.03.001_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvc.2005.12.001","article-title":"The effect of heart disease, heart failure and diuresis on selected laboratory and electrocardiographic parameters in dogs","volume":"8","author":"Boswood","year":"2006","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2023.03.001_bib43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jvim.15662","article-title":"Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease","volume":"34","author":"Adin","year":"2020","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib44","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/jvim.16187","article-title":"Clinical relevance of serum electrolytes in dogs and cats with acute heart failure: a retrospective study","volume":"35","author":"Roche-Catholy","year":"2021","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195832","article-title":"Cellular metabolism and oxidative stress as a possible determinant for longevity in small breed and large breed dogs","volume":"13","author":"Jimenez","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jvc.2023.03.001_bib46","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1939-1676.2008.0150.x","article-title":"Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous mitral valve disease: the QUEST study","volume":"22","author":"H\u00e4ggstr\u00f6m","year":"2008","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib47","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1111\/jvim.15863","article-title":"Efficacy of adding ramipril (VAsotop) to the combination of furosemide (Lasix) and pimobendan (VEtmedin) in dogs with mitral valve degeneration: the VALVE trial","volume":"34","author":"Wess","year":"2020","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2023.03.001_bib48","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/ejhf.477","article-title":"Hypochloraemia is strongly and independently associated with mortality in patients with chronic heart failure","volume":"18","author":"Testani","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jvc.2023.03.001_bib49","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/heartjnl-2016-310112","article-title":"Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure","volume":"103","author":"Matsue","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.jvc.2023.03.001_bib50","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/ejhf.1247","article-title":"Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significance","volume":"20","author":"Cuthbert","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jvc.2023.03.001_bib51","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1748-5827.2010.00910.x","article-title":"Rate of change of heart size before congestive heart failure in dogs with mitral regurgitation","volume":"51","author":"Lord","year":"2010","journal-title":"J Small Anim Pract"},{"key":"10.1016\/j.jvc.2023.03.001_bib52","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/eurheartj\/ehq294","article-title":"Prognostic and therapeutic implications of pulmonary hypertension complicating degenerative mitral regurgitation due to flail leaflet: a multicenter long-term international study","volume":"32","author":"Barbieri","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvc.2023.03.001_bib53","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0735-1097(00)01102-5","article-title":"Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure","volume":"37","author":"Ghio","year":"2001","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Veterinary Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273423000103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273423000103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:40:00Z","timestamp":1761705600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1760273423000103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":53,"alternative-id":["S1760273423000103"],"URL":"https:\/\/doi.org\/10.1016\/j.jvc.2023.03.001","relation":{},"ISSN":["1760-2734"],"issn-type":[{"value":"1760-2734","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selected hematological, biochemical, and echocardiographic variables as predictors of survival in canine patients with myxomatous mitral valve disease and congestive heart failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Veterinary Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvc.2023.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}