{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:53:54Z","timestamp":1792252434850,"version":"4.4.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Veterinary Cardiology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jvc.2026.05.002","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:19:17Z","timestamp":1778761157000},"page":"56-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Use of ambrisentan in the management of refractory pulmonary arterial hypertension following occlusion of a bidirectionally shunting patent ductus arteriosus in a dog"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6889-9426","authenticated-orcid":false,"given":"T.S.","family":"Nemanic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fabella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvc.2026.05.002_bib1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/jvim.15725","article-title":"ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs","volume":"34","author":"Reinero","year":"2020","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2026.05.002_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1939-1676.2004.tb02551.x","article-title":"Allometric scaling of M-mode cardiac measurements in normal adult dogs","volume":"18","author":"Cornell","year":"2004","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2026.05.002_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4322\/acr.2017.006","article-title":"Eisenmenger syndrome","volume":"7","author":"Campos","year":"2017","journal-title":"Autopsy Case Rep"},{"key":"10.1016\/j.jvc.2026.05.002_bib4","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/jvim.16072","article-title":"Clinical features and outcome of dogs and cats with bidirectional and continuous right-to-left shunting patent ductus arteriosus","volume":"35","author":"Greet","year":"2021","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2026.05.002_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1939-1676.2011.00859.x","article-title":"Occlusion devices and approaches in Canine patent ductus arteriosus: Comparison of outcomes","volume":"26","author":"Singh","year":"2012","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2026.05.002_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/children7090139","article-title":"Pulmonary hypertension with prolonged patency of the ductus arteriosus in preterm infants","volume":"7","author":"Philip","year":"2020","journal-title":"Children"},{"key":"10.1016\/j.jvc.2026.05.002_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jvc.2020.09.003","article-title":"Acute effects of intravenous pimobendan administration in dog models of chronic precapillary pulmonary hypertension","volume":"32","author":"Morita","year":"2020","journal-title":"J Vet Cardiol"},{"key":"10.1016\/j.jvc.2026.05.002_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvc.2026.05.002_bib9","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1939-1676.2006.tb00711.x","article-title":"Retrospective evaluation of sildenafil citrate as a therapy for pulmonary hypertension in dogs","volume":"20","author":"Bach","year":"2006","journal-title":"J Vet Intern Med"},{"key":"10.1016\/j.jvc.2026.05.002_bib10","series-title":"Cardiothorac. Crit. Care","first-page":"374","article-title":"Chapter 24 - pulmonary hypertension","author":"Sidebotham","year":"2007"},{"key":"10.1016\/j.jvc.2026.05.002_bib11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.rmed.2015.01.004","article-title":"The role of calcium channel blockers for the treatment of pulmonary arterial hypertension: how much do we actually know and how could they be positioned today?","volume":"109","author":"Medarov","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.jvc.2026.05.002_bib12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cardiores.2003.11.026","article-title":"The endothelin system in pulmonary arterial hypertension","volume":"61","author":"Galie","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jvc.2026.05.002_bib13","article-title":"Adjunct ambrisentan therapy had clinical benefits in 5 dogs with sildenafil-refractory pulmonary hypertension","volume":"7","author":"Goya","year":"2022","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.jvc.2026.05.002_bib14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jacc.2005.04.050","article-title":"Ambrisentan therapy for pulmonary arterial hypertension","volume":"46","author":"Gali\u00e9","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvc.2026.05.002_bib15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/HYPERTENSIONAHA.111.182261","article-title":"Ambrisentan and tadalafil synergistically relax endothelin-induced contraction of rat pulmonary arteries","volume":"59","author":"Liang","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jvc.2026.05.002_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.lfs.2014.01.002","article-title":"Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs","volume":"118","author":"Fukumoto","year":"2014","journal-title":"Life Sci"}],"container-title":["Journal of Veterinary Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273426000482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1760273426000482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:33:03Z","timestamp":1792251183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1760273426000482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":16,"alternative-id":["S1760273426000482"],"URL":"https:\/\/doi.org\/10.1016\/j.jvc.2026.05.002","relation":{},"ISSN":["1760-2734"],"issn-type":[{"value":"1760-2734","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of ambrisentan in the management of refractory pulmonary arterial hypertension following occlusion of a bidirectionally shunting patent ductus arteriosus in a dog","name":"articletitle","label":"Article Title"},{"value":"Journal of Veterinary Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvc.2026.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}