{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:53:25Z","timestamp":1780631605454,"version":"3.54.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Vascular and Interventional Radiology"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.jvir.2008.05.013","type":"journal-article","created":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T09:33:48Z","timestamp":1214645628000},"page":"1187-1195","source":"Crossref","is-referenced-by-count":117,"title":["Hepatic Yttrium-90 Radioembolization of Chemotherapy-refractory Colorectal Cancer Liver Metastases"],"prefix":"10.1016","volume":"19","author":[{"given":"Tobias F.","family":"Jakobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf-Thorsten","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Dehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Trumm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Stemmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Tatsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"La Fougere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Helmberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian F.","family":"Reiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvir.2008.05.013_bib1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3322\/canjclin.49.4.202","article-title":"Adjuvant therapy of colon cancer","volume":"49","author":"Macdonald","year":"1999","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jvir.2008.05.013_bib2","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1200\/JCO.2000.18.16.2938","article-title":"Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer","volume":"18","author":"de Gramont","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib3","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0140-6736(00)02034-1","article-title":"Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial","volume":"355","author":"Douillard","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jvir.2008.05.013_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1200\/JCO.2004.05.113","article-title":"FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study","volume":"22","author":"Tournigand","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib5","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2006.09.6305","article-title":"Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200","volume":"25","author":"Giantonio","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2407-7-91","article-title":"Front-line bevacizumab in combination with oxaliplatin, leucovorin and 5-fluorouracil (FOLFOX) in patients with metastatic colorectal cancer: a multicenter phase II study","volume":"7","author":"Emmanouilides","year":"2007","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jvir.2008.05.013_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1148\/radiol.2211001624","article-title":"Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients","volume":"221","author":"Solbiati","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.jvir.2008.05.013_bib8","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/00004424-200411000-00007","article-title":"Percutaneous radiofrequency ablation of hepatic colorectal metastases: technique, indications, results, and new promises","volume":"39","author":"Lencioni","year":"2004","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib9","first-page":"671","article-title":"Radiofrequency ablation of colorectal liver metastases: mid-term results in 68 patients","volume":"26","author":"Jakobs","year":"2006","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jvir.2008.05.013_bib10","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s00330-004-2416-z","article-title":"Radio-frequency ablation of colorectal liver metastases in 167 patients","volume":"14","author":"Gillams","year":"2004","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1148\/radiol.2302020646","article-title":"Colorectal carcinoma metastases in liver: laser-induced interstitial thermotherapy\u2013local tumor control rate and survival data","volume":"230","author":"Vogl","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.jvir.2008.05.013_bib12","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.surg.2004.07.001","article-title":"Long-term follow up and prognostic factors for cryotherapy of malignant liver tumors","volume":"136","author":"Kerkar","year":"2004","journal-title":"Surgery"},{"key":"10.1016\/j.jvir.2008.05.013_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/153303460400300208","article-title":"Cryotherapy for liver tumors: current status, perspectives, clinical results, and review of literature","volume":"3","author":"Seifert","year":"2004","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.jvir.2008.05.013_bib14","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1007\/s00330-006-0508-7","article-title":"Mid-term results in otherwise treatment refractory primary or secondary liver confined tumours treated with selective internal radiation therapy (SIRT) using (90)yttrium resin-microspheres","volume":"17","author":"Jakobs","year":"2007","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ijrobp.2005.12.051","article-title":"Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases: modern USA experience","volume":"65","author":"Kennedy","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jvir.2008.05.013_bib16","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1200\/JCO.2006.08.7916","article-title":"Radioembolization of liver metastases from colorectal cancer using yttrium-90 microspheres with concomitant systemic oxaliplatin, fluorouracil, and leucovorin chemotherapy","volume":"25","author":"Sharma","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib17","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1445-2197.2006.03834.x","article-title":"Selective internal radiation therapy with 90Y microspheres for colorectal liver metastases: single-centre experience with 100 patients","volume":"76","author":"Stubbs","year":"2006","journal-title":"Aust N Z J Surg"},{"key":"10.1016\/j.jvir.2008.05.013_bib18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jso.20141","article-title":"Randomised phase 2 trial of SIR-Spheres plus fluorouracil\/leucovorin chemotherapy versus fluorouracil\/leucovorin chemotherapy alone in advanced colorectal cancer","volume":"88","author":"Van Hazel","year":"2004","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijrobp.2006.11.060","article-title":"Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: a consensus panel report from the radioembolization brachytherapy oncology consortium","volume":"68","author":"Kennedy","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jvir.2008.05.013_bib20","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/01.RVI.0000164324.79242.B2","article-title":"Angiographic considerations in patients undergoing liver-directed therapy","volume":"16","author":"Liu","year":"2005","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib21","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1097\/01.RVI.0000235779.88652.53","article-title":"Radioembolization with 90yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies","volume":"17","author":"Salem","year":"2006","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib22","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/01.RVI.0000233785.75257.9A","article-title":"Radioembolization with 90Yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies","volume":"17","author":"Salem","year":"2006","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib23","first-page":"1673","article-title":"Treatment of nonresectable hepatocellular carcinoma with intrahepatic 90Y-microspheres","volume":"41","author":"Dancey","year":"2000","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jvir.2008.05.013_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1051-0443(07)61790-4","article-title":"Yttrium-90 microspheres: radiation therapy for unresectable liver cancer","volume":"13","author":"Salem","year":"2002","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.RVI.00001142592.89564.F9","article-title":"Treatment of unresectable hepatocellular carcinoma with intrahepatic yttrium 90 microspheres: factors associated with liver toxicities","volume":"16","author":"Goin","year":"2005","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib26","first-page":"293","article-title":"Clinical evaluation of the partition model for estimating radiation doses from yttrium-90 microspheres in the treatment of hepatic cancer","volume":"24","author":"Ho","year":"1997","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.jvir.2008.05.013_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijrobp.2006.11.060","article-title":"Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: a consensus panel report from the radioembolization brachytherapy oncology consortium","volume":"68","author":"Kennedy","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jvir.2008.05.013_bib28","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00270-007-9064-z","article-title":"Radioembolization with (90)y microspheres: angiographic and technical considerations","volume":"30","author":"Lewandowski","year":"2007","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","article-title":"New guidelines to evaluate the response to treatment in solid tumors","volume":"92","author":"Therasse","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jvir.2008.05.013_bib30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1053-4296(03)00031-6","article-title":"CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment","volume":"13","author":"Trotti","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib31","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJM200009283431302","article-title":"Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer","volume":"343","author":"Saltz","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvir.2008.05.013_bib32","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1200\/JCO.1989.7.11.1646","article-title":"A randomized trial of continuous intravenous versus hepatic intraarterial floxuridine in patients with colorectal cancer metastatic to the liver: the Northern California Oncology Group trial","volume":"7","author":"Hohn","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib33","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/bjc.1998.627","article-title":"Hepatic arterial floxuridine as second-line treatment for systemic fluorouracil-resistant colorectal liver metastases","volume":"78","author":"Fordy","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jvir.2008.05.013_bib34","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0360-3016(94)00591-8","article-title":"The treatment of colorectal liver metastases with conformal radiation therapy and regional chemotherapy","volume":"32","author":"Robertson","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jvir.2008.05.013_bib35","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/BF01084369","article-title":"Partition model for estimating radiation doses from yttrium-90 microspheres in treating hepatic tumours","volume":"23","author":"Ho","year":"1996","journal-title":"Eur J Nucl Med"},{"key":"10.1016\/j.jvir.2008.05.013_bib36","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.ijrobp.2004.09.004","article-title":"Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers","volume":"60","author":"Kennedy","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jvir.2008.05.013_bib37","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0360-3016(97)00818-3","article-title":"Selective internal radiation therapy for nonresectable hepatocellular carcinoma with intraarterial infusion of 90yttrium microspheres","volume":"40","author":"Lau","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jvir.2008.05.013_bib38","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1023\/A:1013569329846","article-title":"Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer","volume":"12","author":"Gray","year":"2001","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib39","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/01.RVI.0000161142.12822.66","article-title":"Yttrium 90 resin microspheres for the treatment of unresectable colorectal hepatic metastases after failure of multiple chemotherapy regimens: preliminary results","volume":"16","author":"Murthy","year":"2005","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/annonc\/mdl336","article-title":"Phase II study of an optimized 5-fluorouracil-oxaliplatin strategy (OPTIMOX2) with celecoxib in metastatic colorectal cancer: a GERCOR study","volume":"18","author":"Andre","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib41","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/annonc\/mdi193","article-title":"Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: a multicenter, randomized, phase II study","volume":"16","author":"Kalofonos","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib42","first-page":"1892","article-title":"Metabolic response after intraarterial 90Y-glass microsphere treatment for colorectal liver metastases: comparison of quantitative and visual analyses by 18F-FDG PET","volume":"45","author":"Wong","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jvir.2008.05.013_bib43","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1097\/01.RVI.0000168104.32849.07","article-title":"Reduction of metastatic load to liver after intraarterial hepatic yttrium-90 radioembolization as evaluated by [18F]fluorodeoxyglucose positron emission tomographic imaging","volume":"16","author":"Wong","year":"2005","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2008.05.013_bib44","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/cbr.2006.21.305","article-title":"Regional yttrium-90 microsphere treatment of surgically unresectable and chemotherapy-refractory metastatic liver carcinoma","volume":"21","author":"Wong","year":"2006","journal-title":"Cancer Biother Radiopharm"},{"key":"10.1016\/j.jvir.2008.05.013_bib45","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1200\/JCO.1997.15.8.2910","article-title":"Phase II trial of irinotecan in patients with metastatic colorectal carcinoma","volume":"15","author":"Pitot","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jvir.2008.05.013_bib46","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(98)03085-2","article-title":"Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer","volume":"352","author":"Rougier","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jvir.2008.05.013_bib47","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0140-6736(98)02309-5","article-title":"Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer","volume":"352","author":"Cunningham","year":"1998","journal-title":"Lancet"}],"container-title":["Journal of Vascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051044308005071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051044308005071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T11:12:21Z","timestamp":1557659541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1051044308005071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S1051044308005071"],"URL":"https:\/\/doi.org\/10.1016\/j.jvir.2008.05.013","relation":{},"ISSN":["1051-0443"],"issn-type":[{"value":"1051-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}