{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:23:41Z","timestamp":1790486621595,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation de l\u2019Association des Radiologistes du Qu\u00e9bec","award":["FRQS-ARQ 31144"],"award-info":[{"award-number":["FRQS-ARQ 31144"]}]},{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010479","name":"Cook Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvir.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular and Interventional Radiology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jvir.2018.09.031","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T18:50:51Z","timestamp":1553885451000},"page":"1116-1127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation"],"prefix":"10.1016","volume":"30","author":[{"given":"Amine M.","family":"Korchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Cengarle-Samak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Martel-Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Pierre","family":"Pelletier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Boesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9e","family":"Doyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paule","family":"Bodson-Clermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lussier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"H\u00e9on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Sapoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie J.","family":"Bureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Soulez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvir.2018.09.031_bib1","first-page":"120","article-title":"Prevalence of disabilities and associated health conditions among adults--United States, 1999","volume":"50","year":"2001","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jvir.2018.09.031_bib2","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1097\/00003086-200110001-00003","article-title":"Symptomatic articular cartilage degeneration: the impact in the new millennium","volume":"391 Suppl","author":"Jackson","year":"2001","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jvir.2018.09.031_bib3","first-page":"2099","article-title":"Knee osteoarthritis clinical practice guidelines -- how are we doing?","volume":"34","author":"DeHaan","year":"2007","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jvir.2018.09.031_bib4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00270-014-0944-8","article-title":"Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis","volume":"38","author":"Okuno","year":"2015","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jvir.2018.09.031_bib5","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jvir.2017.02.033","article-title":"Midterm clinical outcomes and MR imaging changes after transcatheter arterial embolization as a treatment for mild to moderate radiographic knee osteoarthritis resistant to conservative treatment","volume":"28","author":"Okuno","year":"2017","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2018.09.031_bib6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2012.80","article-title":"Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis","volume":"8","author":"Mapp","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jvir.2018.09.031_bib7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.joca.2007.01.020","article-title":"Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis","volume":"15","author":"Walsh","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jvir.2018.09.031_bib8","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1002\/art.30422","article-title":"Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis","volume":"63","author":"Ashraf","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jvir.2018.09.031_bib9","series-title":"Rheumatology","first-page":"1454","article-title":"Animal models of osteoarthritis","author":"Pelletier","year":"2014"},{"key":"10.1016\/j.jvir.2018.09.031_bib10","doi-asserted-by":"crossref","first-page":"764621","DOI":"10.1155\/2012\/764621","article-title":"A\u00a0review of translational animal models for knee osteoarthritis","volume":"2012","author":"Gregory","year":"2012","journal-title":"Arthritis"},{"key":"10.1016\/j.jvir.2018.09.031_bib11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/ard.32.4.387","article-title":"Experimentally-induced osteoarthritis in the dog","volume":"32","author":"Pond","year":"1973","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jvir.2018.09.031_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/03009742.2011.608375","article-title":"Dynamic gadolinium-enhanced magnetic resonance imaging allows accurate assessment of the synovial inflammatory activity in rheumatoid arthritis knee joints: a comparison with synovial histology","volume":"41","author":"Axelsen","year":"2012","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jvir.2018.09.031_bib13","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/1529-0131(199905)42:5<918::AID-ANR10>3.0.CO;2-2","article-title":"Magnetic resonance imaging-determined synovial membrane volume as a marker of disease activity and a predictor of progressive joint destruction in the wrists of patients with rheumatoid arthritis","volume":"42","author":"Ostergaard","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jvir.2018.09.031_bib14","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1136\/ard.2007.077297","article-title":"Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis","volume":"67","author":"Boileau","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jvir.2018.09.031_bib15","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.joca.2010.04.017","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the dog","volume":"18 Suppl 3","author":"Cook","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jvir.2018.09.031_bib16","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00330-004-2486-y","article-title":"Early changes in experimental osteoarthritis using the Pond-Nuki dog model: technical procedure and initial results of in\u00a0vivo MR imaging","volume":"15","author":"Libicher","year":"2005","journal-title":"Eur Radiol"},{"key":"10.1016\/j.jvir.2018.09.031_bib17","first-page":"363","article-title":"Animal models of osteoarthritis","volume":"1","author":"Bendele","year":"2001","journal-title":"J\u00a0Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.jvir.2018.09.031_bib18","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1109\/TBME.2003.814539","article-title":"Computer-aided method for quantification of cartilage thickness and volume changes using MRI: validation study using a synthetic model","volume":"50","author":"Kauffmann","year":"2003","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.jvir.2018.09.031_bib19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1063-4584(03)00029-3","article-title":"Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees","volume":"11","author":"Raynauld","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jvir.2018.09.031_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/03009742.2012.723745","article-title":"Reliability and responsiveness of dynamic contrast-enhanced magnetic resonance imaging in rheumatoid arthritis","volume":"42","author":"Axelsen","year":"2013","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jvir.2018.09.031_bib21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.joca.2014.04.018","article-title":"Knee pain and inflammation in the infrapatellar fat pad estimated by conventional and dynamic contrast-enhanced magnetic resonance imaging in obese patients with osteoarthritis: a cross-sectional study","volume":"22","author":"Ballegaard","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jvir.2018.09.031_bib22","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.joca.2015.05.032","article-title":"Associations between muscle perfusion and symptoms in knee osteoarthritis: a cross sectional study","volume":"23","author":"Bandak","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jvir.2018.09.031_bib23","first-page":"647","article-title":"Dynamic contrast-enhanced, extremity-dedicated MRI identifies synovitis changes in the follow-up of rheumatoid arthritis patients treated with rituximab","volume":"32","author":"Cimmino","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jvir.2018.09.031_bib24","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.ejrad.2016.03.017","article-title":"Synovitis assessed on static and dynamic contrast-enhanced magnetic resonance imaging and its association with pain in knee osteoarthritis: a cross-sectional study","volume":"85","author":"Riis","year":"2016","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jvir.2018.09.031_bib25","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.joca.2016.10.006","article-title":"The association between histological, macroscopic and magnetic resonance imaging assessed synovitis in end-stage knee osteoarthritis: a cross-sectional study","volume":"25","author":"Riis","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jvir.2018.09.031_bib26","first-page":"561","article-title":"Synovial pathology in an ovine model of osteoarthritis: effect of intraarticular hyaluronan (Hyalgan)","volume":"26","author":"Cake","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jvir.2018.09.031_bib27","first-page":"365","article-title":"Synovial membrane inflammation and cytokine production in patients with early osteoarthritis","volume":"24","author":"Smith","year":"1997","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jvir.2018.09.031_bib28","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/art.1780160317","article-title":"Experimentally induced degenerative joint lesions following partial meniscectomy in the rabbit","volume":"16","author":"Moskowitz","year":"1973","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jvir.2018.09.031_bib29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/anr.1780320211","article-title":"Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis","volume":"32","author":"Pelletier","year":"1989","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jvir.2018.09.031_bib30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ejrad.2010.02.017","article-title":"Technical aspects of MR perfusion","volume":"76","author":"Sourbron","year":"2010","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.jvir.2018.09.031_bib31","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2214\/AJR.12.8510","article-title":"Overview of dynamic contrast-enhanced MRI in prostate cancer diagnosis and management","volume":"198","author":"Verma","year":"2012","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.jvir.2018.09.031_bib32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/rheumatology\/ker220","article-title":"Correlation between computer-aided dynamic gadolinium-enhanced MRI assessment of inflammation and semi-quantitative synovitis and bone marrow oedema scores of the wrist in patients with rheumatoid arthritis--a cohort study","volume":"51","author":"Boesen","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jvir.2018.09.031_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.rdc.2012.10.003","article-title":"Imaging of osteoarthritis","volume":"39","author":"Guermazi","year":"2013","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.jvir.2018.09.031_bib34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.semarthrit.2010.12.003","article-title":"Imaging of synovitis in osteoarthritis: current status and outlook","volume":"41","author":"Hayashi","year":"2011","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jvir.2018.09.031_bib35","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.joca.2011.08.010","article-title":"Comparing non-enhanced and enhanced sequences in the assessment of effusion and synovitis in knee osteoarthritis: associations with clinical, macroscopic and microscopic features","volume":"19","author":"Loeuille","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jvir.2018.09.031_bib36","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/ard.2010.139618","article-title":"Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study","volume":"70","author":"Guermazi","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jvir.2018.09.031_bib37","doi-asserted-by":"crossref","first-page":"e014266","DOI":"10.1136\/bmjopen-2016-014266","article-title":"Protocol for a single-centre, parallel-arm, randomised controlled superiority trial evaluating the effects of transcatheter arterial embolisation of abnormal knee neovasculature on pain, function and quality of life in people with knee osteoarthritis","volume":"7","author":"Landers","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.jvir.2018.09.031_bib38","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.2106\/00004623-197961080-00013","article-title":"Microvasculature of the cruciate ligaments and its response to injury. An experimental study in dogs","volume":"61","author":"Arnoczky","year":"1979","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.jvir.2018.09.031_bib39","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2106\/00004623-198062030-00011","article-title":"Transplantation of the canine knee joint on a vascular pedicle. A preliminary study","volume":"62","author":"Goldberg","year":"1980","journal-title":"J\u00a0Bone Joint Surg Am"}],"container-title":["Journal of Vascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051044318315781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051044318315781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T06:03:01Z","timestamp":1760940181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1051044318315781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1051044318315781"],"URL":"https:\/\/doi.org\/10.1016\/j.jvir.2018.09.031","relation":{},"ISSN":["1051-0443"],"issn-type":[{"value":"1051-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular and Interventional Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvir.2018.09.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 SIR, 2018","name":"copyright","label":"Copyright"}]}}