{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:20:57Z","timestamp":1778628057184,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvir.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular and Interventional Radiology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jvir.2020.04.010","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T03:47:03Z","timestamp":1594957623000},"page":"1706-1716.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Idarubicin-Loaded ONCOZENE Drug-Eluting Bead Chemoembolization in a Rabbit Liver Tumor Model: Investigating Safety, Therapeutic Efficacy, and Effects on Tumor Microenvironment"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-5470","authenticated-orcid":false,"given":"Tabea","family":"Borde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Laage Gaupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Francois","family":"Geschwind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn J.","family":"Savic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Miszczuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irvin","family":"Rexha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-5228","authenticated-orcid":false,"given":"John J.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana C.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Sinusas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Schlachter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Gebauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahmeed","family":"Hyder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6289-0817","authenticated-orcid":false,"given":"Daniel","family":"Coman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna M.M.","family":"van Breugel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Chapiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvir.2020.04.010_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000367739","article-title":"Surgical and locoregional therapy of HCC: TACE","volume":"4","author":"Tsurusaki","year":"2015","journal-title":"Liver Cancer"},{"key":"10.1016\/j.jvir.2020.04.010_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clinre.2016.05.013","article-title":"Evaluation of drug-eluting beads versus conventional transcatheter arterial chemoembolization in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis","volume":"41","author":"Chen","year":"2017","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.jvir.2020.04.010_bib3","article-title":"Does drug-eluting bead transcatheter arterial chemoembolization improve the management of patients with hepatocellular carcinoma? A meta-analysis","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jvir.2020.04.010_bib4","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/jgh.12439","article-title":"Doxorubicin-eluting beads versus conventional transarterial chemoembolization for the treatment of hepatocellular carcinoma","volume":"29","author":"Huang","year":"2014","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jvir.2020.04.010_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00270-009-9711-7","article-title":"Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study","volume":"33","author":"Lammer","year":"2010","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib6","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jvir.2015.03.020","article-title":"Transarterial hepatic chemoembolization with 70\u2013150-\u03bcm drug-eluting beads: assessment of clinical safety and liver toxicity profile","volume":"26","author":"Odisio","year":"2015","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib7","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s00270-016-1382-6","article-title":"Pharmacokinetics, safety, and efficacy of chemoembolization with doxorubicin-loaded tightly calibrated small microspheres in patients with hepatocellular carcinoma","volume":"39","author":"Malagari","year":"2016","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00270-013-0777-x","article-title":"Chemoembolization of\u00a0hepatocellular carcinoma with HepaSphere 30-60 mum. Safety\u00a0and efficacy study","volume":"37","author":"Malagari","year":"2014","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib9","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1097\/CAD.0b013e328346a0c5","article-title":"Screening of anticancer drugs for chemoembolization of hepatocellular carcinoma","volume":"22","author":"Boulin","year":"2011","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.jvir.2020.04.010_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jvir.2014.08.021","article-title":"Idarubicin-loaded ONCOZENE drug-eluting embolic agents for chemoembolization of hepatocellular carcinoma: in\u00a0vitro loading and release and in\u00a0vivo pharmacokinetics","volume":"26","author":"Guiu","year":"2015","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib11","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jvir.2014.04.005","article-title":"Pharmacokinetics and antitumor efficacy of chemoembolization using 40-\u03bcm irinotecan-loaded microspheres in a rabbit liver tumor model","volume":"25","author":"Tanaka","year":"2014","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib12","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.jvir.2016.05.015","article-title":"An in\u00a0vitro evaluation of four types of drug-eluting microspheres loaded with doxorubicin","volume":"27","author":"de Baere","year":"2016","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jvir.2014.12.020","article-title":"Safety and efficacy of 70\u2013150-\u03bcm and 100\u2013300-\u03bcm drug-eluting bead transarterial chemoembolization for hepatocellular carcinoma","volume":"26","author":"Deipolyi","year":"2015","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.suronc.2011.09.001","article-title":"The tumor microenvironment","volume":"21","author":"Weber","year":"2012","journal-title":"Surg Oncol"},{"key":"10.1016\/j.jvir.2020.04.010_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40336-017-0231-1","article-title":"Molecular mechanisms of hypoxia in cancer","volume":"5","author":"Challapalli","year":"2017","journal-title":"Clin Transl Imaging"},{"key":"10.1016\/j.jvir.2020.04.010_bib16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10456-008-9107-3","article-title":"Mechanisms of adaptive angiogenesis to tissue hypoxia","volume":"11","author":"Fong","year":"2008","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jvir.2020.04.010_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/HP.S93413","article-title":"The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy","volume":"3","author":"Muz","year":"2015","journal-title":"Hypoxia (Auckl)"},{"key":"10.1016\/j.jvir.2020.04.010_bib18","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/j.1440-1746.2007.04997.x","article-title":"Hypoxia and hepatocellular carcinoma: the therapeutic target for hepatocellular carcinoma","volume":"22","author":"Wu","year":"2007","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.jvir.2020.04.010_bib19","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1158\/1078-0432.CCR-05-2225","article-title":"New intra-arterial drug delivery system for the treatment of liver cancer: preclinical assessment in a rabbit model of liver cancer","volume":"12","author":"Hong","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jvir.2020.04.010_bib20","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s00270-003-2632-y","article-title":"Animal models for therapeutic embolization","volume":"26","author":"Moreira","year":"2003","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/S1051-0443(07)61299-8","article-title":"Chemoembolization of liver tumor in a rabbit model: assessment of tumor cell death with diffusion-weighted MR imaging and histologic analysis","volume":"11","author":"Geschwind","year":"2000","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib22","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.7150\/thno.32943","article-title":"Theranostic application of lipiodol for transarterial chemoembolization in a VX2 rabbit liver tumor model","volume":"9","author":"van Breugel","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jvir.2020.04.010_bib23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1158\/1078-0432.CCR-16-0725","article-title":"Preclinical benefit of hypoxia-activated intra-arterial therapy with evofosfamide in liver cancer","volume":"23","author":"Duran","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jvir.2020.04.010_bib24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1158\/1078-0432.CCR-19-1702","article-title":"Molecular imaging of extracellular tumor pH to reveal effects of locoregional therapy on liver cancer microenvironment","volume":"26","author":"Savic","year":"2020","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jvir.2020.04.010_bib25","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/mrm.28035","article-title":"Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner","volume":"83","author":"Coman","year":"2020","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.jvir.2020.04.010_bib26","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1080\/02656736.2018.1462535","article-title":"Radiofrequency ablation (RFA)-induced systemic tumor growth can be reduced by suppression of resultant heat shock proteins","volume":"34","author":"Ahmed","year":"2018","journal-title":"Int J Hyperthermia"},{"key":"10.1016\/j.jvir.2020.04.010_bib27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jvir.2012.11.023","article-title":"Safety and efficacy of drug-eluting bead chemoembolization for hepatocellular carcinoma: comparison of small versus medium-size particles","volume":"24","author":"Padia","year":"2013","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/01.RVI.0000109400.52762.1F","article-title":"Fatal pulmonary complications after arterial embolization with 40-120- micro m tris-acryl gelatin microspheres","volume":"15","author":"Brown","year":"2004","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/gut.48.1.87","article-title":"Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma","volume":"48","author":"von Marschall","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.jvir.2020.04.010_bib30","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jfma.2011.05.016","article-title":"The influence on liver function after transcatheter arterial chemoembolization combined with percutaneous radiofrequency ablation in patients with hepatocellular carcinoma","volume":"111","author":"Li","year":"2012","journal-title":"J\u00a0Formos Med Assoc"},{"key":"10.1016\/j.jvir.2020.04.010_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jvir.2011.10.019","article-title":"Radiopaque drug-eluting beads for transcatheter embolotherapy: experimental study of drug penetration and coverage in swine","volume":"23","author":"Dreher","year":"2012","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib32","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/jmri.25179","article-title":"Diffusion-weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors","volume":"44","author":"Wu","year":"2016","journal-title":"J\u00a0Magn Reson Imaging"},{"key":"10.1016\/j.jvir.2020.04.010_bib33","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1002\/nbm.2995","article-title":"In\u00a0vivo three-dimensional molecular imaging with biosensor imaging of redundant deviation in shifts (BIRDS) at high spatiotemporal resolution","volume":"26","author":"Coman","year":"2013","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jvir.2020.04.010_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/nbm.3466","article-title":"Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas","volume":"29","author":"Coman","year":"2016","journal-title":"NMR Biomed"},{"key":"10.1016\/j.jvir.2020.04.010_bib35","doi-asserted-by":"crossref","DOI":"10.4161\/onci.22058","article-title":"The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors","volume":"2","author":"Bellone","year":"2013","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.jvir.2020.04.010_bib36","doi-asserted-by":"crossref","unstructured":"Zachary JF. Mechanisms and morphology of cellular injury, adaptation, and death. Pathologic Basis of Veterinary Disease, 6th ed. Zachary JF, ed. St. Louis: Elsevier, 2017; pp. 2\u201343.e19.","DOI":"10.1016\/B978-0-323-35775-3.00001-1"},{"key":"10.1016\/j.jvir.2020.04.010_bib37","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jvir.2015.02.006","article-title":"Segmental transarterial embolization in a translational rat model of hepatocellular carcinoma","volume":"26","author":"Gade","year":"2015","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib38","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/RLI.0b013e318289a70b","article-title":"CAIPIRINHA-Dixon-TWIST (CDT)-volume-interpolated breath-hold examination (VIBE): a new technique for fast time-resolved dynamic 3-dimensional imaging of the abdomen with high spatial resolution","volume":"48","author":"Michaely","year":"2013","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jvir.2020.04.010_bib39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-59745-543-5_1","article-title":"Dynamic imaging of brain function","volume":"489","author":"Hyder","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jvir.2020.04.010_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/nbm.1312","article-title":"Brain temperature and pH measured by (1)H chemical shift imaging of a thulium agent","volume":"22","author":"Coman","year":"2009","journal-title":"NMR Biomed"}],"container-title":["Journal of Vascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051044320303651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051044320303651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T06:05:43Z","timestamp":1760940343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1051044320303651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1051044320303651"],"URL":"https:\/\/doi.org\/10.1016\/j.jvir.2020.04.010","relation":{},"ISSN":["1051-0443"],"issn-type":[{"value":"1051-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Idarubicin-Loaded ONCOZENE Drug-Eluting Bead Chemoembolization in a Rabbit Liver Tumor Model: Investigating Safety, Therapeutic Efficacy, and Effects on Tumor Microenvironment","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular and Interventional Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvir.2020.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 SIR, 2020","name":"copyright","label":"Copyright"}]}}