{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:04:45Z","timestamp":1782975885254,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001661","name":"Heidelberg University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvir.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular and Interventional Radiology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jvir.2025.05.020","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T12:04:31Z","timestamp":1748261071000},"page":"1418-1426.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Degradable Starch Microsphere Transarterial Chemoembolization as Salvage Therapy in Patients with Uveal Melanoma Liver Metastases"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4848-4166","authenticated-orcid":false,"given":"Hannah L.","family":"Steinberg-Vorhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Haubold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Richly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens T.","family":"Siveke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lale","family":"Umutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt M.","family":"Schaarschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5869-7929","authenticated-orcid":false,"given":"Jens M.","family":"Theysohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-8831","authenticated-orcid":false,"given":"Johannes M.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvir.2025.05.020_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/bjophthalmol-2016-309034","article-title":"Metastatic disease from uveal melanoma: treatment options and future prospects","volume":"101","author":"Carvajal","year":"2017","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jvir.2025.05.020_bib2","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.ophtha.2011.01.040","article-title":"Uveal melanoma: trends in incidence, treatment, and survival","volume":"118","author":"Singh","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jvir.2025.05.020_bib3","doi-asserted-by":"crossref","first-page":"8076","DOI":"10.1200\/JCO.2005.02.6534","article-title":"Variates of survival in metastatic uveal melanoma","volume":"23","author":"Rietschel","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib4","doi-asserted-by":"crossref","DOI":"10.1177\/1758834018757175","article-title":"Treatment of uveal melanoma: where are we now?","volume":"10","author":"Yang","year":"2018","journal-title":"Ther Adv Med Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib5","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.3390\/cancers12092557","article-title":"Treatment of metastatic uveal melanoma: systematic review","volume":"12","author":"Rodriguez-Vidal","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jvir.2025.05.020_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2478\/raon-2021-0027","article-title":"Predictive impact of the inflammation-based indices in uveal melanoma liver metastases treated with transarterial hepatic chemoperfusion","volume":"55","author":"Ludwig","year":"2021","journal-title":"Radiol Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib7","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.3390\/cancers13205122","article-title":"European Multicenter Study on Degradable Starch Microsphere TACE: the digestible way to conquer HCC in patients with high tumor burden","volume":"13","author":"Ludwig","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jvir.2025.05.020_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2147\/OTT.S147852","article-title":"Safety and efficacy of transarterial chemoembolization with degradable starch microspheres (DSM-TACE) in the treatment of secondary liver malignancies","volume":"11","author":"Schicho","year":"2018","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.jvir.2025.05.020_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"EASL clinical practice guidelines: management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.jvir.2025.05.020_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ctrv.2018.11.002","article-title":"Updated use of TACE for hepatocellular carcinoma treatment: How and when to use it based on clinical evidence","volume":"72","author":"Raoul","year":"2019","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.jvir.2025.05.020_bib11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jvir.2013.10.007","article-title":"Degradable starch microspheres versus ethiodol and doxorubicin in transarterial chemoembolization of hepatocellular carcinoma","volume":"25","author":"Niessen","year":"2014","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvir.2025.05.020_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/242060","article-title":"Intravital microscopic research of microembolization with degradable starch microspheres","volume":"2013","author":"Ebert","year":"2013","journal-title":"J Drug Deliv"},{"key":"10.1016\/j.jvir.2025.05.020_bib13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00270-014-0966-2","article-title":"Temporary arterial embolization of liver parenchyma with degradable starch microspheres (EmboCept\u00aeS) in a swine model","volume":"38","author":"Pieper","year":"2015","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jvir.2025.05.020_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1158\/1078-0432.CCR-13-2098","article-title":"Tumor growth rate is an early indicator of antitumor drug activity in phase I clinical trials","volume":"20","author":"Fert\u00e9","year":"2014","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jvir.2025.05.020_bib15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0161-6420(91)32285-1","article-title":"Survival of patents with metastases from uveal melanoma","volume":"98","author":"Gragoudas","year":"1991","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jvir.2025.05.020_bib16","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.3390\/cancers15133430","article-title":"Tebentafusp in patients with metastatic uveal melanoma: a real-life retrospective multicenter study","volume":"15","author":"Tomsitz","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jvir.2025.05.020_bib17","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/annonc\/mdt585","article-title":"Hepatic intra-arterial versus intravenous fotemustine in patients with liver metastases from uveal melanoma (EORTC 18021): a multicentric randomized trial","volume":"25","author":"Leyvraz","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib18","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1200\/JCO.2022.40.16_suppl.9511","article-title":"First interim analysis of the SirTac trial: A randomized phase II study of SIRT and DSM-TACE in patients with liver metastases from uveal melanoma","volume":"40","author":"Peuker","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib19","first-page":"406","article-title":"How effective are percutaneous liver-directed therapies in patients with non-colorectal liver metastases?","volume":"31","author":"Vogl","year":"2015","journal-title":"Viszeralmedizin"},{"key":"10.1016\/j.jvir.2025.05.020_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00432-006-0155-z","article-title":"Preliminary experience with transarterial chemoembolization (TACE) in liver metastases of uveal malignant melanoma: local tumor control and survival","volume":"133","author":"Vogl","year":"2007","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib21","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.bulcan.2020.09.010","article-title":"Optimizing the treatment of liver metastases from uveal melanomas with transarterial chemoembolization using melphalan and calibrated microspheres","volume":"107","author":"Carle","year":"2020","journal-title":"Bull Cancer"},{"key":"10.1016\/j.jvir.2025.05.020_bib22","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.2967\/jnumed.122.264996","article-title":"Voxel-based dosimetry predicts hepatotoxicity in hepatocellular carcinoma patients undergoing radioembolization with 90Y glass microspheres","volume":"64","author":"Watanabe","year":"2023","journal-title":"J Nucl Med"},{"key":"10.1016\/j.jvir.2025.05.020_bib23","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2217\/fon.12.191","article-title":"Repetitive chemoembolization of hypovascular liver metastases from the most common primary sites","volume":"9","author":"Farshid","year":"2013","journal-title":"Future Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/CMR.0b013e328334c36e","article-title":"Transarterial chemoembolization of liver metastases from uveal melanoma after failure of systemic therapy: toxicity and outcome","volume":"20","author":"Schuster","year":"2010","journal-title":"Melanoma Res"},{"key":"10.1016\/j.jvir.2025.05.020_bib25","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1056\/NEJMoa2103485","article-title":"Overall survival benefit with tebentafusp in metastatic uveal melanoma","volume":"385","author":"Nathan","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvir.2025.05.020_bib26","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1007\/s00432-020-03289-5","article-title":"Chemosaturation with percutaneous hepatic perfusion is effective in patients with ocular melanoma and cholangiocarcinoma","volume":"146","author":"Schonfeld","year":"2020","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib27","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1016\/j.ejrad.2009.03.064","article-title":"Transarterial chemoembolization of liver metastases in patients with uveal melanoma","volume":"74","author":"Huppert","year":"2010","journal-title":"European Journal of Radiology"},{"key":"10.1016\/j.jvir.2025.05.020_bib28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1471-2407-11-167","article-title":"Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1\u03b1, CAIX, LDH-5, GLUT-1, MCT1 and MCT4","volume":"11","author":"Rademakers","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jvir.2025.05.020_bib29","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.ejca.2012.11.032","article-title":"Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy","volume":"49","author":"Jin","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jvir.2025.05.020_bib30","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.semradonc.2004.04.004","article-title":"Lactate: mirror and motor of tumor malignancy","volume":"14","author":"Walenta","year":"2004","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.jvir.2025.05.020_bib31","doi-asserted-by":"crossref","first-page":"14083","DOI":"10.1007\/s13277-016-5228-2","article-title":"Overall survival of cancer patients with serum lactate dehydrogenase greater than 1000 IU\/L","volume":"37","author":"Liu","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.jvir.2025.05.020_bib32","doi-asserted-by":"crossref","first-page":"8480","DOI":"10.1245\/s10434-022-12368-5","article-title":"Tumor growth rate as a predictive marker for recurrence and survival after liver resection in patients with liver metastases of uveal melanoma","volume":"29","author":"Ramtohul","year":"2022","journal-title":"Ann Surg Oncol"}],"container-title":["Journal of Vascular and Interventional Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051044325003811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1051044325003811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:41:26Z","timestamp":1755697286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1051044325003811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1051044325003811"],"URL":"https:\/\/doi.org\/10.1016\/j.jvir.2025.05.020","relation":{},"ISSN":["1051-0443"],"issn-type":[{"value":"1051-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Degradable Starch Microsphere Transarterial Chemoembolization as Salvage Therapy in Patients with Uveal Melanoma Liver Metastases","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular and Interventional Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvir.2025.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 SIR 2025 .","name":"copyright","label":"Copyright"}]}}