{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T02:20:22Z","timestamp":1774664422167,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Virological Methods"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.jviromet.2009.04.002","type":"journal-article","created":{"date-parts":[[2009,4,11]],"date-time":"2009-04-11T08:12:54Z","timestamp":1239437574000},"page":"233-238","source":"Crossref","is-referenced-by-count":31,"title":["Identification of small interfering RNAs which inhibit the replication of several Enterovirus 71 strains in China"],"prefix":"10.1016","volume":"159","author":[{"given":"Zhiqiang","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jviromet.2009.04.002_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s007050170164","article-title":"Molecular epidemiology of Enterovirus 71 in Taiwan","volume":"146","author":"Chu","year":"2001","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jviromet.2009.04.002_bib2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jviromet.2009.04.002_bib3","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jviromet.2009.04.002_bib4","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/135965350601100411","article-title":"Rapid identification of small interfering RNA that can effectively inhibit the replication of multiple influenza B virus strains","volume":"11","author":"Gao","year":"2006","journal-title":"Antiviral Ther."},{"key":"10.1016\/j.jviromet.2009.04.002_bib5","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nature00873","article-title":"Short interfering RNA confers intracellular antiviral immunity in human cells","volume":"418","author":"Gitlin","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jviromet.2009.04.002_bib6","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/nbt1369","article-title":"RNA interference against viruses: strike and counterstrike","volume":"25","author":"Haasnoot","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jviromet.2009.04.002_bib7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/35052556","article-title":"Post-transcriptional gene silencing by double-stranded RNA","volume":"2","author":"Hammond","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jviromet.2009.04.002_bib8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/00365540701799359","article-title":"Enterovirus 71 in Taiwan, 2004\u20132006: epidemiological and virological features","volume":"40","author":"Huang","year":"2008","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.jviromet.2009.04.002_bib9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0014-5793(03)00893-7","article-title":"Enhanced gene silencing by the application of multiple specific small interfering RNAs","volume":"552","author":"Ji","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jviromet.2009.04.002_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature05901","article-title":"Transvascular delivery of small interfering RNA to the central nervous system","volume":"448","author":"Kumar","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jviromet.2009.04.002_bib11","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1128\/JCM.43.8.3835-3839.2005","article-title":"Genetic characteristics of human Enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China","volume":"43","author":"Li","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jviromet.2009.04.002_bib12","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1093\/nar\/gkm596","article-title":"Design of extended short hairpin RNAs for HIV-1 inhibition","volume":"35","author":"Liu","year":"2007","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jviromet.2009.04.002_bib13","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2004.10.062","article-title":"Selective inhibition of Enterovirus 71 replication by short hairpin RNAs","volume":"325","author":"Lu","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jviromet.2009.04.002_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0092-8674(02)00908-X","article-title":"Single-stranded antisense siRNAs guide target RNA cleavage in RNAi","volume":"110","author":"Martinez","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jviromet.2009.04.002_bib15","doi-asserted-by":"crossref","first-page":"7732","DOI":"10.1128\/JVI.75.16.7732-7738.2001","article-title":"Phylogenetic analysis of Enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia","volume":"75","author":"McMinn","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.jviromet.2009.04.002_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1086\/514508","article-title":"Viral taxonomy","volume":"25","author":"Miller","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jviromet.2009.04.002_bib17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/sj.gt.3302688","article-title":"Lentiviral-mediated delivery of siRNAs for antiviral therapy","volume":"13","author":"Morris","year":"2006","journal-title":"Gene Ther."},{"key":"10.1016\/j.jviromet.2009.04.002_bib18","first-page":"493","article-title":"A simple method of estimating fifty percent end points","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"key":"10.1016\/j.jviromet.2009.04.002_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.virusres.2004.01.010","article-title":"RNA silencing in viral infections: insights from poliovirus","volume":"102","author":"Saleh","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.jviromet.2009.04.002_bib20","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00006454-198702000-00013","article-title":"Monoplegia caused by Enterovirus 71: an outbreak in Hong Kong","volume":"6","author":"Samuda","year":"1987","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.jviromet.2009.04.002_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jmb.2004.11.074","article-title":"Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs","volume":"346","author":"Schubert","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jviromet.2009.04.002_bib22","doi-asserted-by":"crossref","first-page":"490","DOI":"10.11150\/kansenshogakuzasshi1970.75.490","article-title":"Characterization of Enterovirus type 71 isolated in Saitama Prefecture in 2000","volume":"75","author":"Shinohara","year":"2001","journal-title":"Kansenshogaku Zasshi"},{"key":"10.1016\/j.jviromet.2009.04.002_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.virol.2005.06.047","article-title":"RNA interference against Enterovirus 71 infection","volume":"341","author":"Sim","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.jviromet.2009.04.002_bib24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.antiviral.2007.01.004","article-title":"Enhanced potency and efficacy of 29-mer shRNAs in inhibition of Enterovirus 71","volume":"74","author":"Tan","year":"2007","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jviromet.2009.04.002_bib25","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ymthe.2006.07.007","article-title":"Silencing of HIV-1 with RNA interference: a multiple shRNA approach","volume":"14","author":"ter Brake","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jviromet.2009.04.002_bib26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.antiviral.2008.06.017","article-title":"Quick identification of effective small interfering RNAs that inhibit the replication of coxsackievirus A16","volume":"80","author":"Wu","year":"2008","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jviromet.2009.04.002_bib27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/BF02879323","article-title":"The complete genome of Enterovirus 71 China strain","volume":"44","author":"Yang","year":"2001","journal-title":"Sci. China C: Life Sci."},{"key":"10.1016\/j.jviromet.2009.04.002_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.antiviral.2006.05.022","article-title":"Hepatitis B virus is inhibited by RNA interference in cell culture and in mice","volume":"73","author":"Ying","year":"2007","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jviromet.2009.04.002_bib29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature04688","article-title":"RNAi-mediated gene silencing in non-human primates","volume":"441","author":"Zimmermann","year":"2006","journal-title":"Nature"}],"container-title":["Journal of Virological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166093409001645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166093409001645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T20:22:52Z","timestamp":1684959772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166093409001645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0166093409001645"],"URL":"https:\/\/doi.org\/10.1016\/j.jviromet.2009.04.002","relation":{},"ISSN":["0166-0934"],"issn-type":[{"value":"0166-0934","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}