{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:52:49Z","timestamp":1790297569412,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Temasek Life Science Laboratory, Singapore"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Virological Methods"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jviromet.2012.11.038","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T03:25:29Z","timestamp":1354850729000},"page":"76-82","source":"Crossref","is-referenced-by-count":14,"title":["Characterization of a novel monoclonal antibody reactive against the N-terminal region of Enterovirus 71 VP1 capsid protein"],"prefix":"10.1016","volume":"188","author":[{"given":"Xiao Fang","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent T.K.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Kwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jviromet.2012.11.038_bib0005","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.biologicals.2004.09.001","article-title":"Validation of binary ethyleneimine (BEI) used as an inactivant for foot and mouth disease tissue culture vaccine","volume":"32","author":"Aarthi","year":"2004","journal-title":"Biologicals"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1702(99)00019-2","article-title":"Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia","volume":"61","author":"AbuBakar","year":"1999","journal-title":"Virus Res."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0015","doi-asserted-by":"crossref","first-page":"106","DOI":"10.47102\/annals-acadmedsg.V38N2p106","article-title":"Epidemiology and control of hand, foot and mouth disease in Singapore, 2001\u20132007","volume":"38","author":"Ang","year":"2009","journal-title":"Ann. Acad. Med. Singapore"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF01315592","article-title":"Binary ethylenimine as an inactivant for foot-and-mouth disease virus and its application for vaccine production","volume":"47","author":"Bahnemann","year":"1975","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0025","first-page":"R81","article-title":"Epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease in England and Wales","volume":"6","author":"Bendig","year":"1996","journal-title":"Commun. Dis. Rep. CDR Rev."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0030","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0140-6736(74)91684-5","article-title":"Letter: New enterovirus type associated with epidemic of aseptic meningitis and-or hand, foot, and mouth disease","volume":"2","author":"Blomberg","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0035","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1371\/journal.pbio.0050183","article-title":"Imaging poliovirus entry in live cells","volume":"5","author":"Brandenburg","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0040","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1743-422X-7-106","article-title":"Monoclonal antibody induced with inactived EV71-Hn2 virus protects mice against lethal EV71-Hn2 virus infection","volume":"7","author":"Chang","year":"2010","journal-title":"Virol. J."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jviromet.2011.02.003","article-title":"Generation of murine monoclonal antibodies which cross-neutralize human enterovirus genogroup B isolates","volume":"173","author":"Chang","year":"2011","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0050","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF01317504","article-title":"Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria","volume":"60","author":"Chumakov","year":"1979","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.virusres.2006.12.005","article-title":"Identification of neutralizing linear epitopes from the VP1 capsid protein of Enterovirus 71 using synthetic peptides","volume":"125","author":"Foo","year":"2007","journal-title":"Virus Res."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0060","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1128\/JVI.64.5.1934-1945.1990","article-title":"Cell-induced conformational change in poliovirus: externalization of the amino terminus of VP1 is responsible for liposome binding","volume":"64","author":"Fricks","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0065","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1128\/JVI.65.11.6015-6023.1991","article-title":"Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1","volume":"65","author":"Greve","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0070","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000148922","article-title":"Epidemic of hand, foot and mouth disease associated with enterovirus 71 infection","volume":"9","author":"Hagiwara","year":"1978","journal-title":"Intervirology"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.micro.56.012302.160757","article-title":"Poliovirus cell entry: common structural themes in viral cell entry pathways","volume":"56","author":"Hogle","year":"2002","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0080","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nsmb.2276","article-title":"A 3D framework for understanding enterovirus 71","volume":"19","author":"Hogle","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0085","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.2994218","article-title":"Three-dimensional structure of poliovirus at 2.9A resolution","volume":"229","author":"Hogle","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0090","first-page":"609","article-title":"Enterovirus type 71 infection in Melbourne","volume":"51","author":"Kennett","year":"1974","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0095","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/viro.1994.1507","article-title":"Mapping of antigenic domains in poliovirus VP1 involved in structural rearrangements during virus morphogenesis and antigenic alterations of the virion","volume":"204","author":"Ketterlinus","year":"1994","journal-title":"Virology"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0100","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jviromet.2011.12.015","article-title":"Characterization of a monoclonal antibody against the 3D polymerase of enterovirus 71 and its use for the detection of human enterovirus A infection","volume":"180","author":"Kiener","year":"2012","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0105","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1097\/INF.0b013e3181e52945","article-title":"An investigation of epidemic enterovirus 71 infection in Taiwan, 2008: clinical, virologic, and serologic features","volume":"29","author":"Lee","year":"2008","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0110","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.bbrc.2009.09.103","article-title":"Generation of neutralizing monoclonal antibodies against Enterovirus 71 using synthetic peptides","volume":"390","author":"Li","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0115","doi-asserted-by":"crossref","first-page":"e29751","DOI":"10.1371\/journal.pone.0029751","article-title":"Characterization of an isotype-dependent monoclonal antibody against linear neutralizing epitope effective for prophylaxis of Enterovirus 71 infection","volume":"7","author":"Lim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0120","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1016\/j.vaccine.2011.04.010","article-title":"Identification and characterization of a cross-neutralization epitope of Enterovirus 71","volume":"29","author":"Liu","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0125","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1099\/0022-1317-27-3-329","article-title":"Early alteration of poliovirus in infected cells and its specific inhibition","volume":"27","author":"Lonberg-Holm","year":"1975","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0130","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/jmv.23372","article-title":"Identification and characterization of a monoclonal antibody recognizing the linear epitope RVADVI on VP1 protein of enterovirus 71","volume":"84","author":"Man-Li","year":"2012","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0135","doi-asserted-by":"crossref","first-page":"e21757","DOI":"10.1371\/journal.pone.0021757","article-title":"Display of VP1 on the surface of baculovirus and its immunogenicity against heterologous human Enterovirus 71 strains in mice","volume":"6","author":"Meng","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0140","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF01314873","article-title":"Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978","volume":"71","author":"Nagy","year":"1982","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0145","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1128\/JVI.73.3.1941-1948.1999","article-title":"Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification","volume":"73","author":"Oberste","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0150","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1099\/vir.0.79789-0","article-title":"Complete genome sequences of all members of the species human enterovirus A","volume":"85","author":"Oberste","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0155","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"Ooi","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0042-6822(91)90013-2","article-title":"Antigenic regions of poliovirus type 3\/Sabin capsid proteins recognized by human sera in the peptide scanning technique","volume":"180","author":"Roivainen","year":"1991","journal-title":"Virology"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0165","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","article-title":"An apparently new enterovirus isolated from patients with disease of the central nervous system","volume":"129","author":"Schmidt","year":"1974","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0170","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00705-007-0941-1","article-title":"High-titred neutralizing antibodies to human enterovirus 71 preferentially bind to the N-terminal portion of the capsid protein VP1","volume":"152","author":"Tan","year":"2007","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0175","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1128\/JVI.01019-09","article-title":"Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene","volume":"84","author":"Tee","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0180","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nsmb.2255","article-title":"A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71","volume":"19","author":"Wang","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jviromet.2012.11.038_bib0190","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.drudis.2010.10.008","article-title":"Developments towards antiviral therapies against enterovirus 71","volume":"15","author":"Wu","year":"2010","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.jviromet.2012.11.038_bib0185","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im0205s74","article-title":"Production of monoclonal antibodies","author":"Yokoyama","year":"2006","journal-title":"Curr. Protoc. Immunol."}],"container-title":["Journal of Virological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166093412004302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166093412004302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T16:05:28Z","timestamp":1687881928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166093412004302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0166093412004302"],"URL":"https:\/\/doi.org\/10.1016\/j.jviromet.2012.11.038","relation":{},"ISSN":["0166-0934"],"issn-type":[{"value":"0166-0934","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}