{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T15:49:04Z","timestamp":1724687344428},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Virological Methods"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.jviromet.2013.06.015","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T19:03:37Z","timestamp":1371236617000},"page":"341-347","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of hepatitis B virus genotyping and drug resistance gene mutations based on massively parallel sequencing"],"prefix":"10.1016","volume":"193","author":[{"given":"Yingxin","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deming","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jviromet.2013.06.015_bib0005","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/hep.510270628","article-title":"Identification and characterization of mutations in hepatitis B virus resistant to lamivudine","volume":"27","author":"Allen","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0010","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1128\/JCM.37.10.3338-3347.1999","article-title":"Two sensitive PCR-based methods for detection of hepatitis B virus variants associated with reduced susceptibility to lamivudine","volume":"37","author":"Allen","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0015","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0016-5085(03)00939-9","article-title":"Resistance to Adefovirdipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase","volume":"125","author":"Angus","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1126\/science.325649","article-title":"Australia antigen and the biology of hepatitis B","volume":"197","author":"Blumberg","year":"1977","journal-title":"Science"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0025","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1046\/j.1365-2893.2003.00435.x","article-title":"YSDD: a novel mutation in HBV DNA polymerase confers clinical resistance to lamivudine","volume":"10","author":"Bozdayi","year":"2003","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0030","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jhep.2008.03.010","article-title":"Monitoring antiviral resistance in patients receiving nucleos(t)ide analog therapies for hepatitis B: which method should be used?","volume":"48","author":"Degertekin","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0035","doi-asserted-by":"crossref","first-page":"11833","DOI":"10.1128\/JVI.77.21.11833-11841.2003","article-title":"The hepatitis B virus polymerase mutation rtV173 L is selected during lamivudine therapy and enhances viral replication in vitro","volume":"77","author":"Delaney","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0040","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1073\/pnas.90.9.4171","article-title":"Rates of spontaneous mutation among RNA viruses","volume":"90","author":"Drake","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0045","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.molcel.2006.04.025","article-title":"Native hepatitis B virions and capsids visualized by electron cryomicroscopy","volume":"22","author":"Dryden","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0050","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1101\/gr.8.3.175","article-title":"Base-calling of automated sequencer traces using Phred. II. Error probabilities","volume":"8","author":"Ewing","year":"1998","journal-title":"Genome Res"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0055","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jhep.2005.02.017","article-title":"Safety and antiviral activity of emtricitabine (FTC) for the treatment of chronic hepatitis B infection: a two-year study","volume":"43","author":"Gish","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0060","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.ijid.2010.03.020","article-title":"Hepatitis B virus genotyping: current methods and clinical implications","volume":"14","author":"Guirgis","year":"2010","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0065","series-title":"Field's virology","first-page":"2971","article-title":"Hepatitis B virus","author":"Hollinger","year":"2000"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0070","doi-asserted-by":"crossref","first-page":"8457","DOI":"10.1093\/nar\/gkr451","article-title":"Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome","volume":"39","author":"Homs","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0166-0934(99)00125-1","article-title":"Rapid detection of lamivudine-resistant hepatitis B virus polymerase gene variants","volume":"83","author":"Jardi","year":"1999","journal-title":"J Virol Method"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0080","doi-asserted-by":"crossref","first-page":"231","DOI":"10.29074\/ascls.23.4.231","article-title":"Molecular virology in the clinical laboratory","volume":"23","author":"Josko","year":"2010","journal-title":"Clin Lab Sci"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0085","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0016-5085(00)70261-7","article-title":"Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B","volume":"118","author":"Kao","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0090","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1365-2893.2005.00624.x","article-title":"Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy","volume":"12","author":"Kramvis","year":"2005","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0095","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1097\/01.aids.0000252061.35422.84","article-title":"A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient","volume":"20","author":"Lacombe","year":"2006","journal-title":"AIDS"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0100","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12072-008-9080-3","article-title":"Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update","volume":"2","author":"Liaw","year":"2008","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0105","first-page":"941","article-title":"Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine","volume":"14","author":"Ling","year":"2010","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0110","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-2005-915645","article-title":"Molecular virology and the development of resistant mutants: implications for therapy","volume":"25","author":"Locarnini","year":"2005","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12072-008-9048-3","article-title":"Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure","volume":"2","author":"Locarnini","year":"2008","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0125","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1373\/clinchem.2009.124859","article-title":"Multiplex detection of 60 hepatitis B virus variants by MALDI-TOF mass spectrometry","volume":"55","author":"Luan","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0130","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2893.1999.00174.x","article-title":"Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection?","volume":"6","author":"Mayerat","year":"1999","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0135","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in microfabricated high-density picolitre reactors","volume":"437","author":"Margulies","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1371\/journal.pone.0035052","article-title":"Dynamics of hepatitis B virus Quasi species in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing","volume":"7","author":"Nishijima","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0145","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1093\/bioinformatics\/btn512","article-title":"Efficient mapping of applied biosystems SOLiD sequence data to a reference genome for functional genomic applications","volume":"24","author":"Ondov","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0150","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1053\/j.gastro.2007.11.036","article-title":"Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: recommendations for a standardized approach","volume":"134","author":"Pawlotsky","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0155","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nmeth1110","article-title":"Multiplex amplification of large set of human exons","volume":"4","author":"Porreca","year":"2007","journal-title":"Nat Methods"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0160","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1053\/j.gastro.2006.04.007","article-title":"Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B","volume":"130","author":"Sherman","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0165","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1128\/JVI.02011-08","article-title":"Use of massively parallel ultradeep pyrosequencing to characterize the genetic diversity of hepatitis B virus in drug-resistant and drug-naive patients and to detect minor variants in reverse transcriptase and hepatitis B S antigen","volume":"83","author":"Solmone","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0170","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1128\/AAC.00833-06","article-title":"Two-year assessment of entecavir resistance in Lamivudine-refractory hepatitis B virus patients reveals different clinical outcomes depending on the resistance substitutions present","volume":"51","author":"Tenney","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0175","series-title":"Hepatitis B. Fact sheet N 204","author":"World Health Organization (WHO)","year":"2011"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0180","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1128\/AAC.01499-06","article-title":"The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro","volume":"51","author":"Warner","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0185","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1053\/jhep.2000.7296","article-title":"Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy","volume":"31","author":"Yeh","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0190","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jhep.2009.12.036","article-title":"Long-term use of enticavir in nucleoside-na\u00efve Japanese patients with chronic hepatitis B virus","volume":"52","author":"Yokosuka","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.jviromet.2013.06.015_bib0195","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1158\/1055-9965.EPI-09-1001","article-title":"Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study","volume":"19","author":"Yin","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["Journal of Virological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166093413002292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166093413002292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T12:48:12Z","timestamp":1595940492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166093413002292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0166093413002292"],"URL":"https:\/\/doi.org\/10.1016\/j.jviromet.2013.06.015","relation":{},"ISSN":["0166-0934"],"issn-type":[{"value":"0166-0934","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of hepatitis B virus genotyping and drug resistance gene mutations based on massively parallel sequencing","name":"articletitle","label":"Article Title"},{"value":"Journal of Virological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jviromet.2013.06.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}