{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:09:13Z","timestamp":1783566553238,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvoice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Voice"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jvoice.2018.11.002","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T17:15:16Z","timestamp":1544894116000},"page":"280-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vocal Tract Discomfort and Dysphonia in Patients Undergoing Empiric Therapeutic Trial with Proton Pump Inhibitor for Suspected Laryngopharyngeal Reflux"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-4063","authenticated-orcid":false,"given":"F","family":"Mozzanica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Robotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JR","family":"Lechien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-0742","authenticated-orcid":false,"given":"N","family":"Pizzorni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pirola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mengucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dell'Era","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ottaviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Schindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvoice.2018.11.002_bib0001","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1067\/mhn.2002.125760","article-title":"Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the american academy of otolaryngology\u2013head and neck surgery","volume":"127","author":"Koufman","year":"2002","journal-title":"Otolaryngol. Head Neck Surg"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0002","first-page":"S1","article-title":"Rethinking the laryngopharyngeal reflux treatment algorithm: evaluating an alternate empiric dosing regimen and considering up-front, pH-impedance, and manometry testing to minimize cost in treating suspect laryngopharyngeal reflux disease","volume":"217","author":"Carroll","year":"2017","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0003","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MCG.0000000000000324","article-title":"Proton pump inhibitor therapy for the treatment of laryngopharyngeal reflux. A meta-analysis of randomized controlled trials","volume":"50","author":"Guo","year":"2016","journal-title":"J. Clin. Gastroenterol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0004","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0002-9343(94)90061-2","article-title":"Omeprazole for the treatment of posterior laryngitis","volume":"96","author":"Kamel","year":"1994","journal-title":"Am. J. Med"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lary.1991.101.s53.1","volume":"101","author":"Koufman","year":"1991","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/SLA.0000000000001907","article-title":"Diagnosis and treatment of the extraesophageal manifestations of gastroesophageal reflux disease","volume":"265","author":"Sidhwa","year":"2017","journal-title":"Ann. Surg"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0007","article-title":"Instruments evaluating the clinical findings of laryngopharyngeal reflux: a systematic review","author":"Lechien","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0008","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0194-5998(99)70128-2","article-title":"Incidence of abnormal laryngeal findings in asymptomatic singing students","volume":"121","author":"Lundy","year":"1999","journal-title":"Otolaryngol. Head Neck Surg"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0009","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0892-1997(02)00132-7","article-title":"The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers","volume":"16","author":"Hicks","year":"2002","journal-title":"J Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0010","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1001\/jama.294.12.1534","article-title":"Evaluation and management of laryngopharyngeal reflux","volume":"294","author":"Ford","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0011","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1572-0241.2004.40290.x","article-title":"Laryngitis and gastroesophageal reflux disease: increasing prevalence or poor diagnostic tests?","volume":"99","author":"Vaezi","year":"2004","journal-title":"Am. J. Gastroenterol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0012","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0003489400109S1003","article-title":"Ambulatory pH monitoring methodology","volume":"184","author":"Postma","year":"2000","journal-title":"Ann. Otol. Rhinol. Laryngol. Suppl"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0013","first-page":"213","article-title":"Laryngopharyngeal reflux and voice disorders: an overview on disease mechanisms, treatments, and research advances","volume":"10","author":"Sataloff","year":"2010","journal-title":"Discov. Med"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0014","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.amjoto.2005.09.012","article-title":"Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis","volume":"27","author":"Lam","year":"2006","journal-title":"Am. J. Otolaryngol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0015","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.3748\/wjg.v18.i32.4363","article-title":"How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related?","volume":"18","author":"De Bortoli","year":"2012","journal-title":"World. J. Gastroenterol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0016","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/0194599816664330","article-title":"Patient-reported outcome measures related to laryngopharyngeal reflux: a systematic review of instrument development and validation","volume":"155","author":"Francis","year":"2016","journal-title":"Otolaryngol. Head Neck Surg"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0017","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0892-1997(02)00097-8","article-title":"Validity and reliability of the reflux symptom index (RSI)","volume":"16","author":"Belafsky","year":"2002","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0018","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0022-3999(02)00469-5","article-title":"VoiSS: a patient-derived voice symptom scale","volume":"54","author":"Deary","year":"2003","journal-title":"J. Psychosom. Res"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0019","series-title":"Greene and Mathieson's The Voice and Its Disorders","author":"Mathieson","year":"2001"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jvoice.2007.10.002","article-title":"Laryngeal manual therapy: a preliminary study to examine its treatment effects in the management of muscle tension dysphonia","volume":"23","author":"Mathieson","year":"2009","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0021","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/00005537-200108000-00001","article-title":"The validity and reliability of the reflux finding score (RFS)","volume":"111","author":"Belafsky","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0022","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jvoice.2008.08.008","article-title":"Reliability and clinical validity of the italian reflux symptom index","volume":"24","author":"Schindler","year":"2010","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0023","article-title":"Cross-cultural adaptation and validation of the italian version of the vocal tract discomfort scale (I-VTD)","volume":"27","author":"Robotti","year":"2017","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0024","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jvoice.2017.02.001","article-title":"Cross-cultural adaptation and validation of the italian version of the voice symptom scale (I-VoiSS)","volume":"31","author":"Mozzanica","year":"2017","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0025","first-page":"141","article-title":"Applicability of the vocal tract discomfort (VTD) scale in evaluating the effects of voice therapy on occupational voice disorders","volume":"63","author":"Woznicka","year":"2012","journal-title":"Med. Pr"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0026","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jvoice.2013.11.009","article-title":"Cross-cultural adaptation, validation and cut-off values of the Brazilian version of the voice symptom scale \u2013 VoiSS","volume":"28","author":"Moreti","year":"2014","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0027","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.0307-7772.2004.00775.x","article-title":"The Voice Symptom Scale (VoiSS) and the Voice Handicap Index (VHI): a comparison of structure and content","volume":"29","author":"Wilson","year":"2004","journal-title":"Clin. Otolaryngol. Allied Sci"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0028","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jvoice.2008.05.006","article-title":"Measuring quality of life in dysphonic patients: a systematic review of content development in patient-reported outcomes measures","volume":"24","author":"Bransky","year":"2010","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0029","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/00005537-200208000-00014","article-title":"Perspectives in laryngopharyngeal reflux: an international survey","volume":"112","author":"Book","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0030","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00405-010-1475-9","article-title":"Prospective, observational study using rabeprazole in 455 patients with laryngopharyngeal reflux disease","volume":"268","author":"Lee","year":"2011","journal-title":"Eur. Arch. Otorhinolaryngol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0031","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40463-016-0171-1","article-title":"Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study","volume":"8","author":"Lechien","year":"2016","journal-title":"J. Otoloryngol. Head and Neck Surg"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0032","doi-asserted-by":"crossref","DOI":"10.1111\/coa.13140","article-title":"Change of signs, symptoms and voice quality evaluations throughout a 3 to 6-months empirical treatment for laryngopharyngeal reflux disease","author":"Lechien","year":"2018","journal-title":"Clin. Otolaryngol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0033","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/MLG.0b013e3181651c3a","article-title":"Change of acoustic parameters before and after treatment in laryngopharyngeal reflux patients","volume":"118","author":"Jin","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0034","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1017\/S0022215111000120","article-title":"Empirical treatment with pantoprazole as a diagnostic tool for symptomatic adult laryngopharyngeal reflux","volume":"125","author":"Masaany","year":"2011","journal-title":"J. Laryngol. Otol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0035","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/00005537-200106000-00009","article-title":"Laryngopharyngeal reflux symptoms improve before changes in physical findings","volume":"111","author":"Belafsky","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0036","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1017\/S0022215113000832","article-title":"The effect of anti-reflux treatment on subjective voice measurements of patients with laryngopharyngeal reflux","volume":"127","author":"Beech","year":"2013","journal-title":"J. Laryngol. Otol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0037","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jvoice.2015.04.017","article-title":"Prevalence of vocal tract discomfort in the Flemish population without self-perceived voice disorders","volume":"30","author":"Luyten","year":"2016","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0038","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/000348949610501102","article-title":"Muscle tension dysphonia and spasmodic dysphonia: the role of manual laryngeal tension reduction in diagnosis and management","volume":"105","author":"Roy","year":"1996","journal-title":"Ann. Otol. Rhinol. Laryngol"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0039","first-page":"40","article-title":"Vocal tract discomfort in hyperfunctional dysphonia","volume":"2","author":"Mathieson","year":"1993","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jvoice.2013.01.005","article-title":"Vocal tract discomfort in teachers: its relationship to self-reported voice disorders","volume":"27","author":"Rodrigues","year":"2013","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0041","article-title":"Vocal tract discomfort in teachers after teaching activity","volume":"29","author":"Amaral","year":"2017","journal-title":"Codas"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0042","first-page":"1","article-title":"Vocal tract discomfort symptoms in patients with different voice disorders","volume":"22","author":"Lopes","year":"2014","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0043","article-title":"Vocal Tract Discomfort Scale (VTDS) and Voice Symptom Scale (VoiSS) in the evaluation of patients with voice disorders","volume":"4","author":"Lopes","year":"2018","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0044","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jvoice.2017.03.015","article-title":"Laryngopharyngeal reflux and voice disorders: a multifactorial model of etiology and pathophysiology","volume":"31","author":"Lechien","year":"2017","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0045","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jvoice.2013.12.004","article-title":"LPR: how different diagnostic tools shape the outcomes of treatment","volume":"28","author":"Wan","year":"2014","journal-title":"J. Voice"},{"key":"10.1016\/j.jvoice.2018.11.002_bib0046","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.amjoto.2016.01.008","article-title":"Evaluation of a laryngopharyngeal reflux management protocol","volume":"37","author":"Gupta","year":"2016","journal-title":"Am. J. Otolaryngol"}],"container-title":["Journal of Voice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892199718303965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892199718303965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:32:23Z","timestamp":1760211143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892199718303965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0892199718303965"],"URL":"https:\/\/doi.org\/10.1016\/j.jvoice.2018.11.002","relation":{},"ISSN":["0892-1997"],"issn-type":[{"value":"0892-1997","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vocal Tract Discomfort and Dysphonia in Patients Undergoing Empiric Therapeutic Trial with Proton Pump Inhibitor for Suspected Laryngopharyngeal Reflux","name":"articletitle","label":"Article Title"},{"value":"Journal of Voice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvoice.2018.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}