{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:15:00Z","timestamp":1771924500523,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7172228"],"award-info":[{"award-number":["7172228"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvoice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Voice"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.jvoice.2020.01.021","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T09:01:36Z","timestamp":1582016496000},"page":"805.e17-805.e26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Properties of a Novel Animal Model of LPR"],"prefix":"10.1016","volume":"35","author":[{"given":"Jie","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Lun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Guang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo-Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Sheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvoice.2020.01.021_bib0001","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5455\/medarh.2017.71.215-218","article-title":"Laryngopharyngeal reflux disease - LPRD","volume":"71","author":"Salihefendic","year":"2017","journal-title":"Med Arch"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0002","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1572-0241.2006.00630.x","article-title":"The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus","volume":"101","author":"Vakil","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0003","doi-asserted-by":"crossref","first-page":"e22630","DOI":"10.1371\/journal.pone.0022630","article-title":"Mechanisms of esophago-pharyngeal acid regurgitation in human subjects","volume":"6","author":"Szczesniak","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0004","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s00405-012-1968-9","article-title":"Laryngoscopy findings and histological results in a rabbit gastroesophageal reflux model","volume":"269","author":"Hu","year":"2012","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0005","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1469-7793.2000.00403.x","article-title":"P2X purinoceptor-induced sensitization of ferret vagal mechanoreceptors in oesophageal inflammation","volume":"523(Pt 2)","author":"Page","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0006","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00405-018-5234-7","article-title":"Establishment of a novel and effective reflux laryngitis model in rabbits: a preliminary study","volume":"276","author":"Lou","year":"2019","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0007","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1017\/S0022215111002234","article-title":"Biomarkers and laryngopharyngeal reflux","volume":"125","author":"Wood","year":"2011","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0008","doi-asserted-by":"crossref","DOI":"10.1001\/archsurg.142.6.554","article-title":"Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery","volume":"142","author":"Oh","year":"2007","journal-title":"Arch Surg"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0009","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1572-0241.2003.07303.x","article-title":"Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis","volume":"98","author":"Isomoto","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0010","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1158\/1055-9965.EPI-13-0183","article-title":"Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma","volume":"22","author":"Langevin","year":"2013","journal-title":"Cancer Epidem Biomar"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0011","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12935-019-0772-7","article-title":"Pepsin promotes IL-8 signaling-induced epithelial-mesenchymal transition in laryngeal carcinoma","volume":"19","author":"Tan","year":"2019","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0012","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.gastro.2018.09.046","article-title":"Acidic bile salts induce epithelial to mesenchymal transition via VEGF signaling in non-neoplastic Barrett's Cells","volume":"156","author":"Zhang","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152789","article-title":"The proton-sensing G-protein coupled receptor GPR4 promotes angiogenesis in head and neck cancer","volume":"11","author":"Jing","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0014","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s004280050037","article-title":"Association of vascular endothelial growth factor and mast cells with angiogenesis in laryngeal squamous cell carcinoma","volume":"436","author":"Sawatsubashi","year":"2000","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0015","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1007\/s11605-009-0915-6","article-title":"A new technique for measurement of pharyngeal pH: normal values and discriminating pH threshold","volume":"13","author":"Ayazi","year":"2009","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0016","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00405-007-0295-z","article-title":"Dilation of intercellular spaces is associated with laryngo-pharyngeal reflux: an ultrastructural morphometric analysis of laryngeal epithelium","volume":"264","author":"Franchi","year":"2007","journal-title":"Eur Arch Oto-Rhino-L"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0017","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5056\/jnm16093","article-title":"Clinical manifestations of laryngopharyngeal reflux","volume":"22","author":"Han","year":"2016","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0018","first-page":"361","article-title":"Temporary self-expanding metallicstents and pneumatic dilation for the treatment of achalasia: a prospective study with a long-term follow-up","volume":"23","author":"Li","year":"2010","journal-title":"Dis Esophagus"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0019","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/ndt\/gfl764","article-title":"Percutaneous transluminal angioplasty is feasible and effective in patients on chronic dialysis with severe peripheral artery disease","volume":"22","author":"Graziani","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0020","doi-asserted-by":"crossref","first-page":"S466","DOI":"10.1097\/01.CCM.0000186783.34908.18","article-title":"Interleukin-8","volume":"33","author":"Remick","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0021","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1055\/s-2006-925445","article-title":"Diagnosis and treatment of laryngopharyngeal reflux","volume":"85","author":"Reichel","year":"2006","journal-title":"Laryngorhinootologie"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0022","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.otohns.2009.05.033","article-title":"The significance of laryngopharyngeal reflux in benign vocal mucosal lesions","volume":"141","author":"Chung","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0023","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/00005537-200006000-00023","article-title":"High incidence of laryngopharyngeal reflux in patients with head and neck cancer","volume":"110","author":"Copper","year":"2000","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0024","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1365-2036.2003.01713.x","article-title":"Dilated intercellular spaces as a marker of oesophageal damage: comparative results in gastro-oesophageal reflux disease with or without bile reflux","volume":"18","author":"Calabrese","year":"2003","journal-title":"Aliment Pharm Ther"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0025","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1572-0241.2005.40978.x","article-title":"Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure","volume":"100","author":"Caviglia","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0026","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat Rev Mol Cell Bio"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0027","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1080\/00016480802468161","article-title":"Histological changes of the pharynx and larynx in rats with chronic acid reflux esophagitis","volume":"129","author":"Shimazu","year":"2009","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0028","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1158\/1078-0432.CCR-07-4843","article-title":"The interleukin-8 pathway in cancer","volume":"14","author":"Waugh","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0029","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000088478","article-title":"VEGF as a key mediator of angiogenesis in cancer","volume":"69","author":"Carmeliet","year":"2005","journal-title":"Oncology-Basel"},{"key":"10.1016\/j.jvoice.2020.01.021_bib0030","first-page":"6020","article-title":"Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo","volume":"61","author":"Fukumura","year":"2001","journal-title":"Cancer Res"}],"container-title":["Journal of Voice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892199719305995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892199719305995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:36:56Z","timestamp":1760211416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892199719305995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0892199719305995"],"URL":"https:\/\/doi.org\/10.1016\/j.jvoice.2020.01.021","relation":{},"ISSN":["0892-1997"],"issn-type":[{"value":"0892-1997","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Properties of a Novel Animal Model of LPR","name":"articletitle","label":"Article Title"},{"value":"Journal of Voice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvoice.2020.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Voice Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}