{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:49:34Z","timestamp":1775080174157,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2020R1A5A2019413"],"award-info":[{"award-number":["2020R1A5A2019413"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI20C1205"],"award-info":[{"award-number":["HI20C1205"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvoice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Voice"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jvoice.2022.12.010","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T07:40:46Z","timestamp":1672386046000},"page":"855.e7-855.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes of Pepsin Concentration in Saliva Sample According to Storage Period"],"prefix":"10.1016","volume":"39","author":[{"given":"Hee Jin","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Kyung","family":"Noh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon Rang","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Min","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Chan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Gyu","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Gyu","family":"Eun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvoice.2022.12.010_bib0001","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1002\/lary.27591","article-title":"Clinical outcomes of laryngopharyngeal reflux treatment: a systematic review and meta-analysis","volume":"129","author":"Lechien","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0002","doi-asserted-by":"crossref","first-page":"299","DOI":"10.21053\/ceo.2019.01669","article-title":"Management of laryngopharyngeal reflux in Asia","volume":"13","author":"Kim","year":"2020","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0003","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/0194599819827488","article-title":"Evaluation and management of laryngopharyngeal reflux disease: state of the art review","volume":"160","author":"Lechien","year":"2019","journal-title":"Otolaryngol \u2013 Head Neck Surg"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0004","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.amjoto.2016.01.008","article-title":"Evaluation of a laryngopharyngeal reflux management protocol","volume":"37","author":"Gupta","year":"2016","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0005","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1097\/01.MLG.0000165464.75164.E5","article-title":"Changing impact of gastroesophageal reflux in medical and otolaryngology practice","volume":"115","author":"Altman","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0006","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13080","article-title":"Airway reflux","volume":"1381","author":"Johnston","year":"2016","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0007","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jobcr.2015.08.006","article-title":"Saliva as a diagnostic tool for oral and systemic diseases","volume":"6","author":"Javaid","year":"2016","journal-title":"J Oral Biol Craniofac Res"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0008","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/balkanmedj.2015.15824","article-title":"Immunoserologic pepsin detection in the saliva as a non-invasive rapid diagnostic test for laryngopharyngeal reflux","volume":"32","author":"Emre","year":"2015","journal-title":"Balkan Med J"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0009","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/01.mlg.0000172043.51871.d9","article-title":"Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux","volume":"115","author":"Knight","year":"2005","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0010","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.otohns.2009.08.022","article-title":"Pepsin as a causal agent of inflammation during nonacidic reflux","volume":"141","author":"Samuels","year":"2009","journal-title":"Otolaryngol\u2013Head Neck Surg"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0011","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1007\/s00405-021-06865-8","article-title":"Pharyngeal reflux episodes in patients with suspected laryngopharyngeal reflux versus healthy subjects: a prospective cohort study","volume":"278","author":"Kim","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0012","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1002\/lary.26018","article-title":"Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux","volume":"126","author":"Na","year":"2016","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0013","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/gut.6.5.506","article-title":"pH stability and activity curves of pepsin with special reference to their clinical importance","volume":"6","author":"Piper","year":"1965","journal-title":"Gut"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0014","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00405-017-4845-8","article-title":"Pepsin in saliva as a diagnostic biomarker in laryngopharyngeal reflux: a meta-analysis","volume":"275","author":"Wang","year":"2018","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0015","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/lary.23252","article-title":"Rapid salivary pepsin test: blinded assessment of test performance in gastroesophageal reflux disease","volume":"122","author":"Saritas Yuksel","year":"2012","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0016","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MCG.0000000000001066","article-title":"Evaluation of important analytical parameters of the peptest immunoassay that limit its use in diagnosing gastroesophageal reflux disease","volume":"53","author":"Dolina","year":"2019","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0017","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jvoice.2017.10.015","article-title":"Association between pepsin in the saliva and the subjective symptoms in patients with laryngopharyngeal reflux","volume":"33","author":"Jung","year":"2019","journal-title":"J Voice"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0018","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3390\/s20010325","article-title":"Optimization of saliva collection and immunochromatographic detection of salivary pepsin for point-of-care testing of laryngopharyngeal reflux","volume":"20","author":"Lee","year":"2020","journal-title":"Sensors"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0019","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MOO.0000000000000664","article-title":"Pepsin in gastroesophageal and extraesophageal reflux: molecular pathophysiology and diagnostic utility","volume":"28","author":"Samuels","year":"2020","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jvoice.2022.12.010_bib0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/nyas.14366","article-title":"Proximal reflux: biochemical mediators, markers, therapeutic targets, and clinical correlations","volume":"1481","author":"Klimara","year":"2020","journal-title":"Ann NY Acad Sci"}],"container-title":["Journal of Voice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892199722004118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0892199722004118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:47:16Z","timestamp":1775072836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0892199722004118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0892199722004118"],"URL":"https:\/\/doi.org\/10.1016\/j.jvoice.2022.12.010","relation":{},"ISSN":["0892-1997"],"issn-type":[{"value":"0892-1997","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes of Pepsin Concentration in Saliva Sample According to Storage Period","name":"articletitle","label":"Article Title"},{"value":"Journal of Voice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvoice.2022.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}