{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:37:51Z","timestamp":1791106671288,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2274,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.jvs.2007.02.069","type":"journal-article","created":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T13:07:09Z","timestamp":1180962429000},"page":"A33-A38","source":"Crossref","is-referenced-by-count":52,"special_numbering":"S","title":["Integrin \u03b1v\u03b23 as a target in the prevention of neointimal hyperplasia"],"prefix":"10.1016","volume":"45","author":[{"given":"Taku","family":"Kokubo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric T.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl 5","key":"10.1016\/j.jvs.2007.02.069_bib1","first-page":"S4","article-title":"Pathophysiology of coronary artery restenosis","volume":"3","author":"Schwartz","year":"2002","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.jvs.2007.02.069_bib2","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.jacc.2005.11.092","article-title":"Incomplete neointimal coverage of sirolimus-eluting stents: angioscopic findings","volume":"47","author":"Kotani","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2007.02.069_bib3","first-page":"83","article-title":"The vessel wall reaction in restenosis","volume":"2","author":"Schwartz","year":"1997","journal-title":"Semin Interv Cardiol"},{"key":"10.1016\/j.jvs.2007.02.069_bib4","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1586\/14779072.4.4.543","article-title":"Coronary artery restenosis: vascular biology and emerging therapeutic strategies","volume":"4","author":"Sarkar","year":"2006","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.jvs.2007.02.069_bib5","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jvs.2007.02.069_bib6","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0092-8674(03)00468-9","article-title":"Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both?","volume":"113","author":"Hynes","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jvs.2007.02.069_bib7","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0092-8674(86)90259-X","article-title":"Arg-Gly-Asp: a versatile cell recognition signal","volume":"44","author":"Ruoslahti","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.jvs.2007.02.069_bib8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0140-6736(98)11086-3","article-title":"Platelet GPIIb-IIIa blockers","volume":"353","author":"Topol","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2007.02.069_bib9","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.2420006","article-title":"Platelet membrane glycoprotein IIb\/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors","volume":"231","author":"Pytela","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.jvs.2007.02.069_bib10","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1021\/jm00089a014","article-title":"Cyclic RGD peptide analogues as antiplatelet antithrombotics","volume":"35","author":"Barker","year":"1992","journal-title":"J Med Chem"},{"key":"10.1016\/j.jvs.2007.02.069_bib11","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1172\/JCI117718","article-title":"The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins","volume":"95","author":"Liaw","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jvs.2007.02.069_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/01.ATV.13.1.120","article-title":"Osteopontin overexpression is associated with arterial smooth muscle cell proliferation in vitro","volume":"13","author":"Gadeau","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.jvs.2007.02.069_bib13","doi-asserted-by":"crossref","first-page":"9308","DOI":"10.1073\/pnas.94.17.9308","article-title":"Potential roles of osteopontin and alphaVbeta3 integrin in the development of coronary artery restenosis after angioplasty","volume":"94","author":"Panda","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jvs.2007.02.069_bib14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/01.RES.77.4.665","article-title":"Osteopontin and beta 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro","volume":"77","author":"Liaw","year":"1995","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2007.02.069_bib15","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/cvr\/28.12.1815","article-title":"Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis","volume":"28","author":"Brown","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jvs.2007.02.069_bib16","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/jcp.1041510319","article-title":"Regulation of vascular smooth muscle cell integrin expression by transforming growth factor beta1 and by platelet-derived growth factor-BB","volume":"151","author":"Janat","year":"1992","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jvs.2007.02.069_bib17","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/emboj\/18.4.882","article-title":"Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2","volume":"18","author":"Soldi","year":"1999","journal-title":"Embo J"},{"key":"10.1016\/j.jvs.2007.02.069_bib18","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1172\/JCI118808","article-title":"Suppression of p53 activity and p21WAF1\/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis","volume":"98","author":"Stromblad","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jvs.2007.02.069_bib19","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0092-8674(00)81235-0","article-title":"Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3","volume":"85","author":"Brooks","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.jvs.2007.02.069_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/(SICI)1097-0215(20000401)86:1<15::AID-IJC3>3.0.CO;2-B","article-title":"Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase","volume":"86","author":"Deryugina","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jvs.2007.02.069_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/370061a0","article-title":"A matrix metalloproteinase expressed on the surface of invasive tumour cells","volume":"370","author":"Sato","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jvs.2007.02.069_bib22","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1242\/jcs.109.5.953","article-title":"MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis","volume":"109","author":"Kinoh","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jvs.2007.02.069_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1046\/j.1523-1747.2000.00114.x","article-title":"Coexpression of integrin alpha(v)beta3 and matrix metalloproteinase-2 (MMP-2) coincides with MMP-2 activation: correlation with melanoma progression","volume":"115","author":"Hofmann","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jvs.2007.02.069_bib24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0741-5214(94)70127-X","article-title":"Inhibition of neointimal hyperplasia by blocking alpha V beta 3 integrin with a small peptide antagonist GpenGRGDSPCA","volume":"19","author":"Choi","year":"1994","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2007.02.069_bib25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1067\/mlc.2001.114065","article-title":"Mechanisms in the inhibition of neointimal hyperplasia with triflavin in a rat model of balloon angioplasty","volume":"137","author":"Sheu","year":"2001","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.jvs.2007.02.069_bib26","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.RES.77.6.1129","article-title":"Alpha-v beta-3 integrin expression in normal and atherosclerotic artery","volume":"77","author":"Hoshiga","year":"1995","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2007.02.069_bib27","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3109\/15419069809109146","article-title":"Reduced intimal thickening following alpha(v)beta3 blockade is associated with smooth muscle cell apoptosis","volume":"6","author":"van der Zee","year":"1998","journal-title":"Cell Adhes Commun"},{"key":"10.1016\/j.jvs.2007.02.069_bib28","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0008-6363(97)00184-3","volume":"36","author":"Srivatsa","year":"1997","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jvs.2007.02.069_bib29","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1159\/000051095","article-title":"The beta3 integrin antagonist m7E3 reduces matrix metalloproteinase activity and smooth muscle cell migration","volume":"38","author":"Bendeck","year":"2001","journal-title":"J Vasc Res"},{"key":"10.1016\/j.jvs.2007.02.069_bib30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0021-9150(02)00035-7","article-title":"Metalloproteinase inhibitor attenuates neointima formation and constrictive remodeling after angioplasty in rats: augmentative effect of alpha(v)beta(3) receptor blockade","volume":"163","author":"Margolin","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2007.02.069_bib31","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1161\/01.CIR.90.5.2203","article-title":"Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation","volume":"90","author":"Matsuno","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2007.02.069_bib32","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1055\/s-0038-1656006","article-title":"Antiplatelet effect of FK633, a platelet glycoprotein IIb\/IIIa antagonist, on thrombus formation and vascular patency after thrombolysis in the injured hamster carotid artery","volume":"77","author":"Kaida","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jvs.2007.02.069_bib33","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1161\/01.CIR.103.14.1906","article-title":"Selective alpha(v)beta(3)-receptor blockade reduces macrophage infiltration and restenosis after balloon angioplasty in the atherosclerotic rabbit","volume":"103","author":"Bishop","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2007.02.069_bib34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1161\/01.RES.75.2.268","article-title":"Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb\/IIIa in an experimental angioplasty model","volume":"75","author":"Azrin","year":"1994","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2007.02.069_bib35","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1161\/01.ATV.18.11.1730","article-title":"Effects of beta3-integrin blockade (c7E3) on the response to angioplasty and intra-arterial stenting in atherosclerotic nonhuman primates","volume":"18","author":"Deitch","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvs.2007.02.069_bib36","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1056\/NEJM199404073301402","article-title":"Use of a monoclonal antibody directed against the platelet glycoprotein IIb\/IIIa receptor in high-risk coronary angioplasty","volume":"330","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvs.2007.02.069_bib37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1056\/NEJM199907293410503","article-title":"Complementary clinical benefits of coronary-artery stenting and blockade of platelet glycoprotein IIb\/IIIa receptors","volume":"341","author":"Lincoff","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvs.2007.02.069_bib38","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/S0140-6736(96)10172-0","article-title":"Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT-II","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2007.02.069_bib39","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1161\/01.CIR.100.8.799","article-title":"Acute platelet inhibition with abciximab does not reduce in-stent restenosis (ERASER study)","volume":"100","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2007.02.069_bib40","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0140-6736(96)10452-9","article-title":"Randomised placebo-controlled trial of abciximab before and during coronary intervention in refractory unstable angina: the CAPTURE Study","volume":"349","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2007.02.069_bib41","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0140-6736(94)90007-8","article-title":"Randomised trial of coronary intervention with antibody against platelet IIb\/IIIa integrin for reduction of clinical restenosis: results at six months","volume":"343","author":"Topol","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2007.02.069_bib42","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1161\/01.CIR.103.20.2501","article-title":"Beta(3)-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adherent platelets 1 hour after injury","volume":"103","author":"Smyth","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2007.02.069_bib43","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/01.CIR.0000121733.68724.FF","article-title":"Beta3-integrin mediates smooth muscle cell accumulation in neointima after carotid ligation in mice","volume":"109","author":"Choi","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2007.02.069_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.RES.56.1.139","article-title":"Significance of quiescent smooth muscle migration in the injured rat carotid artery","volume":"56","author":"Clowes","year":"1985","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2007.02.069_bib45","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1161\/01.CIR.96.9.3180","article-title":"Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice","volume":"96","author":"Carmeliet","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2007.02.069_bib46","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/01.ATV.0000019360.14554.53","article-title":"Endogenous vitronectin and plasminogen activator inhibitor-1 promote neointima formation in murine carotid arteries","volume":"22","author":"Peng","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvs.2007.02.069_bib47","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1161\/01.RES.0000096651.13001.B4","article-title":"Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries","volume":"93","author":"Tanaka","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2007.02.069_bib48","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1046\/j.1523-1755.1999.00409.x","article-title":"Vascular access for hemodialysis","volume":"55","author":"Schwab","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.jvs.2007.02.069_bib49","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1053\/ajkd.2002.34924","article-title":"Cost analysis of ongoing care of patients with end-stage renal disease: the impact of dialysis modality and dialysis access","volume":"40","author":"Lee","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jvs.2007.02.069_bib50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.ki.5001569","article-title":"Characterization of neointima lesions associated with arteriovenous fistulas in a mouse model","volume":"70","author":"Castier","year":"2006","journal-title":"Kidney Int"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521407004223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521407004223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T15:22:20Z","timestamp":1628954540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521407004223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0741521407004223"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2007.02.069","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}