{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T20:39:04Z","timestamp":1774039144756,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1599,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.jvs.2008.10.004","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T04:35:55Z","timestamp":1232598955000},"page":"711-718","source":"Crossref","is-referenced-by-count":44,"title":["Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C677T mutations: A case-control study and meta-analysis"],"prefix":"10.1016","volume":"49","author":[{"given":"Nader","family":"Khandanpour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Willis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicity J.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Armon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon K.","family":"Loke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.A.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Finglas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara A.","family":"Jennings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2008.10.004_bib3","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1097\/01.RVI.0000240426.53079.46","volume":"17","author":"Hirsch","year":"2006","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.jvs.2008.10.004_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF02133068","article-title":"Femoropopliteal bypass with either adequate ipsilateral reversed saphenous vein or obligatory polytetrafluoroethylene","volume":"8","author":"Archie","year":"1994","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2008.10.004_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0741-5214(86)90073-X","article-title":"Six-year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts in infrainguinal arterial reconstructions","volume":"3","author":"Veith","year":"1986","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2008.10.004_bib6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S1078-5884(03)00381-2","article-title":"The incidence of hyperhomocysteinaemia in vascular patients","volume":"26","author":"Spark","year":"2003","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2008.10.004_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/01.CIR.97.5.437","article-title":"Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease","volume":"97","author":"Robinson","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2008.10.004_bib8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2310\/6670.2007.00031","article-title":"Prevalence of hyperhomocysteinemia in vascular disease: comparative study of thrombotic venous disease vis-a-vis occlusive arterial disease","volume":"15","author":"Bhargava","year":"2007","journal-title":"Vascular"},{"key":"10.1016\/j.jvs.2008.10.004_bib9","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1001\/archinte.160.9.1343","article-title":"Premature cardiovascular disease is common in relatives of patients with premature peripheral atherosclerosis","volume":"160","author":"Valentine","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jvs.2008.10.004_bib10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jvs.2003.07.011","article-title":"Family history is a major determinant of subclinical peripheral arterial disease in young adults","volume":"39","author":"Valentine","year":"2004","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2008.10.004_bib11","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.jvs.2008.10.004_bib12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(05)70152-5","article-title":"Homocysteine and stroke: evidence on a causal link from mendelian randomisation","volume":"365","author":"Casas","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2008.10.004_bib13","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1086\/301825","article-title":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?","volume":"62","author":"van der Put","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jvs.2008.10.004_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/mgme.1998.2714","article-title":"A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity","volume":"64","author":"Weisberg","year":"1998","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.jvs.2008.10.004_bib15","first-page":"414","article-title":"Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase","volume":"43","author":"Kang","year":"1988","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jvs.2008.10.004_bib16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0026-0495(88)90076-5","article-title":"Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease","volume":"37","author":"Kang","year":"1988","journal-title":"Metabolism"},{"key":"10.1016\/j.jvs.2008.10.004_bib17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jn\/129.5.919","article-title":"Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement","volume":"129","author":"Bailey","year":"1999","journal-title":"J Nutr"},{"key":"10.1016\/j.jvs.2008.10.004_bib18","first-page":"425","article-title":"Influence of folic acid, pyridoxal phosphate and cobalamin on plasma homocyst(e)ine levels and the susceptibility of low-density lipoprotein to ex-vivo oxidation","volume":"4","author":"Weiss","year":"1999","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.jvs.2008.10.004_bib19","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/ajcn\/81.4.814","article-title":"Iron absorption in male C282Y heterozygotes","volume":"81","author":"Roe","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jvs.2008.10.004_bib20","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2008"},{"key":"10.1016\/j.jvs.2008.10.004_bib21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1055\/s-0038-1656059","article-title":"The mutation Ala677\u2013>Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis","volume":"77","author":"Arruda","year":"1997","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jvs.2008.10.004_bib22","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1067\/mva.2002.128937","article-title":"Can screening for genetic markers improve peripheral artery bypass patency?","volume":"36","author":"Kibbe","year":"2002","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2008.10.004_bib23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/00005344-200206000-00010","article-title":"Treatment of hyperhomocysteinemia with folic acid: effects on homocysteine levels, coagulation status, and oxidative stress markers","volume":"39","author":"Mayer","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jvs.2008.10.004_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00001721-200109000-00007","article-title":"Homocysteine, vitamins and gene mutations in peripheral arterial disease","volume":"12","author":"Stricker","year":"2001","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.jvs.2008.10.004_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0021-9150(98)00156-7","article-title":"The effect of a common methylenetetrahydrofolate reductase mutation on levels of homocysteine, folate, vitamin B12 and on the risk of premature atherosclerosis","volume":"141","author":"Verhoeff","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2008.10.004_bib26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/000331970005100302","article-title":"Plasma homocysteine and lipoprotein profile in patients with peripheral arterial occlusive disease","volume":"51","author":"Rassoul","year":"2000","journal-title":"Angiology"},{"key":"10.1016\/j.jvs.2008.10.004_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0021-9150(99)00366-4","article-title":"Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study","volume":"150","author":"Fowkes","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2008.10.004_bib28","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1111\/j.1538-7836.2003.00500.x","article-title":"Homocysteine levels are associated with the severity of peripheral arterial disease in Type 2 diabetic patients","volume":"1","author":"Ciccarone","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jvs.2008.10.004_bib29","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejvs.2005.02.047","article-title":"The methylenetetrahydrofolate reductase C677T polymorphism does not associate with susceptibility to abdominal aortic aneurysm","volume":"30","author":"Jones","year":"2005","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2008.10.004_bib30","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jvs.2005.01.039","article-title":"Factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations are not associated with chronic limb ischemia: the Linz Peripheral Arterial Disease (LIPAD) study","volume":"41","author":"Mueller","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2008.10.004_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2840-4-17","article-title":"Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes","volume":"4","author":"Pollex","year":"2005","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jvs.2008.10.004_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jvs.2004.11.015","article-title":"Thrombophilic risk factors for symptomatic peripheral arterial disease","volume":"41","author":"Sofi","year":"2005","journal-title":"J Vasc Surg"},{"issue":"Suppl 3","key":"10.1016\/j.jvs.2008.10.004_bib33","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1097\/00005344-199406030-00003","article-title":"Epidemiology of peripheral arterial disease","volume":"23","author":"Balkau","year":"1994","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jvs.2008.10.004_bib34","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1161\/01.CIR.98.23.2520","article-title":"Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis","volume":"98","author":"Brattstrom","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2008.10.004_bib35","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","article-title":"A quantitative assessment of plasma homocysteine as a risk factor for vascular disease","volume":"274","author":"Boushey","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.jvs.2008.10.004_bib36","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/oxfordjournals.aje.a000179","article-title":"Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations","volume":"156","author":"Little","year":"2002","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jvs.2008.10.004_bib37","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/aje\/kwj046","article-title":"Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations","volume":"163","author":"Trikalinos","year":"2006","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jvs.2008.10.004_bib38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/bmj.328.7433.211","article-title":"Is folic acid the ultimate functional food component for disease prevention?","volume":"328","author":"Lucock","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jvs.2008.10.004_bib39","author":"Willis"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074152140801673X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074152140801673X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T08:35:14Z","timestamp":1558082114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074152140801673X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S074152140801673X"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2008.10.004","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}