{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:59:02Z","timestamp":1790024342778,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":959,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.jvs.2010.06.172","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T10:29:37Z","timestamp":1284719377000},"page":"1580-1586","source":"Crossref","is-referenced-by-count":56,"title":["Sodium 4-phenylbutyrate protects against spinal cord ischemia by inhibition of endoplasmic reticulum stress"],"prefix":"10.1016","volume":"52","author":[{"given":"Taketomo","family":"Mizukami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Orihashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bagus","family":"Herlambang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hamaishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taijiro","family":"Sueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2010.06.172_bib1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0003-4975(02)04139-5","article-title":"Thoracoabdominal aortic aneurysm repair review and update of current strategies","volume":"74","author":"Coselli","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvs.2010.06.172_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00595-004-2889-z","article-title":"Spinal cord protection during thoracoabdominal aneurysm repair","volume":"35","author":"Tabayashi","year":"2005","journal-title":"Surg Today"},{"key":"10.1016\/j.jvs.2010.06.172_bib3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1067\/mva.2000.106492","article-title":"Epidural cooling for spinal cord protection during thoracoabdominal aneurysm repair a five-year experience","volume":"31","author":"Cambria","year":"2000","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2010.06.172_bib4","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S0022-5223(12)70152-6","article-title":"Clinical application of evoked spinal cord potentials elicited by direct stimulation of the cord during temporary occlusion of the thoracic aorta","volume":"107","author":"Matsui","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvs.2010.06.172_bib5","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00000658-199105000-00007","article-title":"The influence of severity of spinal cord ischemia in the etiology of delayed-onset paraplegia","volume":"213","author":"Moore","year":"1991","journal-title":"Ann Surg"},{"key":"10.1016\/j.jvs.2010.06.172_bib6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1067\/mtc.2003.112","article-title":"Survival and death promoting events after transient spinal cord ischemia in rabbits: induction of Akt and caspase3 in motor neurons","volume":"125","author":"Sakurai","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvs.2010.06.172_bib7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.cellbio.15.1.269","article-title":"Biochemical pathways of caspase activation during apoptosis","volume":"15","author":"Budihardjo","year":"1999","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.jvs.2010.06.172_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/bit.10445","article-title":"Endoplasmic reticulum signaling as a determinant of recombinant protein expression","volume":"81","author":"Cudna","year":"2003","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.jvs.2010.06.172_bib9","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/01.WCB.0000077641.41248.EA","article-title":"Induction of GRP78 by ischemic preconditioning reduces endoplasmic reticulum stress and prevents delayed neuronal cell death","volume":"23","author":"Hayashi","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jvs.2010.06.172_bib10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1023\/A:1016175429877","article-title":"Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells","volume":"7","author":"Oyadomari","year":"2002","journal-title":"Apoptosis"},{"key":"10.1016\/j.jvs.2010.06.172_bib11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jvs.2010.06.172_bib12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1056\/NEJM199609193351204","article-title":"Long-term treatment of girls with ornithine transcarbamylase deficiency","volume":"335","author":"Maestri","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvs.2010.06.172_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1182\/blood.V84.1.339.339","article-title":"Induction of fatal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate","volume":"84","author":"Dover","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.jvs.2010.06.172_bib14","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1073\/pnas.97.4.1796","article-title":"Chemical chaperones mediate increased secretion of mutant alpha-1 antitrypsin (\u03b11-AT) Z: a potential pharmacological strategy for prevention of liver injury and emphysema in \u03b11-AT deficiency","volume":"97","author":"Burrows","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jvs.2010.06.172_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/ajpcell.2000.278.2.C259","article-title":"Sodium 4-phenyalbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR","volume":"278","author":"Rubenstein","year":"2000","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jvs.2010.06.172_bib16","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.surg.2005.04.019","article-title":"Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis","volume":"138","author":"Vilatoba","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.jvs.2010.06.172_bib17","first-page":"147","article-title":"Spinal cord compression mechanism of paralysis and treatment","author":"Tarlov","year":"1957"},{"key":"10.1016\/j.jvs.2010.06.172_bib18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm829","article-title":"The unfolded protein response in nutrient sensing and differentiation","volume":"3","author":"Kaufman","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jvs.2010.06.172_bib19","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1101\/gad.12.12.1812","article-title":"A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase\/endoribonuclease (Ire1p) in mammalian cells","volume":"12","author":"Tirasophon","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.jvs.2010.06.172_bib20","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1093\/emboj\/17.19.5708","article-title":"Cloning of mammalian Ire1 reveals diversity in the ER stress responses","volume":"17","author":"Wang","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.jvs.2010.06.172_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004647-199901000-00001","article-title":"Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury?","volume":"19","author":"Paschen","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jvs.2010.06.172_bib22","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/00004647-200304000-00010","article-title":"Dysfunction of the unfolded protein response during global brain ischemia and reperfusion","volume":"23","author":"Kumar","year":"2003","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.jvs.2010.06.172_bib23","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1124\/mol.104.001339","article-title":"Sodium 4-phenylbutyrate protects against cerebral ischemic injury","volume":"66","author":"Qi","year":"2004","journal-title":"Molecular Pharmacol"},{"key":"10.1016\/j.jvs.2010.06.172_bib24","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1471-4159.2005.03077.x","article-title":"Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice","volume":"93","author":"Ryu","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.jvs.2010.06.172_bib25","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1471-4159.2006.03782.x","article-title":"Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress","volume":"97","author":"Kubota","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.jvs.2010.06.172_bib26","first-page":"3047","article-title":"A phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule","volume":"7","author":"Carducci","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jvs.2010.06.172_bib27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10637-006-9017-4","article-title":"Phase I dose escalation clinical trial of phenylbutyrate sodium administered twice daily to patients with advanced solid tumors","volume":"2","author":"Camacho","year":"2007","journal-title":"Invest New Drugs"},{"key":"10.1016\/j.jvs.2010.06.172_bib28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s002800000256","article-title":"Pharmacokinetics and cerebrospinal fluid penetration of phenylacetate and phenylbutyrate in the nonhuman primate","volume":"47","author":"Berg","year":"2001","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.jvs.2010.06.172_bib29","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1203\/00006450-200212000-00004","article-title":"Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking","volume":"52","author":"Perlmutter","year":"2002","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jvs.2010.06.172_bib30","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jss.2005.10.007","article-title":"Evolution of spinal cord injury in a porcine model of prolonged aortic occlusion","volume":"133","author":"Papakostas","year":"2006","journal-title":"J Surg Res"},{"key":"10.1016\/j.jvs.2010.06.172_bib31","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1067\/mva.2003.100","article-title":"Oxidative damage and reduction of redox factor-1 expression after transient spinal cord ischemia in rabbits","volume":"37","author":"Sakurai","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2010.06.172_bib32","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.jtcvs.2005.01.007","article-title":"Endoplasmic reticulum stress induced in motor neurons by transient spinal cord ischemia in rabbits","volume":"130","author":"Sakurai","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvs.2010.06.172_bib33","first-page":"839","article-title":"Lack of evidence for apoptosis as a cause of delayed onset paraplegia after spinal cord ischemia in rabbits","volume":"96","author":"Kiyoshima","year":"2003","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jvs.2010.06.172_bib34","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1439-0264.2005.00603.x","article-title":"Histochemical and electron microscopic study on motor neuron degeneration following transient spinal cord ischaemia at normothermic conditions in rabbits","volume":"34","author":"Lee","year":"2005","journal-title":"Anat Histol Embryol"},{"key":"10.1016\/j.jvs.2010.06.172_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1083\/jcb.144.2.281","article-title":"Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner","volume":"144","author":"Slee","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jvs.2010.06.172_bib36","doi-asserted-by":"crossref","first-page":"33869","DOI":"10.1074\/jbc.M102225200","article-title":"Coupling endoplasmic reticulum stress to the cell death program","volume":"276","author":"Rao","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jvs.2010.06.172_bib37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/01.STR.11.2.200","article-title":"Spinal cord infarction: a highly reproducible stroke model","volume":"11","author":"Zivin","year":"1980","journal-title":"Stroke"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521410016800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521410016800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T10:53:07Z","timestamp":1685789587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521410016800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0741521410016800"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2010.06.172","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}