{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:20:53Z","timestamp":1790774453139,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":777,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.jvs.2011.01.074","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T04:56:15Z","timestamp":1303534575000},"page":"1565-1574.e1","source":"Crossref","is-referenced-by-count":79,"title":["Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia"],"prefix":"10.1016","volume":"53","author":[{"given":"Michael P.","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Rapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Dalsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Hutchins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith L.","family":"March","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2011.01.074_bib1","first-page":"138","article-title":"Predicting which patients will develop chronic critical leg ischemia","volume":"12","author":"Dormandy","year":"1999","journal-title":"Semin Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib2","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.jvs.2006.12.037","article-title":"Inter-society consensus for the management of peripheral Arterial Disease (TASC II)","volume":"45","author":"Norgren","year":"2007","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF02693806","article-title":"Revascularization and quality of life for patients with limb-threatening ischemia","volume":"15","author":"Tretinyak","year":"2001","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1067\/mva.2003.125","article-title":"A decade of experience with dorsalis pedis artery bypass: analysis of outcome in more than 1000 cases","volume":"37","author":"Pomposelli","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib5","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jvs.2005.11.016","article-title":"Two-year outcome with preferential use of infrainguinal angioplasty for critical ischemia","volume":"43","author":"Haider","year":"2006","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib6","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/S0140-6736(05)67704-5","article-title":"Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL): multicentre, randomised controlled trial","volume":"366","author":"Bradbury","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2011.01.074_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jvs.2008.02.027","article-title":"Infrapopliteal angioplasty for critical limb ischemia: relation of TransAtlantic InterSociety Consensus class to outcome in 176 limbs","volume":"48","author":"Giles","year":"2008","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ejvs.2005.01.008","article-title":"Excimer laser assisted angioplasty for critical limb ischemia: results of the LACI Belgium Study","volume":"29","author":"Bosiers","year":"2005","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1583\/04-1316R.1","article-title":"Percutaneous peripheral atherectomy of femoropopliteal stenoses using a new-generation device: six-month results from a single-center experience","volume":"11","author":"Zeller","year":"2004","journal-title":"J Endovasc Ther"},{"key":"10.1016\/j.jvs.2011.01.074_bib10","first-page":"142","article-title":"The fate of patients with critical leg ischemia","volume":"12","author":"Dormandy","year":"1999","journal-title":"Semin Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib11","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200105243442108","article-title":"Medical treatment of peripheral arterial disease and claudication","volume":"344","author":"Hiatt","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvs.2011.01.074_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jvs.2006.03.026","article-title":"Natural history of limbs with arterial insufficiency and chronic ulceration treated without revascularization","volume":"44","author":"Marston","year":"2006","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1067\/msy.2001.115359","article-title":"Postoperative and late survival outcomes after major amputation: findings from the Department of Veterans Affairs National Surgical Quality Improvement Program","volume":"130","author":"Feinglass","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.jvs.2011.01.074_bib14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1078-5884(96)80257-7","article-title":"The costs of managing lower limb-threatening ischaemia","volume":"12","author":"Singh","year":"1996","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0741-5214(92)90417-7","article-title":"Assessment of quality of life of patients with severe ischemia as a result of infrainguinal arterial occlusive disease","volume":"16","author":"Albers","year":"1992","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jvs.2004.11.022","article-title":"Comparison of generic and disease-specific questionnaires for the assessment of quality of life in patients with peripheral arterial disease","volume":"41","author":"de Vries","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib17","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jvs.2011.01.074_bib18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1172\/JCI0214327","article-title":"Origin of endothelial progenitors in human postnatal bone marrow","volume":"109","author":"Reyes","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jvs.2011.01.074_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.RES.85.3.221","article-title":"Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization","volume":"85","author":"Asahara","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2011.01.074_bib20","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/01.CIR.103.6.897","article-title":"Augmentation of postnatal neovascularization with autologous bone marrow transplantation","volume":"103","author":"Shintani","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2011.01.074_bib21","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1073\/pnas.97.7.3422","article-title":"Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization","volume":"97","author":"Kalka","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jvs.2011.01.074_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(02)09670-8","article-title":"Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial","volume":"360","author":"Tateishi-Yuyama","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2011.01.074_bib23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3727\/000000002783985242","article-title":"Neovascularization induced by autologous bone marrow cell implantation in peripheral arterial disease","volume":"11","author":"Esato","year":"2002","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jvs.2011.01.074_bib24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3727\/000000004783983837","article-title":"Therapeutic angiogenesis by autologous bone marrow cell implantation for refractory chronic peripheral arterial disease using assessment of neovascularization by 99mTc-tetrofosmin (TF) perfusion scintigraphy","volume":"13","author":"Miyamoto","year":"2004","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jvs.2011.01.074_bib25","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1253\/circj.68.1189","article-title":"Clinical application of bone marrow implantation in patients with arteriosclerosis obliterans, and the association between efficacy and the number of implanted bone marrow cells","volume":"68","author":"Saigawa","year":"2004","journal-title":"Circ J"},{"key":"10.1016\/j.jvs.2011.01.074_bib26","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jvs.2006.06.023","article-title":"Autologous bone-marrow mononuclear cell implantation for patients with Rutherford grade II\u2013III thromboangiitis obliterans","volume":"44","author":"Durdu","year":"2006","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib27","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1161\/CIRCULATIONAHA.106.644203","article-title":"Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans","volume":"114","author":"Miyamoto","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2011.01.074_bib28","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1152\/japplphysiol.00445.2001","article-title":"Regional measurement of canine skeletal muscle blood flow by positron emission tomography with H2","volume":"92","author":"Fischman","year":"2002","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jvs.2011.01.074_bib29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3727\/096368909788534942","article-title":"Autologous bone marrow cell transplantation increases leg perfusion and reduced amputations in patients with advanced critical limb ischemic due to peripheral artery disease","volume":"18","author":"Amann","year":"2009","journal-title":"Cell Transp"},{"key":"10.1016\/j.jvs.2011.01.074_bib30","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jvs.2009.07.113","article-title":"Use of autologous bone marrow mononuclear cell implantation therapy as a limb salvage procedure in patients with severe peripheral arterial disease","volume":"50","author":"Franz","year":"2009","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib31","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.jvs.2005.11.041","article-title":"Parenteral therapy with lipo-ecraprost, a lipid-based formulation of a PGE1 analog, does not alter six-month outcomes in patients with critical leg ischemia","volume":"43","author":"Brass","year":"2006","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib32","doi-asserted-by":"crossref","first-page":"69S","DOI":"10.1016\/j.jvs.2010.02.001","article-title":"Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) and the (hoped for) dawn of evidence-based treatment for advanced limb ischemia","volume":"51","author":"Conte","year":"2010","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib33","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0140-6736(94)90637-8","article-title":"Surgery as a placebo","volume":"344","author":"Johnson","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2011.01.074_bib34","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1056\/NEJM200105243442106","article-title":"Is the placebo powerless?","volume":"344","author":"Hrobjartsson","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvs.2011.01.074_bib35","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.jacc.2005.06.079","article-title":"A blinded, randomized, placebo-controlled trial of percutaneous laser myocardial revascularization to improve angina symptoms in patients with severe coronary disease","volume":"46","author":"Leon","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2011.01.074_bib36","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/BF02001886","article-title":"TcPO2 as an accurate predictor of therapy in limb salvage","volume":"10","author":"Bunt","year":"1996","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2011.01.074_bib37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/CIRCULATIONAHA.107.727347","article-title":"Results of a double-blind, placebo-controlled study to assess the safety of intramuscular injection of hepatocyte growth factor plasmid to improve limb perfusion in patients with critical limb ischemia","volume":"118","author":"Powell","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2011.01.074_bib38","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1006\/jsre.1996.0059","article-title":"Transcutaneous oxygen (TcPO2) estimates probability of healing in the ischemic extremity","volume":"60","author":"Padberg","year":"1996","journal-title":"J Surg Res"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521411002916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521411002916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T07:09:34Z","timestamp":1560150574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521411002916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0741521411002916"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2011.01.074","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}