{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:24:37Z","timestamp":1778750677625,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":731,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.jvs.2011.06.079","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T23:01:16Z","timestamp":1315954876000},"page":"1778-1783","source":"Crossref","is-referenced-by-count":19,"title":["Telomerase expression on aortic wall endothelial cells is attenuated in abdominal aortic aneurysms compared to healthy nonaneurysmal aortas"],"prefix":"10.1016","volume":"54","author":[{"given":"Dimitrios","family":"Dimitroulis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Katsargyris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Klonaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthymios D.","family":"Avgerinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matrona","family":"Fragou-Plemenou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Kouraklis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos D.","family":"Liapis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2011.06.079_bib1","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1161\/CIRCULATIONAHA.108.802074","article-title":"Circulating markers of abdominal aortic aneurysm presence and progression","volume":"118","author":"Golledge","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2011.06.079_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejvs.2010.04.012","article-title":"Telomere length dynamics in vascular disease: a review","volume":"40","author":"Butt","year":"2010","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2011.06.079_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/35040500","article-title":"Telomere states and cell fates","volume":"408","author":"Blackburn","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jvs.2011.06.079_bib4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nrc929","article-title":"Telomere maintenance and cancer \u2013 look, no telomerase","volume":"2","author":"Neumann","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.jvs.2011.06.079_bib5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(01)00492-5","article-title":"Switching and signaling at the telomere","volume":"106","author":"Blackburn","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jvs.2011.06.079_bib6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrg1656","article-title":"Telomeres and human disease: ageing, cancer and beyond","volume":"6","author":"Blasco","year":"2005","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jvs.2011.06.079_bib7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ejvs.2010.01.013","article-title":"Short leukocyte telomere length is associated with abdominal aortic aneurysm (AAA)","volume":"39","author":"Atturu","year":"2010","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2011.06.079_bib8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.mad.2004.03.007","article-title":"Mathematical modeling confirms the length-dependency of telomere shortening","volume":"125","author":"op den-Buijs","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.jvs.2011.06.079_bib9","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1002\/jnr.22450","article-title":"Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke","volume":"88","author":"Zhang","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jvs.2011.06.079_bib10","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1161\/01.RES.0000251281.00845.18","article-title":"Telomere biology and cardiovascular disease","volume":"99","author":"Fuster","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2011.06.079_bib11","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1097\/HJH.0b013e3282ef6196","article-title":"Telomere dysfunction in hypertension","volume":"25","author":"Fuster","year":"2007","journal-title":"J Hypertens"},{"key":"10.1016\/j.jvs.2011.06.079_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00391-007-0482-y","article-title":"Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase","volume":"40","author":"Jakob","year":"2007","journal-title":"Z Gerontol Geriatr"},{"key":"10.1016\/j.jvs.2011.06.079_bib13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.STR.0000217222.09978.ce","article-title":"Racial and geographic differences in awareness, treatment, and control of hypertension: the REasons for Geographic And Racial Differences in Stroke study","volume":"37","author":"Howard","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2011.06.079_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000320259","article-title":"Toll-like receptor 4 immunohistochemical expression is enhanced in macrophages of symptomatic carotid atherosclerotic plaques","volume":"31","author":"Katsargyris","year":"2011","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jvs.2011.06.079_bib15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/00041433-200210000-00010","article-title":"Role of telomere in endothelial dysfunction in atherosclerosis","volume":"13","author":"Minamino","year":"2002","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.jvs.2011.06.079_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/hrt.80.2.110","article-title":"Olovnikov's clock: telomeres and vascular biology","volume":"80","author":"de Bono","year":"1998","journal-title":"Heart"},{"key":"10.1016\/j.jvs.2011.06.079_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1152\/japplphysiol.91360.2008","article-title":"The telomerase tale in vascular aging: regulation by estrogens and nitric oxide signaling","volume":"106","author":"Farsetti","year":"2009","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jvs.2011.06.079_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0021-9150(99)00482-7","article-title":"Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis","volume":"152","author":"Okuda","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2011.06.079_bib19","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1093\/eurheartj\/ehn386","article-title":"Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease","volume":"29","author":"Wilson","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvs.2011.06.079_bib20","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1097\/HJH.0b013e3282f82c3e","article-title":"The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome","volume":"26","author":"Nilsson","year":"2008","journal-title":"J Hypertens"},{"key":"10.1016\/j.jvs.2011.06.079_bib21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nm.1958","article-title":"Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms","volume":"15","author":"Satoh","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.jvs.2011.06.079_bib22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1161\/CIRCULATIONAHA.105.607168","article-title":"Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice","volume":"114","author":"Thomas","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2011.06.079_bib23","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.ATV.0000013778.72404.30","article-title":"Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling","volume":"22","author":"Miller","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvs.2011.06.079_bib24","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1152\/japplphysiol.91353.2008","article-title":"Vascular endothelial senescence: from mechanisms to pathophysiology","volume":"106","author":"Erusalimsky","year":"2009","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jvs.2011.06.079_bib25","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1128\/MCB.23.13.4598-4610.2003","article-title":"Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707","volume":"23","author":"Haendeler","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jvs.2011.06.079_bib26","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1161\/01.ATV.13.11.1689","article-title":"Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein(a)","volume":"13","author":"J\u00fcrgens","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.jvs.2011.06.079_bib27","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.bcp.2007.10.006","article-title":"Ageing and atherosclerosis: mechanisms and therapeutic options","volume":"75","author":"Costopoulos","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jvs.2011.06.079_bib28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","article-title":"A DNA damage checkpoint response in telomere-initiated senescence","volume":"426","author":"d'Adda di Fagagna","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jvs.2011.06.079_bib29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.yexcr.2005.05.002","article-title":"Comparison of early passage, senescent and hTERT immortalized endothelial cells","volume":"309","author":"Chang","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jvs.2011.06.079_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0531-5565(00)00080-2","article-title":"Subtractive hybridization of mRNA from early passage and senescent endothelial cells","volume":"35","author":"Grillari","year":"2000","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jvs.2011.06.079_bib31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1247\/csf.28.495","article-title":"Searching for genes involved in arteriosclerosis: proteomic analysis of cultured human umbilical vein endothelial cells undergoing replicative senescence","volume":"28","author":"Kamino","year":"2003","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.jvs.2011.06.079_bib32","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0741-5214(03)00324-0","article-title":"Current concepts in the pathogenesis of abdominal aortic aneurysm","volume":"38","author":"Ailawadi","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2011.06.079_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejvs.2010.08.023","article-title":"A randomised placebo-controlled double-blind trial to evaluate lipid-lowering pharmacotherapy on proteolysis and inflammation in abdominal aortic aneurysms","volume":"41","author":"Dawson","year":"2011","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2011.06.079_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/CIRCULATIONAHA.105.611111","article-title":"Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production","volume":"114","author":"P\u00e9rez-Rivero","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2011.06.079_bib35","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.atherosclerosis.2007.09.040","article-title":"Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease","volume":"198","author":"Satoh","year":"2008","journal-title":"Atherosclerosis"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521411015679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521411015679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T14:00:19Z","timestamp":1712844019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521411015679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0741521411015679"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2011.06.079","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}