{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:10:09Z","timestamp":1791396609751,"version":"4.3.3"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.jvs.2012.07.003","type":"journal-article","created":{"date-parts":[[2012,11,3]],"date-time":"2012-11-03T06:02:13Z","timestamp":1351922533000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Intraluminal abdominal aortic aneurysm thrombus is associated with disruption of wall integrity"],"prefix":"10.1016","volume":"57","author":[{"given":"Dave","family":"Koole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman J.A.","family":"Zandvoort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Schoneveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryan","family":"Vink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luuk L.","family":"van den Hoogen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul P.M.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Pasterkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans L.","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost A.","family":"van Herwaarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2012.07.003_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jvs.2010.08.013","article-title":"Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms","volume":"53","author":"Parr","year":"2011","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0741-5214(94)90277-1","article-title":"Computed tomography scanning findings associated with rapid expansion of abdominal aortic aneurysms","volume":"20","author":"Wolf","year":"1994","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jvs.2005.01.004","article-title":"Size and location of thrombus in intact and ruptured abdominal aortic aneurysms","volume":"41","author":"Hans","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1053\/ejvs.2000.1217","article-title":"Growth of thrombus may be a better predictor of rupture than diameter in patients with abdominal aortic aneurysms","volume":"20","author":"Stenbaek","year":"2000","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0741-5214(96)80062-0","article-title":"Intraluminal thrombus predicts rupture of an abdominal aortic aneurysm","volume":"23","author":"Satta","year":"1996","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib6","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.jvs.2008.06.063","article-title":"Bleeding into the intraluminal thrombus in abdominal aortic aneurysms is associated with rupture","volume":"48","author":"Roy","year":"2008","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1148\/radiology.204.3.9280256","article-title":"Abdominal aortic aneurysm: rupture associated with the high-attenuating crescent sign","volume":"204","author":"Arita","year":"1997","journal-title":"Radiology"},{"key":"10.1016\/j.jvs.2012.07.003_bib8","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1161\/01.ATV.0000174129.77391.55","article-title":"Biomechanical determinants of abdominal aortic aneurysm rupture","volume":"25","author":"Vorp","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvs.2012.07.003_bib9","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0741-5214(03)00791-2","article-title":"Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall","volume":"38","author":"Kazi","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.atherosclerosis.2011.05.002","article-title":"Protease activity in the multi-layered intra-luminal thrombus of abdominal aortic aneurysms","volume":"218","author":"Folkesson","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2012.07.003_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/path.2148","article-title":"Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms","volume":"212","author":"Houard","year":"2007","journal-title":"J Pathol"},{"key":"10.1016\/j.jvs.2012.07.003_bib12","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0002-9440(10)64447-1","article-title":"Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms","volume":"161","author":"Fontaine","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jvs.2012.07.003_bib13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000265569","article-title":"Thrombus versus wall biological activities in experimental aortic aneurysms","volume":"47","author":"Coutard","year":"2010","journal-title":"J Vasc Res"},{"key":"10.1016\/j.jvs.2012.07.003_bib14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1067\/mva.2001.114813","article-title":"Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening","volume":"34","author":"Vorp","year":"2001","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib15","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000318160","article-title":"Aneurysm-express: human abdominal aortic aneurysm wall expression in relation to heterogeneity and vascular events - rationale and design","volume":"45","author":"Hurks","year":"2010","journal-title":"Eur Surg Res"},{"issue":"Suppl 1","key":"10.1016\/j.jvs.2012.07.003_bib16","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2010.09.011","article-title":"Management of abdominal aortic aneurysms clinical practice guidelines of the European Society for Vascular Surgery","volume":"41","author":"Moll","year":"2011","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2012.07.003_bib18","first-page":"133","article-title":"Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells","volume":"10","author":"de Jager","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.jvs.2012.07.003_bib19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0022-1759(00)00238-6","article-title":"Multiplexed particle-based flow cytometric assays","volume":"243","author":"Vignali","year":"2000","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.jvs.2012.07.003_bib20","doi-asserted-by":"crossref","first-page":"e27531","DOI":"10.1371\/journal.pone.0027531","article-title":"Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1\/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia","volume":"6","author":"Hartney","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jvs.2012.07.003_bib21","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1161\/ATVBAHA.111.237537","article-title":"Proteomic analysis of polymorphonuclear neutrophils identifies catalase as a novel biomarker of abdominal aortic aneurysm: potential implication of oxidative stress in abdominal aortic aneurysm progression","volume":"31","author":"Ramos-Mozo","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvs.2012.07.003_bib22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/cvr\/cvq337","article-title":"Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans","volume":"90","author":"Michel","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jvs.2012.07.003_bib23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000318806","article-title":"Hypoxia in abdominal aortic aneurysm supports a role for HIF-1\u03b1 and Ets-1 as drivers of matrix metalloproteinase upregulation in human aortic smooth muscle cells","volume":"48","author":"Erdozain","year":"2011","journal-title":"J Vasc Res"},{"key":"10.1016\/j.jvs.2012.07.003_bib24","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.4049\/jimmunol.155.9.4391","article-title":"Macrophage activation by culture in an anoxic environment","volume":"155","author":"Albina","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.jvs.2012.07.003_bib25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1164\/arrd.1983.127.5.631","article-title":"Hypoxic injury to human alveolar macrophages accelerates release of previously bound neutrophil elastase","volume":"127","author":"Campbell","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jvs.2012.07.003_bib26","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/1523-1747.ep12329920","article-title":"Venous ulcer fibroblasts compared with normal fibroblasts show differences in collagen but not fibronectin production under both normal and hypoxic conditions","volume":"106","author":"Herrick","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jvs.2012.07.003_bib27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ejvs.2010.12.010","article-title":"The impact of intraluminal thrombus failure on the mechanical stress in the wall of abdominal aortic aneurysms","volume":"41","author":"Polzer","year":"2011","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jvs.2008.01.036","article-title":"Failure properties of intraluminal thrombus in abdominal aortic aneurysm under static and pulsating mechanical loads","volume":"48","author":"Gasser","year":"2008","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2012.07.003_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00048.2003","article-title":"Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture","volume":"85","author":"Newby","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jvs.2012.07.003_bib30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2141.2007.06632.x","article-title":"Platelets release active matrix metalloproteinase-2 in vivo in humans at a site of vascular injury: lack of inhibition by aspirin","volume":"138","author":"Falcinelli","year":"2007","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jvs.2012.07.003_bib31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jvs.2011.06.113","article-title":"Circumferential heterogeneity in the abdominal aortic aneurysm wall composition suggests lateral sides to be more rupture prone","volume":"55","author":"Hurks","year":"2012","journal-title":"J Vasc Surg"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521412015352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521412015352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:19:44Z","timestamp":1760041184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521412015352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0741521412015352"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2012.07.003","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraluminal abdominal aortic aneurysm thrombus is associated with disruption of wall integrity","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2012.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}