{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:54:01Z","timestamp":1793058841603,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.jvs.2013.08.002","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:00:33Z","timestamp":1381795233000},"page":"447-454.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["A multicenter randomized controlled trial evaluating balneotherapy in patients with advanced chronic venous insufficiency"],"prefix":"10.1016","volume":"59","clinical-trial-number":[{"clinical-trial-number":"nct00838500","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Patrick H.","family":"Carpentier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Blaise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette","family":"Satger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Genty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Rolland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Roques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Bosson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5 Suppl","key":"10.1016\/j.jvs.2013.08.002_bib1","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1016\/j.jvs.2011.01.079","article-title":"The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum","volume":"53","author":"Gloviczki","year":"2011","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2013.08.002_bib2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jvs.2004.09.027","article-title":"Revision of the CEAP classification for chronic venous disorders: consensus statement","volume":"40","author":"Eklof","year":"2004","journal-title":"J\u00a0Vasc Surg"},{"issue":"Suppl 1","key":"10.1016\/j.jvs.2013.08.002_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1258\/phleb.2010.010s09","article-title":"Societal costs of chronic venous disease in CEAP C4, C5, C6 disease","volume":"25","author":"Rabe","year":"2010","journal-title":"Phlebology"},{"key":"10.1016\/j.jvs.2013.08.002_bib4","first-page":"161","article-title":"Socioeconomic impact of chronic venous insufficiency. An underestimated public health problem","volume":"17","author":"Van den Oever","year":"1998","journal-title":"Int Angiol"},{"key":"10.1016\/j.jvs.2013.08.002_bib5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1258\/phleb.2010.010039","article-title":"The patient's burden of chronic venous disorders: construction of a questionnaire","volume":"25","author":"Guex","year":"2010","journal-title":"Phlebology"},{"key":"10.1016\/j.jvs.2013.08.002_bib6","first-page":"309","article-title":"Veno-active drugs in the management of chronic venous disease. An international consensus statement: current medical position, prospective views and final resolution","volume":"33","author":"Ramelet","year":"2005","journal-title":"Clin Hemorheol Microcirc"},{"key":"10.1016\/j.jvs.2013.08.002_bib7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.avsg.2007.07.014","article-title":"Use of compression stockings in chronic venous disease: patient compliance and efficacy","volume":"21","author":"Raju","year":"2007","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2013.08.002_bib8","first-page":"73","article-title":"Physikalische Therapie bei Venenerkrankungen","volume":"27","author":"J\u00fcnger","year":"1998","journal-title":"Vasa"},{"key":"10.1016\/j.jvs.2013.08.002_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/000331979704800209","article-title":"Physical therapy improves venous hemodynamics in cases of primary varicosity: results of a controlled study","volume":"48","author":"Hartmann","year":"1997","journal-title":"Angiology"},{"key":"10.1016\/j.jvs.2013.08.002_bib10","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1001\/archsurg.136.12.1364","article-title":"Hemodynamic effects of supervised calf muscle exercise in patients with venous leg ulceration: a prospective controlled trial","volume":"136","author":"Kan","year":"2001","journal-title":"Arch Surg"},{"key":"10.1016\/j.jvs.2013.08.002_bib11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jvs.2003.09.036","article-title":"Structured exercise improves calf muscle pump function in chronic venous insufficiency: a randomized trial","volume":"39","author":"Padberg","year":"2004","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2013.08.002_bib12","first-page":"147","article-title":"A\u00a0single blind randomized, controlled trial of hydrotherapy for varicose veins","volume":"20","author":"Ernst","year":"1991","journal-title":"Vasa"},{"key":"10.1016\/j.jvs.2013.08.002_bib13","first-page":"26","article-title":"Clinical, functional and quality of life changes after balneokinesis with sulphurous water in patients with varicose veins","volume":"32","author":"Mancini","year":"2003","journal-title":"Vasa"},{"key":"10.1016\/j.jvs.2013.08.002_bib14","first-page":"196","article-title":"Naiade Study Group. Changes in the use of health resources by patients with chronic phlebopathies after thermal hydrotherapy. Report from the Naiade project, a nation-wide survey on thermal therapies in Italy","volume":"21","author":"Coccheri","year":"2002","journal-title":"Int Angiol"},{"key":"10.1016\/j.jvs.2013.08.002_bib15","series-title":"M\u00e9decine Thermale, faits et preuves","first-page":"102","article-title":"Cr\u00e9noth\u00e9rapie des maladies vasculaires","author":"Carpentier","year":"2000"},{"key":"10.1016\/j.jvs.2013.08.002_bib16","first-page":"26","article-title":"\u201cL'Ecole de la Veine\u201d. Un programme d'\u00e9ducation pour les patients atteints d'insuffisance veineuse chronique \u00e0 la station thermale de La L\u00e9ch\u00e8re","volume":"27","author":"Satger","year":"2002","journal-title":"J\u00a0Mal Vasc"},{"key":"10.1016\/j.jvs.2013.08.002_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jvs.2008.07.075","article-title":"Randomized trial of balneotherapy associated with patient education in patients with advanced chronic venous insufficiency","volume":"49","author":"Carpentier","year":"2009","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2013.08.002_bib18","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1067\/mva.2000.107094","article-title":"Venous severity scoring: an adjunct to venous outcome assessment","volume":"31","author":"Rutherford","year":"2000","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2013.08.002_bib19","first-page":"106","article-title":"Evaluation of clinical efficacy of a venotonic drug: lessons of a therapeutic trial with hemisynthesis diosmin in \u201cheavy legs syndrome.\u201d","volume":"23","author":"Carpentier","year":"1998","journal-title":"J\u00a0Mal Vasc"},{"key":"10.1016\/j.jvs.2013.08.002_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10198-011-0351-x","article-title":"Valuing EQ-5D using time trade-off in France","volume":"14","author":"Chevalier","year":"2013","journal-title":"Eur J Health Econ"},{"key":"10.1016\/j.jvs.2013.08.002_bib21","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF00439228","article-title":"Construction and validation of a quality of life questionnaire in chronic lower limb venous insufficiency (CIVIQ)","volume":"5","author":"Launois","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.jvs.2013.08.002_bib22","first-page":"97","article-title":"Incidence de l'\u00e9rysip\u00e8le des membres inf\u00e9rieurs en milieu thermal phl\u00e9bologique. Efficacit\u00e9 d'une strat\u00e9gie d'\u00e9ducation sanitaire (La L\u00e9ch\u00e8re: 1992-1997)","volume":"26","author":"Carpentier","year":"2001","journal-title":"J\u00a0Mal Vasc"},{"key":"10.1016\/j.jvs.2013.08.002_bib23","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/S0140-6736(04)16353-8","article-title":"Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomized controlled trial","volume":"363","author":"Barwell","year":"2004","journal-title":"Lancet"},{"issue":"5 Suppl","key":"10.1016\/j.jvs.2013.08.002_bib24","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1016\/j.jvs.2010.05.068","article-title":"Venous ulcer diagnosis, treatment, and prevention of recurrences","volume":"52","author":"Gillespie","year":"2010","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2013.08.002_bib25","first-page":"1315","article-title":"Effectiveness of spa therapy in chronic low back pain: a randomized clinical trial","volume":"22","author":"Constant","year":"1995","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jvs.2013.08.002_bib26","first-page":"211","article-title":"Influence de l'application locale d'eau thermale de La L\u00e9ch\u00e8re en spray sur la microcirculation cutan\u00e9e des membres inf\u00e9rieurs","volume":"27","author":"Carpentier","year":"2002","journal-title":"J\u00a0Mal Vasc"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521413014882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521413014882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:17:47Z","timestamp":1760041067000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521413014882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0741521413014882"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2013.08.002","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multicenter randomized controlled trial evaluating balneotherapy in patients with advanced chronic venous insufficiency","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2013.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}