{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:12:37Z","timestamp":1778865157738,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jvascsurg.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.jvs.2016.11.065","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T00:00:35Z","timestamp":1487376035000},"page":"1864-1871","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Systemic application of carbon monoxide-releasing molecule 3 protects skeletal muscle from ischemia-reperfusion injury"],"prefix":"10.1016","volume":"66","author":[{"given":"Aurelia","family":"Bihari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gediminas","family":"Cepinskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel-Rahman","family":"Lawendy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2016.11.065_bib1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1001\/jama.1944.02850160009003","article-title":"Ischemic muscle necrosis: crushing injury, traumatic edema, the crush syndrome, traumatic anuria, compression syndrome: a type of injury seen in air raid casualties following burial beneath debris","volume":"124","author":"Bywaters","year":"1944","journal-title":"JAMA"},{"key":"10.1016\/j.jvs.2016.11.065_bib2","first-page":"265","article-title":"Disaster following femoral vein ligation for thrombophlebitis","volume":"17","author":"Dennis","year":"1945","journal-title":"Surgery"},{"key":"10.1016\/j.jvs.2016.11.065_bib3","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0967-2109(02)00070-4","article-title":"The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review","volume":"10","author":"Blaisdell","year":"2002","journal-title":"Cardiovasc Surg"},{"key":"10.1016\/j.jvs.2016.11.065_bib4","first-page":"56","article-title":"Skeletal muscle injury induced by ischemia-reperfusion","volume":"38","author":"Forbes","year":"1995","journal-title":"Can J Surg"},{"key":"10.1016\/j.jvs.2016.11.065_bib5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/mvre.1996.0027","article-title":"Leukocyte activity and tissue injury following ischemia-reperfusion in skeletal muscle","volume":"51","author":"Forbes","year":"1996","journal-title":"Microvasc Res"},{"key":"10.1016\/j.jvs.2016.11.065_bib6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1503\/cjs.048309","article-title":"Compartment syndrome-induced microvascular dysfunction: an experimental rodent model","volume":"54","author":"Lawendy","year":"2011","journal-title":"Can J Surg"},{"key":"10.1016\/j.jvs.2016.11.065_bib7","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00003086-199706000-00029","article-title":"Neutrophil mediated microvascular injury in acute, experimental compartment syndrome","author":"Sadasivan","year":"1997","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.jvs.2016.11.065_bib8","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.injury.2011.03.008","article-title":"The effect of ischemia reperfusion injury on skeletal muscle","volume":"43","author":"Gillani","year":"2012","journal-title":"Injury"},{"key":"10.1016\/j.jvs.2016.11.065_bib9","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0002-9440(10)63515-8","article-title":"Carbon monoxide inhalation protects rat intestinal grafts from ischemia\/reperfusion injury","volume":"163","author":"Nakao","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jvs.2016.11.065_bib10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1096\/fj.04-2514fje","article-title":"Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia\/reperfusion","volume":"19","author":"Ott","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.jvs.2016.11.065_bib11","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1517\/13543784.14.11.1305","article-title":"Therapeutic applications of carbon monoxide-releasing molecules","volume":"14","author":"Motterlini","year":"2005","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.jvs.2016.11.065_bib12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","article-title":"The therapeutic potential of carbon monoxide","volume":"9","author":"Motterlini","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jvs.2016.11.065_bib13","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1042\/BST0351142","article-title":"Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities","volume":"35","author":"Motterlini","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.jvs.2016.11.065_bib14","doi-asserted-by":"crossref","first-page":"G184","DOI":"10.1152\/ajpgi.00348.2007","article-title":"Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice","volume":"294","author":"Cepinskas","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.jvs.2016.11.065_bib15","doi-asserted-by":"crossref","first-page":"H920","DOI":"10.1152\/ajpheart.00305.2009","article-title":"CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase","volume":"297","author":"Mizuguchi","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jvs.2016.11.065_bib16","doi-asserted-by":"crossref","first-page":"e263","DOI":"10.1097\/BOT.0000000000000097","article-title":"The severity of microvascular dysfunction due to compartment syndrome is diminished by the systemic application of CO-releasing molecule-3","volume":"28","author":"Lawendy","year":"2014","journal-title":"J\u00a0Orthop Trauma"},{"key":"10.1016\/j.jvs.2016.11.065_bib17","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/01.RES.0000084381.86567.08","article-title":"Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule","volume":"93","author":"Clark","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2016.11.065_bib18","first-page":"453","article-title":"Peripheral arterial embolism. A 20 year review","volume":"29","author":"Baxter-Smith","year":"1988","journal-title":"J\u00a0Cardiovasc Surg (Torino)"},{"key":"10.1016\/j.jvs.2016.11.065_bib19","first-page":"79","article-title":"Arterial embolectomy. A long-term perspective","volume":"33","author":"Varty","year":"1992","journal-title":"J\u00a0Cardiovasc Surg (Torino)"},{"key":"10.1016\/j.jvs.2016.11.065_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trre.2008.08.003","article-title":"Lymphocytes and ischemia-reperfusion injury","volume":"23","author":"Linfert","year":"2009","journal-title":"Transplant Rev (Orlando)"},{"key":"10.1016\/j.jvs.2016.11.065_bib21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/01.sla.0000086663.49670.d1","article-title":"A\u00a0national and single institutional experience in the contemporary treatment of acute lower extremity ischemia","volume":"238","author":"Eliason","year":"2003","journal-title":"Ann Surg"},{"key":"10.1016\/j.jvs.2016.11.065_bib22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1164\/rccm.200404-446OC","article-title":"Effects of carbon monoxide inhalation during experimental endotoxemia in humans","volume":"171","author":"Mayr","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jvs.2016.11.065_bib23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/87929","article-title":"Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis","volume":"7","author":"Fujita","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.jvs.2016.11.065_bib24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10753-009-9162-y","article-title":"Carbon monoxide liberated from CO-releasing molecule (CORM-2) attenuates ischemia\/reperfusion (I\/R)-induced inflammation in the small intestine","volume":"33","author":"Katada","year":"2010","journal-title":"Inflammation"},{"key":"10.1016\/j.jvs.2016.11.065_bib25","doi-asserted-by":"crossref","first-page":"H1649","DOI":"10.1152\/ajpheart.00971.2003","article-title":"Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in\u00a0vivo","volume":"286","author":"Guo","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jvs.2016.11.065_bib26","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/ki.2010.542","article-title":"Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation","volume":"79","author":"Caumartin","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.jvs.2016.11.065_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-230X-10-42","article-title":"Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats","volume":"10","author":"Wei","year":"2010","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.jvs.2016.11.065_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1159\/000072226","article-title":"Development of 'no-reflow' phenomenon in ischemia\/reperfusion injury: failure of active vasomotility and not simply passive vasoconstriction","volume":"35","author":"Nanobashvili","year":"2003","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.jvs.2016.11.065_bib29","series-title":"Handbook of physiology: microcirculation","author":"Tuma","year":"2008"},{"key":"10.1016\/j.jvs.2016.11.065_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1006832207864","article-title":"Inflammatory responses to ischemia and reperfusion in skeletal muscle","volume":"179","author":"Gute","year":"1998","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jvs.2016.11.065_bib31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0741-5214(90)90360-M","article-title":"The effect of ischemia\/reperfusion on adenine nucleotide metabolism and xanthine oxidase production in skeletal muscle","volume":"12","author":"Lindsay","year":"1990","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2016.11.065_bib32","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.freeradbiomed.2010.08.017","article-title":"Carbon monoxide-releasing molecule CORM-3 suppresses vascular endothelial cell SOD-1\/SOD-2 activity while up-regulating the cell surface levels of SOD-3 in a heparin-dependent manner","volume":"49","author":"Mizuguchi","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jvs.2016.11.065_bib33","doi-asserted-by":"crossref","first-page":"e41836","DOI":"10.1371\/journal.pone.0041836","article-title":"Carbon monoxide improves cardiac function and mitochondrial population quality in a mouse model of metabolic syndrome","volume":"7","author":"Lancel","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jvs.2016.11.065_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.freeradbiomed.2014.02.020","article-title":"Carbon monoxide-releasing molecule 3 inhibits myeloperoxidase (MPO) and protects against MPO-induced vascular endothelial cell activation\/dysfunction","volume":"70","author":"Patterson","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jvs.2016.11.065_bib35","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/0003319712474336","article-title":"No-reflow phenomenon: pathophysiology, diagnosis, prevention, and treatment. A review of the current literature and future perspectives","volume":"65","author":"Galasso","year":"2014","journal-title":"Angiology"},{"key":"10.1016\/j.jvs.2016.11.065_bib36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1440-1827.1999.00829.x","article-title":"Reactive oxygen species-induced molecular damage and its application in pathology","volume":"49","author":"Toyokuni","year":"1999","journal-title":"Pathol Int"},{"key":"10.1016\/j.jvs.2016.11.065_bib37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/hep.510300132","article-title":"Initiation of remote hepatic injury in the rat: interactions between Kupffer cells, tumor necrosis factor-alpha, and microvascular perfusion","volume":"30","author":"Brock","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jvs.2016.11.065_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/2045-9912-2-28","article-title":"Emerging concepts on the anti-inflammatory actions of carbon monoxide-releasing molecules (CO-RMs)","volume":"2","author":"Motterlini","year":"2012","journal-title":"Med Gas Res"},{"key":"10.1016\/j.jvs.2016.11.065_bib39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1399-3089.2009.00521.x","article-title":"In\u00a0vitro and in\u00a0vivo effects of the carbon monoxide-releasing molecule, CORM-3, in the xenogeneic pig-to-primate context","volume":"16","author":"Vadori","year":"2009","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.jvs.2016.11.065_bib40","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1476-5381.2009.00215.x","article-title":"The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of haem oxygenase-1 expression","volume":"157","author":"Song","year":"2009","journal-title":"Br J Pharmacol"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521417300745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521417300745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T17:19:36Z","timestamp":1601659176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521417300745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0741521417300745"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2016.11.065","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic application of carbon monoxide-releasing molecule 3 protects skeletal muscle from ischemia-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2016.11.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}