{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:26:19Z","timestamp":1774581979354,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jvascsurg.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jvs.2017.05.115","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T09:56:07Z","timestamp":1502704567000},"page":"1534-1542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Association between statin therapy and amputation-free survival in patients with critical limb ischemia in the CRITISCH registry"],"prefix":"10.1016","volume":"66","author":[{"given":"Konstantinos","family":"Stavroulakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Borowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Torsello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodosios","family":"Bisdas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzin","family":"Adili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Balzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend","family":"Billing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dittmar","family":"B\u00f6ckler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Brixner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian E.","family":"Debus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Henning","family":"Eckstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Joachim","family":"Florek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asimakis","family":"Gkremoutis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhardt","family":"Grundmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Keck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Ger\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Klonek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"M\u00fchling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Oberhuber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Reinecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Reinhold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf-Gerhard","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Schelzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schlensack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schmitz-Rixen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Ludwig","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Spohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Steinbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Storck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Trede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Uhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Weis-M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Zhorzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2017.05.115_bib1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2015.01.036","article-title":"A\u00a0century of cholesterol and coronaries: from plaques to genes to statins","volume":"161","author":"Goldstein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jvs.2017.05.115_bib2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0014-5793(76)80996-9","article-title":"Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity","volume":"72","author":"Endo","year":"1976","journal-title":"FEBS Lett"},{"issue":"Pt B","key":"10.1016\/j.jvs.2017.05.115_bib3","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.jacc.2013.11.002","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Stone","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2017.05.115_bib4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1056\/NEJMoa043545","article-title":"German Diabetes and Dialysis Study Investigators. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis","volume":"353","author":"Wanner","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvs.2017.05.115_bib5","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1016\/j.jacc.2016.11.007","article-title":"2016 AHA\/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"69","author":"Gerhard-Herman","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2017.05.115_bib6","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1093\/eurheartj\/ehr211","volume":"32","author":"Tendera","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvs.2017.05.115_bib7","first-page":"281","volume":"253","author":"Catapano","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvs.2017.05.115_bib8","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.jacc.2010.08.606","volume":"56","author":"Olin","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2017.05.115_bib9","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jacc.2013.09.073","article-title":"Association between statin medications and mortality, major adverse cardiovascular event, and amputation-free survival in patients with critical limb ischemia","volume":"63","author":"Westin","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2017.05.115_bib10","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1093\/eurheartj\/ehu080","article-title":"Statin therapy and long-term adverse limb outcomes in patients with peripheral artery disease: insights from the REACH registry","volume":"35","author":"Kumbhani","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvs.2017.05.115_bib11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jvs.2007.11.056","article-title":"Statins are independently associated with reduced mortality in patients undergoing infrainguinal bypass graft surgery for critical limb ischemia","volume":"47","author":"Schanzer","year":"2008","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2017.05.115_bib12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jvs.2016.03.429","article-title":"Contemporary cardiovascular risk and secondary preventive drug treatment patterns in peripheral artery disease patients undergoing revascularization","volume":"64","author":"Sigvant","year":"2016","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2017.05.115_bib13","first-page":"5","article-title":"Critical limb ischemia: current trends and future directions","author":"Teraa","year":"2016","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jvs.2017.05.115_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00772-014-1305-2","article-title":"German national registry for first-line treatment strategies in patients with critical limb ischemia (CRITISCH registry): study design and current status","volume":"19","author":"Bisdas","year":"2014","journal-title":"Gefaesschirurgie"},{"key":"10.1016\/j.jvs.2017.05.115_bib15","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.jvs.2015.04.441","article-title":"CRITISCH collaborators. Current practice of first-line treatment strategies in patients with critical limb ischemia","volume":"62","author":"Bisdas","year":"2015","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2017.05.115_bib16","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1016\/j.jcin.2016.09.039","article-title":"Endovascular therapy versus bypass surgery as first-line treatment strategies for critical limb ischemia: results of the interim analysis of the CRITISCH registry","volume":"9","author":"Bisdas","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jvs.2017.05.115_bib17","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis","volume":"382","author":"Fowkes","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2017.05.115_bib18","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1093\/eurheartj\/ehu071","article-title":"Non-coronary atherosclerosis","volume":"35","author":"Gallino","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvs.2017.05.115_bib19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1161\/CIRCULATIONAHA.112.108787","article-title":"Missed opportunities: despite improvement in use of cardioprotective medications among patients with lower-extremity peripheral artery disease, underuse remains","volume":"126","author":"Subherwal","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2017.05.115_bib20","doi-asserted-by":"crossref","first-page":"e4947","DOI":"10.1136\/bmj.e4947","article-title":"Guideline Development Group. Diagnosis and management of lower limb peripheral arterial disease: summary of NICE guidance","volume":"345","author":"Layden","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.jvs.2017.05.115_bib21","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1161\/CIRCINTERVENTIONS.113.000274","article-title":"Preoperative statins and limb salvage after lower extremity revascularization in the Medicare population","volume":"6","author":"Vogel","year":"2013","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jvs.2017.05.115_bib22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jvs.2012.01.054","article-title":"Long-term limb salvage and survival after endovascular and open revascularization for critical limb ischemia after adoption of endovascular-first approach by vascular surgeons","volume":"56","author":"Dosluoglu","year":"2012","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2017.05.115_bib23","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.jvs.2013.03.050","article-title":"Optimal medical therapy predicts amputation-free survival in chronic critical limb ischemia","volume":"58","author":"Chung","year":"2013","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2017.05.115_bib24","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jvs.2011.04.021","article-title":"Completion duplex ultrasound predicts early graft thrombosis after crural bypass in patients with critical limb ischemia","volume":"54","author":"Scali","year":"2011","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2017.05.115_bib25","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.jvir.2016.05.037","article-title":"The influence of statin therapy on restenosis in patients who underwent nitinol stent implantation for de novo femoropopliteal artery disease: two-year follow-up at a single center","volume":"27","author":"Kim","year":"2016","journal-title":"J\u00a0Vasc Interv Radiol"},{"key":"10.1016\/j.jvs.2017.05.115_bib26","doi-asserted-by":"crossref","first-page":"e000697","DOI":"10.1161\/JAHA.113.000697","article-title":"Adherence to guideline-recommended therapy is associated with decreased major adverse cardiovascular events and major adverse limb events among patients with peripheral arterial disease","volume":"3","author":"Armstrong","year":"2014","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jvs.2017.05.115_bib27","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.jcin.2015.07.005","volume":"8","author":"Iida","year":"2015","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jvs.2017.05.115_bib28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jvs.2014.05.093","article-title":"Statin therapy after infrainguinal bypass surgery for critical limb ischemia is associated with improved 5-year survival","volume":"61","author":"Suckow","year":"2015","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2017.05.115_bib29","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.jacc.2010.01.020","volume":"55","author":"Ridker","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2017.05.115_bib30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jvs.2005.05.001","article-title":"Risk factors, medical therapies and perioperative events in limb salvage surgery: observations from the PREVENT III multicenter trial","volume":"42","author":"Conte","year":"2005","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2017.05.115_bib31","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jacc.2015.02.003","article-title":"2015 ACC\/AHA Focused Update of Secondary Prevention Lipid Performance Measures: a report of the American College of Cardiology\/American Heart Association Task Force on Performance Measures","volume":"67","author":"Drozda","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2017.05.115_bib32","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1056\/NEJMoa1110874","article-title":"Effect of two intensive statin regimens on progression of coronary disease","volume":"365","author":"Nicholls","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvs.2017.05.115_bib33","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/clc.22343","article-title":"Is high-intensity statin therapy associated with lower statin adherence compared with low- to moderate-intensity statin therapy? Implications of the 2013 American College of Cardiology\/American Heart Association Cholesterol Management Guidelines","volume":"37","author":"Virani","year":"2014","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jvs.2017.05.115_bib34","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/eurheartj\/ehv043","article-title":"Statin-associated muscle symptoms: impact on statin therapy\u2014European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management","volume":"36","author":"Stroes","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvs.2017.05.115_bib35","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","article-title":"Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials","volume":"376","author":"Baigent","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2017.05.115_bib36","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMra1515161","article-title":"Statin-associated autoimmune myopathy","volume":"374","author":"Mammen","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvs.2017.05.115_bib37","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1001\/jama.2016.3608","article-title":"Efficacy and tolerability of evolocumab vs ezetimibe in patients with muscle-related statin intolerance: the GAUSS-3 randomized clinical trial","volume":"315","author":"Nissen","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jvs.2017.05.115_bib38","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1093\/eurheartj\/ehu107","article-title":"The ACC\/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC\/EAS guidelines for the management of dyslipidaemias 2011","volume":"35","author":"Ray","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvs.2017.05.115_bib39","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jacl.2013.03.001","article-title":"Predictors\u00a0of statin adherence, switching, and discontinuation in the USAGE survey: understanding the use of statins in\u00a0America and gaps in patient education","volume":"7","author":"Wei","year":"2013","journal-title":"J\u00a0Clin Lipidol"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521417316865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521417316865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:38:43Z","timestamp":1659328723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521417316865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0741521417316865"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2017.05.115","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between statin therapy and amputation-free survival in patients with critical limb ischemia in the CRITISCH registry","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2017.05.115","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}