{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:29:04Z","timestamp":1792729744179,"version":"4.5.0"},"reference-count":13,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":732,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000423"],"award-info":[{"award-number":["UL1TR000423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL-109942-01A1"],"award-info":[{"award-number":["R01-HL-109942-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jvs.2018.12.032","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T09:42:41Z","timestamp":1552297361000},"page":"718-723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G&gt;A (p.Arg177Gln)"],"prefix":"10.1016","volume":"70","author":[{"given":"Sherene","family":"Shalhub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen S.","family":"Regalado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Chuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna M.","family":"Milewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2018.12.032_bib1","first-page":"172","article-title":"Precision medical and surgical management for thoracic aortic aneurysms and acute aortic dissections based on the causative mutant gene","volume":"57","author":"Milewicz","year":"2016","journal-title":"J\u00a0Cardiovasc Surg (Torino)"},{"key":"10.1016\/j.jvs.2018.12.032_bib2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jvs.2017.12.023","article-title":"Testing patterns for genetically triggered aortic and arterial aneurysms and dissections at an academic center","volume":"68","author":"Hicks","year":"2018","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2018.12.032_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1055\/s-0038-1639612","article-title":"Genes associated with thoracic aortic aneurysm and dissection: 2018 update and clinical implications","volume":"6","author":"Brownstein","year":"2018","journal-title":"Aorta (Stamford)"},{"key":"10.1016\/j.jvs.2018.12.032_bib4","article-title":"Heritable Thoracic Aortic Disease Overview","author":"Milewicz","year":"1993"},{"key":"10.1016\/j.jvs.2018.12.032_bib5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0196-0644(03)00818-7","article-title":"Nonsyndromic genetic predisposition to aortic dissection: a newly recognized, diagnosable, and preventable occurrence in families","volume":"43","author":"Hasham","year":"2004","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jvs.2018.12.032_bib6","first-page":"26","article-title":"Structure of the elastin-contractile units in the thoracic aorta and how genes that cause thoracic aortic aneurysms and dissections disrupt this structure","volume":"32","author":"Karimi","year":"2016","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jvs.2018.12.032_bib7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ajhg.2013.06.019","article-title":"Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections","volume":"93","author":"Guo","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jvs.2018.12.032_bib8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/eci.12662","article-title":"PRKG1 and genetic diagnosis of early-onset thoracic aortic disease","volume":"46","author":"Gago-Diaz","year":"2016","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jvs.2018.12.032_bib9","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the International Registry of Acute Aortic Dissection: a 20-year experience of collaborative clinical research","volume":"137","author":"Evangelista","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2018.12.032_bib10","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.jvs.2014.12.038","article-title":"The natural history of medically managed acute type B aortic dissection","volume":"61","author":"Durham","year":"2015","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2018.12.032_bib11","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.jacc.2012.11.072","article-title":"Interdisciplinary expert consensus document on management of type B aortic dissection","volume":"61","author":"Fattori","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2018.12.032_bib12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jvs.2017.11.095","article-title":"Endovascular thoracic aortic repair in confirmed or suspected genetically triggered thoracic aortic dissection","volume":"68","author":"Shalhub","year":"2018","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2018.12.032_bib13","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1161\/CIR.0b013e3181d47d48","volume":"121","author":"Hiratzka","year":"2010","journal-title":"Circulation"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521419301740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521419301740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:28:41Z","timestamp":1778693321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521419301740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0741521419301740"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2018.12.032","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The natural history of type B aortic dissection in patients with PRKG1 mutation c.530G>A (p.Arg177Gln)","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2018.12.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}