{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:04:33Z","timestamp":1763748273340,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jvs.2020.08.144","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T12:23:08Z","timestamp":1601900588000},"page":"1731-1740.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Extent of heel ulceration influences the outcomes in patients with isolated infrapopliteal limb threatening critical ischemia"],"prefix":"10.1016","volume":"73","author":[{"given":"Qi","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalithapriya","family":"Jayakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Sideman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Mitromaras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Miserlis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2020.08.144_bib1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1067\/mva.2000.106493","article-title":"Management of ischemic heel ulceration and gangrene: an evaluation of factors associated with successful healing","volume":"31","author":"Treiman","year":"2000","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib2","first-page":"191","article-title":"Physiology and prevention of heel ulcers: the state of science","volume":"30","author":"Wong","year":"2003","journal-title":"J\u00a0Wound Care Nurs"},{"key":"10.1016\/j.jvs.2020.08.144_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.avsg.2017.11.072","article-title":"Heel wounds predict mortality but not amputation after infrapopliteal revascularization","volume":"51","author":"Mohapatra","year":"2018","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.amjsurg.2007.08.008","article-title":"The management of ischemic heel ulcers and gangrene in the endovascular era","volume":"194","author":"Dosluoglu","year":"2007","journal-title":"Am J Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib5","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2337\/diacare.24.8.1433","article-title":"Peripheral arterial disease in diabetic and nondiabetic patients: a comparison of severity and outcome","volume":"24","author":"Jude","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jvs.2020.08.144_bib6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jvs.2007.11.055","article-title":"Patterns of artery disease in 450 patients undergoing revascularization for critical limb ischemia: implications for clinical trial design","volume":"47","author":"Rueda","year":"2008","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib7","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jvs.2019.10.083","article-title":"Short-term contemporary outcomes for staged versus primary lower limb amputation in diabetic foot disease","volume":"72","author":"Cheun","year":"2020","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jvs.2017.11.096","article-title":"Outcomes of re-intervention for recurrent symptomatic disease after tibial endovascular intervention","volume":"68","author":"Baer-Bositis","year":"2018","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib9","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jvs.2011.10.109","article-title":"Impact of metabolic syndrome on the outcomes of superficial femoral artery interventions","volume":"55","author":"Smolock","year":"2012","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib10","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jvs.2009.09.044","article-title":"Suggested objective performance goals and clinical trial design for evaluating catheter-based treatment of critical limb ischemia","volume":"50","author":"Conte","year":"2009","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jvs.2016.03.420","article-title":"Reporting standards of the Society for Vascular Surgery for endovascular treatment of chronic lower extremity peripheral artery disease","volume":"64","author":"Stoner","year":"2016","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/1534734613502043","article-title":"Heel ulcer and blood flow: the importance of the angiosome concept","volume":"12","author":"Faglia","year":"2013","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.jvs.2020.08.144_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0741-5214(99)70077-7","article-title":"Efficacy of dorsal pedal artery bypass in limb salvage for ischemic heel ulcers","volume":"30","author":"Berceli","year":"1999","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0002-9610(98)00168-8","article-title":"A\u00a0regional pedal ischemia scoring system for decision analysis in patients with heel ulceration","volume":"176","author":"Gentile","year":"1998","journal-title":"Am J Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1067\/mva.2001.112301","article-title":"Combined free tissue transfer and infrainguinal bypass graft: an alternative to major amputation in selected patients","volume":"33","author":"Illig","year":"2001","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib16","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jvs.2011.10.089","article-title":"Improved amputation-free survival in unreconstructable critical limb ischemia and its implications for clinical trial design and quality measurement","volume":"55","author":"Benoit","year":"2012","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib17","doi-asserted-by":"crossref","first-page":"e194620","DOI":"10.1001\/jamasurg.2019.4620","article-title":"Association of preoperative patient frailty and operative stress with postoperative mortality","volume":"155","author":"Shinall","year":"2020","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib18","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.avsg.2012.09.015","article-title":"Simplified frailty index to predict adverse outcomes and mortality in vascular surgery patients","volume":"27","author":"Karam","year":"2013","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib19","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jvs.2016.10.102","article-title":"Preoperative frailty is predictive of complications after major lower extremity amputation","volume":"65","author":"Fang","year":"2017","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib20","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.jvs.2017.04.048","article-title":"Influence of frailty on treatment outcomes after revascularization in patients with critical limb ischemia","volume":"66","author":"Morisaki","year":"2017","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib21","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.100.10.1043","article-title":"Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery","volume":"100","author":"Lee","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2020.08.144_bib22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","article-title":"Conference Participants. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute\/American Heart Association conference on scientific issues related to definition","volume":"109","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2020.08.144_bib23","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jvs.2016.10.102","article-title":"Preoperative frailty is predictive of complications after major lower extremity amputation","volume":"65","author":"Fang","year":"2017","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jamcollsurg.2017.11.005","article-title":"New 5-factor modified frailty index using American College of Surgeons NSQIP data","volume":"226","author":"Subramaniam","year":"2018","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jss.2015.10.026","article-title":"Gender and frailty predict poor outcomes in infrainguinal vascular surgery","volume":"201","author":"Brahmbhatt","year":"2016","journal-title":"J\u00a0Surg Res"},{"issue":"Suppl S","key":"10.1016\/j.jvs.2020.08.144_bib26","first-page":"S1","article-title":"TASC-II: Inter-Society Consensus for the management of peripheral vascular arterial disease","volume":"45","year":"2007","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib27","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jvs.2008.04.013","article-title":"Impact of runoff on superficial femoral artery endoluminal interventions for rest pain and tissue loss","volume":"48","author":"Davies","year":"2008","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jvs.2013.08.003","article-title":"The Society for Vascular Surgery lower extremity threatened limb classification system: risk stratification based on wound, ischemia, and foot infection (WIfI)","volume":"59","author":"Mills","year":"2014","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib29","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jvs.2009.05.055","article-title":"Validation of the PIII CLI risk score for the prediction of amputation-free survival in patients undergoing infrainguinal autogenous vein bypass for critical limb ischemia","volume":"50","author":"Schanzer","year":"2009","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00268-006-0242-y","article-title":"Risk-scoring method for prediction of 30-day postoperative outcome after infrainguinal surgical revascularization for critical lower-limb ischemia: a FinnVasc registry study","volume":"31","author":"Biancari","year":"2007","journal-title":"World J Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib31","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jvs.2009.09.044","article-title":"Suggested objective performance goals and clinical trial design for evaluating catheter-based treatment of critical limb ischemia","volume":"50","author":"Conte","year":"2009","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2020.08.144_bib32","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0741-5214(97)70045-4","article-title":"Recommended standards for reports dealing with lower extremity ischemia: revised version","volume":"26","author":"Rutherford","year":"1997","journal-title":"J\u00a0Vasc Surg"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521420321315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521420321315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:31:19Z","timestamp":1760041879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521420321315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0741521420321315"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2020.08.144","relation":{},"ISSN":["0741-5214"],"issn-type":[{"type":"print","value":"0741-5214"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extent of heel ulceration influences the outcomes in patients with isolated infrapopliteal limb threatening critical ischemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2020.08.144","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc. on behalf of the Society for Vascular Surgery.","name":"copyright","label":"Copyright"}]}}