{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:07:32Z","timestamp":1782932852941,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R43HL142428"],"award-info":[{"award-number":["R43HL142428"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jvs.2021.06.478","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T10:44:47Z","timestamp":1627123487000},"page":"279-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Machine learning analysis of multispectral imaging and clinical risk factors to predict amputation wound healing"],"prefix":"10.1016","volume":"75","author":[{"given":"John J.","family":"Squiers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Thatcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Bastawros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Applewhite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D.","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faliu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiran","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"DiMaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis R.","family":"Gable","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2021.06.478_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2337\/dc18-1380","article-title":"Resurgence of diabetes-related nontraumatic lower-extremity amputation in the young and middle-aged adult U.S. population","volume":"42","author":"Geiss","year":"2019","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jvs.2021.06.478_bib2","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.avsg.2012.02.011","article-title":"Identifying the incidence of and risk factors for reamputation among patients who underwent foot amputation","volume":"26","author":"Kono","year":"2012","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2021.06.478_bib3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.apmr.2004.06.072","article-title":"Reamputation, mortality, and health care costs among persons with dysvascular lower-limb amputation","volume":"86","author":"Dillingham","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.jvs.2021.06.478_bib4","doi-asserted-by":"crossref","first-page":"e657","DOI":"10.1161\/CIR.0000000000000708","article-title":"Perfusion assessment in critical limb ischemia: principles for understanding and the development of evidence and evaluation of devices. A scientific statement from the American Heart Association","volume":"140","author":"Misra","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2021.06.478_bib5","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1089\/wound.2015.0684","article-title":"Imaging techniques for clinical burn assessment with a focus on multispectral imaging","volume":"5","author":"Thatcher","year":"2016","journal-title":"Adv Wound Care"},{"key":"10.1016\/j.jvs.2021.06.478_bib6","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.burns.2015.05.009","article-title":"Surgical wound debridement sequentially characterized in a porcine burn model with multispectral imaging","volume":"41","author":"King","year":"2015","journal-title":"Burns"},{"key":"10.1016\/j.jvs.2021.06.478_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/BCR.0000000000000317","article-title":"Multispectral and photoplethysmography optical imaging techniques identify important tissue characteristics in an animal model of tangential burn excision","volume":"37","author":"Thatcher","year":"2016","journal-title":"J\u00a0Burn Care Res"},{"key":"10.1016\/j.jvs.2021.06.478_bib8","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1046\/j.0022-202x.2001.01577.x","article-title":"Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in\u00a0vivo using diffuse reflectance spectroscopy","volume":"117","author":"Zonios","year":"2001","journal-title":"J\u00a0Invest Derm"},{"key":"10.1016\/j.jvs.2021.06.478_bib9","first-page":"1556","article-title":"Very deep convolutional networks for large-scale image recognition","volume":"1409","author":"Simonyan","year":"2014","journal-title":"arXiv"},{"key":"10.1016\/j.jvs.2021.06.478_bib10","first-page":"07871","article-title":"FiLM: visual reasoning with a general conditioning layer","volume":"1709","author":"Perez","year":"2017","journal-title":"arXiv"},{"key":"10.1016\/j.jvs.2021.06.478_bib11","series-title":"The elements of statistical learning. Spring Series in Statistics","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21606-5","author":"Hastie","year":"2001"},{"key":"10.1016\/j.jvs.2021.06.478_bib12","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1161\/CIR.0b013e318276fbcb","article-title":"Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association","volume":"126","author":"Aboyans","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2021.06.478_bib13","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/j.jcin.2017.08.026","article-title":"Heterogeneity of ankle-brachial indices in patients undergoing revasculariation for critical limb ischemia","volume":"10","author":"Sukul","year":"2017","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jvs.2021.06.478_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/1358863X14565372","article-title":"Validation of the relationship between ankle-brachial and toe-brachial indices and infragenicular arterial patency in critical limb ischemia","volume":"20","author":"Bunte","year":"2015","journal-title":"Vasc Med"},{"key":"10.1016\/j.jvs.2021.06.478_bib15","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jacc.2011.09.055","article-title":"Survival in patients with poorly compressible leg arteries","volume":"59","author":"Arain","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2021.06.478_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.12968\/jowc.2006.15.1.26860","article-title":"Can transcutaneous oxygen tension measurement determine re-amputation levels?","volume":"15","author":"Keyzer-Dekker","year":"2006","journal-title":"J\u00a0Wound Care"},{"key":"10.1016\/j.jvs.2021.06.478_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1078-5884(98)80092-0","article-title":"A\u00a0comparison of laser Doppler fluximetry and transcutaneous oxygen pressure measurement in the dysvascular patient requiring amputation","volume":"16","author":"Mars","year":"1998","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2021.06.478_bib18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jvs.2018.09.043","article-title":"Current status of noninvasive perfusion assessment in individuals with diabetic foot ulceration","volume":"69","author":"Goodall","year":"2019","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2021.06.478_bib19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.ejvs.2006.12.027","article-title":"Predictive values of transcutaneous oxygen tension for above-the-ankle amputation in diabetic patients with critical limb ischemia","volume":"33","author":"Faglia","year":"2007","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2021.06.478_bib20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.burns.2008.01.009","article-title":"Assessment of burn depth and burn wound healing potential","volume":"34","author":"Monstrey","year":"2008","journal-title":"Burns"},{"key":"10.1016\/j.jvs.2021.06.478_bib21","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jvs.2016.12.090","article-title":"The application of the Society for Vascular Surgery Wound, Ischemia and foot Infection (WIfI) classification to stratify amputation risk","volume":"65","author":"Mills","year":"2017","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2021.06.478_bib22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jvs.2013.08.003","article-title":"The Society of Vascular Surgery lower extremity threatened limb classification system: risk stratification based on Wound, Ischemia, and foot Infection (WIfI)","volume":"59","author":"Mills","year":"2014","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2021.06.478_bib23","article-title":"Global Vascular Guidelines on the management of chronic limb-threatening ischemia","volume":"1S","author":"Conte","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2021.06.478_bib24","doi-asserted-by":"crossref","first-page":"e003219","DOI":"10.1161\/JAHA.116.003219","article-title":"Design and rationale of the best endovascular versus best surgical therapy for patients with critical limb ischemia (BEST-CLI) Trial","volume":"5","author":"Menard","year":"2016","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jvs.2021.06.478_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13063-015-1114-2","article-title":"Bypass versus angio plasty in severe ischaemia of the leg \u2013 2 (BASIL-2) trial: study protocol for a randomised controlled trial","volume":"17","author":"Popplewell","year":"2016","journal-title":"Trials"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521421016864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521421016864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:26:31Z","timestamp":1777573591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521421016864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0741521421016864"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2021.06.478","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Machine learning analysis of multispectral imaging and clinical risk factors to predict amputation wound healing","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2021.06.478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}