{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:30:01Z","timestamp":1789662601407,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":730,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["0.00-0.11"],"award-info":[{"award-number":["0.00-0.11"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jvs.2021.06.480","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T22:39:48Z","timestamp":1629758388000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Persistent under-representation of female patients in United States trials of common vascular diseases from 2008 to 2020"],"prefix":"10.1016","volume":"75","author":[{"given":"Jessica M.","family":"Mayor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ourania","family":"Preventza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"McGinigle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Sr.","given":"Joseph L.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Montero-Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramyar","family":"Gilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Pallister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayer","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2021.06.480_bib1","series-title":"National Institutes of Health Revitalization Act of 1993: act to amend the Public Health Service Act to revise and extend the programs of the National Institutes of Health, and for other purposes","year":"1993"},{"key":"10.1016\/j.jvs.2021.06.480_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/CIRCOUTCOMES.110.868307","article-title":"Representation of women in randomized clinical trials of cardiovascular disease prevention","volume":"3","author":"Melloni","year":"2010","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jvs.2021.06.480_bib3","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.jacc.2018.02.070","article-title":"Participation of women in clinical trials supporting FDA approval of cardiovascular drugs","volume":"71","author":"Scott","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2021.06.480_bib4","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.athoracsur.2020.08.075","article-title":"Sex, racial, and ethnic disparities in US cardiovascular trials in more than 230,000 patients","volume":"112","author":"Preventza","year":"2021","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvs.2021.06.480_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1056\/NEJM200008173430706","article-title":"Enrollment of women in cardiovascular clinical trials funded by the National Heart, Lung, and Blood Institute","volume":"343","author":"Harris","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvs.2021.06.480_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jvs.2009.01.012","article-title":"Under-representation of women and ethnic minorities in vascular surgery randomized controlled trials","volume":"50","author":"Hoel","year":"2009","journal-title":"Jo Vasc Surg"},{"key":"10.1016\/j.jvs.2021.06.480_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000452426","article-title":"Risk factors for incident carotid artery revascularization among older adults: the cardiovascular health study","volume":"6","author":"Garg","year":"2016","journal-title":"Cerebrovasc Dis Extra"},{"key":"10.1016\/j.jvs.2021.06.480_bib8","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jvs.2014.03.290","article-title":"Epidemiology of peripheral arterial disease and critical limb ischemia in an insured national population","volume":"60","author":"Nehler","year":"2014","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2021.06.480_bib9","doi-asserted-by":"crossref","first-page":"e463","DOI":"10.1161\/CIRCULATIONAHA.106.174526","volume":"113","author":"Hirsch","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2021.06.480_bib10","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jama.283.7.897","article-title":"The International Registry of Acute Aortic\u00a0Dissection (IRAD): new insights into an old disease","volume":"283","author":"Hagan","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jvs.2021.06.480_bib11","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1089\/jwh.2012.3753","article-title":"Participation of women and sex analyses in late-phase clinical trials of new molecular entity drugs and biologics approved by the FDA in 2007\u20132009","volume":"22","author":"Poon","year":"2013","journal-title":"J\u00a0Womens Health"},{"key":"10.1016\/j.jvs.2021.06.480_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta9380","article-title":"The causes and effects of socio-demographic exclusions from clinical trials","volume":"9","author":"Bartlett","year":"2005","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.jvs.2021.06.480_bib13","series-title":"Demographic turning points for the United States: population projections for 2020 to 2060","first-page":"25","author":"Vespa","year":"2020"},{"key":"10.1016\/j.jvs.2021.06.480_bib14","first-page":"653","article-title":"Temporal trends of women enrollment in major cardiovascular randomized clinical trials","volume":"35","author":"Gong","year":"2019","journal-title":"Can J Cardiol"},{"issue":"Suppl 1","key":"10.1016\/j.jvs.2021.06.480_bib15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11606-009-1116-4","article-title":"Integration of women veterans into VA quality improvement research efforts: what researchers need to know","volume":"25","author":"Yano","year":"2010","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.jvs.2021.06.480_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/09581596.2018.1529861","article-title":"Disadvantaged, outnumbered, and discouraged: women\u2019s experiences as healthy volunteers in U.S. phase I trials","volume":"30","author":"Jain","year":"2020","journal-title":"Crit Public Health"},{"key":"10.1016\/j.jvs.2021.06.480_bib17","first-page":"600","article-title":"Females in clinical studies: where are we going?","volume":"81","author":"Uhl","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jvs.2021.06.480_bib18","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1001\/jamainternmed.2014.4758","article-title":"Underrepresentation of women, elderly patients, and racial minorities in the randomized trials used for cardiovascular guidelines","volume":"174","author":"Sardar","year":"2014","journal-title":"JAMA Intern Med"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521421019583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521421019583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:40:10Z","timestamp":1760042410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521421019583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0741521421019583"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2021.06.480","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistent under-representation of female patients in United States trials of common vascular diseases from 2008 to 2020","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2021.06.480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}