{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:03:25Z","timestamp":1776121405798,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":508,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jvs.2022.04.048","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T11:23:09Z","timestamp":1654946589000},"page":"1021-1029.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased long-term bleeding complications in females undergoing endovascular revascularization for peripheral arterial disease"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7883-5313","authenticated-orcid":false,"given":"Kathleen","family":"Marulanda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Duchesneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapna","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney E.","family":"Browder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna M.","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris B.","family":"Agala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Kindell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Curcio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina R.","family":"Kibbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-159X","authenticated-orcid":false,"given":"Katharine","family":"McGinigle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2022.04.048_bib1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1161\/CIR.0b013e31824c39ba","article-title":"A\u00a0call to action: women and peripheral artery disease: a scientific statement from the American Heart Association","volume":"125","author":"Hirsch","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2022.04.048_bib2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCULATIONAHA.113.001560","article-title":"Management of patients after endovascular interventions for peripheral artery disease","volume":"128","author":"Sobieszczyk","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2022.04.048_bib3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/ajhp\/zxz315","article-title":"Antithrombotic therapy for postinterventional management of peripheral arterial disease","volume":"77","author":"Zavgorodnyaya","year":"2020","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.jvs.2022.04.048_bib4","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.jvs.2020.11.034","article-title":"Sex-related disparities in intervention rates and type of intervention in patients with aortic and peripheral arterial diseases in the National Inpatient Sample Database","volume":"73","author":"McGinigle","year":"2021","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejvs.2019.03.001","article-title":"Comparison of Immediate and Long-term Outcomes in Men and Women Undergoing Revascularisation for Chronic Limb Threatening Ischaemia in the Bypass vs. Angioplasty in Severe Ischaemia of the Leg (BASIL-1) Trial","volume":"58","author":"Benson","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jvs.2013.07.114","article-title":"Presentation, treatment, and outcome differences between men and women undergoing revascularization or amputation for lower extremity peripheral arterial disease","volume":"59","author":"Lo","year":"2014","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib7","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.jvs.2007.07.053","article-title":"Female gender and oral anticoagulants are associated with wound complications in lower extremity vein bypass: an analysis of 1404 operations for critical limb ischemia","volume":"46","author":"Nguyen","year":"2007","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jvs.2009.01.012","article-title":"Under-representation of women and ethnic minorities in vascular surgery randomized controlled trials","volume":"50","author":"Hoel","year":"2009","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jss.2020.03.030","article-title":"Racial and gender disparity in aortoiliac disease open revascularization procedures","volume":"252","author":"Alshwaily","year":"2020","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.jvs.2022.04.048_bib10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib11","first-page":"141","article-title":"An empirical transition matrix for non-homogeneous Markov chains based on censored observations","volume":"5","author":"Aalen","year":"1978","journal-title":"Scand J Stat"},{"key":"10.1016\/j.jvs.2022.04.048_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/pds.3719","article-title":"Using claims data to predict dependency in activities of daily living as a proxy for frailty","volume":"24","author":"Faurot","year":"2015","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jvs.2022.04.048_bib13","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/1708538120958858","article-title":"Characteristics and outcomes of patients with peripheral artery disease undergoing endovascular revascularization: a community hospital perspective","volume":"29","author":"Michael Gharacholou","year":"2021","journal-title":"Vascular"},{"key":"10.1016\/j.jvs.2022.04.048_bib14","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jacc.2014.12.048","article-title":"Trends in settings for peripheral vascular intervention and the effect of changes in the outpatient prospective payment system","volume":"65","author":"Jones","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.avsg.2010.08.006","article-title":"Emerging national trends in the management and outcomes of lower extremity peripheral arterial disease","volume":"25","author":"Hong","year":"2011","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib16","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.jacc.2014.03.036","article-title":"Impact of sex on morbidity and mortality rates after lower extremity interventions for peripheral arterial disease: observations from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium","volume":"63","author":"Jackson","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.avsg.2013.05.006","article-title":"The impact of sex on angioplasty and primary stenting for femoropopliteal occlusive disease: results of the DURABILITY II trial","volume":"28","author":"Tadros","year":"2014","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib18","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.jvs.2014.01.010","article-title":"The influence of gender on patency rates after iliac artery stenting","volume":"59","author":"Bechter-Hugl","year":"2014","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s002709900281","article-title":"Complications of lower-limb percutaneous transluminal angioplasty: a prospective analysis of 410 procedures on 295 consecutive patients","volume":"21","author":"Matsi","year":"1998","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1358863X13475836","article-title":"Gender-related variation in the clinical presentation and outcomes of critical limb ischemia","volume":"18","author":"McCoach","year":"2013","journal-title":"Vasc Med"},{"key":"10.1016\/j.jvs.2022.04.048_bib21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jvs.2008.03.007","article-title":"Percutaneous intervention for infrainguinal occlusive disease in women: equivalent outcomes despite increased severity of disease compared with men","volume":"48","author":"DeRubertis","year":"2008","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jvs.2011.07.050","article-title":"Gender-related outcomes in the endovascular treatment of infrainguinal arterial obstructive disease","volume":"55","author":"Pulli","year":"2012","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jvs.2009.09.006","article-title":"Analysis of gender-related differences in lower extremity peripheral arterial disease","volume":"51","author":"Egorova","year":"2010","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib24","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1177\/1538574411418008","article-title":"Gender differences in outcomes of endovascular treatment of infrainguinal peripheral artery disease","volume":"45","author":"Gallagher","year":"2011","journal-title":"Vasc Endovascular Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib25","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jvs.2016.11.030","article-title":"The effect of gender on outcomes after lower extremity revascularization","volume":"65","author":"Wang","year":"2017","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib26","doi-asserted-by":"crossref","first-page":"e010849","DOI":"10.1161\/JAHA.118.010849","article-title":"Sex differences in outcomes following endovascular treatment for symptomatic peripheral artery disease: an analysis from the K-VIS ELLA registry","volume":"8","author":"Choi","year":"2019","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jvs.2022.04.048_bib27","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jvs.2010.05.106","article-title":"Lessons learned from the analysis of gender effect on risk factors and procedural outcomes of lower extremity arterial disease","volume":"52","author":"Vouyouka","year":"2010","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib28","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jvs.2015.03.066","article-title":"Association between gender and outcomes of lower extremity peripheral vascular interventions","volume":"62","author":"Ferranti","year":"2015","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib29","first-page":"433","article-title":"Impact of gender on in-hospital outcomes following contemporary percutaneous intervention for peripheral arterial disease","volume":"17","author":"Kawamura","year":"2005","journal-title":"J\u00a0Invasive Cardiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib30","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jvs.2013.06.049","article-title":"Factors associated with femoral artery access site hematoma following peripheral vascular intervention","volume":"58","author":"Kalish","year":"2013","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib31","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/joic.12431","article-title":"Gender disparities among patients with peripheral arterial disease treated via endovascular approach: a propensity score matched analysis","volume":"30","author":"Doshi","year":"2017","journal-title":"J\u00a0Interv Cardiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0735-1097(99)00181-3","article-title":"Implications of small reference vessel diameter in patients undergoing percutaneous coronary revascularization","volume":"34","author":"Schunkert","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11883-018-0742-x","article-title":"Peripheral arterial disease in women: an overview of risk factor profile, clinical features, and outcomes","volume":"20","author":"Jelani","year":"2018","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.jvs.2022.04.048_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jvs.2011.07.074","article-title":"Gender is an independent risk factor for distribution pattern and lesion morphology in chronic critical limb ischemia","volume":"55","author":"Ortmann","year":"2012","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jacc.2010.09.042","article-title":"Women with peripheral arterial disease experience faster functional decline than men with peripheral arterial disease","volume":"57","author":"McDermott","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib36","first-page":"499","article-title":"Case 4--1990. A 66-year-old woman who is taking aspirin continues to bleed after routine care","volume":"4","author":"Campbell","year":"1990","journal-title":"J\u00a0Cardiothorac Anesth"},{"key":"10.1016\/j.jvs.2022.04.048_bib37","first-page":"54","article-title":"Continuous heparin anticoagulation in patients with arteriosclerosis and arterial emboli","volume":"150","author":"Campbell","year":"1980","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.jvs.2022.04.048_bib38","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/CIRCULATIONAHA.108.814996","article-title":"Predictors of initial nontherapeutic anticoagulation with unfractionated heparin in ST-segment elevation myocardial infarction","volume":"119","author":"Cheng","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2022.04.048_bib39","first-page":"187103","article-title":"Sex differences in drug disposition","volume":"2011","author":"Soldin","year":"2011","journal-title":"J\u00a0Biomed Biotechnol"},{"key":"10.1016\/j.jvs.2022.04.048_bib40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2165\/00003088-200948030-00001","article-title":"Sex differences in pharmacokinetics and pharmacodynamics","volume":"48","author":"Soldin","year":"2009","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jvs.2022.04.048_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0038-1636515","article-title":"Gender differences in peripheral vascular disease","volume":"35","author":"Schramm","year":"2018","journal-title":"Semin Intervent Radiol"},{"key":"10.1016\/j.jvs.2022.04.048_bib42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0021-9150(03)00204-1","article-title":"High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross-sectional study","volume":"172","author":"Diehm","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2022.04.048_bib43","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0140-6736(17)30770-5","article-title":"Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events: a population-based cohort study","volume":"390","author":"Li","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2022.04.048_bib44","doi-asserted-by":"crossref","first-page":"E667","DOI":"10.1016\/j.ejvs.2019.09.173","article-title":"Sex differences in mortality after endovascular treatment for PAD","volume":"58","author":"Ramkumar Niveditta","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib45","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1067\/mva.2002.120043","article-title":"Sex-related differences in outcome after vascular interventions for lower limb ischemia","volume":"35","author":"Hultgren","year":"2002","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2022.04.048_bib46","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/clpt.1986.214","article-title":"Rates of sensitivity reactions to aspirin: problems in interpreting the data","volume":"40","author":"Kwoh","year":"1986","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jvs.2022.04.048_bib47","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1001\/jama.292.24.3017","article-title":"Aspirin sensitivity: implications for patients with coronary artery disease","volume":"292","author":"Gollapudi","year":"2004","journal-title":"JAMA"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521422016299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521422016299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:37:57Z","timestamp":1760042277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521422016299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0741521422016299"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2022.04.048","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased long-term bleeding complications in females undergoing endovascular revascularization for peripheral arterial disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2022.04.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}