{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:10:24Z","timestamp":1789060224059,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jvs.2023.11.004","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:02:26Z","timestamp":1699315346000},"page":"695-703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Recent advances and controversial issues in the optimal management of asymptomatic carotid stenosis"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-2919","authenticated-orcid":false,"given":"Kosmas I.","family":"Paraskevas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brajesh K.","family":"Lal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-429X","authenticated-orcid":false,"given":"Piotr","family":"Myrcha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1666-017X","authenticated-orcid":false,"given":"Sean P.","family":"Lyden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Poredos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri P.","family":"Mikhailidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Secemsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Musialek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Mansilha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil A.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Silvestrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl J.","family":"Lavie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5022-7367","authenticated-orcid":false,"given":"Alan","family":"Dardik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4395-9791","authenticated-orcid":false,"given":"Matthew","family":"Blecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-9108","authenticated-orcid":false,"given":"Christos D.","family":"Liapis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark J.","family":"Zeebregts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Nederkoorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Poredos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Gurevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Jawien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-2839","authenticated-orcid":false,"given":"William A.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei V.","family":"Svetlikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Fernandes e Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Nicolaides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Meschia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack L.","family":"Cronenwett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-2573","authenticated-orcid":false,"given":"Marc L.","family":"Schermerhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali F.","family":"AbuRahma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2023.11.004_bib1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1474-4422(21)00359-8","article-title":"Management of atherosclerotic extracranial carotid artery stenosis","volume":"21","author":"Bonati","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jvs.2023.11.004_bib2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ejvs.2023.01.020","article-title":"Optimal management of asymptomatic carotid artery stenosis: a systematic review and network meta-analysis","volume":"65","author":"Gasior","year":"2023","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib3","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1136\/jnis-2022-018732","article-title":"Asymptomatic carotid artery stenosis: a summary of current state of evidence for revascularization and emerging high-risk features","volume":"15","author":"Kim","year":"2023","journal-title":"J\u00a0Neurointerv Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib4","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1161\/STROKEAHA.122.038994","article-title":"Carotid stenting versus endarterectomy for asymptomatic carotid artery stenosis: a systematic review and meta-analysis","volume":"53","author":"Wang","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106182","article-title":"Optimal management of asymptomatic carotid stenosis in 2021: the Jury is still out. An international, multispecialty, Expert review and position statement","volume":"31","author":"Paraskevas","year":"2022","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jvs.2023.11.004_bib6","first-page":"202","article-title":"Management of patients with asymptomatic carotid stenosis may need to Be individualized: a multidisciplinary call for action","volume":"23","author":"Paraskevas","year":"2021","journal-title":"J\u00a0Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib7","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/archneurol.2009.289","article-title":"Effects of intensive medical therapy on microemboli and cardiovascular risk in asymptomatic carotid stenosis","volume":"67","author":"Spence","year":"2010","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jvs.2023.11.004_bib8","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1161\/STROKEAHA.109.561837","article-title":"Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment: a prospective, population-based study","volume":"41","author":"Marquardt","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib9","doi-asserted-by":"crossref","first-page":"e573","DOI":"10.1161\/STROKEAHA.109.556068","article-title":"Medical (nonsurgical) intervention alone is now best for prevention of stroke associated with asymptomatic severe carotid stenosis: results of a systematic review and analysis","volume":"40","author":"Abbott","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/ncpneuro0682","article-title":"Asymptomatic carotid artery stenosis--it\u2019s time to stop operating","volume":"4","author":"Abbott","year":"2008","journal-title":"Nat Clin Pract Neurol"},{"key":"10.1016\/j.jvs.2023.11.004_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1474-4422(20)30484-1","article-title":"Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis","volume":"20","author":"Howard","year":"2021","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jvs.2023.11.004_bib12","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.jvs.2023.06.024","article-title":"A\u00a0comparative effectiveness study of carotid intervention for long-term stroke prevention in patients with severe asymptomatic stenosis from a large integrated health system","volume":"78","author":"Chang","year":"2023","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib13","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1161\/STROKEAHA.122.041921","article-title":"Temporal trends and determinants of stroke risk in patients with medically treated asymptomatic carotid stenosis","volume":"54","author":"Poorthuis","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib14","doi-asserted-by":"crossref","first-page":"4S","DOI":"10.1016\/j.jvs.2021.04.073","article-title":"Society for Vascular Surgery clinical practice guidelines for management of extracranial cerebrovascular disease","volume":"75","author":"AbuRahma","year":"2022","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib15","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1016\/j.jvs.2021.04.074","article-title":"The Society for Vascular Surgery implementation document for management of extracranial cerebrovascular disease","volume":"75","author":"AbuRahma","year":"2022","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejvs.2022.04.011","article-title":"Editor\u2019s choice - European society for vascular surgery (ESVS) 2023 clinical practice guidelines on the management of atherosclerotic carotid and vertebral artery disease","volume":"65","author":"Naylor","year":"2023","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(22)00916-3","article-title":"Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial","volume":"400","author":"Kim","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2023.11.004_bib18","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa1500858","article-title":"Open-Label Study of Long-Term Evaluation against LDL Cholesterol (OSLER) Investigators. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events","volume":"372","author":"Sabatine","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvs.2023.11.004_bib19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.amjcard.2015.10.021","article-title":"A\u00a0phase 3 study of evolocumab (AMG 145) in statin-treated Japanese patients at high cardiovascular risk","volume":"117","author":"Kiyosue","year":"2016","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jvs.2023.11.004_bib20","doi-asserted-by":"crossref","first-page":"23S","DOI":"10.1016\/j.jvs.2021.06.002","article-title":"Emerging evidence suggests that patients with high-grade asymptomatic carotid stenosis should be revascularized","volume":"75","author":"Liapis","year":"2022","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib21","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0140-6736(21)01910-3","article-title":"Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy","volume":"398","author":"Halliday","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2023.11.004_bib22","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.jvs.2021.10.020","article-title":"Treatment of carotid stenosis in asymptomatic, nonoctagenarian, standard risk patients with stenting versus endarterectomy trials","volume":"75","author":"Matsumura","year":"2022","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejvs.2021.10.029","article-title":"30 Day outcomes after carotid interventions: an updated meta-analysis of randomised controlled trials in asymptomatic patients","volume":"63","author":"Saratzis","year":"2022","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib24","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1056\/NEJMoa1515706","article-title":"Randomized trial of stent versus surgery for asymptomatic carotid stenosis","volume":"374","author":"Rosenfield","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvs.2023.11.004_bib25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/STROKEAHA.110.610212","article-title":"Safety of stenting and endarterectomy by symptomatic status in the carotid revascularization endarterectomy versus stenting trial (CREST)","volume":"42","author":"Silver","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib26","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMoa0708028","article-title":"Long-term results of carotid stenting versus endarterectomy in high-risk patients","volume":"358","author":"Gurm","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvs.2023.11.004_bib27","article-title":"Angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy compared to best medical treatment: one-year interim results of SPACE-2","volume":"15","author":"Reiff","year":"2019","journal-title":"Int J Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib28","first-page":"814","article-title":"A\u00a0prospective randomized trial comparing endarterectomy to stenting in severe asymptomatic carotid stenosis","volume":"58","author":"Mannheim","year":"2017","journal-title":"J\u00a0Cardiovasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib29","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1474-4422(22)00290-3","article-title":"Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial","volume":"21","author":"Reiff","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jvs.2023.11.004_bib30","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/STROKEAHA.121.036178","article-title":"Comparative effectiveness of carotid stenting to medical therapy among patients with asymptomatic carotid stenosis","volume":"53","author":"Keyhani","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib31","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.avsg.2020.05.070","article-title":"A\u00a0systematic review and meta-analysis of transcarotid artery revascularization with dynamic flow reversal versus transfemoral carotid artery stenting and carotid endarterectomy","volume":"69","author":"Naazie","year":"2020","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib32","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/SLA.0000000000004496","article-title":"TransCarotid revascularization with dynamic flow reversal versus carotid endarterectomy in the vascular quality initiative surveillance project","volume":"276","author":"Malas","year":"2022","journal-title":"Ann Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jvs.2021.07.242","article-title":"Propensity score-matched analysis of 1-year outcomes of transcarotid revascularization with dynamic flow reversal, carotid endarterectomy, and transfemoral carotid artery stenting","volume":"75","author":"Malas","year":"2022","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib34","article-title":"Outcomes of transcarotid artery revascularization: a systematic review","author":"Wu","year":"2022","journal-title":"Interv Neuroradiol"},{"key":"10.1016\/j.jvs.2023.11.004_bib35","article-title":"Procedural safety comparison between transcarotid artery revascularization, carotid endarterectomy, and carotid stenting: perioperative and 1-year rates of stroke or death","volume":"11","author":"Columbo","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.jvs.2023.11.004_bib36","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.jvs.2022.01.020","article-title":"Risk factors for mortality within 5 years of carotid endarterectomy for asymptomatic stenosis","volume":"75","author":"Blecha","year":"2022","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/STROKEAHA.120.032527","article-title":"External validation of risk prediction models to improve selection of patients for carotid endarterectomy","volume":"53","author":"Poorthuis","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib38","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1161\/STROKEAHA.114.006912","article-title":"Identifying which patients with asymptomatic carotid stenosis could benefit from intervention","volume":"45","author":"Paraskevas","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib39","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(98)11415-0","article-title":"Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study. European Carotid Surgery Trialists\u2019 Collaborative Group","volume":"353","author":"Rothwell","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2023.11.004_bib41","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/s13063-022-06429-z","volume":"23","author":"Cheng","year":"2022","journal-title":"Trials"},{"key":"10.1016\/j.jvs.2023.11.004_bib43","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.ejvs.2021.03.024","article-title":"Editor\u2019s choice - asymptomatic carotid stenosis and cognitive impairment: a systematic review","volume":"61","author":"Paraskevas","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib44","first-page":"167","article-title":"Asymptomatic carotid stenosis and cognitive impairment","volume":"64","author":"Paraskevas","year":"2023","journal-title":"J\u00a0Cardiovasc Surg"},{"key":"10.1016\/j.jvs.2023.11.004_bib45","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/0271678X221133859","article-title":"Low-grade carotid artery stenosis is associated with progression of brain atrophy and cognitive decline: the SMART-MR study","volume":"43","author":"Ghaznawi","year":"2023","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.jvs.2023.11.004_bib46","first-page":"92","article-title":"Cortical thinning in high-Grady asymptomatic carotid stenosis","volume":"25","author":"Marshall","year":"2023","journal-title":"J\u00a0Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib47","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1177\/1747493018790088","article-title":"Carotid revascularization and medical management for asymptomatic carotid stenosis - hemodynamics (CREST-H): study design and rationale","volume":"13","author":"Marshall","year":"2018","journal-title":"Int J Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib48","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1161\/STROKEAHA.120.032972","article-title":"Baseline cognitive impairment in patients with asymptomatic carotid stenosis in the CREST-2 trial","volume":"52","author":"Lazar","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2023.11.004_bib49","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1161\/STROKEAHA.108.546135","article-title":"Relative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trial","volume":"40","author":"Amarenco","year":"2009","journal-title":"Stroke"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521423022036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521423022036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T02:16:21Z","timestamp":1776737781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521423022036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0741521423022036"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2023.11.004","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advances and controversial issues in the optimal management of asymptomatic carotid stenosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2023.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}