{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:58:36Z","timestamp":1792511916941,"version":"4.5.0"},"reference-count":180,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jvs.2025.05.022","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T03:43:29Z","timestamp":1747799009000},"page":"1421-1437.e18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interpretable machine learning prediction model for major adverse cardiovascular events in patients with peripheral artery disease"],"prefix":"10.1016","volume":"82","author":[{"given":"Pan","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-7163","authenticated-orcid":false,"given":"Meihong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2025.05.022_bib1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.hlc.2017.10.014","article-title":"Peripheral arterial disease","volume":"27","author":"Conte","year":"2018","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.jvs.2025.05.022_bib2","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1001\/jama.286.11.1317","article-title":"Peripheral arterial disease detection, awareness, and treatment in primary care","volume":"286","author":"Hirsch","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jvs.2025.05.022_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/1358836X0100600204","article-title":"The minnesota regional peripheral arterial disease screening program: toward a definition of community standards of care","volume":"6","author":"Hirsch","year":"2001","journal-title":"Vasc Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib4","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.clinthera.2023.09.021","article-title":"Peripheral artery disease: underappreciated impact and residual cardiovascular risk despite revascularization","volume":"45","author":"Jansen","year":"2023","journal-title":"Clin Ther"},{"key":"10.1016\/j.jvs.2025.05.022_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/jama.300.2.197","article-title":"Ankle brachial index combined with Framingham risk score to predict cardiovascular events and mortality: a meta-analysis","volume":"300","author":"Fowkes","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.jvs.2025.05.022_bib6","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1001\/jama.297.11.1197","article-title":"One-year cardiovascular event rates in outpatients with atherothrombosis","volume":"297","author":"Steg","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.jvs.2025.05.022_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41598-023-50751-8","article-title":"Association of immunologic findings of atheromatous plaques with subsequent cardiovascular events in patients with peripheral artery disease","volume":"14","author":"Kim","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jvs.2025.05.022_bib8","first-page":"357","article-title":"Contemporary medical management of peripheral arterial disease","volume":"39","author":"Cook","year":"2025","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jvs.2025.05.022_bib9","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s40261-024-01365-z","article-title":"The economic burden of atherosclerotic cardiovascular disease in Italy","volume":"44","author":"Mennini","year":"2024","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.jvs.2025.05.022_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s40273-024-01440-5","article-title":"Recurrence of cardiovascular events after an acute myocardial infarction in patients with multivessel disease and associated healthcare costs: a German claims data analysis","volume":"43","author":"Starry","year":"2025","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.jvs.2025.05.022_bib11","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.jacc.2018.03.008","article-title":"Major adverse limb events and mortality in patients with peripheral artery disease: the COMPASS trial","volume":"71","author":"Anand","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib12","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1161\/CIRCRESAHA.121.318535","article-title":"Epidemiology of peripheral artery disease and polyvascular disease","volume":"128","author":"Aday","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2025.05.022_bib13","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global vascular guidelines on the management of chronic limb-threatening ischemia","volume":"58","author":"Conte","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib14","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.amjcard.2019.03.022","article-title":"Incidence and cost of major adverse cardiovascular events and major adverse limb events in patients with chronic coronary artery disease or peripheral artery disease","volume":"123","author":"Berger","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib15","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.007385","article-title":"Polyvascular disease: reappraisal of the current clinical landscape","volume":"12","author":"Gutierrez","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jvs.2025.05.022_bib16","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1161\/CIRCRESAHA.116.303566","article-title":"Pathogenesis of the limb manifestations and exercise limitations in peripheral artery disease","volume":"116","author":"Hiatt","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2025.05.022_bib17","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1161\/CIRCULATIONAHA.109.865600","article-title":"Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease","volume":"120","author":"Diehm","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2025.05.022_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024279","article-title":"Cardiovascular and limb events following endovascular revascularization among patients \u226565 years old: an American College of Cardiology PVI registry analysis","volume":"11","author":"Weissler","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib19","article-title":"Multiple metabolic comorbidities and their consequences among patients with peripheral arterial disease","volume":"17","author":"Park","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jvs.2025.05.022_bib20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.5551\/jat.49767","article-title":"The geriatric nutritional risk index predicts long-term survival and cardiovascular or limb events in peripheral arterial disease","volume":"27","author":"Matsuo","year":"2020","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jvs.2025.05.022_bib21","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/1708538120932713","article-title":"Atherectomy with balloon angioplasty compared to balloon angioplasty alone for the treatment of chronic limb threatening ischemia: a national surgical quality improvement program database analysis","volume":"28","author":"Lam","year":"2020","journal-title":"Vascular"},{"key":"10.1016\/j.jvs.2025.05.022_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.amjcard.2023.08.110","article-title":"Real-world incidence of adverse clinical outcomes among people with coronary artery disease and\/or peripheral artery disease in relation to vascular risk in the United States","volume":"208","author":"Desai","year":"2023","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.118.004741","article-title":"Predicting future cardiovascular events in patients with peripheral artery disease using electronic health record data","volume":"12","author":"Ross","year":"2019","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jvs.2025.05.022_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0303610","article-title":"Clinical use of polygenic risk scores for detection of peripheral artery disease and cardiovascular events","volume":"19","author":"Omiye","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.jvs.2025.05.022_bib25","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jvs.2009.07.095","article-title":"Prediction rule for cardiovascular events and mortality in peripheral arterial disease patients: data from the prospective second manifestations of ARTerial disease (SMART) cohort study","volume":"50","author":"Sprengers","year":"2009","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib26","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/STROKEAHA.111.647958","article-title":"Clinical prediction rule to estimate the absolute 3-year risk of major cardiovascular events after carotid endarterectomy","volume":"43","author":"van Lammeren","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2025.05.022_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/bjsopen\/zrad166","article-title":"Tailored risk assessment and forecasting in intermittent claudication","volume":"8","author":"Ravindhran","year":"2024","journal-title":"BJS Open"},{"key":"10.1016\/j.jvs.2025.05.022_bib28","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1161\/CIRCRESAHA.121.318224","article-title":"Leveraging machine learning and artificial intelligence to improve peripheral artery disease detection, treatment, and outcomes","volume":"128","author":"Flores","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jvs.2025.05.022_bib29","first-page":"1","article-title":"Machine learning models predict the need of amputation and\/or peripheral artery revascularization in hypertensive patients within 7-years follow-up","volume":"2023","author":"Tsarapatsani","year":"2023","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.jvs.2025.05.022_bib30","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.jvs.2016.04.026","article-title":"The use of machine learning for the identification of peripheral artery disease and future mortality risk","volume":"64","author":"Ross","year":"2016","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026987","article-title":"Machine learning approach to predict in-hospital mortality in patients Admitted for peripheral artery disease in the United States","volume":"11","author":"Zhang","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0277507","article-title":"Risk stratification with explainable machine learning for 30-day procedure-related mortality and 30-day unplanned readmission in patients with peripheral arterial disease","volume":"17","author":"Cox","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jvs.2025.05.022_bib33","article-title":"Construction of a novel lower-extremity peripheral artery disease subtype prediction model using unsupervised machine learning and neutrophil-related biomarkers","volume":"10","author":"Zhang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jvs.2025.05.022_bib34","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.2147\/DMSO.S383960","article-title":"Machine learning models for predicting the risk of hard-to-heal diabetic foot ulcers in a Chinese population","volume":"15","author":"Wang","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.jvs.2025.05.022_bib35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijcard.2023.04.040","article-title":"Application of machine learning algorithms in electronic medical records to predict amputation-free survival after first revascularization in patients with peripheral artery disease","volume":"383","author":"Liu","year":"2023","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib36","first-page":"500","article-title":"Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis","volume":"38","author":"Motwani","year":"2017","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jvs.2025.05.022_bib37","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0140-6736(20)32519-8","article-title":"Machine learning-based prediction of adverse events following an acute coronary syndrome (PRAISE): a modelling study of pooled datasets","volume":"397","author":"D'Ascenzo","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2025.05.022_bib38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/jama.2017.7797","article-title":"Unintended consequences of machine learning in medicine","volume":"318","author":"Cabitza","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jvs.2025.05.022_bib39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ejvs.2017.07.018","article-title":"Editor's choice - 2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS)","volume":"55","author":"Aboyans","year":"2018","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib40","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.jvs.2025.05.022_bib41","article-title":"TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods","volume":"385","author":"Collins","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.jvs.2025.05.022_bib42","article-title":"TRIPOD+AI: an updated reporting guideline for clinical prediction models","volume":"385","author":"Cohen","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.jvs.2025.05.022_bib43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jclinepi.2016.02.031","article-title":"Adequate sample size for developing prediction models is not simply related to events per variable","volume":"76","author":"Ogundimu","year":"2016","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jvs.2024.02.036","article-title":"Development and validation of a major adverse limb events prediction model for peripheral arterial disease with frailty","volume":"80","author":"Xiong","year":"2024","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib45","series-title":"From explanations to Feature Selection: assessing SHAP Values As Feature Selection Mechanism","first-page":"340","author":"Marcilio","year":"2020"},{"key":"10.1016\/j.jvs.2025.05.022_bib46","series-title":"A unified approach to interpreting model predictions","author":"Lundberg","year":"2017"},{"key":"10.1016\/j.jvs.2025.05.022_bib47","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.chest.2023.06.038","article-title":"Methodologic Issues specific to prediction model development and evaluation","volume":"164","author":"Jin","year":"2023","journal-title":"Chest"},{"key":"10.1016\/j.jvs.2025.05.022_bib48","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/S0140-6736(20)30226-9","article-title":"Artificial intelligence and the future of global health","volume":"395","author":"Schwalbe","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jvs.2025.05.022_bib49","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1021\/acs.jcim.6b00591","article-title":"Extreme gradient boosting as a method for quantitative structure-activity relationships","volume":"56","author":"Sheridan","year":"2016","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.jvs.2025.05.022_bib50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41746-020-00331-1","article-title":"Machine learning and atherosclerotic cardiovascular disease risk prediction in a multi-ethnic population","volume":"3","author":"Ward","year":"2020","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.1042996","article-title":"Prediction model of obstructive sleep apnea-related hypertension: machine learning-based development and interpretation study","volume":"9","author":"Shi","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174944","article-title":"Can machine-learning improve cardiovascular risk prediction using routine clinical data?","volume":"12","author":"Weng","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jvs.2025.05.022_bib53","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"Libby","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jvs.2025.05.022_bib54","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1055\/s-0038-1636530","article-title":"Rivaroxaban: a new treatment paradigm in the setting of vascular protection?","volume":"118","author":"Bauersachs","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jvs.2025.05.022_bib55","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jvs.2005.03.060","article-title":"C-reactive protein in peripheral arterial disease: relation to severity of the disease and to future cardiovascular events","volume":"42","author":"Vainas","year":"2005","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3390\/biom8030080","article-title":"Research progress on the relationship between atherosclerosis and inflammation","volume":"8","author":"Zhu","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.jvs.2025.05.022_bib57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41569-019-0326-7","article-title":"Neutrophils as regulators of cardiovascular inflammation","volume":"17","author":"Silvestre-Roig","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib58","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/cvr\/cvab302","article-title":"Neutrophils in cardiovascular disease: warmongers, peacemakers, or both?","volume":"118","author":"Sreejit","year":"2022","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jvs.2025.05.022_bib59","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/ijms24021169","article-title":"The role of neutrophils in lower limb peripheral artery disease: State of the art and future perspectives","volume":"24","author":"Buso","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jvs.2025.05.022_bib60","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ancard.2020.07.012","article-title":"Serum albumin and cardiovascular disease: state-of-the-art review","volume":"69","author":"Arques","year":"2020","journal-title":"Ann Cardiol Angeiol (Paris)"},{"key":"10.1016\/j.jvs.2025.05.022_bib61","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12933-016-0446-x","article-title":"Presentations of major peripheral arterial disease and risk of major outcomes in patients with type 2 diabetes: results from the ADVANCE-ON study","volume":"15","author":"Mohammedi","year":"2016","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jvs.2025.05.022_bib62","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ejim.2011.02.001","article-title":"Prevalence and clinical profile and management of peripheral arterial disease in elderly patients with diabetes","volume":"22","author":"Escobar","year":"2011","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib63","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.2337\/diacare.26.12.3357","article-title":"High prevalence of peripheral arterial disease but low antiplatelet treatment rates in elderly primary care patients with diabetes","volume":"26","author":"Lange","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jvs.2025.05.022_bib64","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3126\/kumj.v6i4.1739","article-title":"Association of cardiovascular events with glycosylated haemoglobin in diabetic patients","volume":"6","author":"Deo","year":"2008","journal-title":"Kathmandu Univ Med J (Kumj)"},{"key":"10.1016\/j.jvs.2025.05.022_bib65","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12933-024-02226-x","article-title":"Risk factors for and risk of all-cause and atherosclerotic cardiovascular disease mortality in people with type 2 diabetes and peripheral artery disease: an observational, register-based cohort study","volume":"23","author":"Avdic","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jvs.2025.05.022_bib66","doi-asserted-by":"crossref","first-page":"e1313","DOI":"10.1161\/CIR.0000000000001251","article-title":"2024 ACC\/AHA\/AACVPR\/APMA\/ABC\/SCAI\/SVM\/SVN\/SVS\/SIR\/VESS guideline for the management of lower extremity peripheral artery disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"149","author":"Gornik","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2025.05.022_bib67","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1213\/ANE.0b013e3182290551","article-title":"Preoperative pulse pressure and major perioperative adverse cardiovascular outcomes after lower extremity vascular bypass surgery","volume":"114","author":"Asopa","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.jvs.2025.05.022_bib68","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/1538574413493679","article-title":"Low hemoglobin concentration is associated with poor outcome after peripheral arterial surgery","volume":"47","author":"Oshin","year":"2013","journal-title":"Vasc Endovascular Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib69","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3325\/cmj.2015.56.351","article-title":"C-reactive protein, renal function, and cardiovascular outcome in patients with symptomatic peripheral artery disease and preserved left ventricular systolic function","volume":"56","author":"Vrsalovi\u0107","year":"2015","journal-title":"Croat Med J"},{"key":"10.1016\/j.jvs.2025.05.022_bib70","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/ehjqcco\/qcy024","article-title":"Asymptomatic cerebral infarction is a predictor of long-term survival and vascular or limb events in peripheral arterial disease","volume":"5","author":"Kumakura","year":"2019","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.jvs.2025.05.022_bib71","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jss.2018.09.088","article-title":"Radial artery tonometry is associated with major adverse cardiac events in patients with peripheral artery disease","volume":"235","author":"Ramirez","year":"2019","journal-title":"J Surg Res"},{"key":"10.1016\/j.jvs.2025.05.022_bib72","doi-asserted-by":"crossref","first-page":"134","DOI":"10.5551\/jat.49767","article-title":"The geriatric nutritional risk index predicts long-term survival and cardiovascular or limb events in peripheral arterial disease","volume":"27","author":"Matsuo","year":"2020","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.jvs.2025.05.022_bib73","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/s41440-021-00648-8","article-title":"Impact of in-hospital blood pressure variability on clinical outcomes in patients with symptomatic peripheral arterial disease","volume":"44","author":"Suzuki","year":"2021","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jvs.2025.05.022_bib74","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3400\/avd.oa.21-00045","article-title":"Influence of microalbuminuria on long-term survival and cardiovascular or limb events in peripheral arterial disease","volume":"14","author":"Nakashima","year":"2021","journal-title":"Ann Vasc Dis"},{"key":"10.1016\/j.jvs.2025.05.022_bib75","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1161\/STROKEAHA.118.023534","article-title":"Stroke in patients with peripheral artery disease","volume":"50","author":"Kolls","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2025.05.022_bib76","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12933-024-02226-x","article-title":"Risk factors for and risk of all-cause and atherosclerotic cardiovascular disease mortality in people with type 2 diabetes and peripheral artery disease: an observational, register-based cohort study","volume":"23","author":"Avdic","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jvs.2025.05.022_bib77","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/ATVBAHA.113.302731","article-title":"Skin autofluorescence is associated with 5-year mortality and cardiovascular events in patients with peripheral artery disease","volume":"34","author":"De Vos","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvs.2025.05.022_bib78","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jjcc.2014.02.019","article-title":"Predictive value of elevated neutrophil to lymphocyte ratio for long-term cardiovascular mortality in peripheral arterial occlusive disease","volume":"64","author":"Erturk","year":"2014","journal-title":"J Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib79","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.001823","article-title":"Long-term prognostic risk in lower extremity peripheral arterial disease as a function of the number of peripheral arterial lesions","volume":"4","author":"Smolderen","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib80","doi-asserted-by":"crossref","first-page":"482","DOI":"10.14503\/THIJ-14-4986","article-title":"Aspirin resistance predicts adverse cardiovascular events in patients with symptomatic peripheral artery disease","volume":"43","author":"Pasala","year":"2016","journal-title":"Tex Heart Inst J"},{"key":"10.1016\/j.jvs.2025.05.022_bib81","first-page":"32","article-title":"Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease","volume":"13","author":"Uzun","year":"2017","journal-title":"Postepy Kardiol Interwencyjnej"},{"key":"10.1016\/j.jvs.2025.05.022_bib82","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12933-020-01118-0","article-title":"Major adverse cardiovascular and limb events in patients with diabetes and concomitant peripheral artery disease treated with sodium glucose cotransporter 2 inhibitor vs dipeptidyl peptidase-4 inhibitor","volume":"19","author":"Lee","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jvs.2025.05.022_bib83","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/clc.23344","article-title":"Four-year incidence of major adverse cardiovascular events in patients with atherosclerosis and atrial fibrillation","volume":"43","author":"Miao","year":"2020","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib84","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.jvs.2022.07.003","article-title":"Prolonged lower extremity endovascular procedures for patients with claudication increase risk of adverse outcomes","volume":"76","author":"Ost apenko","year":"2022","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib85","first-page":"755","article-title":"Protective effects of statins on limb and cardiovascular outcomes in patients with peripheral artery disease and end-stage renal disease","volume":"39","author":"Lu","year":"2023","journal-title":"Acta Cardiol Sin"},{"key":"10.1016\/j.jvs.2025.05.022_bib86","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s10557-023-07502-8","article-title":"Effect of beta-blocker on long-term major cardiovascular events in high atherosclerotic risk population","volume":"38","author":"Osataphan","year":"2024","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jvs.2025.05.022_bib87","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/17085381211059383","article-title":"Sarcopenia is a risk factor for major adverse cardiac events after surgical revascularization for critical limb ischemia","volume":"31","author":"Sel\u00e7uk","year":"2023","journal-title":"Vascular"},{"key":"10.1016\/j.jvs.2025.05.022_bib88","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12928-023-00925-y","article-title":"The association of calcium channel blocker with risk of adverse limb events in patients with chronic limb-threatening ischemia after endovascular treatment","volume":"38","author":"Ueshima","year":"2023","journal-title":"Cardiovasc Interv Ther"},{"key":"10.1016\/j.jvs.2025.05.022_bib89","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.avsg.2023.11.028","article-title":"Predictive value of the Naples prognostic score on long-term outcomes in patients with peripheral artery disease revascularized via percutaneous intervention","volume":"102","author":"Artac","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib90","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41598-023-50751-8","article-title":"Association of immunologic findings of atheromatous plaques with subsequent cardiovascular events in patients with peripheral artery disease","volume":"14","author":"Kim","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jvs.2025.05.022_bib91","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/15347346231211959","article-title":"Chronic kidney disease predicts adverse major cardiovascular events and adverse limb events in patients with diabetes and peripheral arterial disease","volume":"23","author":"Rerkasem","year":"2024","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.jvs.2025.05.022_bib92","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ejvs.2011.08.016","article-title":"Thrombotic risk factors and cardiovascular events after endovascular intervention for peripheral arterial disease","volume":"42","author":"Sartori","year":"2011","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib93","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/ehjqcco\/qcw057","article-title":"Long-term survival and fate of the leg in de novo intermittent claudication","volume":"3","author":"Kumakura","year":"2017","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"10.1016\/j.jvs.2025.05.022_bib94","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1016\/j.jacc.2018.09.078","article-title":"Cardiovascular and limb outcomes in patients with diabetes and peripheral artery disease: the EUCLID trial","volume":"72","author":"Low Wang","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib95","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009943","article-title":"Association of computed tomographic leg muscle characteristics with lower limb and cardiovascular events in patients with peripheral artery disease","volume":"7","author":"Morris","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib96","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.avsg.2017.12.002","article-title":"Frailty is associated with an increased risk of major adverse cardiac events in patients with stable claudication","volume":"50","author":"Schaller","year":"2018","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib97","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00392-017-1185-z","article-title":"Myocardial injury after endovascular revascularization in critical limb ischemia predicts 1-year mortality: a prospective observational cohort study","volume":"107","author":"Szczeklik","year":"2018","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib98","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.avsg.2018.05.054","article-title":"Metformin is associated with improved survival and decreased cardiac events with no impact on patency and limb salvage after revascularization for peripheral arterial disease","volume":"55","author":"Khan","year":"2019","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib99","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/00015385.2019.1653565","article-title":"Coronary artery disease and restenosis after peripheral endovascular intervention are predictors of poor outcome in peripheral arterial disease","volume":"75","author":"Favaretto","year":"2020","journal-title":"Acta Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib100","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13431","article-title":"Peripheral artery disease and clinical outcomes in patients with atrial fibrillation: a report from the FANTASIIA registry","volume":"51","author":"Bertomeu-Gonzalez","year":"2021","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jvs.2025.05.022_bib101","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3349\/ymj.2022.63.4.333","article-title":"Impact of statin treatment intensity after endovascular revascularization on lower extremity peripheral artery disease","volume":"63","author":"Kim","year":"2022","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.jvs.2025.05.022_bib102","article-title":"Multiple metabolic comorbidities and their consequences among patients with peripheral arterial disease","volume":"17","author":"Park","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jvs.2025.05.022_bib103","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3389\/fcvm.2022.853583","article-title":"Novel insight into long-term risk of major adverse cardiovascular and cerebrovascular events following lower extremity arteriosclerosis obliterans","volume":"9","author":"Sun","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib104","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024279","article-title":"Cardiovascular and limb events following endovascular revascularization among patients \u226565 years old: an American College of Cardiology PVI registry analysis","volume":"11","author":"Weissler","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib105","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.118.004741","article-title":"Predicting future cardiovascular events in patients with peripheral artery disease using electronic health record data","volume":"12","author":"Ross","year":"2019","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jvs.2025.05.022_bib106","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.jvs.2009.07.095","article-title":"Prediction rule for cardiovascular events and mortality in peripheral arterial disease patients: data from the prospective second manifestations of ARTerial disease (SMART) cohort study","volume":"50","author":"Sprengers","year":"2009","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib107","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/STROKEAHA.111.647958","article-title":"Clinical prediction rule to estimate the absolute 3-year risk of major cardiovascular events after carotid endarterectomy","volume":"43","author":"Van Lammeren","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jvs.2025.05.022_bib108","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jjcc.2015.05.003","article-title":"Treatment with cilostazol improves clinical outcome after endovascular therapy in hemodialysis patients with peripheral artery disease","volume":"67","author":"Ishii","year":"2016","journal-title":"J Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib109","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/bjs.11214","article-title":"Observational study of the medical management of patients with peripheral artery disease","volume":"106","author":"Saratzis","year":"2019","journal-title":"Br J Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib110","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4239\/wjd.v12.i6.883","article-title":"Control of modifiable risk factors and major adverse cardiovascular events in people with peripheral artery disease and diabetes","volume":"12","author":"Golledge","year":"2021","journal-title":"World J Diabetes"},{"key":"10.1016\/j.jvs.2025.05.022_bib111","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.5551\/jat.60772","article-title":"Prognostic value of the CHA(2)DS(2)-VASc score after endovascular therapy for femoral popliteal artery lesions","volume":"28","author":"Tomoi","year":"2021","journal-title":"J Atheroscler Thrombos"},{"key":"10.1016\/j.jvs.2025.05.022_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0303610","article-title":"Clinical use of polygenic risk scores for detection of peripheral artery disease and cardiovascular events","volume":"19","author":"Omiye","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.jvs.2025.05.022_bib113","doi-asserted-by":"crossref","DOI":"10.1093\/bjsopen\/zrad166","article-title":"Tailored risk assessment and forecasting in intermittent claudication","volume":"8","author":"Ravindhran","year":"2024","journal-title":"BJS Open"},{"key":"10.1016\/j.jvs.2025.05.022_bib114","doi-asserted-by":"crossref","DOI":"10.1177\/2042018820960294","article-title":"Worse cardiovascular prognosis after endovascular surgery for intermittent claudication caused by infrainguinal atherosclerotic disease in patients with diabetes","volume":"11","author":"Dakhel","year":"2020","journal-title":"Ther Adv Endocrinol Metab"},{"key":"10.1016\/j.jvs.2025.05.022_bib115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/1358863X19879751","article-title":"Impact of diabetes mellitus on 5-year clinical outcomes following successful endovascular revascularization for peripheral artery disease","volume":"25","author":"Lee","year":"2020","journal-title":"Vasc Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib116","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.amjcard.2009.10.048","article-title":"Cardiovascular event rates in diabetic and nondiabetic individuals with and without established atherothrombosis (from the REduction of Atherothrombosis for Continued Health [REACH] Registry)","volume":"105","author":"Krempf","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib117","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.atherosclerosis.2013.11.034","article-title":"Association of chronic kidney disease categories defined with different formulae with major adverse events in patients with peripheral vascular disease","volume":"232","author":"Golledge","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2025.05.022_bib118","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.008018","article-title":"Clinical outcomes in patients with type 2 diabetes mellitus and peripheral artery disease: results from the EXSCEL Trial","volume":"12","author":"Badjatiya","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jvs.2025.05.022_bib119","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1253\/circj.CJ-18-0726","article-title":"Decreased psoas muscle computed tomography value predicts poor outcome in peripheral artery disease","volume":"82","author":"Sugai","year":"2018","journal-title":"Circ J"},{"key":"10.1016\/j.jvs.2025.05.022_bib120","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/1358863X16689831","article-title":"Non-compressible ABIs are associated with an increased risk of major amputation and major adverse cardiovascular events in patients with critical limb ischemia","volume":"22","author":"Singh","year":"2017","journal-title":"Vasc Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib121","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S0735-1097(17)34779-4","article-title":"Impact of comorbid coronary artery disease and severe peripheral artery disease on major adverse cardiovascular events","volume":"69","author":"Ting","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib122","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.amjcard.2020.04.043","article-title":"Effect of cerebrovascular and\/or peripheral artery disease with or without attainment of lipid goals on long-term outcomes in patients with coronary artery disease","volume":"128","author":"Volis","year":"2020","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib123","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1161\/HYPERTENSIONAHA.124.22832","article-title":"Cardiovascular outcomes in hypertension-treated patients with peripheral artery disease: the VALUE trial","volume":"81","author":"Vrsalovic","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.jvs.2025.05.022_bib124","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1053\/j.ajkd.2019.08.028","article-title":"Peripheral artery disease: its adverse consequences with and without CKD","volume":"75","author":"Bourrier","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jvs.2025.05.022_bib125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.atherosclerosis.2019.12.016","article-title":"Chronic kidney disease and outcomes of lower extremity revascularization for peripheral artery disease","volume":"297","author":"Smilowitz","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2025.05.022_bib126","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s12325-019-01132-z","article-title":"Real-World predictors of major adverse cardiovascular events and major adverse limb events among patients with chronic coronary artery disease and\/or peripheral arterial disease","volume":"37","author":"Berger","year":"2020","journal-title":"Adv Ther"},{"key":"10.1016\/j.jvs.2025.05.022_bib127","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jfma.2019.10.011","article-title":"Contemporary cardiovascular outcomes in Taiwanese patients undergoing endovascular therapy for symptomatic lower extremity peripheral arterial disease","volume":"119","author":"Huang","year":"2020","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib128","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000697","article-title":"Adherence to guideline-recommended therapy is associated with decreased major adverse cardiovascular events and major adverse limb events among patients with peripheral arterial disease","volume":"3","author":"Armstrong","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib129","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3390\/jcm11071936","article-title":"The impact of atrial fibrillation on one-year mortality in patients with severe lower extremity arterial disease","volume":"11","author":"Su","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib130","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2147\/COPD.S292978","article-title":"Association of chronic obstructive pulmonary disease with morbidity and mortality in patients with peripheral artery disease: insights from the EUCLID trial","volume":"16","author":"Galani","year":"2021","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.jvs.2025.05.022_bib131","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ahj.2018.03.013","article-title":"Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome","volume":"201","author":"Inohara","year":"2018","journal-title":"Am Heart J"},{"key":"10.1016\/j.jvs.2025.05.022_bib132","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1159\/000497790","article-title":"Association between peripheral artery disease and major adverse cardiovascular events in patients with acute coronary syndrome: findings from the Gulf COAST registry","volume":"28","author":"Al-Zakwani","year":"2019","journal-title":"Med Princ Pract"},{"key":"10.1016\/j.jvs.2025.05.022_bib133","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jacc.2015.11.052","article-title":"Statins for prevention of cardiovascular events in a low-risk population with low ankle brachial index","volume":"67","author":"Ramos","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib134","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.5239","article-title":"Polyvascular disease and risk of major adverse cardiovascular events in peripheral artery disease: a secondary analysis of the EUCLID trial","volume":"1","author":"Gutierrez","year":"2018","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jvs.2025.05.022_bib135","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.avsg.2024.04.032","article-title":"The association between completion of supervised exercise therapy and long-term outcomes in patients with intermittent claudication, concomitant sarcopenia and cardiometabolic multimorbidity","volume":"110","author":"Ravindhran","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib136","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejvs.2023.11.040","article-title":"Supervised exercise therapy for intermittent claudication: a propensity score matched analysis of retrospective data on long term cardiovascular outcomes","volume":"67","author":"Ravindhran","year":"2024","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib137","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1097\/SLA.0000000000002558","article-title":"Carotid artery reactivity predicts events in peripheral arterial disease patients","volume":"269","author":"Van Mil","year":"2019","journal-title":"Ann Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib138","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/1708538120932713","article-title":"Atherectomy with balloon angioplasty compared to balloon angioplasty alone for the treatment of chronic limb threatening ischemia: a national surgical quality improvement program database analysis","volume":"28","author":"Lam","year":"2020","journal-title":"Vascular"},{"key":"10.1016\/j.jvs.2025.05.022_bib139","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1001\/jamasurg.2024.3083","article-title":"Counseling intervention and cardiovascular events in people with peripheral artery disease: a post hoc analysis of the BIP Randomized clinical trial","volume":"159","author":"Golledge","year":"2024","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib140","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.atherosclerosis.2020.04.005","article-title":"Comparison of different ankle-brachial indices in the prediction of overall and cardiovascular mortality","volume":"304","author":"Hsu","year":"2020","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2025.05.022_bib141","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0242228","article-title":"High ankle brachial index predicts high risk of cardiovascular events amongst people with peripheral artery disease","volume":"15","author":"Golledge","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jvs.2025.05.022_bib142","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12933-023-01872-x","article-title":"Development of a biomarker panel for assessing cardiovascular risk in diabetic patients with chronic limb-threatening ischemia (CLTI): a prospective study","volume":"22","author":"Nardella","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jvs.2025.05.022_bib143","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijcard.2011.03.030","article-title":"Markers of inflammation in relation to long-term cardiovascular mortality in patients with lower-extremity peripheral arterial disease","volume":"160","author":"Urbonaviciene","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib144","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010748","article-title":"Cohort study examining the association between blood pressure and cardiovascular events in patients with peripheral artery disease","volume":"8","author":"Thomas Manapurathe","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib145","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.120.006512","article-title":"Association of hypertension and arterial blood pressure on limb and cardiovascular outcomes in symptomatic peripheral artery disease: the EUCLID trial","volume":"13","author":"Fudim","year":"2020","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jvs.2025.05.022_bib146","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cca.2014.08.031","article-title":"Prognostic relevance of ischemia-modified albumin and NT-proBNP in patients with peripheral arterial occlusive disease","volume":"438","author":"Falkensammer","year":"2015","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jvs.2025.05.022_bib147","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jacc.2013.09.073","article-title":"Association between statin medications and mortality, major adverse cardiovascular event, and amputation-free survival in patients with critical limb ischemia","volume":"63","author":"Westin","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib148","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/00033197231161394","article-title":"Validation and comparison of the prognosis predicting ability of inflammation-based scores following endovascular treatment for peripheral artery disease","volume":"75","author":"Itagaki","year":"2024","journal-title":"Angiology"},{"key":"10.1016\/j.jvs.2025.05.022_bib149","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.atherosclerosis.2009.11.009","article-title":"Leukocyte count in peripheral arterial disease: a simple, reliable, inexpensive approach to cardiovascular risk prediction","volume":"210","author":"Giugliano","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2025.05.022_bib150","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.avsg.2019.03.035","article-title":"Impact of femoral ossification on local and systemic cardiovascular patients' condition","volume":"60","author":"Danvin","year":"2019","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib151","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3390\/biomedicines11030866","article-title":"Biomarkers of neutrophil activation in patients with symptomatic chronic peripheral artery disease predict worse cardiovascular outcome","volume":"11","author":"Buso","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jvs.2025.05.022_bib152","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jvs.2017.04.056","article-title":"Reduced high-density lipoprotein cholesterol: a valuable, independent prognostic marker in peripheral arterial disease","volume":"66","author":"Martinez-Aguilar","year":"2017","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib153","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12933-020-01123-3","article-title":"Sortilin levels correlate with major cardiovascular events of diabetic patients with peripheral artery disease following revascularization: a prospective study","volume":"19","author":"Biscetti","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jvs.2025.05.022_bib154","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ejvs.2017.02.012","article-title":"Toe pressure and toe brachial index are predictive of cardiovascular mortality, overall mortality, and amputation free survival in patients with peripheral artery disease","volume":"53","author":"Wickstr\u00f6m","year":"2017","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib155","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12872-020-01387-3","article-title":"Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study","volume":"20","author":"Moreno-Ajona","year":"2020","journal-title":"BMC Cardiovasc Disord"},{"key":"10.1016\/j.jvs.2025.05.022_bib156","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1016\/j.ejvsvf.2021.12.044","article-title":"Increased FVIII activity is associated with development of myocardial infarction in patients with peripheral artery disease within one year after endovascular or open procedures","volume":"54","author":"Suchkov","year":"2022","journal-title":"EJVES Vasc Forum"},{"key":"10.1016\/j.jvs.2025.05.022_bib157","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/1358863X231161655","article-title":"Nondipping blood pressure pattern predicts cardiovascular events and mortality in patients with atherosclerotic peripheral vascular disease","volume":"28","author":"Dahle","year":"2023","journal-title":"Vasc Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib158","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1177\/1358863X241240428","article-title":"Urinary vanin-1 as a novel biomarker for survival in peripheral artery disease","volume":"29","author":"Zierfuss","year":"2024","journal-title":"Vasc Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib159","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.jvs.2017.05.103","article-title":"Preoperative anemia associated with adverse outcomes after infrainguinal bypass surgery in patients with chronic limb-threatening ischemia","volume":"66","author":"Bodewes","year":"2017","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib160","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1055\/s-0038-1636543","article-title":"Angiopoietin-2 and survival in peripheral artery disease patients","volume":"118","author":"H\u00f6baus","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jvs.2025.05.022_bib161","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1210\/jc.2016-3717","article-title":"Statin therapy reduces future risk of lower-limb amputation in patients with diabetes and peripheral artery disease","volume":"102","author":"Hsu","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 106","key":"10.1016\/j.jvs.2025.05.022_bib162","first-page":"30","article-title":"Long term effectiveness and safety of initiating statin therapy after index revascularization in patients with peripheral arterial occlusive disease","volume":"50","author":"Behrendt","year":"2021","journal-title":"VASA Eur J Vasc Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib163","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021412","article-title":"Efficacy and safety of vorapaxar by intensity of background lipid-lowering therapy in patients with peripheral artery disease: insights from the TRA2P-TIMI 50 trial","volume":"10","author":"Gilchrist","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib164","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.29706","article-title":"Association of statin therapy with major adverse cardiovascular and limb outcomes in patients with end-stage kidney disease and peripheral artery disease receiving maintenance dialysis","volume":"5","author":"Lo","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jvs.2025.05.022_bib165","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001272.pub2","article-title":"Antiplatelet agents for intermittent claudication","author":"Wong","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jvs.2025.05.022_bib166","first-page":"21","article-title":"Rivaroxaban and aspirin in patients with symptomatic lower extremity peripheral artery disease: a subanalysis of the COMPASS randomized clinical trial","volume":"6","author":"Kaplovitch","year":"2021","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jvs.2025.05.022_bib167","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jvs.2015.01.051","article-title":"Association of dual-antiplatelet therapy with reduced major adverse cardiovascular events in patients with symptomatic peripheral arterial disease","volume":"62","author":"Armstrong","year":"2015","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib168","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.mayocp.2024.05.004","article-title":"Effects of colchicine on major adverse limb and cardiovascular events in patients with peripheral artery disease","volume":"99","author":"Lin","year":"2024","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jvs.2025.05.022_bib169","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s40256-018-0307-y","article-title":"Long-term effects of bosentan on cardiovascular events in hispanic patients with intermittent claudication: four-year follow-up of the CLAU trial: the CLAU randomized trial long-term outcome","volume":"19","author":"De Haro","year":"2019","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.jvs.2025.05.022_bib170","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.atherosclerosis.2011.09.016","article-title":"Impact of soluble TWEAK and CD163\/TWEAK ratio on long-term cardiovascular mortality in patients with peripheral arterial disease","volume":"219","author":"Urbonaviciene","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2025.05.022_bib171","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/circ.132.suppl_3.12428","article-title":"Efficacy of a risk reduction program to improve cardiovascular outcomes in patients with peripheral arterial disease: a propensity score-matched study","volume":"132","author":"Hussain","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2025.05.022_bib172","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/bjs.10460","article-title":"Assessment and validation of a novel angiographic scoring system for peripheral artery disease","volume":"104","author":"Morris","year":"2017","journal-title":"Br J Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib173","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.atherosclerosis.2017.07.023","article-title":"Crural Index and extensive atherosclerosis of crural vessels are associated with long-term cardiovascular mortality in patients with symptomatic peripheral artery disease","volume":"264","author":"Wickstr\u00f6m","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2025.05.022_bib174","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41598-019-52082-z","article-title":"Trimethylamine-N-Oxide (TMAO) predicts cardiovascular mortality in peripheral artery disease","volume":"9","author":"Roncal","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jvs.2025.05.022_bib175","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016573","article-title":"Association of health status scores with cardiovascular and limb outcomes in patients with symptomatic peripheral artery disease: insights from the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) trial","volume":"9","author":"Rymer","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib176","first-page":"34","article-title":"Association between omentin-1 and major cardiovascular events after lower extremity endovascular revascularization in diabetic patients: a prospective cohort study","volume":"8","author":"Biscetti","year":"2021","journal-title":"Eur J Case Rep Intern Med"},{"key":"10.1016\/j.jvs.2025.05.022_bib177","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031880","article-title":"Artificial intelligence of arterial Doppler waveforms to predict major adverse outcomes among patients evaluated for peripheral artery disease","volume":"13","author":"Mcbane","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jvs.2025.05.022_bib178","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ejvs.2022.10.045","article-title":"Plasma extracellular vesicle serpin G1 and CD14 levels are associated with major adverse cardiovascular events and major adverse limb events in patients undergoing femoral endarterectomy","volume":"65","author":"Verwer","year":"2023","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2025.05.022_bib179","doi-asserted-by":"crossref","first-page":"6902","DOI":"10.1038\/s41467-024-50994-7","article-title":"A platelet reactivity expression score derived from patients with peripheral artery disease predicts cardiovascular risk","volume":"15","author":"Berger","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jvs.2025.05.022_bib180","doi-asserted-by":"crossref","DOI":"10.1177\/17539447231194861","article-title":"Carotid total plaque area as an independent predictor of short-term subclinical polyvascular atherosclerosis progression and major adverse cardiac and cerebrovascular events","volume":"17","author":"Genkel","year":"2023","journal-title":"Ther Adv Cardiovasc Dis"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521425010948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521425010948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:22:41Z","timestamp":1760775761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521425010948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":180,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0741521425010948"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2025.05.022","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interpretable machine learning prediction model for major adverse cardiovascular events in patients with peripheral artery disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2025.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Society for Vascular Surgery. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}