{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:45:19Z","timestamp":1790351119813,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jvs.2025.09.030","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T22:57:43Z","timestamp":1758581863000},"page":"172-180.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical wound complications after major lower limb amputations for chronic limb-threatening ischemia"],"prefix":"10.1016","volume":"83","author":[{"given":"Mirva","family":"Virolainen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1644-2272","authenticated-orcid":false,"given":"Eszter","family":"Bako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-5202","authenticated-orcid":false,"given":"Milla","family":"Kallio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-6165","authenticated-orcid":false,"given":"Henrik","family":"Nuutinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Halonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Karjalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-0467","authenticated-orcid":false,"given":"Jussi M.","family":"K\u00e4rkk\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2025.09.030_bib1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(13)61249-0","article-title":"Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis","volume":"382","author":"Fowkes","year":"2013","journal-title":"Lancet"},{"issue":"1S","key":"10.1016\/j.jvs.2025.09.030_bib2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global vascular guidelines on the management of chronic limb-threatening ischemia","volume":"58","author":"Conte","year":"2019","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib3","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.jacc.2018.03.008","article-title":"Major adverse limb events and mortality in patients with peripheral artery disease: the COMPASS trial","volume":"71","author":"Anand","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2025.09.030_bib4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1001\/archsurg.139.4.395","article-title":"Major lower extremity amputation: outcome of a modern series","volume":"139","author":"Aulivola","year":"2004","journal-title":"Arch Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.atherosclerosis.2019.05.026","article-title":"Cost and inpatient burden of peripheral artery disease: findings from the national inpatient sample","volume":"286","author":"Kohn","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2025.09.030_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF03325220","article-title":"Predictors for institutionalization and prosthetic ambulation after major lower extremity amputation during an eight-year follow-up","volume":"21","author":"Remes","year":"2009","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.jvs.2025.09.030_bib7","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1177\/000313480807400707","article-title":"\"Successful outcome\" after below-knee amputation: an objective definition and influence of clinical variables","volume":"74","author":"Taylor","year":"2008","journal-title":"Am Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib8","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jvs.2017.08.061","article-title":"Risk factors for unplanned readmission and stump complications after major lower extremity amputation","volume":"67","author":"Phair","year":"2018","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib9","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jvs.2015.09.017","article-title":"Predictors of hospital readmissions after lower extremity amputations in Canada","volume":"63","author":"Kayssi","year":"2016","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib10","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.jvs.2014.05.050","article-title":"Risk factors and indications for readmission after lower extremity amputation in the American College of Surgeons National Surgical Quality Improvement Program","volume":"60","author":"Curran","year":"2014","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib11","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.jvs.2011.04.048","article-title":"Predictors of wound complications following major amputation for critical limb ischemia","volume":"54","author":"Hasanadka","year":"2011","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jamcollsurg.2012.12.041","article-title":"Risk factors for early failure of surgical amputations: an analysis of 8,878 isolated lower extremity amputation procedures","volume":"216","author":"O'Brien","year":"2013","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib13","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jamcollsurg.2011.05.019","article-title":"Risk factors for 30-day postoperative complications and mortality after below-knee amputation: a study of 2,911 patients from the national surgical quality improvement program","volume":"213","author":"Belmont","year":"2011","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib14","first-page":"83","article-title":"Mortality and reoperations following lower limb amputations","volume":"16","author":"Rosen","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.jvs.2025.09.030_bib15","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.amjsurg.2003.07.027","article-title":"Major lower extremity amputations at a veterans affairs hospital","volume":"186","author":"Cruz","year":"2003","journal-title":"Am J Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0741-5214(03)00092-2","article-title":"Functional outcome in a contemporary series of major lower extremity amputations","volume":"38","author":"Nehler","year":"2003","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.atherosclerosis.2018.11.007","article-title":"Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in young Finns study","volume":"280","author":"V\u00e4h\u00e4murto","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jvs.2025.09.030_bib18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.52312\/jdrs.2025.2030","article-title":"Risk factors and rates of revision amputation following ischemic lower major limb amputations: a 10-year retrospective analysis","volume":"36","author":"Sel\u00e7uk","year":"2025","journal-title":"Jt Dis Relat Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib19","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1177\/17085381211026498","article-title":"Popliteal artery patency is an indicator of ambulation and healing after below-knee amputation in vasculopaths","volume":"30","author":"Alfawaz","year":"2022","journal-title":"Vascular"},{"key":"10.1016\/j.jvs.2025.09.030_bib20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.avsg.2023.09.097","article-title":"Internal iliac artery patency as a predictor of above-knee amputation stump healing","volume":"102","author":"Aimanan","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib21","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jvs.2019.10.083","article-title":"Short-term contemporary outcomes for staged versus primary lower limb amputation in diabetic foot disease","volume":"72","author":"Cheun","year":"2020","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib22","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/15347346231198940","article-title":"Analysis of the factors of wound healing problems after transtibial amputation in diabetic patients","volume":"24","author":"Lee","year":"2025","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.jvs.2025.09.030_bib23","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.amjsurg.2012.11.018","article-title":"Corticosteroids and wound healing: clinical considerations in the perioperative period","volume":"206","author":"Wang","year":"2013","journal-title":"Am J Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib24","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1177\/0003134820964190","article-title":"5-Item modified frailty index predicts outcomes after below-knee amputation in the vascular quality initiative amputation registry","volume":"86","author":"Andersen","year":"2020","journal-title":"Am Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib25","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0741-5214(88)90106-1","article-title":"One-stage versus two-stage amputation for wet gangrene of the lower extremity: a randomized study","volume":"8","author":"Fisher","year":"1988","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jvs.2021.07.232","article-title":"Procedural and 12-month in-hospital costs of primary infra-popliteal bypass surgery, infrapopliteal best endovascular treatment, and major lower limb amputation for chronic limb threatening ischemia","volume":"75","author":"Popplewell","year":"2022","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2025.09.030_bib27","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jvs.2012.02.069","article-title":"Cost-effectiveness in the contemporary management of critical limb ischemia with tissue loss","volume":"56","author":"Barshes","year":"2012","journal-title":"J Vasc Surg"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074152142501763X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074152142501763X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T16:49:30Z","timestamp":1766076570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074152142501763X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S074152142501763X"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2025.09.030","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surgical wound complications after major lower limb amputations for chronic limb-threatening ischemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2025.09.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 THE AUTHOR(S). Published by Elsevier Inc. on behalf of the Society for Vascular Surgery.","name":"copyright","label":"Copyright"}]}}