{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:58:04Z","timestamp":1791892684459,"version":"4.3.4"},"reference-count":16,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jvs.2026.07.013","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:25:11Z","timestamp":1784676311000},"page":"1275-1284.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serotonergic antidepressant initiation associated with increased platelet inhibition variability after lower-extremity revascularization"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-1971","authenticated-orcid":false,"given":"Radha","family":"Bansal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shezan","family":"Fouzdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-9322","authenticated-orcid":false,"given":"Swechha","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6884-3117","authenticated-orcid":false,"given":"Tiffany","family":"Bellomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseman Bagheri","family":"Sheshdeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2354-7848","authenticated-orcid":false,"given":"Prajakta","family":"Lokhande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3349-4233","authenticated-orcid":false,"given":"Anahita","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvs.2026.07.013_bib1","article-title":"Depression and peripheral artery disease: a narrative review","volume":"17","author":"Giosdekos","year":"2025","journal-title":"Cureus"},{"key":"10.1016\/j.jvs.2026.07.013_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.avsg.2023.03.002","article-title":"Depression in patients with peripheral artery disease: an underdiagnosis with increased mortality","volume":"95","author":"Welch","year":"2023","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvs.2026.07.013_bib3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jvs.2006.11.057","article-title":"Depression is associated with worse patency and recurrent leg symptoms after lower extremity revascularization","volume":"45","author":"Cherr","year":"2007","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2026.07.013_bib4","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jvs.2022.09.008","article-title":"Association of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide","volume":"77","author":"Harris","year":"2023","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2026.07.013_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2024.111824","article-title":"Depression and anxiety symptoms are underestimated risk factors for postoperative prognosis in patients with type 2 diabetes and peripheral artery disease undergoing partial foot amputation","volume":"183","author":"Shalaeva","year":"2024","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.jvs.2026.07.013_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jvs.2023.09.001","article-title":"The association of comorbid depression with mortality and amputation risk in patients with chronic limb-threatening ischemia","volume":"79","author":"Zielke","year":"2024","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvs.2026.07.013_bib7","doi-asserted-by":"crossref","first-page":"E1550","DOI":"10.1073\/pnas.1720553115","article-title":"Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration","volume":"115","author":"Cloutier","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jvs.2026.07.013_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/07853890.2021.2017474","article-title":"Use of serotonin reuptake inhibitor antidepressants and the risk of bleeding complications in patients on anticoagulant or antiplatelet agents: a systematic review and meta-analysis","volume":"54","author":"Nochaiwong","year":"2022","journal-title":"Ann Med"},{"key":"10.1016\/j.jvs.2026.07.013_bib9","first-page":"335","article-title":"Predicting bleeding risk in PAD patients on antiplatelets using TEG coagulation testing","volume":"8","author":"Alvarez","year":"2025","journal-title":"J Surg Res"},{"key":"10.1016\/j.jvs.2026.07.013_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-022-06276-5","article-title":"Systematic review of studies using platelet serotonin content to assess bioeffect of serotonin reuptake inhibitors at the serotonin transporter","volume":"240","author":"Anderson","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jvs.2026.07.013_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1124\/molpharm.124.000881","article-title":"Allosteric inhibition and pharmacochaperoning of the serotonin transporter by the antidepressant drugs trazodone and nefazodone","volume":"106","author":"El-Kasaby","year":"2024","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jvs.2026.07.013_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/cts.70164","article-title":"Effect of selective serotonin reuptake inhibitors on coagulation: fact or fiction?","volume":"18","author":"Mokhtarian","year":"2025","journal-title":"Clin Transl Sci"},{"key":"10.1016\/j.jvs.2026.07.013_bib13","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.3208","article-title":"Concomitant use of selective serotonin reuptake inhibitors with oral anticoagulants and risk of major bleeding","volume":"7","author":"Rahman","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jvs.2026.07.013_bib14","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1161\/CIRCULATIONAHA.109.912550","article-title":"Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET\/OFFSET study","volume":"120","author":"Gurbel","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jvs.2026.07.013_bib15","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.jacc.2010.03.100","article-title":"Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO PLATELET substudy","volume":"56","author":"Storey","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jvs.2026.07.013_bib16","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1016\/j.jacc.2024.02.013","article-title":"2024 ACC\/AHA\/AACVPR\/APMA\/ABC\/SCAI\/SVM\/SVN\/SVS\/SIR\/VESS guideline for the management of lower extremity peripheral artery disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"83","author":"Gornik","year":"2024","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Vascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521426014473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741521426014473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:01:52Z","timestamp":1791889312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741521426014473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0741521426014473"],"URL":"https:\/\/doi.org\/10.1016\/j.jvs.2026.07.013","relation":{},"ISSN":["0741-5214"],"issn-type":[{"value":"0741-5214","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serotonergic antidepressant initiation associated with increased platelet inhibition variability after lower-extremity revascularization","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvs.2026.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Society for Vascular Surgery. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}