{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:17:50Z","timestamp":1775769470302,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvascsurgcases.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery Cases, Innovations and Techniques"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jvscit.2023.101292","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T21:48:24Z","timestamp":1691704104000},"page":"101292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total arch replacement using frozen elephant trunk and repair of bilateral subclavian artery aneurysms in a patient with type 2 Loeys-Dietz syndrome"],"prefix":"10.1016","volume":"9","author":[{"given":"Sheela T.","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maksim V.","family":"Gusev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anees J.","family":"Razzouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvscit.2023.101292_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A\u00a0syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.jvscit.2023.101292_bib2","doi-asserted-by":"crossref","first-page":"S757","DOI":"10.1016\/j.athoracsur.2006.10.091","article-title":"Early surgical experience with Loeys-Dietz: a new syndrome of aggressive thoracic aortic aneurysm disease","volume":"83","author":"Williams","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib3","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.1016\/j.jacc.2022.08.004","article-title":"2022 ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American heart association\/American college of cardiology joint committee on clinical practice guidelines","volume":"80","author":"Isselbacher","year":"2022","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.jvscit.2023.101292_bib4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.110.990549","article-title":"Increased vertebral artery tortuosity index is associated with adverse outcomes in children and young adults with connective tissue disorders","volume":"124","author":"Morris","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jvscit.2023.101292_bib5","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-beta receptor","volume":"355","author":"Loeys","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvscit.2023.101292_bib6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/gim.2014.11","article-title":"Loeys-Dietz syndrome: a primer for diagnosis and management","volume":"16","author":"MacCarrick","year":"2014","journal-title":"Genet Med"},{"key":"10.1016\/j.jvscit.2023.101292_bib7","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.athoracsur.2014.11.021","article-title":"Adult surgical experience with Loeys-Dietz syndrome","volume":"99","author":"Williams","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib8","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.athoracsur.2012.05.111","article-title":"Surgical experience with aggressive aortic pathologic process in Loeys-Dietz syndrome","volume":"94","author":"Iba","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib9","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.athoracsur.2011.06.090","article-title":"Midterm outcome of valve-sparing aortic root replacement in inherited connective tissue disorders","volume":"92","author":"Tanaka","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib10","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.athoracsur.2011.04.003","article-title":"Valve-sparing aortic root replacement in Loeys-Dietz syndrome","volume":"92","author":"Patel","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib11","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1161\/CIRCGENETICS.116.001485","article-title":"International registry of patients carrying TGFBR1 or TGFBR2 mutations: results of the MAC (Montalcino Aortic Consortium)","volume":"9","author":"Jondeau","year":"2016","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.jvscit.2023.101292_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5761\/atcs.oa.20-00223","article-title":"Surgical outcome and histological differences between individuals with TGFBR1 and TGFBR2 mutations in Loeys-Dietz Syndrome","volume":"27","author":"Seike","year":"2021","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib13","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jvs.2017.11.095","article-title":"Endovascular thoracic aortic repair in confirmed or suspected genetically triggered thoracic aortic dissection","volume":"68","author":"Shalhub","year":"2018","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib14","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jtcvs.2016.10.088","article-title":"Cardiovascular operations for Loeys-Dietz syndrome: intermediate-term results","volume":"153","author":"Patel","year":"2017","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib15","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.jtcvs.2019.07.130","article-title":"Management of the aortic arch in patients with Loeys-Dietz syndrome","volume":"160","author":"Schoenhoff","year":"2020","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jtcvs.2020.07.089","article-title":"The differences in surgical long-term outcomes between Marfan syndrome and Loeys-Dietz syndrome","volume":"164","author":"Seike","year":"2022","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jtcvs.2018.03.172","article-title":"Loeys-Dietz syndrome: intermediate-term outcomes of medically and surgically managed patients","volume":"157","author":"Aftab","year":"2019","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib18","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1111\/jocs.16855","article-title":"Long-term risk of arch complications in Loeys Dietz syndrome patients undergoing proximal ascending aortic replacement","volume":"37","author":"Weininger","year":"2022","journal-title":"J\u00a0Card Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib19","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jtcvs.2008.06.024","article-title":"Aortic decision-making in the Loeys-Dietz syndrome: aortic root aneurysm and a normal-caliber ascending aorta and aortic arch","volume":"138","author":"Augoustides","year":"2009","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtcvs.2020.08.019","article-title":"Commentary: how aggressive should we be in a prophylactic surgery for patients with Loeys-Dietz or Marfan syndrome?","volume":"164","author":"Yang","year":"2022","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib21","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/archsurg.1972.04180080184031","article-title":"Multiple arteriosclerotic arterial aneurysms","volume":"105","author":"Dent","year":"1972","journal-title":"Arch Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib22","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0741-5214(99)70102-3","article-title":"The epidemiology of surgically repaired aneurysms in the United States","volume":"30","author":"Lawrence","year":"1999","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib23","doi-asserted-by":"crossref","first-page":"396.e1","DOI":"10.1016\/j.avsg.2021.10.051","article-title":"Complex multi-stage total aortic and subclavian artery replacement in a 9-year old boy with Loeys-Dietz-Syndrome","volume":"80","author":"Dueppers","year":"2022","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytaa163","article-title":"Prosthetic graft replacement of a large subclavian aneurysm in a child with Loeys-Dietz syndrome: a case report","volume":"4","author":"Sobh","year":"2020","journal-title":"Eur Heart J Case Rep"},{"key":"10.1016\/j.jvscit.2023.101292_bib25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.avsg.2016.06.007","article-title":"Surgical management of peripheral vascular manifestations of Loeys-Dietz Syndrome","volume":"38","author":"Beaulieu","year":"2017","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jvs.2012.09.074","article-title":"Intrathoracic subclavian artery aneurysm repair in the thoracic endovascular aortic repair era","volume":"57","author":"Andersen","year":"2013","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejvs.2010.03.011","article-title":"Changing profiles of diagnostic and treatment options in subclavian artery aneurysms","volume":"40","author":"Vierhout","year":"2010","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib28","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1378\/chest.91.5.704","article-title":"Surgical treatment of aneurysms of the intrathoracic segment of the subclavian artery","volume":"91","author":"Coselli","year":"1987","journal-title":"Chest"},{"key":"10.1016\/j.jvscit.2023.101292_bib29","doi-asserted-by":"crossref","first-page":"101081","DOI":"10.1016\/j.jvscit.2022.11.018","article-title":"Operative repair of right intrathoracic subclavian artery aneurysms in patients with genetic arteriopathy","volume":"9","author":"French","year":"2023","journal-title":"J\u00a0Vasc Surg Cases Innov Tech"},{"key":"10.1016\/j.jvscit.2023.101292_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0003-4975(03)00459-4","article-title":"A\u00a0double patch sandwich technique for surgical repair of acute aortic dissection type A","volume":"76","author":"Fleck","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib31","doi-asserted-by":"crossref","first-page":"708","DOI":"10.21037\/cdt-22-330","article-title":"The frozen elephant trunk procedure: indications, outcomes and future directions","volume":"12","author":"Acharya","year":"2022","journal-title":"Cardiovasc Diagn Ther"},{"key":"10.1016\/j.jvscit.2023.101292_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.xjtc.2022.08.022","article-title":"Frozen elephant trunk aortic reconstruction in a patient with Loeys-Dietz syndrome","volume":"16","author":"Eldeiry","year":"2022","journal-title":"JTCVS Tech"},{"key":"10.1016\/j.jvscit.2023.101292_bib33","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.athoracsur.2020.02.017","article-title":"Distal stent graft-induced new entries after the frozen elephant trunk procedure","volume":"110","author":"Kreibich","year":"2020","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib34","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/ejcts\/ezt252","article-title":"Experience with the conventional and frozen elephant trunk techniques: a single-centre study","volume":"44","author":"Leontyev","year":"2013","journal-title":"Eur J Cardio Thorac Surg"},{"key":"10.1016\/j.jvscit.2023.101292_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jtcvs.2019.10.031","article-title":"Neurologic complications after the frozen elephant trunk procedure: a meta-analysis of more than 3000 patients","volume":"160","author":"Preventza","year":"2020","journal-title":"J\u00a0Thorac Cardiovasc Surg"}],"container-title":["Journal of Vascular Surgery Cases, Innovations and Techniques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468428723002010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468428723002010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:22:57Z","timestamp":1775766177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468428723002010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2468428723002010"],"URL":"https:\/\/doi.org\/10.1016\/j.jvscit.2023.101292","relation":{},"ISSN":["2468-4287"],"issn-type":[{"value":"2468-4287","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total arch replacement using frozen elephant trunk and repair of bilateral subclavian artery aneurysms in a patient with type 2 Loeys-Dietz syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery Cases, Innovations and Techniques","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvscit.2023.101292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc. on behalf of Society for Vascular Surgery.","name":"copyright","label":"Copyright"}],"article-number":"101292"}}