{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:37:00Z","timestamp":1773931020662,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["25POST1375561"],"award-info":[{"award-number":["25POST1375561"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130086"],"award-info":[{"award-number":["R01HL130086"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL156957"],"award-info":[{"award-number":["R01HL156957"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","jvsvs.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JVS-Vascular Science"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jvssci.2025.100396","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:47:19Z","timestamp":1764118039000},"page":"100396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Galectin-3 is dispensable for thoracic aortic aneurysmal formation and rupture in mice"],"prefix":"10.1016","volume":"7","author":[{"given":"Nithya","family":"Ramesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Downey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudheer Kumar","family":"Kanumuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-7717","authenticated-orcid":false,"given":"Venkateswaran","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvssci.2025.100396_bib1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.jtcvs.2024.07.020","article-title":"Longitudinal outcomes of thoracic endovascular aortic repair for ruptured thoracic aortic aneurysms","volume":"169","author":"Fiandeiro","year":"2025","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jvssci.2025.100396_bib2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00395-024-01053-1","article-title":"Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections","volume":"119","author":"Ganizada","year":"2024","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jvssci.2025.100396_bib3","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1161\/ATVBAHA.123.320402","article-title":"Beta-Aminopropionitrile induces distinct pathologies in the ascending and descending thoracic aortic regions of mice","volume":"44","author":"Franklin","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvssci.2025.100396_bib4","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/CIRCULATIONAHA.121.058173","article-title":"Second heart field-derived cells contribute to angiotensin II-Mediated ascending aortopathies","volume":"145","author":"Sawada","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jvssci.2025.100396_bib5","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.3390\/diagnostics13213348","article-title":"Galectin-3 as a prognostic biomarker in patients with first acute myocardial infarction without heart failure","volume":"13","author":"Vucic","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.jvssci.2025.100396_bib6","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.2147\/IJGM.S335300","article-title":"Correlation study of galectin-3 in patients with an ascending aortic aneurysm and ventricular remodeling before and after surgical correction","volume":"14","author":"Gu","year":"2021","journal-title":"Int J Gen Med"},{"key":"10.1016\/j.jvssci.2025.100396_bib7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tips.2023.06.001","article-title":"Targeting galectin-3 in inflammatory and fibrotic diseases","volume":"44","author":"Bouffette","year":"2023","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jvssci.2025.100396_bib8","doi-asserted-by":"crossref","first-page":"L784","DOI":"10.1152\/ajplung.00186.2018","article-title":"Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis","volume":"316","author":"Barman","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jvssci.2025.100396_bib9","first-page":"90","article-title":"Animal models, pathogenesis, and potential treatment of thoracic aortic aneurysm","volume":"25","author":"Wang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jvssci.2025.100396_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jvssci.2021.12.002","article-title":"Beta-aminopropionitrile-induced aortic aneurysm and dissection in mice","volume":"3","author":"Sawada","year":"2022","journal-title":"JVS Vasc Sci"},{"key":"10.1016\/j.jvssci.2025.100396_bib11","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.ejvs.2019.10.014","article-title":"Intermittent hypoxia alleviates beta-aminopropionitrile monofumarate induced thoracic aortic dissection in C57BL\/6 mice","volume":"59","author":"Yang","year":"2020","journal-title":"Eur J Vasc Endovascular Surg"},{"key":"10.1016\/j.jvssci.2025.100396_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/FJC.0b013e318235d5ea","article-title":"Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice","volume":"59","author":"Subramanian","year":"2012","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jvssci.2025.100396_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14719-9","article-title":"Calpain inhibition attenuates adipose tissue inflammation and fibrosis in diet-induced obese mice","volume":"7","author":"Muniappan","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jvssci.2025.100396_bib14","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1161\/ATVBAHA.120.315546","article-title":"Inducible depletion of Calpain-2 mitigates abdominal aortic aneurysm in mice","volume":"41","author":"Muniappan","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvssci.2025.100396_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1042\/CS20090372","article-title":"Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-\/- mice","volume":"118","author":"Daugherty","year":"2010","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jvssci.2025.100396_bib16","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/CIRCRESAHA.110.222844","article-title":"Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-\/- mice","volume":"108","author":"Rateri","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.jvssci.2025.100396_bib17","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1164\/rccm.201711-2308LE","article-title":"Galectin-3 promotes vascular remodeling and contributes to pulmonary hypertension","volume":"197","author":"Barman","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jvssci.2025.100396_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cytogfr.2024.10.002","article-title":"Central role of galectin-3 at the cross-roads of cardiac inflammation and fibrosis: implications for heart failure and transplantation","volume":"80","author":"Seropian","year":"2024","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jvssci.2025.100396_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10974-012-9283-z","article-title":"Structure and dynamics of the actin-based smooth muscle contractile and cytoskeletal apparatus","volume":"33","author":"Lehman","year":"2012","journal-title":"J Muscle Res Cell Motil"},{"key":"10.1016\/j.jvssci.2025.100396_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13697","article-title":"The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections","volume":"52","author":"Rombouts","year":"2022","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jvssci.2025.100396_bib21","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.1161\/ATVBAHA.123.319476","article-title":"Galectin-3 mediates vascular dysfunction in obesity by regulating NADPH oxidase 1","volume":"43","author":"Padgett","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvssci.2025.100396_bib22","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1161\/ATVBAHA.120.314252","article-title":"Galectin-3 identifies a subset of macrophages with a potential beneficial role in atherosclerosis","volume":"40","author":"Di Gregoli","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jvssci.2025.100396_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2024.100155","article-title":"Tissue material properties, whole-bone morphology and mechanical behavior in the Fbn1 (C1041G\/+) mouse model of Marfan syndrome","volume":"23","author":"Zimmermann","year":"2024","journal-title":"Matrix Biol Plus"}],"container-title":["JVS-Vascular Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666350325001178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666350325001178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:48:48Z","timestamp":1773920928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666350325001178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":23,"alternative-id":["S2666350325001178"],"URL":"https:\/\/doi.org\/10.1016\/j.jvssci.2025.100396","relation":{},"ISSN":["2666-3503"],"issn-type":[{"value":"2666-3503","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Galectin-3 is dispensable for thoracic aortic aneurysmal formation and rupture in mice","name":"articletitle","label":"Article Title"},{"value":"JVS-Vascular Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvssci.2025.100396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of the Society for Vascular Surgery.","name":"copyright","label":"Copyright"}],"article-number":"100396"}}