{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:26:45Z","timestamp":1770744405868,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":1255,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvsvenous.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery: Venous and Lymphatic Disorders"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jvsv.2019.11.015","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T01:26:31Z","timestamp":1581643591000},"page":"734-740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Role of an age-adjusted D-dimer cutoff level in the diagnosis algorithm of lower limb deep venous thrombosis in outpatients"],"prefix":"10.1016","volume":"8","author":[{"given":"Xavier","family":"Jimenez-Guiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Romera-Villegas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malka","family":"Huici-Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Martinez-Rico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Vila-Coll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvsv.2019.11.015_bib1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrcardio.2015.83","article-title":"Epidemiology of venous thromboembolism","volume":"12","author":"Heit","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jvsv.2019.11.015_bib2","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMoa023153","article-title":"Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis","volume":"349","author":"Wells","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jvsv.2019.11.015_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12959-016-0120-2","article-title":"Pathways for outpatient management of venous thromboembolism in a UK centre","volume":"14","author":"Condliffe","year":"2016","journal-title":"Thromb J"},{"key":"10.1016\/j.jvsv.2019.11.015_bib4","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/00365513.2017.1390783","article-title":"Age-adjusted D-dimer cut-off in the diagnostic strategy for deep vein thrombosis: a systematic review","volume":"77","author":"Nybo","year":"2017","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.jvsv.2019.11.015_bib5","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3324\/haematol.2011.060657","article-title":"Using an age-dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded","volume":"97","author":"Douma","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.jvsv.2019.11.015_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3324\/haematol.2012.072231","article-title":"The use of age-dependent D-dimer cut-off values to exclude deep vein thrombosis","volume":"97","author":"Hamblin","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.jvsv.2019.11.015_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/ijlh.12184","article-title":"D-dimer use for deep venous thrombosis exclusion in elderly patients: a comparative analysis of three different approaches to establish cut-off values for an assay with results expressed in D-dimer units","volume":"36","author":"Cini","year":"2014","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.jvsv.2019.11.015_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.thromres.2016.08.011","article-title":"Predicting the need for further thrombosis diagnostics in suspected DVT is increased by using age adjusted D-dimer values","volume":"145","author":"Broen","year":"2016","journal-title":"Thromb Res"},{"key":"10.1016\/j.jvsv.2019.11.015_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1538-7836.2011.04564.x","article-title":"Isolated distal deep vein thrombosis: what we know and what we are doing","volume":"10","author":"Palareti","year":"2011","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jvsv.2019.11.015_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.thromres.2014.03.033","article-title":"Two years outcome of isolated distal deep vein thrombosis","volume":"134","author":"Sartori","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.jvsv.2019.11.015_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chest.2015.11.026","article-title":"Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report","volume":"149","author":"Kearon","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.jvsv.2019.11.015_bib12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jvs.2007.04.040","article-title":"Short-term and mid-term outcome of isolated symptomatic muscular calf vein thrombosis","volume":"46","author":"Gillet","year":"2007","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvsv.2019.11.015_bib13","first-page":"132","article-title":"Thrombose veineuse musculaire du mollet et embolie pulmonaire","volume":"24","author":"Guias","year":"1999","journal-title":"J\u00a0Mal Vasc"},{"key":"10.1016\/j.jvsv.2019.11.015_bib14","first-page":"66","article-title":"Sonographic diagnosis of thrombosis of the calf muscle veins and the risk of pulmonary embolism","volume":"21","author":"Hollerweger","year":"2000","journal-title":"Ultraschall Med"},{"key":"10.1016\/j.jvsv.2019.11.015_bib15","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/000331979804901008","article-title":"Pulmonary embolism in patients with isolated soleal vein thrombosis","volume":"49","author":"Ohgi","year":"1998","journal-title":"Angiology"},{"key":"10.1016\/j.jvsv.2019.11.015_bib16","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(97)08140-3","article-title":"Value of assessment of pretest probability of deep-vein thrombosis in clinical management","volume":"350","author":"Wells","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jvsv.2019.11.015_bib17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2141.2003.04723.x","article-title":"The diagnosis of deep vein thrombosis in symptomatic outpatients and the potential for clinical assessment and D-dimer assays to reduce the need for diagnostic imaging","volume":"124","author":"Keeling","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jvsv.2019.11.015_bib18","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1136\/bmj.c1475","article-title":"Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts","volume":"340","author":"Douma","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jvsv.2019.11.015_bib19","series-title":"Statistical methods in diagnostic medicine","author":"Zhou","year":"2011"},{"key":"10.1016\/j.jvsv.2019.11.015_bib20","series-title":"R: a language and environment for statistical computing","year":"2018"},{"key":"10.1016\/j.jvsv.2019.11.015_bib21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jvs.2011.05.092","article-title":"The controversy of managing calf vein thrombosis","volume":"55","author":"Masuda","year":"2012","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvsv.2019.11.015_bib22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jvs.2011.09.087","article-title":"A\u00a0meta-analysis of anticoagulation for calf deep venous thrombosis","volume":"56","author":"De Martino","year":"2012","journal-title":"J\u00a0Vasc Surg"},{"key":"10.1016\/j.jvsv.2019.11.015_bib23","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1111\/jth.13424","article-title":"Questioning the use of an age-adjusted D-dimer threshold to exclude venous thromboembolism: analysis of individual patient data from two diagnostic studies","volume":"14","author":"Takach Lapner","year":"2016","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jvsv.2019.11.015_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0268355517718762","article-title":"Age-adjusted D-dimer for the diagnosis of deep vein thrombosis","volume":"33","author":"G\u00f3mez-Jabalera","year":"2018","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2019.11.015_bib25","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.thromres.2009.07.013","article-title":"Multicenter evaluation of a new quantitative highly sensitive D-dimer assay, the Hemosil D-dimer HS 500, in patients with clinically suspected venous thromboembolism","volume":"125","author":"Legnani","year":"2010","journal-title":"Thromb Res"},{"key":"10.1016\/j.jvsv.2019.11.015_bib26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.7326\/0003-4819-138-10-200305200-00006","article-title":"A\u00a0diagnostic strategy involving a quantitative latex D-dimer assay reliably excludes deep venous thrombosis","volume":"138","author":"Bates","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jvsv.2019.11.015_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/MBC.0000000000000020","article-title":"Comparison of five D-dimer reagents and application of an age-adjusted cut-off for the diagnosis of venous thromboembolism in emergency department","volume":"25","author":"Mullier","year":"2014","journal-title":"Blood Coagul Fibrinolysis"}],"container-title":["Journal of Vascular Surgery: Venous and Lymphatic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213333X19306389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213333X19306389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T07:00:16Z","timestamp":1761980416000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213333X19306389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S2213333X19306389"],"URL":"https:\/\/doi.org\/10.1016\/j.jvsv.2019.11.015","relation":{},"ISSN":["2213-333X"],"issn-type":[{"value":"2213-333X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of an age-adjusted D-dimer cutoff level in the diagnosis algorithm of lower limb deep venous thrombosis in outpatients","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery: Venous and Lymphatic Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvsv.2019.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 by the Society for Vascular Surgery. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}