{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:33:20Z","timestamp":1793306000071,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvsvenous.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery: Venous and Lymphatic Disorders"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jvsv.2026.102468","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:25:19Z","timestamp":1772583919000},"page":"102468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combined treatment of deep and superficial venous reflux accelerates ulcer healing and improves symptoms: A real-world retrospective study"],"prefix":"10.1016","volume":"14","author":[{"given":"Wei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongheng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changbao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3415-8400","authenticated-orcid":false,"given":"Yingfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvsv.2026.102468_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCULATIONAHA.113.006898","article-title":"Chronic venous insufficiency","volume":"130","author":"Eberhardt","year":"2014","journal-title":"Circulation"},{"issue":"Suppl 1","key":"10.1016\/j.jvsv.2026.102468_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s40261-023-01264-9","article-title":"Quality of life in chronic venous disease: bridging the gap between patients and physicians","volume":"43","author":"Santiago","year":"2023","journal-title":"Clin Drug Investig"},{"key":"10.1016\/j.jvsv.2026.102468_bib3","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jvs.2003.12.007","article-title":"Relationship between clinical classification of chronic venous disease and patient-reported quality of life","volume":"39","author":"Kahn","year":"2004","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jvsv.2019.12.075","article-title":"The 2020 update of the CEAP classification system and reporting standards","volume":"8","author":"Lurie","year":"2020","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102468_bib5","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.jvs.2010.06.161","article-title":"Revision of the venous clinical severity score: venous outcomes consensus statement","volume":"52","author":"Vasquez","year":"2010","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib6","first-page":"268","article-title":"Correlation of venous clinical severity score and clinical, etiological, anatomical and pathophysiological classification with quality of life in patients with varicose veins","volume":"9","author":"Mallick","year":"2020","journal-title":"J Fam Med Prim Care"},{"key":"10.1016\/j.jvsv.2026.102468_bib7","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1002\/bjs.7555","article-title":"Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins","volume":"98","author":"Rasmussen","year":"2011","journal-title":"Br J Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib8","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1056\/NEJMoa1400781","article-title":"A randomized trial comparing treatments for varicose veins","volume":"371","author":"Brittenden","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvsv.2026.102468_bib9","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1056\/NEJMoa1805186","article-title":"Five-year outcomes of a randomized trial of treatments for varicose veins","volume":"381","author":"Brittenden","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvsv.2026.102468_bib10","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1056\/NEJMoa1801214","article-title":"A randomized trial of early endovenous ablation in venous ulceration","volume":"378","author":"Gohel","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jvsv.2026.102468_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/wrr.13065","article-title":"Iliac vein recanalisation and stenting accelerate healing of venous leg ulcers associated with severe venous outflow obstruction","volume":"31","author":"Ruiz","year":"2023","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jvsv.2026.102468_bib12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.avsg.2021.05.026","article-title":"Deep venous stenting improves healing of lower extremity venous ulcers","volume":"78","author":"Pantoja","year":"2022","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.avsg.2015.11.036","article-title":"Iliac vein interrogation augments venous ulcer healing in patients who have failed standard compression therapy along with pathological venous closure","volume":"34","author":"Mousa","year":"2016","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.124.014160","article-title":"Consensus statement on the management of nonthrombotic iliac vein lesions from the VIVA Foundation, the American Venous Forum, and the American Vein and Lymphatic Society","volume":"17","author":"Desai","year":"2024","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jvsv.2026.102468_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jvsv.2022.11.001","article-title":"The complex relationship between deep and superficial venous reflux in the lower extremity","volume":"11","author":"Scovell","year":"2023","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102468_bib16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jvsv.2020.04.031","article-title":"Effect of concomitant deep venous reflux on truncal endovenous ablation outcomes in the Vascular Quality Initiative","volume":"9","author":"Brown","year":"2021","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102468_bib17","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jvs.2010.10.120","article-title":"Incidence of and risk factors for iliocaval venous obstruction in patients with active or healed venous leg ulcers","volume":"53","author":"Marston","year":"2011","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1053\/ejvs.2002.1894","article-title":"Role of superficial venous surgery in patients with combined superficial and segmental deep venous reflux","volume":"25","author":"Adam","year":"2003","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib19","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jvsv.2023.07.003","article-title":"Systematic review and meta-analysis of deep venous reflux correction in chronic venous insufficiency","volume":"11","author":"Maleti","year":"2023","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102468_bib20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.avsg.2023.08.043","article-title":"The effect of superficial venous incompetence treatment on combined segmental deep venous reflux","volume":"100","author":"Korany","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1445-1433.2003.02703.x","article-title":"Deep venous valve reconstruction for non-healing leg ulcers","volume":"74","author":"Tripathi","year":"2004","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/096721099500300207","article-title":"Deep venous valve reconstruction","volume":"3","author":"Kistner","year":"1995","journal-title":"Cardiovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib23","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0741-5214(94)70066-4","article-title":"Long-term results of venous valve reconstruction: a four- to twenty-one-year follow-up","volume":"19","author":"Masuda","year":"1994","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ejvs.2007.09.007","article-title":"Deep venous reconstructions: long-term outcome in patients with primary or post-thrombotic deep venous incompetence","volume":"35","author":"Lehtola","year":"2008","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib25","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jvs.2005.11.020","article-title":"Reduction in deep vein reflux after concomitant subfascial endoscopic perforating vein surgery and superficial vein ablation in advanced primary chronic venous insufficiency","volume":"43","author":"Ting","year":"2006","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib26","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jvsv.2019.09.016","article-title":"Treatment of superficial and perforator reflux and deep venous stenosis improves healing of chronic venous leg ulcers","volume":"8","author":"Lawrence","year":"2020","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102468_bib27","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF00439228","article-title":"Construction and validation of a quality of life questionnaire in chronic lower limb venous insufficiency (CIVIQ)","volume":"5","author":"Launois","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.jvsv.2026.102468_bib28","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ejvs.2010.03.034","article-title":"International psychometric validation of the chronic venous disease quality of life questionnaire (CIVIQ-20)","volume":"40","author":"Launois","year":"2010","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib29","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.ejvs.2011.04.007","article-title":"Validation of the chronic venous insufficiency quality of life questionnaire in Dutch patients treated for varicose veins","volume":"42","author":"Biemans","year":"2011","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib30","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejvs.2021.12.024","article-title":"Editor\u2019s Choice\u2014European Society for Vascular Surgery (ESVS) 2022 clinical practice guidelines on the management of chronic venous disease of the lower limbs","volume":"63","author":"De Maeseneer","year":"2022","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102468_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jvsv.2022.09.004","volume":"11","author":"Gloviczki","year":"2023","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102468_bib32","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jvs.2008.03.039","article-title":"The importance of deep venous reflux velocity as a determinant of outcome in patients with combined superficial and deep venous reflux treated with endovenous saphenous ablation","volume":"48","author":"Marston","year":"2008","journal-title":"J Vasc Surg"}],"container-title":["Journal of Vascular Surgery: Venous and Lymphatic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213333X26000284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213333X26000284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:24:17Z","timestamp":1793305457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213333X26000284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2213333X26000284"],"URL":"https:\/\/doi.org\/10.1016\/j.jvsv.2026.102468","relation":{},"ISSN":["2213-333X"],"issn-type":[{"value":"2213-333X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined treatment of deep and superficial venous reflux accelerates ulcer healing and improves symptoms: A real-world retrospective study","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery: Venous and Lymphatic Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvsv.2026.102468","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of the Society for Vascular Surgery.","name":"copyright","label":"Copyright"}],"article-number":"102468"}}