{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:33:34Z","timestamp":1793306014737,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jvsvenous.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Vascular Surgery: Venous and Lymphatic Disorders"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jvsv.2026.102490","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:24:18Z","timestamp":1774052658000},"page":"102490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of cyanoacrylate ablation vs endovenous radiofrequency ablation for varicose veins in chronic great saphenous vein insufficiency: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1511-2528","authenticated-orcid":false,"given":"Xin","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jvsv.2026.102490_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCULATIONAHA.113.006898","article-title":"Chronic venous insufficiency","volume":"130","author":"Eberhardt","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jvsv.2026.102490_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1177\/1708538116648035","article-title":"Which endovenous ablation method does offer a better long-term technical success in the treatment of the incompetent great saphenous vein? Review","volume":"24","author":"Balint","year":"2016","journal-title":"Vascular"},{"key":"10.1016\/j.jvsv.2026.102490_bib3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-024813","article-title":"Endovenous ablation and surgery in great saphenous vein reflux: a systematic review and network meta-analysis of randomised controlled trials protocol","volume":"9","author":"Siribumrungwong","year":"2019","journal-title":"BMJ open"},{"key":"10.1016\/j.jvsv.2026.102490_bib4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/0268355519885471","article-title":"Assessment and grading of pigmentation in chronic venous insufficiency","volume":"35","author":"Tiwary","year":"2020","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib5","doi-asserted-by":"crossref","DOI":"10.1201\/9781003328971","volume":"12","author":"Gloviczki","year":"2024","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejvs.2021.12.024","article-title":"Editor\u2019s choice - european society for vascular surgery (ESVS) 2022 clinical practice guidelines on the management of chronic venous disease of the lower limbs","volume":"63","author":"De Maeseneer","year":"2022","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1258\/phleb.2012.012s21","article-title":"Complications of radiofrequency ablation of varicose veins","volume":"27","author":"Anwar","year":"2012","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1258\/phleb.2012.012s18","article-title":"Complications of endovenous lasers","volume":"27","author":"Dexter","year":"2012","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0268355515593186","article-title":"The advent of non-thermal, non-tumescent techniques for treatment of varicose veins","volume":"31","author":"Bootun","year":"2016","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib10","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jvs.2014.11.071","article-title":"Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose)","volume":"61","author":"Morrison","year":"2015","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.ejvs.2018.05.028","article-title":"A randomised clinical trial comparing N-butyl cyanoacrylate, radiofrequency ablation and endovenous laser ablation for the treatment of superficial venous incompetence: two year follow up results","volume":"56","author":"Eroglu","year":"2018","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jvsv.2014.09.001","article-title":"The European multicenter cohort study on cyanoacrylate embolization of refluxing great saphenous veins","volume":"3","author":"Proebstle","year":"2015","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib13","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.jvsv.2026.102490_bib14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.avsg.2023.08.016","article-title":"Outcomes of cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins","volume":"98","author":"Alhewy","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib15","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.jvs.2018.09.007","article-title":"A randomised clinical trial comparing N-butyl cyanoacrylate, radiofrequency ablation and endovenous laser ablation for the treatment of superficial venous incompetence: two year follow up results","volume":"68","author":"Eroglu","year":"2018","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib16","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.jvsv.2019.12.080","article-title":"Five-year extension study of patients from a randomized clinical trial (VeClose) comparing cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins","volume":"8","author":"Morrison","year":"2020","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jvsv.2016.12.005","article-title":"VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins","volume":"5","author":"Morrison","year":"2017","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib18","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jvsv.2018.04.009","article-title":"Twenty-four month results from a randomized trial of cyanoacrylate closure versus radiofrequency ablation for the treatment of incompetent great saphenous veins","volume":"6","author":"Gibson","year":"2018","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/0268355518810259","article-title":"Comparison of cyanoacrylate closure and radiofrequency ablation for the treatment of incompetent great saphenous veins: 36-month outcomes of the VeClose randomized controlled trial","volume":"34","author":"Morrison","year":"2019","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/0268355520947292","article-title":"Comparative efficacy and life quality effects of surgical stripping, radiofrequency ablation, and cyanoacrylate embolization in patients undergoing treatment for great saphenous vein insufficiency","volume":"36","author":"Ay","year":"2021","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib21","article-title":"Clinical outcomes of cyanoacrylate closure versus radiofrequency ablation for saphenous varicose veins: a single-center retrospective study","volume":"2025","author":"Kamikawa","year":"2025","journal-title":"Int J Vasc Med"},{"key":"10.1016\/j.jvsv.2026.102490_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.avsg.2023.09.088","article-title":"A comparison of venaseal versus radiofrequency ablation outcomes within a managed care organization","volume":"99","author":"Lim","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib23","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1016\/j.ejvs.2024.10.025","article-title":"Clinical outcomes of nonthermal ablation, thermal ablation, and surgical stripping for varicose veins","volume":"68","author":"Kim","year":"2024","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.avsg.2023.12.076","article-title":"Comparison of radiofrequency ablation and cyanoacrylate closure for large-diameter great saphenous vein insufficiency","volume":"103","author":"Kavala","year":"2024","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib25","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.jvsv.2022.05.009","article-title":"Thrombotic complications after radiofrequency and cyanoacrylate endovenous ablation: outcomes of a multicenter real-world experience","volume":"10","author":"O\u2019Banion","year":"2022","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jvsv.2021.10.009","article-title":"Long-term outcomes of endovenous laser ablation, n-butyl cyanoacrylate, and radiofrequency ablation for treatment of chronic venous insufficiency","volume":"10","author":"El Kilic","year":"2022","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib27","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jvsv.2021.09.001","article-title":"Comparative analysis of the results of cyanoacrylate ablation and radiofrequency ablation in the treatment of venous insufficiency","volume":"10","author":"Daylan","year":"2022","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib28","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1177\/17085381211026154","article-title":"Early period results of radiofrequency ablation and cyanoacrylate embolization for great saphenous vein insufficiency","volume":"30","author":"Balc\u0131","year":"2022","journal-title":"Vascular"},{"key":"10.1016\/j.jvsv.2026.102490_bib29","first-page":"94","article-title":"What is the optimal treatment technique for great saphenous vein diameter of \u226510 mm? Comparison of five different approaches","volume":"121","author":"Kubat","year":"2021","journal-title":"Acta Chir Belg"},{"key":"10.1016\/j.jvsv.2026.102490_bib30","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.4328\/ACAM.20335","article-title":"The comparison of radiofrequency and cyanoacrylate embolization therapy in vena saphena magna ablation","volume":"12","author":"Er","year":"2021","journal-title":"Ann Clin Anal Med"},{"key":"10.1016\/j.jvsv.2026.102490_bib31","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1177\/0268355518794105","article-title":"Comparison of cyanoacrylate embolization and radiofrequency ablation for the treatment of varicose veins","volume":"34","author":"Yang","year":"2019","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jvsv.2018.10.019","article-title":"Twelve-month efficacy and complications of cyanoacrylate embolization compared with radiofrequency ablation for incompetent great saphenous veins","volume":"7","author":"Oval\u0131","year":"2019","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib33","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jvsv.2018.12.017","article-title":"Single-center retrospective review of early outcomes of radiofrequency ablation versus cyanoacrylate ablation of isolated great saphenous vein insufficiency","volume":"7","author":"Bademci","year":"2019","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib34","article-title":"Clinical outcomes of nonthermal ablation, thermal ablation, and surgical stripping for varicose veins","volume":"12","author":"Kim","year":"2024","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.avsg.2024.11.101","article-title":"Real-world safety and efficiency of treating symptomatic varicose veins with endovenous closure of great, small, and anterior accessory veins using cyanoacrylate glue (VenaSealTM): a single-surgeon multicenter retrospective study","volume":"112","author":"Lu","year":"2025","journal-title":"Ann Vasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib36","first-page":"1322","article-title":"Persistent iliac vein thrombosis after cyanoacrylate closure of the great saphenous vein","volume":"18","author":"Gressenberger","year":"2020","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.jvsv.2026.102490_bib37","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jvsv.2020.01.009","article-title":"Incidence, classification, and risk factors of endovenous glue-induced thrombosis after cyanoacrylate closure of the incompetent saphenous vein","volume":"8","author":"Cho","year":"2020","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib38","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.jvsv.2023.03.018","article-title":"Cyanoacrylate glue reactions: a systematic review, cases, and proposed mechanisms","volume":"11","author":"Athavale","year":"2023","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/0268355519878618","article-title":"Frequency and severity of hypersensitivity reactions in patients after VenaSealTM cyanoacrylate treatment of superficial venous insufficiency","volume":"35","author":"Gibson","year":"2020","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib40","article-title":"Safety assessment of cyanoacrylate closure for treatment of varicose veins in a large-scale national survey in Japan","volume":"13","author":"Umetsu","year":"2025","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib41","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/02683555211008762","article-title":"A systematic review and meta-analysis comparing the efficacy of cyanoacrylate ablation over endovenous thermal ablation for treating incompetent saphenous veins","volume":"36","author":"Guo","year":"2021","journal-title":"Phlebology"},{"key":"10.1016\/j.jvsv.2026.102490_bib42","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jvsv.2019.09.010","article-title":"Systematic review and meta-analysis of endovenous cyanoacrylate adhesive ablation for incompetent saphenous veins","volume":"8","author":"Garc\u00eda-Carpintero","year":"2020","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"key":"10.1016\/j.jvsv.2026.102490_bib43","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1097\/DSS.0000000000003061","article-title":"Comparison between cyanoacrylate embolization and radiofrequency ablation for superficial venous incompetence: a systematic review and meta-analysis","volume":"47","author":"Chen","year":"2021","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib44","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ejvs.2015.02.007","article-title":"Editor\u2019s choice - management of chronic venous disease: clinical practice guidelines of the European Society for Vascular Surgery (ESVS)","volume":"49","author":"Wittens","year":"2015","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1016\/j.jvsv.2026.102490_bib45","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1016\/j.jvs.2011.01.079","article-title":"The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum","volume":"53","author":"Gloviczki","year":"2011","journal-title":"J Vasc Surg"}],"container-title":["Journal of Vascular Surgery: Venous and Lymphatic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213333X26000508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213333X26000508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:25:08Z","timestamp":1793305508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213333X26000508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2213333X26000508"],"URL":"https:\/\/doi.org\/10.1016\/j.jvsv.2026.102490","relation":{},"ISSN":["2213-333X"],"issn-type":[{"value":"2213-333X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of cyanoacrylate ablation vs endovenous radiofrequency ablation for varicose veins in chronic great saphenous vein insufficiency: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Vascular Surgery: Venous and Lymphatic Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jvsv.2026.102490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of the Society for Vascular Surgery.","name":"copyright","label":"Copyright"}],"article-number":"102490"}}